Head-to head comparison of mGlu1 and mGlu5 receptor activation in chronic treatment of absence epilepsy in WAG/Rij rats

Neuropharmacology

Volumn 85, Issue , 2014, Pages 91-103

  D'Amore, V ^a   Santolini, I ^a   Celli, R ^a   Lionetto, L ^b   De Fusco, A ^a   Simmaco, M ^b   Van Rijn, C M ^c   Vieira, E ^d   Stauffer, S R ^e   Conn, P J ^e   Bosco, P ^f   Nicoletti, F ^a,g   Van Luijtelaar, G ^c   Ngomba, R T ^a  

^a IRCCS NEUROMED   (Italy)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

^c RADBOUD UNIVERSITY NIJMEGEN   (Netherlands)

^d F HOFFMANN LA ROCHE LTD   (Switzerland)

^e VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f IRCCS Oasi Maria SS Institute for Research on Mental Retardation and Brain Aging   (Italy)

^g SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

Absence epilepsy; Chronic treatment; Group I mGlu receptors; RO0711401; Spike wave discharges; Tolerance; VU0360172; WAG Rij rats

Indexed keywords

9H XANTHENE 9 CARBOXYLIC ACID (4 TRIFLUOROMETHYLOXAZOL 2 YL)AMIDE; METABOTROPIC RECEPTOR 1; METABOTROPIC RECEPTOR 5; METABOTROPIC RECEPTOR AGONIST; N CLYCLOBUTYL 6 [2-3 (FLUOROPHENYL)ETHYNYL]PYRIDINE 3 CARBOXAMINE; RO 0711401; UNCLASSIFIED DRUG; VU 0360172; AMINO ACID RECEPTOR AFFECTING AGENT; ANTICONVULSIVE AGENT; GRM5 PROTEIN, RAT; METABOTROPIC GLUTAMATE RECEPTOR TYPE 1; METABOTROPIC RECEPTOR; N-CYCLOBUTYL-6-((3-FLUOROPHENYL)ETHYNYL)NICOTINAMIDE; NICOTINAMIDE;

ABSENCE; ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; CHRONIC DRUG ADMINISTRATION; CONTROLLED STUDY; DOWN REGULATION; DRUG BRAIN LEVEL; DRUG MECHANISM; DRUG RESPONSE; DRUG TOLERANCE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; THALAMUS; ANALOGS AND DERIVATIVES; ANIMAL; AUGUST COPENHAGEN IRISH RAT; DISEASE MODEL; DRUG EFFECTS; ELECTRODE IMPLANT; ELECTROENCEPHALOGRAPHY; EPILEPSY, ABSENCE; GENETICS; METABOLISM; PATHOPHYSIOLOGY; TIME; TRANSGENIC MOUSE; WESTERN BLOTTING; WISTAR RAT;

ANIMALS; ANTICONVULSANTS; BLOTTING, WESTERN; CEREBRAL CORTEX; DISEASE MODELS, ANIMAL; DRUG TOLERANCE; ELECTRODES, IMPLANTED; ELECTROENCEPHALOGRAPHY; EPILEPSY, ABSENCE; EXCITATORY AMINO ACID AGENTS; MALE; MICE, TRANSGENIC; NIACINAMIDE; RATS; RATS, INBRED ACI; RATS, WISTAR; RECEPTOR, METABOTROPIC GLUTAMATE 5; RECEPTORS, METABOTROPIC GLUTAMATE; THALAMUS; TIME FACTORS;

EID: 84902152379     PISSN: 00283908     EISSN: 18737064     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2014.05.005     Document Type: Article

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