메뉴 건너뛰기




Volumn 4, Issue 8, 2013, Pages 635-643

Treatment for hepatocellular carcinoma in elderly patients: A literature review

Author keywords

Cancer treatment; Clinical characteristics; Clinical outcome; Elderly patients; Hepatocellular carcinoma

Indexed keywords

ANTINEOPLASTIC AGENT; SORAFENIB;

EID: 84885439523     PISSN: None     EISSN: 18379664     Source Type: Journal    
DOI: 10.7150/jca.7279     Document Type: Review
Times cited : (90)

References (106)
  • 1
    • 77954498329 scopus 로고    scopus 로고
    • Radiofrequency ablation for hepatocellular carcinoma: updated review in 2010
    • Kudo M. Radiofrequency ablation for hepatocellular carcinoma: updated review in 2010. Oncology 2010; 78: 113-24.
    • (2010) Oncology , vol.78 , pp. 113-124
    • Kudo, M.1
  • 2
    • 79952943436 scopus 로고    scopus 로고
    • Treatment options in hepatocellular carcinoma today
    • Livraghi T, Mäkisalo H, Line PD. Treatment options in hepatocellular carcinoma today. Scand J Surg 2011; 100: 22-9.
    • (2011) Scand J Surg , vol.100 , pp. 22-29
    • Livraghi, T.1    Mäkisalo, H.2    Line, P.D.3
  • 3
    • 84860287080 scopus 로고    scopus 로고
    • Epidemiology of viral hepatitis and hepatocellular carcinoma
    • El-Serag HB. Epidemiology of viral hepatitis and hepatocellular carcinoma. Gastroenterology 2012; 142: 1264-73.
    • (2012) Gastroenterology , vol.142 , pp. 1264-1273
    • El-Serag, H.B.1
  • 5
    • 80053088189 scopus 로고    scopus 로고
    • Hepatocellular carcinoma
    • El-Serag HB. Hepatocellular carcinoma. N Engl J Med 2011; 365(12): 1118-27.
    • (2011) N Engl J Med , vol.365 , Issue.12 , pp. 1118-1127
    • El-Serag, H.B.1
  • 6
    • 75349095780 scopus 로고    scopus 로고
    • Changing trends in hepatitis C infection over the past 50 years in Japan
    • Chung H, Ueda T, Kudo M. Changing trends in hepatitis C infection over the past 50 years in Japan. Intervirology. 2010; 53(1): 39-43.
    • (2010) Intervirology , vol.53 , Issue.1 , pp. 39-43
    • Chung, H.1    Ueda, T.2    Kudo, M.3
  • 8
    • 80054108345 scopus 로고    scopus 로고
    • [Internet] Ministry of Health. Labour and Welfare
    • [Internet] Ministry of Health. Labour and Welfare. Abridged life tables for Japan 2006. http://www.mhlw.go.jp/english/database/db-hw/lifetb06/index.html.
    • Abridged life tables for Japan 2006
  • 9
    • 34547652164 scopus 로고    scopus 로고
    • Do young hepatocellular carcinoma patients with relatively good liver function have poorer outcomes than elderly patients?
    • Cho SJ, Yoon JH, Hwang SS, et al. Do young hepatocellular carcinoma patients with relatively good liver function have poorer outcomes than elderly patients? J Gastroenterol Hepatol 2007; 22: 1226-1231.
    • (2007) J Gastroenterol Hepatol , vol.22 , pp. 1226-1231
    • Cho, S.J.1    Yoon, J.H.2    Hwang, S.S.3
  • 10
    • 77955739982 scopus 로고    scopus 로고
    • Effect of aging on risk for hepatocellular carcinoma in chronic hepatitis C virus infection
    • Asahina Y, Tsuchiya K, Tamaki N, et al. Effect of aging on risk for hepatocellular carcinoma in chronic hepatitis C virus infection. Hepatology 2010; 52: 518-527.
    • (2010) Hepatology , vol.52 , pp. 518-527
    • Asahina, Y.1    Tsuchiya, K.2    Tamaki, N.3
  • 11
    • 0036293973 scopus 로고    scopus 로고
    • Characteristics of hepatocellular carcinoma in Japan
    • Kiyosawa K, Tanaka E. Characteristics of hepatocellular carcinoma in Japan. Oncology 2002; 62 Suppl 1: 5-7.
    • (2002) Oncology , vol.62 , Issue.SUPPL. 1 , pp. 5-7
    • Kiyosawa, K.1    Tanaka, E.2
  • 12
    • 34447335306 scopus 로고    scopus 로고
    • Report of the 17th Nationwide Follow-up Survey of Primary Liver Cancer in Japan
    • The Liver Cancer Study Group of Japan, Kyoto, Japan
    • Ikai I, Arii S, Okazaki M, et al: The Liver Cancer Study Group of Japan, Kyoto, Japan. Report of the 17th Nationwide Follow-up Survey of Primary Liver Cancer in Japan. Hepatol Res 2007; 37: 676-691.
    • (2007) Hepatol Res , vol.37 , pp. 676-691
    • Ikai, I.1    Arii, S.2    Okazaki, M.3
  • 13
    • 77953724339 scopus 로고    scopus 로고
    • The changing pattern of epidemiology in hepatocellular carcinoma
    • Nordenstedt H, White DL, El-Serag HB. The changing pattern of epidemiology in hepatocellular carcinoma. Dig Liver Dis. 2010; 42 Suppl 3: S206-S214.
