Adapter protein Shc regulates Janus kinase 3 phosphorylation

Journal of Biological Chemistry

Volumn 289, Issue 23, 2014, Pages 15951-15956

  Mishra, Jayshree ^a   Kumar, Narendra ^a  

^a TEXAS A AND M HEALTH SCIENCE CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; CHEMICAL ACTIVATION; PHOSPHATASES; PHOSPHORYLATION; PROTEINS;

DIRECT INTERACTIONS; INTRACELLULAR REGULATION; MOLECULAR MECHANISM; RATE-LIMITING STEPS; SRC HOMOLOGY 2 DOMAINS; STRUCTURAL DETERMINANTS; TRANSPHOSPHORYLATION; TYROSINE PHOSPHATASE;

MOLECULAR INTERACTIONS;

INTERLEUKIN 2; JANUS KINASE 3; PROTEIN SHC;

ARTICLE; AUTOPHOSPHORYLATION; CONTROLLED STUDY; ENZYME PHOSPHORYLATION; EPITHELIUM CELL; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEPHOSPHORYLATION; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; STRUCTURE ACTIVITY RELATION;

APOPTOSIS; JANUS KINASE (JAK); NONRECEPTOR TYROSINE KINASE (NRTK); PHOSPHATASE; PROTEIN PHOSPHATASE; WOUND HEALING;

BLOTTING, WESTERN; HT29 CELLS; HUMANS; IMMUNOPRECIPITATION; INTESTINAL MUCOSA; JANUS KINASE 3; MICROSCOPY, FLUORESCENCE; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN TYROSINE PHOSPHATASES; SHC SIGNALING ADAPTOR PROTEINS;

EID: 84902180756     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.C113.527523     Document Type: Article

References (25)

