Effect of an arginine-containing nutritional supplement on pressure ulcer healing in community spinal patients

Journal of Wound Care

Volumn 19, Issue 7, 2010, Pages 311-316

  Brewer, S ^a   Desneves, K ^b   Pearce, L ^b   Mills, K ^b   Dunn, L ^b   Brown, D ^b   Crowe, T ^a  

^a DEAKIN UNIVERSITY   (Australia)

^b AUSTIN HEALTH   (Australia)

Author keywords

Arginine; Community; Nutrition; Pressure ulcer; Spinal cord injuries; Wound healing

Indexed keywords

ARGININE;

ARTICLE; AUSTRALIA; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DECUBITUS; DIET SUPPLEMENTATION; DIET THERAPY; DRUG EFFECT; FEMALE; HOSPITALIZATION; HUMAN; MALE; MIDDLE AGED; NUTRITIONAL ASSESSMENT; NUTRITIONAL STATUS; ORAL DRUG ADMINISTRATION; PROSPECTIVE STUDY; RISK FACTOR; SPINAL CORD INJURY; STANDARD; TIME; TREATMENT OUTCOME; WOUND HEALING;

ADMINISTRATION, ORAL; ARGININE; DIETARY SUPPLEMENTS; FEMALE; HUMANS; MALE; MIDDLE AGED; NUTRITION ASSESSMENT; NUTRITIONAL STATUS; PRESSURE ULCER; PROSPECTIVE STUDIES; RISK FACTORS; SEVERITY OF ILLNESS INDEX; SPINAL CORD INJURIES; TIME FACTORS; TREATMENT OUTCOME; VICTORIA; WOUND HEALING;

EID: 77956869389     PISSN: 09690700     EISSN: None     Source Type: Journal    
DOI: 10.12968/jowc.2010.19.7.48905     Document Type: Article

References (30)

1. Johnson, R. L., Gerhart, K. A., McCray, J. et al. Secondary conditions following spinal cord injury in a population-based sample. Spinal Cord 1998;36:1, 45-50.
2. Savic, G., Short, D. J., Weitzenkamp, D. et al. Hospital readmissions in people with chronic spinal cord injury. Spinal Cord 2000;38:6, 371-377.
3. Cuddigan, J., Berlowitz, D. R., Ayello, E. A. Pressure ulcers in America: prevalence, incidence, and implications for the future. Adv Skin Wound Care 2001;14:4, 208-215.
4. Raghavan, P., Raza, W. A., Ahmed, Y. S., Chamberlain, M. A. Prevalence of pressure sores in a community sample of spinal injury patients. Clin Rehabil 2003;17:8, 879-884.
5. Redelings, M. D., Lee, N. E., Sorvillo, F. Pressure ulcers: more lethal than we thought? Adv Skin Wound Care 2005;18:7, 367-372.
6. Elsner, J. J., Gefen, A. Is obesity a risk factor for deep tissue injury in patients with spinal cord injury? J Biomech 2008;41:16, 3322-3331.
7. Allman, R. M. Pressure ulcer prevalence, incidence, risk factors, and impact. Clin Geriatr Med 1997;13:3, 421-436.
8. Grey, J. E., Harding, K. G. ABC of wound healing: Pressure Ulcers. BMJ/Blackwell Pub., 2006.
9. Thiyagarajan, C., Silver, J. R. Aetiology of pressure sores in patients with spinal cord injury. Br Med J (Clin Res Ed) 1984;289:6457, 1487-1490.
10. Dorner, B., Posthauer, M. E., Thomas, D. The role of nutrition in pressure ulcer prevention and treatment: National Pressure Ulcer Advisory Panel white paper. Adv Skin Wound Care 2009;22:5, 212-221.
11. Stratton, R., Ek, A., Engfer, M. et al. Enteral nutrition support in prevention and treatment of pressure ulcers: A systematic review and meta-analysis. Aging Res Rev 2005;4:3, 422-450.
12. Stechmiller, J. K., Childress, B., Cowan, L. Arginine supplementation and wound healing. Nutr Clin Pract 2005;20:1, 52-61.
13. Barbul, A. Arginine biochemistry, physiology and therapeutic implications. JPEN J Parenter Enteral Nutr 1986;10:2, 227-238.
14. Barbul, A., Lazarou, S. A., Efron, D. T. et al. Arginine enhances wound healing and lymphocyte immune response in humans. Surgery 1990;108:2, 331-337.
15. Witte, M. B., Barbul, A. Arginine phsyiology and its implication for wound healing. Wound Repair Regen 2003;11:6, 419-423.
16. Schäffer, M. R., Efron, P. A., Thornton, F. J. et al. Nitric oxide, an autocrine regulator of wound fibroblast synthetic function. J Immunol 1997;158:5, 2375-2381.
17. Seifter, E., Rettura, G., Barbul, A., Levenson, S. M. Arginine: an essential amino acid for injured rats. Surgery 1978;84:2, 224-230.
18. Barbul, A., Rettura, G., Levenson, S. M., Seifter, E. Wound healing and thymotropic effects of arginine: a pituitary mechanism of action. Am J Clin Nutr 1983;37:5, 786-794.
19. Kirk, S. J., Hurson, M., Regan, M. C. et al. Arginine stimulates wound healing and immune function in elderly human beings. Surgery 1993;114:2, 155-160.
20. Frias Soriano, L., Lage Vazquez, M. A., Maristany, C. et al. The effectiveness of nutritional supplementation in the healing of pressure ulcers. J Wound Care 2004;13:8, 319-322.
21. Heyman, H., Van De Looverbosch, D. E., Meijer, E. P., Schols, J. M. Benefits of an oral nutritional supplement on pressure ulcer healing in long-term care residents. J Wound Care 2008;17:11, 476-478, 480.
22. Benati, G., Delvecchio, S., Cilla, D., Pedone, V. Impact on pressure ulcer healing of an arginineenriched nutritional solution in patients with severe cognitive impairment. Arch Gerontol Geriatr Suppl 2001;7:43-47.
23. Desneves, K. J., Todorovic, B. E., Cassar, A., Crowe, T. C. Treatment with supplementary arginine, vitamin C and zinc in patients with pressure ulcers: A randomised controlled trial. Clin Nutr 2005;24:6, 979-987.
24. Cereda, E., Gini, A., Pedrolli, C., Vanotti, A. Disease-Specific, Versus Standard, Nutritional Support for the Treatment of Pressure Ulcers in Institutionalized Older Adults: A Randomized Controlled Trial. J Am Geriatr Soc 2009;57:8, 1395-1402.
25. Australian Wound Management Association. Clinical Practice Guidelines for the Prediction and Prevention of Pressure Ulcers. Cambridge Publishing, 2001.
26. Sussman, G. The impact of medicines on wound healing. Pharmacist 2007;26:11, 874-878
27. National Pressure Ulcer Advisory Panel. PUSH Tool Version 3. (Accessed 02/03/2009, at http://www.npuap.org)
28. Detsky, A. S., McLaughlin, J. R., Baker, J. P. et al. What is subjective global assessment of nutritional status? JPEN J Parenter Enteral Nutr 1987;11:1, 8-13.
29. Bennett, G., Dealey, C., Posnett, J. The cost of pressure ulcers in the UK. Age Ageing 2004;33:3, 230-235.
30. Schäffer, M. R., Tantry, U., Efron, P. A. et al. Diabetesimpaired healing and reduced wound nitric oxide synthesis: a possible pathophysiologic correlation. Surgery 1997;121:5, 513-519.