    • (2010) Dig Liver Dis. , vol.42 , Issue.SUPPL. 3
    • Nordenstedt, H.1    White, D.L.2    El-Serag, H.B.3
  • 14
    • 84877281966 scopus 로고    scopus 로고
    • Trans-arterial chemo-embolization is safe and effective for very elderly patients with hepatocellular carcinoma
    • Cohen MJ, Bloom AI, Barak O, et al. Trans-arterial chemo-embolization is safe and effective for very elderly patients with hepatocellular carcinoma. World J Gastroenterol. 2013; 19(16): 2521-8.
    • (2013) World J Gastroenterol. , vol.19 , Issue.16 , pp. 2521-2528
    • Cohen, M.J.1    Bloom, A.I.2    Barak, O.3
  • 15
    • 0141491273 scopus 로고    scopus 로고
    • Hepatocellular carcinoma
    • Llovet JM, Burroughs A, Bruix J. Hepatocellular carcinoma. Lancet 2003; 362(9399): 1907-17.
    • (2003) Lancet , vol.362 , Issue.9399 , pp. 1907-1917
    • Llovet, J.M.1    Burroughs, A.2    Bruix, J.3
  • 16
    • 79951683605 scopus 로고    scopus 로고
    • Hepatocellular carcinoma: current management and perspectives for the future
    • Rahbari NN, Mehrabi A, Mollberg NM, et al. Hepatocellular carcinoma: current management and perspectives for the future. Ann Surg 2011; 253(3): 453-69.
    • (2011) Ann Surg , vol.253 , Issue.3 , pp. 453-469
    • Rahbari, N.N.1    Mehrabi, A.2    Mollberg, N.M.3
  • 17
    • 1842610868 scopus 로고    scopus 로고
    • Sex- and age-specific carriers of hepatitis B and C viruses in Japan estimated by the prevalence in the 3,485,648 first-time blood donors during 1995-2000
    • Tanaka J, Kumagai J, Katayama K, et al. Sex- and age-specific carriers of hepatitis B and C viruses in Japan estimated by the prevalence in the 3,485,648 first-time blood donors during 1995-2000. Intervirology. 2004; 47(1): 32-40.
    • (2004) Intervirology , vol.47 , Issue.1 , pp. 32-40
    • Tanaka, J.1    Kumagai, J.2    Katayama, K.3
  • 18
    • 84873604286 scopus 로고    scopus 로고
    • Antiviral resistance and the future landscape of hepatitis C virus infection therapy
    • Wyles DL. Antiviral resistance and the future landscape of hepatitis C virus infection therapy. J Infect Dis. 2013; 207 Suppl 1: S33-9.
    • (2013) J Infect Dis. , vol.207 , Issue.SUPPL. 1
    • Wyles, D.L.1
  • 19
    • 84875925389 scopus 로고    scopus 로고
    • HCV RNA viral load assessments in the era of direct-acting antivirals
    • Cobb B, Pockros PJ, Vilchez RA, et al. HCV RNA viral load assessments in the era of direct-acting antivirals. Am J Gastroenterol. 2013; 108(4): 471-5.
    • (2013) Am J Gastroenterol. , vol.108 , Issue.4 , pp. 471-475
    • Cobb, B.1    Pockros, P.J.2    Vilchez, R.A.3
  • 20
    • 84872038038 scopus 로고    scopus 로고
    • Interferon free therapy with direct acting antivirals for HCV
    • Asselah T, Marcellin P. Interferon free therapy with direct acting antivirals for HCV. Liver Int. 2013; 33 Suppl 1: 93-104.
    • (2013) Liver Int. , vol.33 , Issue.SUPPL. 1 , pp. 93-104
    • Asselah, T.1    Marcellin, P.2
  • 21
    • 84875058847 scopus 로고    scopus 로고
    • Percutaneous radiofrequency ablation for hepatocellular carcinoma: clinical outcome and safety in elderly patients
    • Nishikawa H, Osaki Y, Iguchi E, et al. Percutaneous radiofrequency ablation for hepatocellular carcinoma: clinical outcome and safety in elderly patients. J Gastrointestin Liver Dis 2012; 21(4): 397-405.
    • (2012) J Gastrointestin Liver Dis , vol.21 , Issue.4 , pp. 397-405
    • Nishikawa, H.1    Osaki, Y.2    Iguchi, E.3
  • 22
    • 77957245589 scopus 로고    scopus 로고
    • Efficacy and safety of radiofrequency ablation for elderly hepatocellular carcinoma patients
    • Takahashi H, Mizuta T, Kawazoe S, et al. Efficacy and safety of radiofrequency ablation for elderly hepatocellular carcinoma patients. Hepatol Res. 2010; 40(10): 997-1005.
    • (2010) Hepatol Res. , vol.40 , Issue.10 , pp. 997-1005
    • Takahashi, H.1    Mizuta, T.2    Kawazoe, S.3
  • 23
    • 84856481801 scopus 로고    scopus 로고
    • Younger hepatocellular carcinoma patients have better prognosis after percutaneous radiofrequency ablation therapy
    • Kao WY, Chiou YY, Hung HH, et al. Younger hepatocellular carcinoma patients have better prognosis after percutaneous radiofrequency ablation therapy. J Clin Gastroenterol. 2012; 46(1): 62-70.
    • (2012) J Clin Gastroenterol. , vol.46 , Issue.1 , pp. 62-70
    • Kao, W.Y.1    Chiou, Y.Y.2    Hung, H.H.3
  • 24
    • 51649086596 scopus 로고    scopus 로고
    • Hepatic resection is justified for elderly patients with hepatocellular carcinoma
    • Kondo K, Chijiiwa K, Funagayama M, et al. Hepatic resection is justified for elderly patients with hepatocellular carcinoma. World J Surg. 2008; 32(10): 2223-9.
