The use of a specialised amino acid mixture for pressure ulcers: A placebo-controlled trial

Journal of Wound Care

Volumn 23, Issue 5, 2014, Pages 259-269

  Wong, A ^a   Chew, A ^a   Wang, C M ^a   Ong, L ^a   Zhang, S H ^a   Young, S ^a  

^a CHANGI GENERAL HOSPITAL   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

3 HYDROXYISOVALERIC ACID; ALBUMINOID; ARGININE; BETA-HYDROXYISOVALERIC ACID; C REACTIVE PROTEIN; GLUTAMINE; PLACEBO; VALERIC ACID DERIVATIVE;

AGED; ARTICLE; COMPARATIVE STUDY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DECUBITUS; DIET SUPPLEMENTATION; DOUBLE BLIND PROCEDURE; DRUG EFFECT; FEMALE; HUMAN; MALE; METABOLISM; ORAL DRUG ADMINISTRATION; PILOT STUDY; RANDOMIZED CONTROLLED TRIAL; TREATMENT OUTCOME; WOUND HEALING;

ADMINISTRATION, ORAL; AGED; ALBUMINS; ARGININE; C-REACTIVE PROTEIN; DIETARY SUPPLEMENTS; DOUBLE-BLIND METHOD; FEMALE; GLUTAMINE; HUMANS; MALE; PILOT PROJECTS; PLACEBOS; PRESSURE ULCER; TREATMENT OUTCOME; VALERATES; WOUND HEALING;

EID: 84902211599     PISSN: 09690700     EISSN: None     Source Type: Journal    
DOI: 10.12968/jowc.2014.23.5.259     Document Type: Article

References (30)

