BCR-ABL disrupts PTEN nuclear-cytoplasmic shuttling through phosphorylation-dependent activation of HAUSP

Leukemia

Volumn 28, Issue 6, 2014, Pages 1326-1333

  Morotti, A ^a,b   Panuzzo, C ^b   Crivellaro, S ^b   Pergolizzi, B ^a   Familiari, U ^c   Berger, A H ^a,c   Saglio, G ^b   Pandolfi, P P ^a  

^a UNIVERSITY OF TURIN   (Italy)

^b UNIVERSITY OF TURIN   (Italy)

^c SAN LUIGI GONZAGA HOSPITAL   (Italy)

Author keywords

BCR ABL; chronic myeloid leukemia; HAUSP; PML; PTEN

Indexed keywords

ARSENIC TRIOXIDE; BCR ABL PROTEIN; DEUBIQUITINASE; HAUSP PROTEIN; IMATINIB; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN; UNCLASSIFIED DRUG; ABELSON KINASE; PROMYELOCYTIC LEUKEMIA PROTEIN; PROTEIN HAUSP; TYROSINE;

ANIMAL CELL; ARTICLE; CELL PROLIFERATION; CHRONIC MYELOID LEUKEMIA; CONTROLLED STUDY; CYTOPLASM; ENZYME ACTIVITY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; INTRACELLULAR SPACE; MASS SPECTROMETRY; MUTAGENESIS; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTO ONCOGENE; SEQUENCE ANALYSIS; STABLE EXPRESSION; UBIQUITINATION; WESTERN BLOTTING; 3T3 CELL LINE; APOPTOSIS; BONE MARROW; BONE MARROW CELL; CELL DIFFERENTIATION; CELL NUCLEUS INCLUSION BODY; GENE DISRUPTION; GENE OVEREXPRESSION; GROWTH DISORDER; HEK293 CELL LINE; HEMATOPOIETIC STEM CELL; IMMUNOBLOTTING; K562 CELL LINE; PATHOGENESIS; PROTEIN FUNCTION; PROTEIN INTERACTION; STEM CELL;

ANIMALS; BLOTTING, WESTERN; CELL NUCLEUS; CELLS, CULTURED; CYTOPLASM; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE; FUSION PROTEINS, BCR-ABL; HUMANS; IMMUNOENZYME TECHNIQUES; IMMUNOPRECIPITATION; LEUKEMIA, MYELOGENOUS, CHRONIC, BCR-ABL POSITIVE; MICE; NUCLEAR PROTEINS; PHOSPHORYLATION; PTEN PHOSPHOHYDROLASE; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; TRANSCRIPTION FACTORS; TUMOR SUPPRESSOR PROTEINS; UBIQUITIN THIOLESTERASE; UBIQUITINATION;

EID: 84902115473     PISSN: 08876924     EISSN: 14765551     Source Type: Journal    
DOI: 10.1038/leu.2013.370     Document Type: Article

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