Stability of gene expression and epigenetic profiles highlights the utility of patient-derived paediatric acute lymphoblastic leukaemia xenografts for investigating molecular mechanisms of drug resistance

BMC Genomics

Volumn 15, Issue 1, 2014, Pages

  Wong, Nicholas C ^a,b,d   Bhadri, Vivek A ^c   Maksimovic, Jovana ^a   Parkinson Bates, Mandy ^a   Ng, Jane ^a   Craig, Jeff M ^a,d   Saffery, Richard ^a,d   Lock, Richard B ^c  

^a ROYAL CHILDREN'S HOSPITAL   (Australia)

^b AUSTIN HOSPITAL   (Australia)

^c CHILDREN S CANCER INSTITUTE AUSTRALIA FOR MEDICAL RESEARCH   (Australia)

^d UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

Acute lymphoblastic leukaemia; Genome wide DNA methylation; Glucocorticoid resistance; Microarray analysis of gene expression; Xenografts

Indexed keywords

BIOLOGICAL MARKER; PREDNISOLONE; ANTINEOPLASTIC HORMONE AGONISTS AND ANTAGONISTS;

ACUTE LYMPHOBLASTIC LEUKEMIA; ADOLESCENT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARHGAP21 GENE; ARTICLE; ARX GENE; CAPS2 GENE; CELL STRUCTURE; CHILD; CHILDHOOD CANCER; CLINICAL ARTICLE; DNA METHYLATION; DRUG RESISTANCE; DRUG RESPONSE; EPIGENETICS; FEMALE; GENE; GENE EXPRESSION PROFILING; GENETIC ANALYSIS; GENOME; HOXB6 GENE; HUMAN; HUMAN CELL; HUMAN TISSUE; INTRACELLULAR SIGNALING; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRE B LYMPHOCYTE; PRESCHOOL CHILD; PRIMARY TUMOR; SCHOOL CHILD; TUMOR XENOGRAFT; UNINDEXED SEQUENCE; VALIDATION STUDY; ANIMAL; DISEASE MODEL; DRUG EFFECTS; DRUG SCREENING; GENE EXPRESSION REGULATION; GENETIC EPIGENESIS; GENETICS; INFANT; NONOBESE DIABETIC MOUSE; PATHOLOGY; PRECURSOR B-CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA;

ADOLESCENT; ANIMALS; ANTINEOPLASTIC AGENTS, HORMONAL; CHILD; DISEASE MODELS, ANIMAL; DNA METHYLATION; DRUG RESISTANCE, NEOPLASM; EPIGENESIS, GENETIC; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; INFANT; MALE; MICE, INBRED NOD; PRECURSOR B-CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; PREDNISOLONE; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84902121562     PISSN: None     EISSN: 14712164     Source Type: Journal    
DOI: 10.1186/1471-2164-15-416     Document Type: Article

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