    • (2008) World J Surg. , vol.32 , Issue.10 , pp. 2223-2229
    • Kondo, K.1    Chijiiwa, K.2    Funagayama, M.3
  • 25
    • 70349427046 scopus 로고    scopus 로고
    • Long-term outcomes and prognostic factors of elderly patients with hepatocellular carcinoma undergoing hepatectomy
    • Huang J, Li BK, Chen GH, et al. Long-term outcomes and prognostic factors of elderly patients with hepatocellular carcinoma undergoing hepatectomy. J Gastrointest Surg. 2009; 13(9): 1627-35.
    • (2009) J Gastrointest Surg. , vol.13 , Issue.9 , pp. 1627-1635
    • Huang, J.1    Li, B.K.2    Chen, G.H.3
  • 26
    • 84863119498 scopus 로고    scopus 로고
    • The effect of age on the long-term prognosis of patients with hepatocellular carcinoma after resection surgery: a propensity score matching analysis
    • Su CW, Lei HJ, Chau GY, et al. The effect of age on the long-term prognosis of patients with hepatocellular carcinoma after resection surgery: a propensity score matching analysis. Arch Surg. 2012; 147(2): 137-44 27.
    • (2012) Arch Surg. , vol.147 , Issue.2
    • Su, C.W.1    Lei, H.J.2    Chau, G.Y.3
  • 27
    • 0033199994 scopus 로고    scopus 로고
    • Hepatocellular carcinoma in the elderly: results of surgical and nonsurgical management
    • Poon RT, Fan ST, Lo CM, et al. Hepatocellular carcinoma in the elderly: results of surgical and nonsurgical management. Am J Gastroenterol. 1999; 94(9): 2460-6.
    • (1999) Am J Gastroenterol. , vol.94 , Issue.9 , pp. 2460-2466
    • Poon, R.T.1    Fan, S.T.2    Lo, C.M.3
  • 28
    • 10744226402 scopus 로고    scopus 로고
    • Hepatic resection for hepatocellular carcinoma in elderly patients
    • Yeh CN, Lee WC, Jeng LB, et al. Hepatic resection for hepatocellular carcinoma in elderly patients. Hepatogastroenterology. 2004; 51(55): 219-23.
    • (2004) Hepatogastroenterology. , vol.51 , Issue.55 , pp. 219-223
    • Yeh, C.N.1    Lee, W.C.2    Jeng, L.B.3
  • 29
    • 84879906346 scopus 로고    scopus 로고
    • Surgical resection for hepatocellular carcinoma: clinical outcomes and safety in elderly patients
    • [Epub ahead of print]
    • Nishikawa H, Arimoto A, Wakasa T, et al. Surgical resection for hepatocellular carcinoma: clinical outcomes and safety in elderly patients. Eur J Gastroenterol Hepatol. 2013; [Epub ahead of print]
    • (2013) Eur J Gastroenterol Hepatol.
    • Nishikawa, H.1    Arimoto, A.2    Wakasa, T.3
  • 30
    • 33747756127 scopus 로고    scopus 로고
    • Clinicopathological features, post-surgical survival and prognostic indicators of elderly patients with hepatocellular carcinoma
    • Zhou L, Rui JA, Wang SB, et al. Clinicopathological features, post-surgical survival and prognostic indicators of elderly patients with hepatocellular carcinoma. Eur J Surg Oncol. 2006; 32(7): 767-72.
    • (2006) Eur J Surg Oncol. , vol.32 , Issue.7 , pp. 767-772
    • Zhou, L.1    Rui, J.A.2    Wang, S.B.3
  • 31
    • 79955579965 scopus 로고    scopus 로고
    • Major liver resection in elderly patients: a multi-institutional analysis
    • Reddy SK, Barbas AS, Turley RS, et al. Major liver resection in elderly patients: a multi-institutional analysis. J Am Coll Surg. 2011; 212(5): 787-95.
    • (2011) J Am Coll Surg. , vol.212 , Issue.5 , pp. 787-795
    • Reddy, S.K.1    Barbas, A.S.2    Turley, R.S.3
  • 32
    • 77749317233 scopus 로고    scopus 로고
    • Treatments for hepatocellular carcinoma in elderly patients are as effective as in younger patients: a 20-year multicentre experience
    • Italian Liver Cancer Group
    • Mirici-Cappa F, Gramenzi A, Santi V, et al; Italian Liver Cancer Group. Treatments for hepatocellular carcinoma in elderly patients are as effective as in younger patients: a 20-year multicentre experience. Gut. 2010; 59(3): 387-96.
    • (2010) Gut. , vol.59 , Issue.3 , pp. 387-396
    • Mirici-Cappa, F.1    Gramenzi, A.2    Santi, V.3
  • 33
    • 0028095430 scopus 로고
    • Liver resection for hepatocellular carcinoma in the elderly
    • Takenaka K, Shimada M, Higashi H, et al. Liver resection for hepatocellular carcinoma in the elderly. Arch Surg. 1994; 129(8): 846-50.
    • (1994) Arch Surg. , vol.129 , Issue.8 , pp. 846-850
    • Takenaka, K.1    Shimada, M.2    Higashi, H.3
  • 34
    • 77950861302 scopus 로고    scopus 로고
    • Outcome of repeat hepatectomy in patients with hepatocellular carcinoma aged 75 years and older
    • Tsujita E, Utsunomiya T, Ohta M, et al. Outcome of repeat hepatectomy in patients with hepatocellular carcinoma aged 75 years and older. Surgery. 2010; 147(5): 696-703.
