AML1/ETO and POU4F1 synergy drives B-lymphoid gene expression typical of t(8;21) acute myeloid leukemia

Leukemia

Volumn 26, Issue 5, 2012, Pages 1131-1135

  Dunne, J ^a   Mannari, D ^a   Farzaneh, T ^b   Gessner, A ^c   Van Delft, F W ^d   Heidenreich, O ^c   Young, B D ^a   Gascoyne, D M ^b,e  

^a QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c NEWCASTLE UNIVERSITY   (United Kingdom)

^d INSTITUTE OF CANCER RESEARCH   (United Kingdom)

^e UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CD19 ANTIGEN; EARLY B CELL FACTOR 1 PROTEIN; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 6; PEPTIDES AND PROTEINS; SHORT HAIRPIN RNA; STEM CELL FACTOR; TRANSCRIPTION FACTOR PAX5; TRANSCRIPTION FACTOR POU4F1; TRANSCRIPTION FACTOR RUNX1; UNCLASSIFIED DRUG;

ACUTE GRANULOCYTIC LEUKEMIA; CELL SPECIFICITY; GENE EXPRESSION; GENE INTERACTION; GENETIC ANALYSIS; GENETIC TRANSDUCTION; HUMAN; IN VITRO STUDY; LETTER; MORPHOLOGY; NONHUMAN; PRIORITY JOURNAL;

B-LYMPHOCYTES; CHROMOSOMES, HUMAN, PAIR 21; CHROMOSOMES, HUMAN, PAIR 8; CORE BINDING FACTOR ALPHA 2 SUBUNIT; GENE EXPRESSION; HUMANS; LEUKEMIA, MYELOID, ACUTE; ONCOGENE PROTEINS, FUSION; TRANSCRIPTION FACTOR BRN-3A; TRANSLOCATION, GENETIC;

EID: 84860729659     PISSN: 08876924     EISSN: 14765551     Source Type: Journal    
DOI: 10.1038/leu.2011.316     Document Type: Letter

References (15)

1. Kita K, Nakase K, Miwa H, Masuya M, Nishii K, Morita N et al. Phenotypical characteristics of acute myelocytic leukemia associated with the t(8;21)(q22;q22) chromosomal abnormality: frequent expression of immature B-cell antigen CD19 together with stem cell antigen CD34. Blood 1992; 80: 470-477.
2. Tiacci E, Pileri S, Orleth A, Pacini R, Tabarrini A, Frenguelli F et al. PAX5 expression in acute leukemias: higher B-lineage specificity than CD79a and selective association with t(8;21)-acute myelogenous leukemia. Cancer Res 2004; 64: 7399-7404.
3. Valbuena JR, Medeiros LJ, Rassidakis GZ, Hao S, Wu CD, Chen L et al. Expression of B cell-specific activator protein/PAX5 in acute myeloid leukemia with t(8;21)(q22;q22). Am J Clin Pathol 2006; 126: 235-240.
4. Peterson LF, Boyapati A, Ahn EY, Biggs JR, Okumura AJ, Lo MC et al. Acute myeloid leukemia with the 8q22;21q22 translocation: secondary mutational events and alternative t(8;21) transcripts. Blood 2007; 110: 799-805.
5. Schoch C, Kohlmann A, Schnittger S, Brors B, Dugas M, Mergenthaler S et al. Acute myeloid leukemias with reciprocal rearrangements can be distinguished by specific gene expression profiles. Proc Natl Acad Sci USA 2002; 99: 10008-10013.
6. Dunne J, Gascoyne DM, Lister TA, Brady HJ, Heidenreich O, Young BD. AML1/ETO proteins control POU4F1/BRN3A expression and function in t(8;21) acute myeloid leukemia. Cancer Res 2010; 70: 3985-3995.
7. Greenbaum S, Lazorchak AS, Zhuang Y. Differential functions for the transcription factor E2A in positive and negative gene regulation in pre-B lymphocytes. J Biol Chem 2004; 279: 45028-45035.
8. Gascoyne DM, Long E, Veiga-Fernandes H, de Boer J, Williams O, Seddon B et al. The basic leucine zipper transcription factor E4BP4 is essential for natural killer cell development. Nat Immunol 2009; 10: 1118-1124.
9. Kamizono S, Duncan GS, Seidel MG, Morimoto A, Hamada K, Grosveld G et al. Nfil3/E4bp4 is required for the development and maturation of NK cells in vivo. J Exp Med 2009; 206: 2977-2986.
10. Okumura AJ, Peterson LF, Okumura F, Boyapati A, Zhang DE. t(8;21)(q22;q22) Fusion proteins preferentially bind to duplicated AML1/RUNX1 DNA-binding sequences to differentially regulate gene expression. Blood 2008; 112: 1392-1401.
11. Walter K, Cockerill PN, Barlow R, Clarke D, Hoogenkamp M, Follows GA et al. Aberrant expression of CD19 in AML with t(8;21) involves a poised chromatin structure and PAX5. Oncogene 2010; 29: 2927-2937.
12. Anderson K, Rusterholz C, Mansson R, Jensen CT, Bacos K, Zandi S et al. Ectopic expression of PAX5 promotes maintenance of biphenotypic myeloid progenitors coexpressing myeloid and B-cell lineage-associated genes. Blood 2007; 109: 3697-3705.
13. Tagoh H, Ingram R, Wilson N, Salvagiotto G, Warren AJ, Clarke D et al. The mechanism of repression of the myeloid-specific c-fms gene by Pax5 during B lineage restriction. EMBO J 2006; 25: 1070-1080.
14. Fortier JM, Payton JE, Cahan P, Ley TJ, Walter MJ, Graubert TA. POU4F1 is associated with t(8;21) acute myeloid leukemia and contributes directly to its unique transcriptional signature. Leukemia 2010; 24: 950-957.
15. Dayyani F, Wang J, Yeh JR, Ahn EY, Tobey E, Zhang DE et al. Loss of TLE1 and TLE4 from the del(9q) commonly deleted region in AML cooperates with AML1-ETO to affect myeloid cell proliferation and survival. Blood 2008; 111: 4338-4347.