Liver resection in hepatitis B related-hepatocellular carcinoma: Clinical outcomes and safety in elderly patients

World Journal of Gastroenterology

Volumn 20, Issue 21, 2014, Pages 6620-6625

  Wang, Hai Qing ^a   Yang, Jian ^a   Yan, Lu Nan ^a   Zhang, Xiao Wu ^a   Yang, Jia Yin ^a  

^a SICHUAN UNIVERSITY   (China)

Author keywords

Complication; Elderly; Hepatectomy; Hepatitis B; Hepatocellular carcinoma

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; HEMOGLOBIN; HEPATITIS B SURFACE ANTIGEN; HEPATITIS B(E) ANTIGEN; VIRUS DNA;

ADULT; AGE; AGED; ARTICLE; ASCITES; BILE LEAKAGE; BLEEDING; CARDIOVASCULAR DISEASE; CHARLSON COMORBIDITY INDEX; COMORBIDITY; COMPARATIVE STUDY; DISEASE ASSOCIATION; DISEASE SEVERITY; FEMALE; HEPATITIS B; HUMAN; INFECTION; INTENSIVE CARE UNIT; INTRAOPERATIVE PERIOD; LIVER CELL CARCINOMA; LIVER FAILURE; LIVER RESECTION; LUNG DISEASE; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; MORBIDITY; MORTALITY; NEUROLOGIC DISEASE; PERIOPERATIVE PERIOD; POSTOPERATIVE COMPLICATION; PREOPERATIVE COMPLICATION; RETROSPECTIVE STUDY; SAFETY; TREATMENT OUTCOME; ADVERSE EFFECTS; BLOOD; CARCINOMA, HEPATOCELLULAR; COMPLICATION; LIVER NEOPLASMS; PROCEDURES;

ADULT; AGE FACTORS; AGED; CARCINOMA, HEPATOCELLULAR; COMORBIDITY; FEMALE; HEPATECTOMY; HEPATITIS B; HEPATITIS B E ANTIGENS; HEPATITIS B SURFACE ANTIGENS; HUMANS; LIVER NEOPLASMS; MALE; MIDDLE AGED; POSTOPERATIVE COMPLICATIONS; RETROSPECTIVE STUDIES; TREATMENT OUTCOME;

EID: 84902106886     PISSN: 10079327     EISSN: 22192840     Source Type: Journal    
DOI: 10.3748/wjg.v20.i21.6620     Document Type: Article

References (33)

