Concerted structural changes in the peptidase and the propeller domains of prolyl oligopeptidase are required for substrate binding

Journal of Molecular Biology

Volumn 340, Issue 3, 2004, Pages 627-637

  Szeltner, Zoltán ^a   Rea, Dean ^b   Juhász, Tünde ^a   Renner, Veronika ^a   Fülöp, Vilmos ^b   Polgár, László ^a  

^a INSTITUTE OF EXPERIMENTAL MEDICINE   (Hungary)

^b UNIVERSITY OF WARWICK   (United Kingdom)

Author keywords

Abz, 2.aminobenzoyl; disulfide bond formation; DTE, 1,4 dithioerythritol; GSSG, oxidized glutathione; Mes, 2 (N morpholino)ethanesulfonic acid; Nap, 2 naphthylamide; protein stability; site specific mutagenesis; substrate binding

Indexed keywords

PEPTIDASE; PROLYL ENDOPEPTIDASE;

ARTICLE; CATALYSIS; CRYSTAL STRUCTURE; DISULFIDE BOND; ENZYME ACTIVITY; ENZYME STRUCTURE; ENZYME SUBSTRATE COMPLEX; OSCILLATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; SITE DIRECTED MUTAGENESIS;

EID: 2942741114     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2004.05.011     Document Type: Article

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