Identification and characterization of GABAA receptor autoantibodies in autoimmune encephalitis

Journal of Neuroscience

Volumn 34, Issue 24, 2014, Pages 8151-8163

  Ohkawa, Toshika ^a   Satake, Shin'Ichiro ^a   Yokoi, Norihiko ^a   Miyazaki, Yu ^b   Ohshita, Tomohiko ^c   Sobue, Gen ^b   Takashima, Hiroshi ^d   Watanabe, Osamu ^d   Fukata, Yuko ^a   Fukata, Masaki ^a  

^a GRADUATE UNIVERSITY FOR ADVANCED STUDIES   (Japan)

^b NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c Suiseikai Kajikawa Hospital   (Japan)

^d KAGOSHIMA UNIVERSITY   (Japan)

Author keywords

Autoantibody; Autoimmune encephalitis; Cognitive impairment; Seizure; Thymoma

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR ANTIBODY; 4 AMINOBUTYRIC ACID A RECEPTOR BETA3; AUTOANTIBODY; EPITOPE; GEPHYRIN; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; AUTOIMMUNE DISEASE; BINDING ASSAY; CLINICAL FEATURE; CONTROLLED STUDY; ELECTROPHYSIOLOGY; ENCEPHALITIS; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HIPPOCAMPAL NEURONAL CULTURE; HUMAN; IMMUNOFLUORESCENCE TEST; IMMUNOPRECIPITATION; IMMUNOREACTIVITY; MAJOR CLINICAL STUDY; MALE; MASS SPECTROMETRY; MIDDLE AGED; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEOMICS; RAT; RECOMBINANT PLASMID; WESTERN BLOTTING;

AUTOANTIBODY; AUTOIMMUNE ENCEPHALITIS; COGNITIVE IMPAIRMENT; GABAA RECEPTOR; SEIZURE; THYMOMA;

ANIMALS; APOPTOSIS REGULATORY PROTEINS; AUTOANTIBODIES; BRAIN; BRAIN DISEASES; CELLS, CULTURED; CERCOPITHECUS AETHIOPS; COGNITION DISORDERS; FEMALE; HASHIMOTO DISEASE; HIPPOCAMPUS; HUMANS; MALE; MEMBRANE POTENTIALS; MIDDLE AGED; NEURONS; NEUROTRANSMITTER AGENTS; PROTEIN BINDING; PROTEINS; RATS; RECEPTORS, GABA-A;

EID: 84902138177     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.4415-13.2014     Document Type: Article

References (30)