1. Shariff MI, Cox IJ, Gomaa AI, Khan SA, Gedroyc W, Taylor- Robinson SD. Hepatocellular carcinoma: current trends in worldwide epidemiology, risk factors, diagnosis and therapeutics. Expert Rev Gastroenterol Hepatol 2009; 3: 353-367 [PMID: 19673623 DOI: 10.1586/egh.09.35]
2. Bosch FX, Ribes J, Díaz M, Cléries R. Primary liver cancer: worldwide incidence and trends. Gastroenterology 2004; 127: S5-S16 [PMID: 15508102]
3. Nishikawa H, Kimura T, Kita R, Osaki Y. Treatment for Hepatocellular Carcinoma in Elderly Patients: A Literature Review. J Cancer 2013; 4: 635-643 [PMID: 24155775 DOI: 10.7150/jca.7279]
4. Golfieri R, Bilbao JI, Carpanese L, Cianni R, Gasparini D, Ezziddin S, Paprottka PM, Fiore F, Cappelli A, Rodriguez M, Ettorre GM, Saltarelli A, Geatti O, Ahmadzadehfar H, Haug AR, Izzo F, Giampalma E, Sangro B, Pizzi G, Notarianni E, Vit A, Wilhelm K, Jakobs TF, Lastoria S. Comparison of the survival and tolerability of radioembolization in elderly vs. younger patients with unresectable hepatocellular carcinoma. J Hepatol 2013; 59: 753-761 [PMID: 23707371 DOI: 10.1016/j.jhep.2013.05.025]
5. Breitenstein S, DeOliveira ML, Raptis DA, Slankamenac K, Kambakamba P, Nerl J, Clavien PA. Novel and simple preoperative score predicting complications after liver resection in noncirrhotic patients. Ann Surg 2010; 252: 726-734 [PMID: 21037427 DOI: 10.1097/SLA.0b013e3181fb8c1a]
6. Wen T, Chen Z, Yan L, Li B, Zeng Y, Wu G, Zheng G. Continuous normothermic hemihepatic vascular inflow occlusion over 60 min for hepatectomy in patients with cirrhosis caused by hepatitis B virus. Hepatol Res 2007; 37: 346-352 [PMID: 17441807 DOI: 10.1111/j.1872-034X.2007.00061.x]
7. Pringle JH. V. Notes on the Arrest of Hepatic Hemorrhage Due to Trauma. Ann Surg 1908; 48: 541-549 [PMID: 17862242]
8. Clavien PA, Barkun J, de Oliveira ML, Vauthey JN, Dindo D, Schulick RD, de Santibañes E, Pekolj J, Slankamenac K, Bassi C, Graf R, Vonlanthen R, Padbury R, Cameron JL, Makuuchi M. The Clavien-Dindo classification of surgical complications: five-year experience. Ann Surg 2009; 250: 187-196 [PMID: 19638912 DOI: 10.1097/SLA.0b013e3181b13ca2]
9. Bruix J, Sherman M. Management of hepatocellular carcinoma. Hepatology 2005; 42: 1208-1236 [PMID: 16250051 DOI: 10.1002/hep.20933]
10. Romano PS, Roos LL, Jollis JG. Adapting a clinical comorbidity index for use with ICD-9-CM administrative data: differing perspectives. J Clin Epidemiol 1993; 46: 1075-1079; discussion 1081-1090 [PMID: 8410092]
11. Charlson ME, Pompei P, Ales KL, MacKenzie CR. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis 1987; 40: 373-383 [PMID: 3558716]
12. Balzan S, Belghiti J, Farges O, Ogata S, Sauvanet A, Delefosse D, Durand F. The "50-50 criteria" on postoperative day 5: an accurate predictor of liver failure and death after hepatectomy. Ann Surg 2005; 242: 824-828, discussion 828-829 [PMID: 16327492]
13. Portolani N, Baiocchi GL, Coniglio A, Tiberio GA, Prestini K, Gheza F, Benetti A, Maria Giulini S. Limited liver resection: a good indication for the treatment of hepatocellular carcinoma in elderly patients. Jpn J Clin Oncol 2011; 41: 1358-1365 [PMID: 22039578 DOI: 10.1093/jjco/hyr154]
14. Reddy SK, Barbas AS, Turley RS, Gamblin TC, Geller DA, Marsh JW, Tsung A, Clary BM, Lagoo-Deenadayalan S. Major liver resection in elderly patients: a multi-institutional analysis. J Am Coll Surg 2011; 212: 787-795 [PMID: 21435922 DOI: 10.1016/j.jamcollsurg.2010.12.048]
15. Schmucker DL. Age-related changes in liver structure and function: Implications for disease? Exp Gerontol 2005; 40: 650-659 [PMID: 16102930 DOI: 10.1016/j.exger.2005.06.009]
16. Shirabe K, Kajiyama K, Harimoto N, Gion T, Tsujita E, Abe T, Wakiyama S, Nagaie T, Maehara Y. Early outcome following hepatic resection in patients older than 80 years of age. World J Surg 2009; 33: 1927-1932 [PMID: 19603226 DOI: 10.1007/ s00268-009-0122-3]
17. Cho SW, Steel J, Tsung A, Marsh JW, Geller DA, Gamblin TC. Safety of liver resection in the elderly: how important is age? Ann Surg Oncol 2011; 18: 1088-1095 [PMID: 21046265 DOI: 10.1245/s10434-010-1404-6]