    • (2010) Surgery. , vol.147 , Issue.5 , pp. 696-703
    • Tsujita, E.1    Utsunomiya, T.2    Ohta, M.3
  • 35
    • 0034085866 scopus 로고    scopus 로고
    • Who gets chemotherapy for metastatic lung cancer?
    • Earle CC, Venditti LN, Neumann PJ, et al. Who gets chemotherapy for metastatic lung cancer? Chest. 2000; 117: 1239-1246.
    • (2000) Chest , vol.117 , pp. 1239-1246
    • Earle, C.C.1    Venditti, L.N.2    Neumann, P.J.3
  • 36
    • 0345299824 scopus 로고    scopus 로고
    • Liver transplantation for the treatment of small hepatocellular carcinomas in patients with cirrhosis
    • Mazzaferro V, Regalia E, Doci R, et al. Liver transplantation for the treatment of small hepatocellular carcinomas in patients with cirrhosis. N Engl J Med 1996; 334(11): 693-9.
    • (1996) N Engl J Med , vol.334 , Issue.11 , pp. 693-699
    • Mazzaferro, V.1    Regalia, E.2    Doci, R.3
  • 37
    • 61549106905 scopus 로고    scopus 로고
    • A prospective, randomized, controlled trial of preoperative transarterial chemoembolization for resectable large hepatocellular carcinoma
    • Zhou WP, Lai EC, Li AJ, et al. A prospective, randomized, controlled trial of preoperative transarterial chemoembolization for resectable large hepatocellular carcinoma. Ann Surg 2009; 249(2): 195-202.
    • (2009) Ann Surg , vol.249 , Issue.2 , pp. 195-202
    • Zhou, W.P.1    Lai, E.C.2    Li, A.J.3
  • 38
    • 84873657788 scopus 로고    scopus 로고
    • Effect of transcatheter arterial chemoembolization prior to surgical resection for hepatocellular carcinoma
    • Nishikawa H, Arimoto A, Wakasa T, et al. Effect of transcatheter arterial chemoembolization prior to surgical resection for hepatocellular carcinoma. Int J Oncol 2013; 42(1): 151-60.
    • (2013) Int J Oncol , vol.42 , Issue.1 , pp. 151-160
    • Nishikawa, H.1    Arimoto, A.2    Wakasa, T.3
  • 39
    • 84872660484 scopus 로고    scopus 로고
    • Percutaneous radiofrequency ablation therapy for recurrent hepatocellular carcinoma
    • Nishikawa H, Osaki Y, Iguchi E, et al. Percutaneous radiofrequency ablation therapy for recurrent hepatocellular carcinoma. Anticancer Res 2012; 32(11): 5059-65.
    • (2012) Anticancer Res , vol.32 , Issue.11 , pp. 5059-5065
    • Nishikawa, H.1    Osaki, Y.2    Iguchi, E.3
  • 40
    • 84865041479 scopus 로고    scopus 로고
    • Transcatheter arterial infusion chemotherapy prior to radiofrequency thermal ablation for single hepatocellular carcinoma reduces the risk of intrahepatic distant recurrence
    • Nishikawa H, Osaki Y, Kita R, et al. Transcatheter arterial infusion chemotherapy prior to radiofrequency thermal ablation for single hepatocellular carcinoma reduces the risk of intrahepatic distant recurrence. Int J Oncol 2012; 41(3): 903-9.
    • (2012) Int J Oncol , vol.41 , Issue.3 , pp. 903-909
    • Nishikawa, H.1    Osaki, Y.2    Kita, R.3
  • 41
    • 84858658381 scopus 로고    scopus 로고
    • European Organisation For Research Treatment Of Cancer. EASL-EORTC clinical practice guidelines: management of hepatocellular carcinoma
    • European Association For The Study Of The Liver
    • European Association For The Study Of The Liver; European Organisation For Research And Treatment Of Cancer. EASL-EORTC clinical practice guidelines: management of hepatocellular carcinoma. J Hepatol 2012; 56(4): 908-43.
    • (2012) J Hepatol , vol.56 , Issue.4 , pp. 908-943
  • 42
    • 80051758429 scopus 로고    scopus 로고
    • Management of hepatocellular carcinoma in Japan: Consensus- Based Clinical Practice Guidelines proposed by the Japan Society of Hepatology (JSH) 2010 updated version
    • HCC Expert Panel of Japan Society of Hepatology
    • Kudo M, Izumi N, Kokudo N, et al; HCC Expert Panel of Japan Society of Hepatology. Management of hepatocellular carcinoma in Japan: Consensus- Based Clinical Practice Guidelines proposed by the Japan Society of Hepatology (JSH) 2010 updated version. Dig Dis 2011; 29(3): 339-64.
    • (2011) Dig Dis , vol.29 , Issue.3 , pp. 339-364
    • Kudo, M.1    Izumi, N.2    Kokudo, N.3
  • 43
    • 79960327993 scopus 로고    scopus 로고
    • Clinical characteristics of hepatocellular carcinoma in elderly patients
    • Honda T, Miyaaki H, Ichikawa T, et al. Clinical characteristics of hepatocellular carcinoma in elderly patients. Oncol Lett. 2011; 2(5): 851-854.
