Decoding the structural events in substrate-gating mechanism of eukaryotic prolyl oligopeptidase using normal mode analysis and molecular dynamics simulations

Proteins: Structure, Function and Bioinformatics

Volumn 82, Issue 7, 2014, Pages 1428-1443

  Kaushik, Swati ^a   Etchebest, Catherine ^b   Sowdhamini, Ramanathan ^a  

^a TATA INSTITUTE OF FUNDAMENTAL RESEARCH   (India)

^b INSTITUT NATIONAL DE LA TRANSFUSION SANGUINE   (France)

Author keywords

Domain interface; Enzyme mechanism; Serine proteases; Substrate entry

Indexed keywords

PROLYL ENDOPEPTIDASE; SERINE PROTEINASE;

ARTICLE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; ELECTRIC POTENTIAL; ENERGY; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME CONFORMATION; EUKARYOTE; HINGE REGION; MOLECULAR DYNAMICS; MOTION; MYXOCOCCUS XANTHUS; NONHUMAN; ORTHOLOGY; PRIORITY JOURNAL; PROTEIN CROSS LINKING; SEQUENCE ALIGNMENT; SWINE; ANIMAL; CHEMISTRY; ENZYME SPECIFICITY; METABOLISM; PIG; PROTEIN TERTIARY STRUCTURE;

ANIMALS; CATALYTIC DOMAIN; MOLECULAR DYNAMICS SIMULATION; PROTEIN STRUCTURE, TERTIARY; SERINE ENDOPEPTIDASES; SUBSTRATE SPECIFICITY; SWINE;

EID: 84902109432     PISSN: 08873585     EISSN: 10970134     Source Type: Journal    
DOI: 10.1002/prot.24511     Document Type: Article

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