18. Cescon M, Grazi GL, Del Gaudio M, Ercolani G, Ravaioli M, Nardo B, Cavallari A. Outcome of right hepatectomies in patients older than 70 years. Arch Surg 2003; 138: 547-552 [PMID: 12742961 DOI: 10.1001/archsurg.138.5.547]
19. Hanazaki K, Kajikawa S, Shimozawa N, Shimada K, Hiraguri M, Koide N, Adachi W, Amano J. Hepatic resection for hepatocellular carcinoma in the elderly. J Am Coll Surg 2001; 192: 38-46 [PMID: 11192921]
20. Lee CR, Lim JH, Kim SH, Ahn SH, Park YN, Choi GH, Choi JS, Kim KS. A comparative analysis of hepatocellular carcinoma after hepatic resection in young versus elderly patients. J Gastrointest Surg 2012; 16: 1736-1743 [PMID: 22810298 DOI: 10.1007/s11605-012-1966-7]
21. Ferrero A, Viganò L, Polastri R, Ribero D, Lo Tesoriere R, Muratore A, Capussotti L. Hepatectomy as treatment of choice for hepatocellular carcinoma in elderly cirrhotic patients. World J Surg 2005; 29: 1101-1105 [PMID: 16088422 DOI: 10.1007/s00268-005-7768-2]
22. Aldrighetti L, Arru M, Caterini R, Finazzi R, Comotti L, Torri G, Ferla G. Impact of advanced age on the outcome of liver resection. World J Surg 2003; 27: 1149-1154 [PMID: 12917756 DOI: 10.1007/s00268-003-7072-y]
23. Honda T, Miyaaki H, Ichikawa T, Taura N, Miuma S, Shibata H, Isomoto H, Takeshima F, Nakao K. Clinical characteristics of hepatocellular carcinoma in elderly patients. Oncol Lett 2011; 2: 851-854 [PMID: 22866139 DOI: 10.3892/ ol.2011.359]
24. Mirici-Cappa F, Gramenzi A, Santi V, Zambruni A, Di Micoli A, Frigerio M, Maraldi F, Di Nolfo MA, Del Poggio P, Benvegnù L, Rapaccini G, Farinati F, Zoli M, Borzio F, Giannini EG, Caturelli E, Bernardi M, Trevisani F. Treatments for hepatocellular carcinoma in elderly patients are as effective as in younger patients: a 20-year multicentre experience. Gut 2010; 59: 387-396 [PMID: 20207642 DOI: 10.1136/ gut.2009.194217]
25. Zhou L, Rui JA, Wang SB, Chen SG, Qu Q, Chi TY, Wei X, Han K, Zhang N, Zhao HT. Clinicopathological features, post-surgical survival and prognostic indicators of elderly patients with hepatocellular carcinoma. Eur J Surg Oncol 2006; 32: 767-772 [PMID: 16725304 DOI: 10.1016/j.ejso.2006.03.050]
26. Kaibori M, Matsui K, Ishizaki M, Saito T, Kitade H, Matsui Y, Kwon AH. Hepatic resection for hepatocellular carcinoma in the elderly. J Surg Oncol 2009; 99: 154-160 [PMID: 19123236 DOI: 10.1002/jso.21221]
27. Huang J, Li BK, Chen GH, Li JQ, Zhang YQ, Li GH, Yuan YF. Long-term outcomes and prognostic factors of elderly patients with hepatocellular carcinoma undergoing hepatectomy. J Gastrointest Surg 2009; 13: 1627-1635 [PMID: 19506976 DOI: 10.1007/s11605-009-0933-4]
28. Kondo K, Chijiiwa K, Funagayama M, Kai M, Otani K, Ohuchida J. Hepatic resection is justified for elderly patients with hepatocellular carcinoma. World J Surg 2008; 32: 2223-2229 [PMID: 18642042 DOI: 10.1007/s00268-008-9688-4]
29. El-Serag HB. Epidemiology of viral hepatitis and hepatocellular carcinoma. Gastroenterology 2012; 142: 1264-1273.e1 [PMID: 22537432 DOI: 10.1053/j.gastro.2011.12.061]
30. Oishi K, Itamoto T, Kobayashi T, Oshita A, Amano H, Ohdan H, Tashiro H, Asahara T. Hepatectomy for hepatocellular carcinoma in elderly patients aged 75 years or more. J Gastrointest Surg 2009; 13: 695-701 [PMID: 19050982 DOI: 10.1007/s11605-008-0758-6]
31. Yau T, Yao TJ, Chan P, Epstein RJ, Ng KK, Chok SH, Cheung TT, Fan ST, Poon RT. The outcomes of elderly patients with hepatocellular carcinoma treated with transarterial chemoembolization. Cancer 2009; 115: 5507-5515 [PMID: 19701904 DOI: 10.1002/cncr.24636]
32. Nakamuta M, Morizono S, Kohjima M, Kotoh K, Enjoji M. Baseline characterization of patients aged 70 years and above with hepatocellular carcinoma. World J Gastroenterol 2005; 11: 7512-7514 [PMID: 16437725]
33. Ramacciato G, D'Angelo F, Baldini R, Petrucciani N, Antolino L, Aurello P, Nigri G, Bellagamba R, Pezzoli F, Balesh A, Cucchetti A, Cescon M, Del Gaudio M, Ravaioli M, Pinna AD. Hepatocellular carcinomas and primary liver tumors as predictive factors for postoperative mortality after liver resection: a meta-analysis of more than 35,000 hepatic resections. Am Surg 2012; 78: 456-467 [PMID: 22472405]