    • (2011) Oncol Lett. , vol.2 , Issue.5 , pp. 851-854
    • Honda, T.1    Miyaaki, H.2    Ichikawa, T.3
  • 44
    • 72249100065 scopus 로고    scopus 로고
    • The outcomes of elderly patients with hepatocellular carcinoma treated with transarterial chemoembolization
    • Yau T, Yao TJ, Chan P, et al. The outcomes of elderly patients with hepatocellular carcinoma treated with transarterial chemoembolization. Cancer. 2009; 115(23): 5507-15.
    • (2009) Cancer. , vol.115 , Issue.23 , pp. 5507-5515
    • Yau, T.1    Yao, T.J.2    Chan, P.3
  • 45
    • 34250020201 scopus 로고    scopus 로고
    • Hepatocellular carcinoma: epidemiology and molecular carcinogenesis
    • El-Serag HB, Rudolph KL. Hepatocellular carcinoma: epidemiology and molecular carcinogenesis. Gastroenterology. 2007; 132(7): 2557-76.
    • (2007) Gastroenterology. , vol.132 , Issue.7 , pp. 2557-2576
    • El-Serag, H.B.1    Rudolph, K.L.2
  • 46
    • 48449104049 scopus 로고    scopus 로고
    • Clinicopathological features of elderly patients with hepatitis C virus-related hepatocellular carcinoma
    • Miki D, Aikata H, Uka K, et al. Clinicopathological features of elderly patients with hepatitis C virus-related hepatocellular carcinoma. J Gastroenterol. 2008; 43(7): 550-7.
    • (2008) J Gastroenterol. , vol.43 , Issue.7 , pp. 550-557
    • Miki, D.1    Aikata, H.2    Uka, K.3
  • 47
    • 67349114551 scopus 로고    scopus 로고
    • Hepatectomy for hepatocellular carcinoma in elderly patients aged 75 years or more
    • Oishi K, Itamoto T, Kobayashi T, et al. Hepatectomy for hepatocellular carcinoma in elderly patients aged 75 years or more. J Gastrointest Surg. 2009; 13(4): 695-701.
    • (2009) J Gastrointest Surg. , vol.13 , Issue.4 , pp. 695-701
    • Oishi, K.1    Itamoto, T.2    Kobayashi, T.3
  • 48
    • 77952730428 scopus 로고    scopus 로고
    • The incidence and risk factors of hepatocellular carcinoma in patients with nonalcoholic steatohepatitis
    • Ascha MS, Hanouneh IA, Lopez R, et al. The incidence and risk factors of hepatocellular carcinoma in patients with nonalcoholic steatohepatitis. Hepatology. 2010; 51(6): 1972-8.
    • (2010) Hepatology. , vol.51 , Issue.6 , pp. 1972-1978
    • Ascha, M.S.1    Hanouneh, I.A.2    Lopez, R.3
  • 49
    • 84863772732 scopus 로고    scopus 로고
    • Clinical and pathological progression of non-alcoholic steatohepatitis to hepatocellular carcinoma
    • The Japan NASH Study Group
    • Yasui K, Hashimoto E, Tokushige K, et al; The Japan NASH Study Group. Clinical and pathological progression of non-alcoholic steatohepatitis to hepatocellular carcinoma. Hepatol Res. 2012; 42(8): 767-773.
    • (2012) Hepatol Res. , vol.42 , Issue.8 , pp. 767-773
    • Yasui, K.1    Hashimoto, E.2    Tokushige, K.3
  • 50
    • 0038644536 scopus 로고    scopus 로고
    • Nonalcoholic steatohepatitis: summary of an AASLD Single Topic Conference
    • Neuschwander-Tetri BA, Caldwell SH. Nonalcoholic steatohepatitis: summary of an AASLD Single Topic Conference. Hepatology. 2003; 37(5): 1202-19.
    • (2003) Hepatology , vol.37 , Issue.5 , pp. 1202-1219
    • Neuschwander-Tetri, B.A.1    Caldwell, S.H.2
  • 51
    • 0032791710 scopus 로고    scopus 로고
    • Reduction of telomeric repeats as a possible predictor for development of hepatocellular carcinoma: convenient evaluation by slot-blot analysis
    • Isokawa O, Suda T, Aoyagi Y, et al. Reduction of telomeric repeats as a possible predictor for development of hepatocellular carcinoma: convenient evaluation by slot-blot analysis. Hepatology. 1999; 30(2): 408-12.
    • (1999) Hepatology , vol.30 , Issue.2 , pp. 408-412
    • Isokawa, O.1    Suda, T.2    Aoyagi, Y.3
  • 52
    • 84885449766 scopus 로고    scopus 로고
    • Aging and DNA methylation in colorectal mucosa and cancer
    • Ahuja N, Li Q, Mohan AL, et al. Aging and DNA methylation in colorectal mucosa and cancer. Hepatol Res. 2012; 42(8): 767-773.
    • (2012) Hepatol Res. , vol.42 , Issue.8 , pp. 767-773
    • Ahuja, N.1    Li, Q.2    Mohan, A.L.3
  • 53
    • 0037694859 scopus 로고    scopus 로고
    • Outcome of right hepatectomies in patients older than 70 years
    • Cescon M, Grazi GL, Del Gaudio M, et al. Outcome of right hepatectomies in patients older than 70 years. Arch Surg. 2003; 138(5): 547-52.
    • (2003) Arch Surg. , vol.138 , Issue.5 , pp. 547-552
    • Cescon, M.1    Grazi, G.L.2    Del Gaudio, M.3
  • 54
    • 69049089794 scopus 로고    scopus 로고
    • Early outcome following hepatic resection in patients older than 80 years of age
    • Shirabe K, Kajiyama K, Harimoto N, et al. Early outcome following hepatic resection in patients older than 80 years of age. World J Surg. 2009; 33(9): 1927-32.
