Comparison of the survival and tolerability of radioembolization in elderly vs. younger patients with unresectable hepatocellular carcinoma

Journal of Hepatology

Volumn 59, Issue 4, 2013, Pages 753-761

  Golfieri, Rita ^a   Bilbao, Josè Ignacio ^b   Carpanese, Livio ^c   Cianni, Roberto ^d   Gasparini, Daniele ^e   Ezziddin, Samer ^f   Paprottka, Philipp Marius ^g   Fiore, Francesco ^h   Cappelli, Alberta ^a   Rodriguez, Macarena ^b   Ettorre, Giuseppe Maria ⁱ   Saltarelli, Adelchi ^d   Geatti, Onelio ^e   Ahmadzadehfar, Hojjat ^f   Haug, Alexander R ^g   Izzo, Francesco ^h   Giampalma, Emanuela ^a   Sangro, Bruno ^b,j   Pizzi, Giuseppe ^c   Notarianni, Ermanno ^d   Vit, Alessandro ^e   Wilhelm, Kai ^f   Jakobs, Tobias F ^g   Lastoria, Secondo ^h   Galaverni, Maria Cristina ^a   Gavaruzzi, Gilberto ^a   Fanti, Stefano ^a   Santoro, Roberto ⁱ   Pelle, Giuseppe ^d   Filippi, Luca ^d   Kuhl, Christiane ^f   Reiser, Maximilian F ^g   Arbizu, Javier ^b   Benito, Alberto ^b   D'Avola, Delia ^b   Iñarrairaegui, Mercedes ^b   Maini, Carlo L ^c   Milella, Michele ^c   Sciuto, Rosa ^c   Vennarecci, Giovanni ^c   Angelelli, Bruna ^a   Mosconi, Cristina ^a   Renzulli, Matteo ^a   Pettinato, Cinzia ^a   Monari, Fabio ^a   Mazzarotto, Renzo ^a   Ferretti, Guido ^e   Manazzone, Orfea ^e   Soardo, Giorgio ^e   Toniutto, Pierluigi ^e   Bagni, Oreste ^d   D'Agostini, Antonio ^d   Salvatori, Rita ^d   Urigo, Carlo ^d   Albino, Vittorio ^h   Aloy, Luigi ^h   Arrichiello, Cecilia ^h   D'Angelo, Roberto ^h   Meyer, Carsten ^f   Palmedo, Holger ^f   Schild, Hans Heinz ^f   Schmitz, Volker ^f   Bartenstein, Peter ^g   Hoffmann, Ralf T ^g   Kolligs, Frank T ^g   Trumm, Christoph ^g   more..

^a UNIVERSITY OF BOLOGNA   (Italy)

^b UNIVERSITY CLINIC OF NAVARRA   (Spain)

^c REGINA ELENA NATIONAL CANCER INSTITUTE   (Italy)

^d SANTA MARIA GORETTI HOSPITAL   (Italy)

^e SANTA MARIA DELLA MISERICORDIA UNIVERSITY HOSPITAL   (Italy)

^f Uniklinik Bonn   (Germany)

^g UNIVERSITY OF MUNICH   (Germany)

^h NATIONAL CANCER INSTITUTE   (Italy)

ⁱ SAN CAMILLO FORLANINI HOSPITAL   (Italy)

^j INSTITUTO DE SALUD CARLOS III   (Spain)

more..

Author keywords

Elderly patients; HCC; Hepatocellular carcinoma; Radioembolization; Safety; SIRT; Survival; Tolerability

Indexed keywords

ALANINE AMINOTRANSFERASE; ALBUMIN; ALPHA FETOPROTEIN; BILIRUBIN; CREATININE; RESIN;

ABDOMINAL PAIN; ADULT; AGED; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALBUMIN BLOOD LEVEL; ARTICLE; ARTIFICIAL EMBOLISM; ASCITES; BILIRUBIN BLOOD LEVEL; BRAIN DISEASE; CANCER DIAGNOSIS; CANCER SURVIVAL; CHEMOEMBOLIZATION; CHILD PUGH SCORE; COMPARATIVE STUDY; CONTROLLED STUDY; DIGESTIVE SYSTEM ULCER; DISEASE SEVERITY; DRUG SAFETY; DRUG TOLERABILITY; FATIGUE; FEMALE; FEVER; GROUPS BY AGE; HEPATITIS B; HEPATITIS C; HUMAN; HYPOALBUMINEMIA; INTERNATIONAL NORMALIZED RATIO; LIVER CELL CARCINOMA; LIVER WEIGHT; MAJOR CLINICAL STUDY; MALE; METASTASIS; OVERALL SURVIVAL; PORTAL VEIN OBSTRUCTION; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RADIOEMBOLIZATION; RETROSPECTIVE STUDY; SURVIVAL TIME; TREATMENT OUTCOME; TUMOR VOLUME; VOMITING;