1. Safford, M. G., Levenstein, M., Tsifrina, E., Amin, S., Hawkins, A. L., Griffin, C. A., Civin, C. I., and Small, D. (1997) JAK3: expression and mapping to chromosome 19p12-13.1. Exp. Hematol. 25, 374-386
2. Cornejo, M. G., Boggon, T. J., and Mercher, T. (2009) JAK3: a two-faced player in hematological disorders. Int. J. Biochem. Cell Biol. 41, 2376-2379
3. Lin, Q., Lai, R., Chirieac, L. R., Li, C., Thomazy, V. A., Grammatikakis, I., Rassidakis, G. Z., Zhang, W., Fujio, Y., Kunisada, K., Hamilton, S. R., and Amin, H. M. (2005) Constitutive activation of JAK3/STAT3 in colon carcinoma tumors and cell lines: inhibition of JAK3/STAT3 signaling induces apoptosis and cell cycle arrest of colon carcinoma cells. Am. J. Pathol. 167, 969-980
4. Mishra, J., Verma, R. K., Alpini, G., Meng, F., and Kumar, N. (2013) Role of Janus kinase 3 in mucosal differentiation and predisposition to colitis. J. Biol. Chem. 288, 31795-31806
5. Huang, L. J., Constantinescu, S. N., and Lodish, H. F. (2001) The N-terminal domain of Janus kinase 2 is required for Golgi processing and cell surface expression of erythropoietin receptor. Mol. Cell 8, 1327-1338
6. Mishra, J., Karanki, S. S., and Kumar, N. (2012) Identification of molecular switch regulating interactions of Janus kinase 3 with cytoskeletal proteins. J. Biol. Chem. 287, 41386-41391
7. Mishra, J., Waters, C. M., and Kumar, N. (2012) Molecular mechanism of interleukin-2-induced mucosal homeostasis. Am. J. Physiol. Cell Physiol. 302, C735-C747
8. Kumar, N., Mishra, J., Narang, V. S., and Waters, C. M. (2007) Janus kinase 3 regulates interleukin 2-induced mucosal wound repair through tyrosine phosphorylation of villin. J. Biol. Chem. 282, 30341-30345
9. Wills, M. K., and Jones, N. (2012) Teaching an old dogma new tricks: twenty years of Shc adaptor signalling. Biochem. J. 447, 1-16
10. Sakai, R., Henderson, J. T., O'Bryan, J. P., Elia, A. J., Saxton, T. M., and Pawson, T. (2000) The mammalian ShcB and ShcC phosphotyrosine docking proteins function in the maturation of sensory and sympathetic neurons. Neuron 28, 819-833
11. Bonfini, L., Migliaccio, E., Pelicci, G., Lanfrancone, L., and Pelicci, P. G. (1996) Not all Shc's roads lead to Ras. Trends Biochem. Sci. 21, 257-261
12. Lai, K. M., and Pawson, T. (2000) The ShcA phosphotyrosine docking protein sensitizes cardiovascular signaling in the mouse embryo. Genes Dev. 14, 1132-1145
13. Kumar, N., and Khurana, S. (2004) Identification of a functional switch for actin severing by cytoskeletal proteins. J. Biol. Chem. 279, 24915-24918
14. Genescà, M., Sola, A., and Hotter, G. (2006) Actin cytoskeleton derangement induces apoptosis in renal ischemia/reperfusion. Apoptosis 11, 563-571
15. Macchi, P., Villa, A., Giliani, S., Sacco, M. G., Frattini, A., Porta, F., Ugazio, A. G., Johnston, J. A., Candotti, F., O'Shea, J. J., et al. (1995) Mutations of Jak-3 gene in patients with autosomal severe combined immune deficiency (SCID). Nature 377, 65-68
16. Chen, E., Staudt, L. M., and Green, A. R. (2012) Janus kinase deregulation in leukemia and lymphoma. Immunity 36, 529-541
17. Chrencik, J. E., Patny, A., Leung, I. K., Korniski, B., Emmons, T. L., Hall, T., Weinberg, R. A., Gormley, J. A., Williams, J. M., Day, J. E., Hirsch, J. L., Kiefer, J. R., Leone, J. W., Fischer, H. D., Sommers, C. D., Huang, H. C., Jacobsen, E. J., Tenbrink, R. E., Tomasselli, A. G., and Benson, T. E. (2010) Structural and thermodynamic characterization of the TYK2 and JAK3 kinase domains in complex with CP-690550 and CMP-6. J. Mol. Biol. 400, 413-433
18. Ursini-Siegel, J., and Muller, W. J. (2008) The ShcA adaptor protein is a critical regulator of breast cancer progression. Cell Cycle 7, 1936-1943
19. Haan, C., Kreis, S., Margue, C., and Behrmann, I. (2006) Jaks and cytokine receptors: an intimate relationship. Biochem. Pharmacol. 72, 1538-1546
20. George, R., Schuller, A. C., Harris, R., and Ladbury, J. E. (2008) A phosphorylation-dependent gating mechanism controls the SH2 domain interactions of the Shc adaptor protein. J. Mol. Biol. 377, 740-747
21. Sato, K., Otsuki, T., Kimoto, M., Kakumoto, M., Tokmakov, A. A., Watanabe, Y., and Fukami, Y. (1998) c-Src and phosphatidylinositol 3-kinase are involved in NGF-dependent tyrosine phosphorylation of Shc in PC12 cells. Biochem. Biophys. Res. Commun. 250, 223-228
22. Koo, G. C., Tan, S. Y., Tang, T., Poon, S. L., Allen, G. E., Tan, L., Chong, S. C., Ong, W. S., Tay, K., Tao, M., Quek, R., Loong, S., Yeoh, K. W., Yap, S. P., Lee, K. A., Lim, L. C., Tan, D., Goh, C., Cutcutache, I., Yu, W., Ng, C. C., Rajasegaran, V., Heng, H. L., Gan, A., Ong, C. K., Rozen, S., Tan, P., Teh, B. T., and Lim, S. T. (2012) Janus kinase 3-activating mutations identified in natural killer/T-cell lymphoma. Cancer Discov. 2, 591-597
23. Ugi, S., Imamura, T., Ricketts, W., and Olefsky, J. M. (2002) Protein phosphatase 2A forms a molecular complex with Shc and regulates Shc tyrosine phosphorylation and downstream mitogenic signaling. Mol. Cell. Biol. 22, 2375-2387
24. Lord, J. D., McIntosh, B. C., Greenberg, P. D., and Nelson, B. H. (1998) The IL-2 receptor promotes proliferation, bcl-2 and bcl-x induction, but not cell viability through the adapter molecule Shc. J. Immunol. 161, 4627-4633
25. Kumar, N., Tomar, A., Parrill, A. L., and Khurana, S. (2004) Functional dissection and molecular characterization of calcium-sensitive actin-capping and actin-depolymerizing sites in villin. J. Biol. Chem. 279, 45036-45046