Leptin enhances the invasive ability of glioma stem-like cells depending on leptin receptor expression

Brain Research

Volumn 1543, Issue , 2014, Pages 1-8

  Han, Guosheng ^a   Zhao, Wenyuan ^a   Wang, Laixing ^a   Yue, Zhijian ^a   Zhao, Rui ^a   Li, Yanan ^a   Zhou, Xiaoping ^a   Hu, Xiaowu ^a   Liu, Jianmin ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Glioma stem like cells; Invasion; Leptin; Leptin receptor

Indexed keywords

ADIPOCYTOKINE; CD133 ANTIGEN; LEPTIN; LEPTIN RECEPTOR; STAT3 PROTEIN;

ARTICLE; BIOACCUMULATION; CONTROLLED STUDY; GLIOBLASTOMA; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; STEM CELL; TUMOR CELL; TUMOR INVASION; TUMOR RECURRENCE;

GLIOMA STEM-LIKE CELLS; INVASION; LEPTIN; LEPTIN RECEPTOR;

ANTIGENS, CD; BRAIN NEOPLASMS; CELL MOVEMENT; CHROMONES; COLONY-FORMING UNITS ASSAY; ENZYME INHIBITORS; GENE EXPRESSION REGULATION, NEOPLASTIC; GLIOMA; GLYCOPROTEINS; HUMANS; LEPTIN; MATRIX METALLOPROTEINASE 9; MORPHOLINES; NEOPLASM INVASIVENESS; NEOPLASTIC STEM CELLS; ORGANIC CHEMICALS; PEPTIDES; RECEPTORS, LEPTIN; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR; TUMOR CELLS, CULTURED;

EID: 84891740429     PISSN: 00068993     EISSN: 18726240     Source Type: Journal    
DOI: 10.1016/j.brainres.2013.10.027     Document Type: Article

References (35)

1. S. Attoub et al. Leptin promotes invasiveness of kidney and colonic epithelial cells via phosphoinositide 3-kinase-, rho-, and rac-dependent signaling pathways Faseb J 14 2000 2329 2338
2. F. Bianchini, R. Kaaks, and H. Vainio Overweight, obesity, and cancer risk Lancet Oncol. 3 2002 565 574
3. E.E. Calle et al. Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults N Engl J Med. 348 2003 1625 1638
4. G. Fava et al. Leptin enhances cholangiocarcinoma cell growth Cancer Res. 68 2008 6752 6761
5. D.E. Feldman et al. Proc Natl Acad Sci USA 109 2012 829 834
6. K.A. Frankenberry et al. Leptin induces cell migration and the expression of growth factors in human prostate cancer cells Am J Surg 188 2004 560 565
7. K.A. Frankenberry et al. Leptin receptor expression and cell signaling in breast cancer Int J Oncol 28 2006 985 993
8. J.M. Friedman, and J.L. Halaas Leptin and the regulation of body weight in mammals Nature 395 1998 763 770
9. J. Gao et al. Leptin induces functional activation of cyclooxygenase-2 through JAK2/STAT3, MAPK/ERK, and PI3K/AKT pathways in human endometrial cancer cells Cancer Sci. 100 2009 389 395
10. O.A. Guryanova et al. Nonreceptor tyrosine kinase BMX maintains self-renewal and tumorigenic potential of glioblastoma stem cells by activating STAT3 Cancer Cell 19 2011 498 511
11. G. Han et al. Leptin promotes human glioblastoma growth through activating signal transducers and activators of transcription 3 signaling Brain Res Bull. 87 2012 274 279
12. C.Y. Huang et al. Leptin increases motility and integrin up-regulation in human prostate cancer cells J. Cell Physiol. 226 2011 1274 1282
13. A. Inoue et al. Cancer stem-like cells of glioblastoma characteristically express MMP-13 and display highly invasive activity Int. J. Oncol. 37 2010 1121 1131
14. H. Jiang et al. Upregulation of survivin by leptin/STAT3 signaling in MCF-7 cells Biochem Biophys Res Commun 368 2008 1 5
15. M.M. Kamal et al. REST regulates oncogenic properties of glioblastoma stem cells Stem Cells 30 2012 405 414
16. J.E. Lawrence et al. Leptin promotes glioblastoma Neurol. Res. Int. 2012 870807
17. S. Liu et al. Expression of intercellular adhesion molecule 1 by hepatocellular carcinoma stem cells and circulating tumor cells Gastroenterology 144 2013 1031 1041 (e10)
18. D.N. Louis et al. The 2007 WHO classification of tumours of the central nervous system Acta Neuropathol 114 2007 97 109
19. J.R. Molina et al. Invasive glioblastoma cells acquire stemness and increased Akt activation Neoplasia 12 2010 453 463
20. B. Morash et al. Leptin gene expression in the brain and pituitary gland Endocrinology 140 1999 5995 5998
21. L.V. Nguyen et al. Cancer stem cells: an evolving concept Nat Rev Cancer 2012 133 143
22. A. Perez-Perez et al. Leptin prevents apoptosis of trophoblastic cells by activation of MAPK pathway Arch. Biochem. Biophys. 477 2008 390 395
23. J. Ratke et al. Leptin stimulates the migration of colon carcinoma cells by multiple signaling pathways Endocr. Relat. Cancer 17 2011 179 189
24. T. Reya et al. Stem cells, cancer, and cancer stem cells Nature 414 2001 105 111
25. M. Riolfi et al. Leptin and its receptor are overexpressed in brain tumors and correlate with the degree of malignancy Brain Pathol. 20 2010 481 489
26. N.K. Saxena et al. Concomitant activation of the JAK/STAT, PI3K/AKT, and ERK signaling is involved in leptin-mediated promotion of invasion and migration of hepatocellular carcinoma cells Cancer Res 67 2007 2497 2507
27. S.K. Singh et al. Identification of a cancer stem cell in human brain tumors Cancer Res. 63 2003 5821 5828
28. P. Somasundar et al. Prostate cancer cell proliferation is influenced by leptin J Surg Res 118 2004 71 82
29. T. Sun et al. Expression and functional significance of Twist1 in hepatocellular carcinoma: its role in vasculogenic mimicry Hepatology. 51 2010 545 556
30. G. Tabatabai et al. Molecular diagnostics of gliomas: the clinical perspective Acta Neuropathol. 120 2010 585 592
31. T. Yamashita et al. EpCAM-positive hepatocellular carcinoma cells are tumor-initiating cells with stem/progenitor cell features Gastroenterology 136 2009 1012 1024
32. S.N. Yang et al. Leptin enhances cell migration in human chondrosarcoma cells through OBRl leptin receptor Carcinogenesis 30 2009 566 574
33. W.L. Yeh et al. Leptin induces migration and invasion of glioma cells through MMP-13 production Glia 57 2009 454 464
34. S.C. Yu, and X.W. Bian Enrichment of cancer stem cells based on heterogeneity of invasiveness Stem Cell Rev. 5 2009 66 71
35. B.B. Zhou et al. Tumour-initiating cells: challenges and opportunities for anticancer drug discovery Nat Rev. Drug Discov. 8 2009 806 823