(90)Y; (99M)TC-MAA; ADVERSE EVENTS; AES; AFP; ALANINE TRANSAMINASE; ALPHA FETOPROTEIN; ALT; ANALYSIS OF VARIANCE; ANOVA; BARCELONA CLINIC LIVER CANCER; BCLC; COMMON TOXICITY CRITERIA ADVERSE EVENTS; COMPUTED TOMOGRAPHY; CT; CTCAE; EASL; ECOG; ELDERLY PATIENTS; ENRY; EUROPEAN ASSOCIATION FOR THE STUDY OF THE LIVER; EUROPEAN COOPERATIVE ONCOLOGY GROUP; EUROPEAN NETWORK ON RADIOEMBOLIZATION WITH YTTRIUM-90; GAMMA-GLUTAMYL TRANSPEPTIDASE; GASTROINTESTINAL; GBQ; GGTP; GI; GIGABECQUEREL; HBV; HCC; HCV; HEPATITIS B VIRUS; HEPATITIS C VIRUS; HEPATOCELLULAR CARCINOMA; INR; INTERNATIONAL NORMALIZED RATIO; MELD; MODEL FOR END-STAGE LIVER DISEASE; NASH; NON-ALCOHOLIC STEATOHEPATITIS; PEI; PERCUTANEOUS ETHANOL INJECTION; RADIOEMBOLIZATION; RADIOEMBOLIZATION-INDUCED LIVER DISEASE; RADIOFREQUENCY ABLATION; REILD; RFA; SAFETY; SD; SELECTIVE INTERNAL RADIATION THERAPY; SIRT; STANDARD DEVIATION; SURVIVAL; TACE; TECHNETIUM-99M MACROAGGREGATED ALBUMIN; TOLERABILITY; TRANSARTERIAL CHEMOEMBOLIZATION; YTTRIUM-90;

ADULT; AGE FACTORS; AGED; AGED, 80 AND OVER; CARCINOMA, HEPATOCELLULAR; EMBOLIZATION, THERAPEUTIC; FEMALE; HUMANS; KAPLAN-MEIER ESTIMATE; LIVER NEOPLASMS; MALE; MICROSPHERES; MIDDLE AGED; RADIOPHARMACEUTICALS; RETROSPECTIVE STUDIES; TREATMENT OUTCOME; YOUNG ADULT; YTTRIUM RADIOISOTOPES;

EID: 84884418790     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2013.05.025     Document Type: Article

References (42)