1. Cash SS, Larvie M, Dalmau J (2011) Case records of the Massachusetts General Hospital. Case 34-2011: A 75-year-old man with memory loss and partial seizures. N Engl J Med 365:1825-1833. CrossRef Medline
2. Dalmau J, Tüzün E, Wu HY, Masjuan J, Rossi JE, Voloschin A, Baehring JM, Shimazaki H, Koide R, King D, Mason W, Sansing LH, Dichter MA, Rosenfeld MR, Lynch DR (2007) Paraneoplastic anti-N-methyl-Daspartate receptor encephalitis associated with ovarian teratoma. Ann Neurol 61:25-36. CrossRef Medline
3. Dalmau J, Gleichman AJ, Hughes EG, Rossi JE, Peng X, Lai M, Dessain SK, Rosenfeld MR, Balice-Gordon R, Lynch DR (2008) Anti-NMDAreceptor encephalitis: case series and analysis of the effects of antibodies. Lancet Neurol 7:1091-1098. CrossRef Medline
4. A receptor have the epilepsy phenotype and many of the behavioral characteristics of Angelman syndrome. J Neurosci 18:8505-8514. Medline
5. A receptors is required for normal assembly and function of GABAergic inhibitory synapses. J Neurosci 26:12758-12768. CrossRef Medline
6. Fukata Y, Lovero KL, Iwanaga T, Watanabe A, Yokoi N, Tabuchi K, Shigemoto R, Nicoll RA, Fukata M (2010) Disruption of LGI1-linked synaptic complex causes abnormal synaptic transmission and epilepsy. Proc Natl Acad Sci U S A 107:3799-3804. CrossRef Medline
7. Fukata Y, Dimitrov A, Boncompain G, Vielemeyer O, Perez F, Fukata M (2013) Local palmitoylation cycles define activity-regulated postsynaptic subdomains. J Cell Biol 202:145-161. CrossRef Medline
8. Hughes EG, Peng X, Gleichman AJ, Lai M, Zhou L, Tsou R, Parsons TD, Lynch DR, Dalmau J, Balice-Gordon RJ (2010) Cellular and synaptic mechanisms of anti-NMDA receptor encephalitis. J Neurosci 30:5866-5875. CrossRef Medline
9. Hutchinson M, Waters P, McHugh J, Gorman G, O'Riordan S, Connolly S, Hager H, Yu P, Becker CM, Vincent A (2008) Progressive encephalomyelitis, rigidity, and myoclonus: a novel glycine receptor antibody. Neurology 71:1291-1292. CrossRef Medline
10. Irani SR, Alexander S, Waters P, Kleopa KA, Pettingill P, Zuliani L, Peles E, Buckley C, Lang B, Vincent A (2010) Antibodies to Kv1 potassium channel-complex proteins leucine-rich, glioma inactivated 1 protein and contactin-associated protein-2 in limbic encephalitis, Morvan's syndrome and acquired neuromyotonia. Brain 133:2734-2748. CrossRef Medline
11. A receptor trafficking and its role in the dynamic modulation of neuronal inhibition. Nat Rev Neurosci 9:331-343. CrossRef Medline
12. Lai M, Hughes EG, Peng X, Zhou L, Gleichman AJ, Shu H, Matà S, Kremens D, Vitaliani R, Geschwind MD, Bataller L, Kalb RG, Davis R, Graus F, Lynch DR, Balice-Gordon R, Dalmau J (2009) AMPA receptor antibodies in limbic encephalitis alter synaptic receptor location. Ann Neurol 65:424-434. CrossRef Medline
13. Lai M, Huijbers MG, Lancaster E, Graus F, Bataller L, Balice-Gordon R, Cowell JK, Dalmau J (2010) Investigation of LGI1 as the antigen in limbic encephalitis previously attributed to potassium channels: a case series. Lancet Neurol 9:776-785. CrossRef Medline
14. Lancaster E, Dalmau J (2012) Neuronal autoantigens-pathogenesis, associated disorders and antibody testing. Nat Rev Neurol 8:380-390. CrossRef Medline
15. B receptor in limbic encephalitis with seizures: case series and characterisation of the antigen. Lancet Neurol 9:67-76. CrossRef Medline
16. Lancaster E, Martinez-Hernandez E, Dalmau J (2011) Encephalitis and antibodies to synaptic and neuronal cell surface proteins. Neurology 77: 179-189. CrossRef Medline
17. A receptor channels. Annu Rev Neurosci 17:569-602. CrossRef Medline
18. A receptor subunits associated with genetic epilepsies. J Physiol 588:1861-1869. CrossRef Medline
19. McKeon A, Martinez-Hernandez E, Lancaster E, Matsumoto JY, Harvey RJ, McEvoy KM, Pittock SJ, Lennon VA, Dalmau J (2013) Glycine receptor autoimmune spectrum with stiff-man syndrome phenotype. JAMA Neurol 70:44-50. CrossRef Medline
20. Miyazaki Y, Hirayama M, Watanabe H, Usami N, Yokoi K, Watanabe O, Sobue G (2012) Paraneoplastic encephalitis associated with myasthenia gravis and malignant thymoma. J Clin Neurosci 19:336-338. CrossRef Medline
21. Moscato EH, Jain A, Peng X, Hughes EG, Dalmau J, Balice-Gordon RJ (2010) Mechanisms underlying autoimmune synaptic encephalitis leading to disorders of memory, behavior and cognition: insights from molecular, cellular and synaptic studies. Eur J Neurosci 32:298-309. CrossRef Medline
22. Ohkawa T, Fukata Y, Yamasaki M, Miyazaki T, Yokoi N, Takashima H, Watanabe M, Watanabe O, Fukata M (2013) Autoantibodies to epilepsyrelated LGI1 in limbic encephalitis neutralize LGI1-ADAM22 interaction and reduce synaptic AMPA receptors. J Neurosci 33:18161-18174. CrossRef Medline
23. Ohshita T, Kawakami H, Maruyama H, Kohriyama T, Arimura K, Matsumoto M (2006) Voltage-gated potassium channel antibodies associated limbic encephalitis in a patient with invasive thymoma. J Neurol Sci 250: 167-169. CrossRef Medline
24. A receptor: a case series, characterisation of the antigen, and analysis of the eff ects of antibodies. Lancet Neurol 13:276-286. CrossRef Medline
25. A receptors: immunocytochemical distribution of 13 subunits in the adult rat brain. Neuroscience 101:815-850. CrossRef Medline
26. A receptor subtypes. Nat Rev Drug Discov 10:685-697. CrossRef Medline
27. 2+ sensors at rat cerebellar granule cells. J Neurosci 34:1462-1474. CrossRef Medline
28. Satake S, Saitow F, Rusakov D, Konishi S (2004) AMPA receptor-mediated presynaptic inhibition at cerebellar GABAergic synapses: a characterization of molecular mechanisms. Eur J Neurosci 19:2464-2474. CrossRef Medline
29. Sillevis Smitt P, Kinoshita A, De Leeuw B, Moll W, Coesmans M, Jaarsma D, Henzen-Logmans S, Vecht C, De Zeeuw C, Sekiyama N, Nakanishi S, Shigemoto R (2000) Paraneoplastic cerebellar ataxia due to autoantibodies against a glutamate receptor. N Engl J Med 342:21-27. CrossRef Medline
30. Vincent A, Lang B, Kleopa KA (2006) Autoimmune channelopathies and related neurological disorders. Neuron 52:123-138. CrossRef Medline