    • (2009) World J Surg. , vol.33 , Issue.9 , pp. 1927-1932
    • Shirabe, K.1    Kajiyama, K.2    Harimoto, N.3
  • 55
    • 61449206266 scopus 로고    scopus 로고
    • Hepatic resection for hepatocellular carcinoma in the elderly
    • Kaibori M, Matsui K, Ishizaki M, et al. Hepatic resection for hepatocellular carcinoma in the elderly. J Surg Oncol. 2009; 99(3): 154-60.
    • (2009) J Surg Oncol. , vol.99 , Issue.3 , pp. 154-160
    • Kaibori, M.1    Matsui, K.2    Ishizaki, M.3
  • 56
    • 84875382309 scopus 로고    scopus 로고
    • The effect of long-term supplementation with branched-chain amino acid granules in patients with hepatitis C virus-related hepatocellular carcinoma after radiofrequency thermal ablation
    • Nishikawa H, Osaki Y, Iguchi E, et al. The effect of long-term supplementation with branched-chain amino acid granules in patients with hepatitis C virus-related hepatocellular carcinoma after radiofrequency thermal ablation. J Clin Gastroenterol. 2013; 47(4): 359-66.
    • (2013) J Clin Gastroenterol. , vol.47 , Issue.4 , pp. 359-366
    • Nishikawa, H.1    Osaki, Y.2    Iguchi, E.3
  • 57
    • 33845760039 scopus 로고    scopus 로고
    • Prevention of hepatocellular carcinoma recurrence with alpha-interferon after liver resection in HCV cirrhosis
    • HCC Italian Task Force
    • Mazzaferro V, Romito R, Schiavo M, et al; HCC Italian Task Force. Prevention of hepatocellular carcinoma recurrence with alpha-interferon after liver resection in HCV cirrhosis. Hepatology. 2006; 44(6): 1543-54.
    • (2006) Hepatology , vol.44 , Issue.6 , pp. 1543-1554
    • Mazzaferro, V.1    Romito, R.2    Schiavo, M.3
  • 58
    • 1242352399 scopus 로고    scopus 로고
    • The surgical approach to HCC: our progress and results in Japan
    • Makuuchi M, Sano K. The surgical approach to HCC: our progress and results in Japan. Liver Transpl 2004; 10(2 Suppl 1): S46-52.
    • (2004) Liver Transpl , vol.10 , Issue.SUPPL. 1
    • Makuuchi, M.1    Sano, K.2
  • 59
    • 79952109611 scopus 로고    scopus 로고
    • Surgical technique: new advances for expanding indications and increasing safety in liver resection for HCC: the Eastern perspective
    • Ishizawa T, Mise Y, Aoki T, et al. Surgical technique: new advances for expanding indications and increasing safety in liver resection for HCC: the Eastern perspective. J Hepatobiliary Pancreat Sci. 2010; 17(4): 389-93.
    • (2010) J Hepatobiliary Pancreat Sci. , vol.17 , Issue.4 , pp. 389-393
    • Ishizawa, T.1    Mise, Y.2    Aoki, T.3
  • 60
    • 84879132800 scopus 로고    scopus 로고
    • Factors predicting survival after post-transplant hepatocellular carcinoma recurrence
    • Toso C, Cader S, Mentha-Dugerdil A, et al. Factors predicting survival after post-transplant hepatocellular carcinoma recurrence. J Hepatobiliary Pancreat Sci. 2013; 20(3): 342-7.
    • (2013) J Hepatobiliary Pancreat Sci. , vol.20 , Issue.3 , pp. 342-347
    • Toso, C.1    Cader, S.2    Mentha-Dugerdil, A.3
  • 61
    • 84866349859 scopus 로고    scopus 로고
    • Mortality and morbidity of hepatectomy, radiofrequency ablation, and embolization for hepatocellular carcinoma: a national survey of 54,145 patients
    • Sato M, Tateishi R, Yasunaga H, et al. Mortality and morbidity of hepatectomy, radiofrequency ablation, and embolization for hepatocellular carcinoma: a national survey of 54,145 patients. J Gastroenterol. 2012; 47(10): 1125-33.
    • (2012) J Gastroenterol. , vol.47 , Issue.10 , pp. 1125-1133
    • Sato, M.1    Tateishi, R.2    Yasunaga, H.3
  • 62
    • 82955229587 scopus 로고    scopus 로고
    • Limited liver resection: a good indication for the treatment of hepatocellular carcinoma in elderly patients
    • Portolani N, Baiocchi GL, Coniglio A, et al. Limited liver resection: a good indication for the treatment of hepatocellular carcinoma in elderly patients. Jpn J Clin Oncol. 2011; 41(12): 1358-65.
    • (2011) Jpn J Clin Oncol. , vol.41 , Issue.12 , pp. 1358-1365
    • Portolani, N.1    Baiocchi, G.L.2    Coniglio, A.3
  • 63
    • 77349124041 scopus 로고    scopus 로고
    • Current strategy for staging and treatment: the BCLC update and future prospects
    • Forner A, Reig ME, de Lope CR, et al. Current strategy for staging and treatment: the BCLC update and future prospects. Semin Liver Dis 2010; 30(1): 61-74.