1. H.B. El-Serag, and K.L. Rudolph Hepatocellular carcinoma: epidemiology and molecular carcinogenesis Gastroenterology 132 2007 2557 2576 (Pubitemid 46890874)
2. V. Ozenne, M. Bouattour, N. Gouttè, M.P. Vullierme, M.P. Ripault, and C. Castelnau Prospective evaluation of the management of hepatocellular carcinoma in the elderly Dig Liver Dis 43 2011 1001 1005
3. T. Stroffolini, F. Trevisani, G. Pinzello, F. Brunello, M.A. Tommasini, and M. Iavarone Changing aetiological factors of hepatocellular carcinoma and their potential impact on the effectiveness of surveillance Dig Liver Dis 43 2011 875 880
4. T. Teratani, T. Ishikawa, Y. Shiratori, S. Shiina, H. Yoshida, and M. Imamura Hepatocellular carcinoma in elderly patients Cancer 95 2002 816 823
5. A. Nanashima, T. Abo, T. Nonaka, H. Fukuoka, S. Hidaka, and H. Takeshita Prognosis of patients with hepatocellular carcinoma after hepatic resection: are elderly patients suitable for surgery? J Surg Onc 104 2011 284 291
6. F. Mirici-Cappa, A. Gramenzi, V. Santi, A. Zambruni, A. Di Micoli, and M. Frigerio Treatments for hepatocellular carcinoma in elderly patients are as effective as in younger patients: a 20-year multicentre experience Gut 59 2010 387 396
7. S. Boehm, C. Rothermundt, D. Hess, and M. Joerger Antiangiogenic drugs in oncology: a focus on drug safety and the elderly - a mini-review Gerontology 56 2010 303 309
8. M. Morimoto, K. Numata, M. Kondo, H. Hidaka, J. Takada, and A. Shibuya Higher discontinuation and lower survival rates are likely in elderly Japanese patients with advanced hepatocellular carcinoma receiving sorafenib Hepatol Res 41 2011 296 302
9. R.T. Poon, S.T. Fan, C.M. Lo, C.H. Liu, H. Ngan, and I.O. Ng Hepatocellular carcinoma in the elderly: results of surgical and non-surgical management Am J Gastroenterol 94 1999 2460 2466 (Pubitemid 29420674)
10. J. Huang, B.K. Li, G.H. Chen, J.Q. Li, Y.Q. Zhang, and G.H. Li Long-term outcomes and prognostic factors of elderly patients with hepatocellular carcinoma undergoing hepatectomy J Gastrointest Surg 13 2009 1627 1635
11. K. Oishi, T. Itamoto, T. Kobayashi, A. Oshita, H. Amano, and H. Ohdan Hepatectomy for hepatocellular carcinoma in elderly patients aged 75 years or more J Gastrointest Surg 13 2009 695 701
12. Y. Hoshida, K. Ikeda, M. Kobayashi, Y. Suzuki, A. Tsubota, and S. Saitoh Chronic liver disease in the extremely elderly of 80 years or more: clinical characteristics, prognosis and patient survival analysis J Hepatol 31 1999 860 866 (Pubitemid 29514219)
13. T. Yau, T.J. Yao, P. Chan, R.J. Epstein, K.K. Ng, and S.H. Chok The outcomes of elderly patients with hepatocellular carcinoma treated with transarterial chemoembolization Cancer 1 2009 5507 5515
14. M. Biselli, P. Forti, F. Mucci, F.G. Foschi, L. Marsigli, and F. Caputo Chemoembolization versus chemotherapy in elderly patients with unresectable hepatocellular carcinoma and contrast uptake as prognostic factor J Gerontol A Biol Sci Med Sci 52 1997 M305 M309
15. L. Mondazzi, R. Bottelli, G. Brambilla, A. Ramboldi, I. Rezakovic, and C. Zavaglia Transarterial oily chemoembolization for hepatocellular carcinoma: a multivariate analysis of prognostic factors Hepatology 19 1994 1115 1123
16. J.M. Llovet, M. Ducreux, R. Lencioni, A.M. Di Bisceglie, P.R. Galle, and J.F. Dufour EASL-EORTC clinical practice guidelines: management of hepatocellular carcinoma J Hepatol 56 2012 908 943
17. A. Hiraoka, K. Michitaka, N. Horiike, S. Hidaka, T. Uehara, and S. Ichikawa Radiofrequency ablation therapy for hepatocellular carcinoma in elderly patients J Gastroenterol Hepatol 25 2010 403 407
18. H. Takahashi, T. Mizuta, S. Kawazoe, Y. Eguchi, Y. Kawaguchi, and T. Otuka Efficacy and safety of radiofrequency ablation for elderly hepatocellular carcinoma patients Hepatol Res 40 2010 997 1005
19. J. Schwartz Liver transplantation in septuagenarians receiving MELD exception points for HCC: the national experience Liver Transpl 18 2012 1395 1396
20. R. Lencioni, M. Kudo, S.L. Ye, J.P. Bronowicki, X.P. Chen, and L. Dagher First interim analysis of the GIDEON (Global Investigation of therapeutic decisions in hepatocellular carcinoma and of its treatment with sorafeNib) non-interventional study Int J Clin Pract 66 2012 675 683
21. H. Wong, Y.F. Tang, T.J. Yao, J. Chiu, R. Leung, and P. Chan The outcomes and safety of single-agent sorafenib in the treatment of elderly patients with advanced hepatocellular carcinoma (HCC) Oncologist 16 2011 1721 1728
