Quantitative analysis and pharmacokinetics study of tigecycline in human serum using a validated sensitive liquid chromatography with tandem mass spectrometry method

Journal of Separation Science

Volumn 37, Issue 12, 2014, Pages 1396-1403

  Xie, Jiao ^a   Wang, Taotao ^a   Wang, Xue ^a   Cheng, Xiaoliang ^a   Dong, Haiyan ^a   Wang, Yan ^a   Zheng, Xiaowei ^a   Zhou, Liang ^b   Xing, Jianfeng ^a   Dong, Yalin ^a  

^a XI'AN JIAOTONG UNIVERSITY   (China)

^b Thermo Fisher Scientific   (United States)

Author keywords

Intensive care medicine; liquid chromatography with tandem mass spectrometry; Pharmacokinetics; Tetracycline; Tigecycline

Indexed keywords

BODY FLUIDS; CHROMATOGRAPHY; MASS SPECTROMETRY; PHARMACOKINETICS;

CHROMATOGRAPHIC SEPARATIONS; CRITICALLY-ILL PATIENTS; INTENSIVE CARE MEDICINES; LIQUID CHROMATOGRAPHY WITH TANDEM MASS SPECTROMETRIES; PHARMACOKINETIC STUDIES; SELECTED REACTION MONITORING; TETRACYCLINE; TIGECYCLINE;

HIGH PRESSURE LIQUID CHROMATOGRAPHY;

TIGECYCLINE; TRICHLOROACETIC ACID; MINOCYCLINE;

ACINETOBACTER INFECTION; ADULT; AGED; ANALYTICAL EQUIPMENT; AREA UNDER THE CURVE; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CRITICALLY ILL PATIENT; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG HALF LIFE; DRUG STABILITY; ELUTION; FEMALE; HUMAN; LIMIT OF QUANTITATION; LIQUID CHROMATOGRAPHY; LUNG INFECTION; MALE; MAXIMUM PLASMA CONCENTRATION; MEASUREMENT ACCURACY; PLASMA CONCENTRATION-TIME CURVE; PRECIPITATION; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SENSITIVITY AND SPECIFICITY; STEADY STATE; TANDEM MASS SPECTROMETRY; TIME TO MAXIMUM PLASMA CONCENTRATION; ANALOGS AND DERIVATIVES; BLOOD; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; PROCEDURES; VALIDATION STUDY;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HUMANS; MINOCYCLINE; SENSITIVITY AND SPECIFICITY; TANDEM MASS SPECTROMETRY;

EID: 84902134772     PISSN: 16159306     EISSN: 16159314     Source Type: Journal    
DOI: 10.1002/jssc.201400152     Document Type: Article

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