    • (2010) Semin Liver Dis , vol.30 , Issue.1 , pp. 61-74
    • Forner, A.1    Reig, M.E.2    De Lope, C.R.3
  • 64
    • 84855314307 scopus 로고    scopus 로고
    • Recommendations for liver transplantation for hepatocellular carcinoma: an international consensus conference report
    • OLT for HCC Consensus Group
    • Clavien PA, Lesurtel M, Bossuyt PM, et al; OLT for HCC Consensus Group. Recommendations for liver transplantation for hepatocellular carcinoma: an international consensus conference report. Lancet Oncol 2012; 13(1): e11-22.
    • (2012) Lancet Oncol , vol.13 , Issue.1
    • Clavien, P.A.1    Lesurtel, M.2    Bossuyt, P.M.3
  • 65
    • 84868229180 scopus 로고    scopus 로고
    • New therapeutic paradigm for patients with cirrhosis
    • Tsochatzis EA, Bosch J, Burroughs AK. New therapeutic paradigm for patients with cirrhosis. Hepatology 2012; 56(5): 1983-92.
    • (2012) Hepatology , vol.56 , Issue.5 , pp. 1983-1992
    • Tsochatzis, E.A.1    Bosch, J.2    Burroughs, A.K.3
  • 66
    • 33750920867 scopus 로고    scopus 로고
    • Living donor liver transplantation: present status and recent advances
    • Sugawara Y, Makuuchi M. Living donor liver transplantation: present status and recent advances. Br Med Bull 2006; 75-76: 15-28.
    • (2006) Br Med Bull , vol.75-76 , pp. 15-28
    • Sugawara, Y.1    Makuuchi, M.2
  • 67
    • 2942704043 scopus 로고    scopus 로고
    • Advances in adult living donor liver transplantation: a review based on reports from the 10th anniversary of the adult-to-adult living donor liver transplantation meeting in Tokyo
    • Sugawara Y, Makuuchi M. Advances in adult living donor liver transplantation: a review based on reports from the 10th anniversary of the adult-to-adult living donor liver transplantation meeting in Tokyo. Liver Transpl 2004; 10(6): 715-20.
    • (2004) Liver Transpl , vol.10 , Issue.6 , pp. 715-720
    • Sugawara, Y.1    Makuuchi, M.2
  • 68
    • 84885450596 scopus 로고    scopus 로고
    • Age is not a contraindication for orthotopic liver transplantation: a single institution experience with recipients older than 75 years
    • In press
    • Taner CB, Ung RL, Rosser BG, et al. Age is not a contraindication for orthotopic liver transplantation: a single institution experience with recipients older than 75 years. Hepatology International. 2011; In press.
    • (2011) Hepatology International
    • Taner, C.B.1    Ung, R.L.2    Rosser, B.G.3
  • 69
    • 77949850018 scopus 로고    scopus 로고
    • Liver transplantation in the United States, 1999-2008
    • Thuluvath PJ, Guidinger MK, Fung JJ, et al. Liver transplantation in the United States, 1999-2008. Am J Transplant. 2010; 10: 1003-1019.
    • (2010) Am J Transplant. , vol.10 , pp. 1003-1019
    • Thuluvath, P.J.1    Guidinger, M.K.2    Fung, J.J.3
  • 70
    • 70350556841 scopus 로고    scopus 로고
    • Recipient age affects long-term outcome and hepatitis C recurrence in old donor livers following transplantation
    • Selzner M, KashfiA, Selzner N, et al. Recipient age affects long-term outcome and hepatitis C recurrence in old donor livers following transplantation. Liver Transpl. 2009; 15(10): 1288-95.
    • (2009) Liver Transpl. , vol.15 , Issue.10 , pp. 1288-1295
    • Selzner, M.1    Kashfi, A.2    Selzner, N.3
  • 71
    • 0141993066 scopus 로고    scopus 로고
    • Transplantation in elderly patients
    • Randall HB, Cao S, deVera ME. Transplantation in elderly patients. Arch Surg. 2003; 138(10): 1089-92.
    • (2003) Arch Surg. , vol.138 , Issue.10 , pp. 1089-1092
    • Randall, H.B.1    Cao, S.2    De Vera, M.E.3
  • 72
    • 0032572694 scopus 로고    scopus 로고
    • Age and liver transplantation: a report of the Liver Transplantation Database
    • Zetterman RK, Belle SH, Hoofnagle JH, et al. Age and liver transplantation: a report of the Liver Transplantation Database. Transplantation. 1998; 66(4): 500-6.
    • (1998) Transplantation , vol.66 , Issue.4 , pp. 500-506
    • Zetterman, R.K.1    Belle, S.H.2    Hoofnagle, J.H.3
  • 73
    • 84868307752 scopus 로고    scopus 로고
    • Image-guided ablation for hepatocellular carcinoma
    • Lencioni R, Crocetti L. Image-guided ablation for hepatocellular carcinoma. Recent Results Cancer Res. 2013; 190: 181-94.
    • (2013) Recent Results Cancer Res. , vol.190 , pp. 181-194
    • Lencioni, R.1    Crocetti, L.2
  • 74
    • 84882751297 scopus 로고    scopus 로고
    • Radiofrequency ablation for hepatocellular carcinoma: the relationship between a new grading system for the ablative margin and clinical outcomes
    • Epub ahead of print
    • Nishikawa H, Osaki Y, Iguchi E, et al. Radiofrequency ablation for hepatocellular carcinoma: the relationship between a new grading system for the ablative margin and clinical outcomes. J Gastroenterol 2012; Epub ahead of print.