22. B.J. Carr, V. Kondragunta, S.C. Buch, and R.A. Branch Therapeutic equivalence in survival for hepatic arterial chemoembolization and Yttrium 90 microsphere treatments in unresectable hepatocellular carcinoma. A two-cohort study Cancer 2010 1 10
23. R. Salem, R.J. Lewandowski, M.F. Mulcahy, A. Riaz, R.K. Ryu, and S. Ibrahim Radioembolization for hepatocellular carcinoma using yttrium-90 microspheres: a comprehensive report of long-term outcomes Gastroenterology 138 2010 52 64
24. P. Hilgard, M. Hamami, A.E. Fouly, A. Scherag, S. Muller, and J. Ertle Radioembolization with yttrium-90 glass microspheres in hepatocellular carcinoma: European experience on safety and long-term survival Hepatology 52 2010 1741 1749
25. 90Y resin microsphere radioembolization of hepatocellular carcinoma across BCLC stages: a European evaluation Hepatology 57 2013 1826 1837
26. V. Mazzaferro, C. Sposito, S. Bhoori, R. Romito, C. Chiesa, and C. Morosi Yttrium(90) radioembolization for intermediate-advanced hepatocarcinoma: a phase II study Hepatology 57 2013 1826 1837
27. M. Iñarrairaegui, J.I. Bilbao, M. Rodríguez, A. Benito, and B. Sangro Liver radioembolization using 90Y resin microspheres in elderly patients: tolerance and outcome Hosp Pract 38 2010 103 109
28. J. Bruix, and M. Sherman Practice Guidelines Committee, American Association for the Study of Liver Diseases. Management of hepatocellular carcinoma Hepatology 42 2005 1208 1236
29. V. Santi, D. Buccione, A. Di Micoli, G. Fatti, M. Frigerio, and F. Farinati The changing scenario of hepatocellular carcinoma over the last two decades in Italy J Hepatol 56 2012 397 405
30. K.A. McGlynn, and W.T. London Epidemiology and natural history of hepatocellular carcinoma Best Pract Clin Gastroenterol 19 2005 3 23 (Pubitemid 40331495)
31. T. Yang, J.H. Lu, J. Zhai, C. Lin, G.S. Yang, and R.H. Zhao High viral load is associated with poor overall and recurrence-free survival of hepatitis B virus-related hepatocellular carcinoma after curative resection: a prospective cohort study Eur J Surg Oncol 38 2012 683 691
32. O.N. Kozyreva, D. Chi, J.W. Clark, H. Wang, K.P. Theall, and D.P. Ryan A multicenter retrospective study on clinical characteristics, treatment patterns, and outcome in elderly patients with hepatocellular carcinoma Oncologist 16 2011 310 318
33. H. Fujii, Y. Itoh, N. Ohnishi, M. Sakamoto, T. Ohkawara, and Y. Sawa Factors associated with the overall survival of elderly patients with hepatocellular carcinoma World J Gastroenterol 18 2012 1926 1932
34. F. Nomura, K. Ohnishi, M. Honda, Y. Satomura, T. Nakai, and K. Okuda Clinical features of hepatocellular carcinoma in the elderly: a study of 91 patients older than 70 years Br J Cancer 70 1994 690 693 (Pubitemid 24305600)
35. K. Dohmen, M. Shirahama, Y. Miyamoto, Y. Torii, K. Irie, and H. Ishibashi Differences in survival based on the type of follow-up for the detection of hepatocellular carcinoma: an analysis of 547 patients Hepatol Res 18 2000 110 121 (Pubitemid 30458681)
36. J.N. Vauthey, E.K. Abdalla, D.A. Doherty, P. Gertsch, M.J. Fenstermacher, and E.M. Loyer Body surface area and body weight predict total liver volume in western adults Liver Transpl 8 2002 233 240 (Pubitemid 34257205)
37. B. Sangro, B. Gil-Alzugaray, J. Rodriguez, I. Sola, A. Martinez-Cuesta, and A. Viudez Liver disease induced by radioembolization of liver tumors: description and possible risk factors Cancer 112 2008 1538 1546 (Pubitemid 351441166)
38. B. Sangro, M. Inarrairaegui, and J.I. Bilbao Radioembolization for hepatocellular carcinoma J Hepatol 56 2012 464 473
39. B. Gil-Alzugaray, A. Chopitea, M. Iñarrairaegui, J.I. Bilbao, M. Rodriguez-Fraile, and J. Rodriguez Prognostic factors and prevention of radioembolization-induced liver disease Hepatology 57 2013 1078 1087
40. J. Bruix, J.L. Raoul, M. Sherman, V. Mazzaferro, L. Bolondi, and A. Craxi Efficacy and safety of sorafenib in patients with advanced hepatocellular carcinoma: subanalyses of a phase III trial J Hepatol 57 2012 821 829
41. R. Salem, R.J. Lewandowski, L. Kulik, E. Wang, A. Riaz, and K.T. Sato Radioembolization results in longer time-to-progression and reduced toxicity compared with chemoembolization in patients with hepatocellular carcinoma Gastroenterology 140 2011 497 507
42. D. Coldwell, B. Sangro, H. Wasan, R. Salem, and A. Kennedy General selection criteria of patients for radioembolization of liver tumors: an international working group report Am J Clin Oncol 34 2011 337 341