1. Chan, E.Y., Tan, S.L., Lee, C.K., Lee, J.Y. Prevalence, incidence and predictors of pressure ulcers in a tertiary hospital in Singapore. J Wound Care 2005; 14: 8, 383-388.
2. Nursing research report on the prevalence and incidence of pressure sores among patients in Alexandra Hospital, Changi General Hospital and Tan Tock Seng Hospital. Singapore: Ministry of Health, 1998.
3. Ho, C.H., Powell, H.L., Collins, J.F., et al. Poor nutrition is a relative contraindication to negative pressure wound therapy for pressure ulcers: preliminary observations in patients with spinal cord injury. Adv Skin Wound Care 2010; 23: 11, 508-516.
4. Brewer, S., Desneves, K., Pearce, L., et al. Effect of an arginine-containing nutritional supplement on pressure ulcer healing in community spinal patients. J Wound Care 2010; 19: 7, 311-316.
5. van Anholt, R., Sobotka, L., Meijer, E., et al. Specific nutritional support accelerates pressure ulcer healing and reduces wound care intensity in non-malnourished patients. Nutrition 2010; 26: 9, 867-872.
6. Cereda, E., Gini, A., Pedrolli, C., Vanotti, A. Disease-specific, versus standard, nutritional support for the treatment of pressure ulcers in institutionalized older adults: a randomized controlled trial. J Am Geriatr Soc 2009; 57: 8, 1395-1402.
7. Schols, J.M., Heyman, H., Meijer, E.P. Nutritional support in the treatment and prevention of pressure ulcers: an overview of studies with an arginine enriched oral nutritional supplement. J Tissue Viability 2009; 18: 3, 72-79.
8. Stechmiller, J.K., Childress, B., Cowan, L. Arginine supplementation and wound healing. Nutr Clin Pract 2005; 20: 1, 52-61. (Pubitemid 40261940)
9. Benati, G., Delvecchio, S., Cilla, D., Pedone, V. Impact on pressure ulcer healing of an arginine-enriched nutritional solution in patients with severe cognitive impairment. Arch Gerontol Geriatr Suppl 2001; (7 Suppl): 43-47. (Pubitemid 32727465)
10. Windle, E.M. Glutamine supplementation in critical illness: evidence, recommendations, and implications for clinical practice in burn care. J Burn Care Res 2006; 27: 6, 764-772. (Pubitemid 44715313)
11. Eley, H.L., Russell, S.T., Baxter, J.H., et al. Signaling pathways initiated by beta-hydroxy-beta-methylbutyrate to attenuate the depression of protein synthesis in skeletal muscle in response to cachectic stimuli. Am J Physiol Endocrinol Metab 2007; 293: 4, E923-931. (Pubitemid 47535823)
12. Baier, S., Johannsen, D., Abumrad N., et al. Year-long changes in protein metabolism in elderly men and women supplemented with a nutrition cocktail of beta-hydroxy-beta-methylbutyrate (HMB), L-arginine, and L-lysine. JPEN J Parenter Enteral Nutr 2009; 33: 1, 71-82.
13. Hsieh, L.C., Chien, S.L., Huang, M.S., et al. Anti-inflammatory and anticatabolic effects of short-term beta-hydroxy-beta-methylbutyrate supplementation on chronic obstructive pulmonary disease patients in intensive care unit. Asia Pac J Clin Nutr 2006; 15: 4, 544-550.
14. Hsieh, L.C., Chow, C.J., Chang, W.C., et al. Effect of beta-hydroxy-beta-methylbutyrate on protein metabolism in bed-ridden elderly receiving tube feeding. Asia Pac J Clin Nutr 2010; 19: 2, 200-208.
15. Kuhls, D.A., Rathmacher, J.A., Musngi, M.D., et al. Beta-hydroxy-beta- methylbutyrate supplementation in critically ill trauma patients. J Trauma 2007; 62: 1, 125-131. (Pubitemid 46102842)
16. Williams, J.Z., Abumrad, N., Barbul, A. Effect of a specialized amino acid mixture on human collagen deposition. Ann Surg 2002; 236: 3, 369-374.
17. Detsky, A.S., McLaughlin, J.R., Baker, J.P., et al. What is subjective global assessment of nutritional status? JPEN J Parenter Enteral Nutr 1987; 11: 1, 8-13. (Pubitemid 17009508)
18. Pressure Ulcer Treatment: Technical Report. Washington DC: National Pressure Ulcer Advisory Panel; 2009 [Accessed May 2014].
19. Thomas, D.R., Rodeheaver, G.T., Bartolucci, A.A., et al. Pressure ulcer scale for healing: derivation and validation of the PUSH tool. The PUSH Task Force. Adv Wound Care 1997; 10: 5, 96-101.
20. Makhsous, M., Lin, F., Knaus, E., et al. Promote pressure ulcer healing in individuals with spinal cord injury using an individualized cyclic pressure-relief protocol. Adv Skin Wound Care 2009; 22: 11, 514-521.
21. Chapman, B.R. Use of an arginine-enriched oral nutrition supplement in the healing of pressure ulcers in patients with spinal cord injuries: An observational study. Nutr Diet 2011; 68: 3, 208-213.
22. Desneves, K.J., Todorovic, B.E., Cassar, A., Crowe, T.C. Treatment with supplementary arginine, vitamin C and zinc in patients with pressure ulcers: a randomised controlled trial. Clin Nutr 2005; 24: 6, 979-987. (Pubitemid 41782455)
23. van Anholt, R.D., Sobotka, L., Meijer, E.P., et al. Specific nutritional support accelerates pressure ulcer healing and reduces wound care intensity in non-malnourished patients. Nutrition 2010; 26: 9, 867-872.
24. Theilla, M., Schwartz, B., Cohen, J., et al. Impact of a nutritional formula enriched in fish oil and micronutrients on pressure ulcers in critical care patients. Am J Crit Care 2012; 21: 4, 102-109.
25. Theilla, M., Singer, P., Cohen, J., Dekeyser, F. A diet enriched in eicosapentanoic acid, gamma-linolenic acid and antioxidants in the prevention of new pressure ulcer formation in critically ill patients with acute lung injury: A randomized, prospective, controlled study. Clin Nutr 2007; 26: 6, 752-757. (Pubitemid 350082493)
26. Blass, S.C., Goost, H., Tolba, R.H., et al. Time to wound closure in trauma patients with disorders in wound healing is shortened by supplements containing antioxidant micronutrients and glutamine: a PRCT. Clin Nutr 2012; 31: 4, 469-475.
27. Zhou, Y.P., Jiang, Z.M., Sun, Y.H., et al. The effect of supplemental enteral glutamine on plasma levels, gut function, and outcome in severe burn: a randomised, double-blind, controlled clinical trial. JPEN J Parenter Enteral Nutr 2003; 27: 4, 241-245.
28. Leigh, B., Desneves, K., Rafferty, J., et al. The effect of different doses of an arginine-containing supplement on the healing of pressure ulcers. J Wound Care 2012; 21: 3, 150-156.
29. Eley, H.L., Russell, S.T., Tisdale, M.J. Mechanism of attenuation of muscle protein degradation induced by tumor necrosis factor-alpha and angiotensin II by beta-hydroxy-beta-methylbutyrate. Am J Physiol Endocrinol Metab 2008; 295: 6, E1417-1426.
30. Bauer, J.D., Isenring, E., Waterhouse, M. The effectiveness of a specialised oral nutrition supplement on outcomes in patients with chronic wounds: a pragmatic randomised study. J Hum Nutr Diet 2013; 26: 5, 452-458.