    • (2012) J Gastroenterol
    • Nishikawa, H.1    Osaki, Y.2    Iguchi, E.3
  • 75
    • 84655163503 scopus 로고    scopus 로고
    • Percutaneous radiofrequency ablation therapy for hepatocellular carcinoma: a proposed new grading system for the ablative margin and prediction of local tumor progression and its validation
    • Nishikawa H, Inuzuka T, Takeda H, et al. Percutaneous radiofrequency ablation therapy for hepatocellular carcinoma: a proposed new grading system for the ablative margin and prediction of local tumor progression and its validation. J Gastroenterol 2011; 46(12): 1418-26.
    • (2011) J Gastroenterol , vol.46 , Issue.12 , pp. 1418-1426
    • Nishikawa, H.1    Inuzuka, T.2    Takeda, H.3
  • 76
    • 84859586321 scopus 로고    scopus 로고
    • Radiofrequency ablation for hepatocellular carcinoma: 10-year outcome and prognostic factors
    • Shiina S, Tateishi R, Arano T, et al. Radiofrequency ablation for hepatocellular carcinoma: 10-year outcome and prognostic factors. Am J Gastroenterol 2012; 107(4): 569-77.
    • (2012) Am J Gastroenterol , vol.107 , Issue.4 , pp. 569-577
    • Shiina, S.1    Tateishi, R.2    Arano, T.3
  • 77
    • 20044386501 scopus 로고    scopus 로고
    • Percutaneous radiofrequency ablation for hepatocellular carcinoma. An analysis of 1000 cases
    • Tateishi R, Shiina S, Teratani T, et al. Percutaneous radiofrequency ablation for hepatocellular carcinoma. An analysis of 1000 cases. Cancer 2005; 103(6): 1201-9.
    • (2005) Cancer , vol.103 , Issue.6 , pp. 1201-1209
    • Tateishi, R.1    Shiina, S.2    Teratani, T.3
  • 78
    • 79960748644 scopus 로고    scopus 로고
    • Systematic review and meta-analysis of survival and disease recurrence after radiofrequency ablation for hepatocellular carcinoma
    • Tiong L, Maddern GJ. Systematic review and meta-analysis of survival and disease recurrence after radiofrequency ablation for hepatocellular carcinoma. Br J Surg 2011; 98(9): 1210-24.
    • (2011) Br J Surg , vol.98 , Issue.9 , pp. 1210-1224
    • Tiong, L.1    Maddern, G.J.2
  • 79
    • 78649570066 scopus 로고    scopus 로고
    • Midterm outcomes in patients with intermediate-sized hepatocellular carcinoma: a randomized controlled trial for determining the efficacy of radiofrequency ablation combined with transcatheter arterial chemoembolization
    • Morimoto M, Numata K, Kondou M, et al. Midterm outcomes in patients with intermediate-sized hepatocellular carcinoma: a randomized controlled trial for determining the efficacy of radiofrequency ablation combined with transcatheter arterial chemoembolization. Cancer 2010; 116(23): 5452-60.
    • (2010) Cancer , vol.116 , Issue.23 , pp. 5452-5460
    • Morimoto, M.1    Numata, K.2    Kondou, M.3
  • 80
    • 84860451057 scopus 로고    scopus 로고
    • Factors associated with the overall survival of elderly patients with hepatocellular carcinoma
    • Fujii H, Itoh Y, Ohnishi N, et al. Factors associated with the overall survival of elderly patients with hepatocellular carcinoma. World J Gastroenterol 2012; 18: 1926-1932
    • (2012) World J Gastroenterol , vol.18 , pp. 1926-1932
    • Fujii, H.1    Itoh, Y.2    Ohnishi, N.3
  • 81
    • 84864438332 scopus 로고    scopus 로고
    • Chemoembolization for hepatocellular carcinoma
    • Lencioni R. Chemoembolization for hepatocellular carcinoma. Semin Oncol. 2012; 39(4): 503-9.
    • (2012) Semin Oncol. , vol.39 , Issue.4 , pp. 503-509
    • Lencioni, R.1
  • 82
    • 33746528885 scopus 로고    scopus 로고
    • Prospective cohort study of transarterial chemoembolization for unresectable hepatocellular carcinoma in 8510 patients
    • Liver Cancer Study Group of Japan
    • Takayasu K, Arii S, Ikai I, et al; Liver Cancer Study Group of Japan. Prospective cohort study of transarterial chemoembolization for unresectable hepatocellular carcinoma in 8510 patients. Gastroenterology 2006; 131: 461-9.
    • (2006) Gastroenterology , vol.131 , pp. 461-469
    • Takayasu, K.1    Arii, S.2    Ikai, I.3
  • 83
    • 84864667059 scopus 로고    scopus 로고
    • Current status of hepatocellular carcinoma treatment in Japan: transarterial chemoembolization
    • Matsui O. Current status of hepatocellular carcinoma treatment in Japan: transarterial chemoembolization. Clin Drug Investig 2012; 32 Suppl 2:3-13.
    • (2012) Clin Drug Investig , vol.32 , Issue.SUPPL. 2 , pp. 3-13
    • Matsui, O.1
  • 84
    • 79952112429 scopus 로고    scopus 로고
    • Interventional oncology: new options for interstitial treatments and intravascular approaches: superselective TACE using iodized oil for HCC: rationale, technique and outcome
    • Matsui O, Miyayama S, Sanada J, et al. Interventional oncology: new options for interstitial treatments and intravascular approaches: superselective TACE using iodized oil for HCC: rationale, technique and outcome. J Hepatobiliary Pancreat Sci 2010; 17(4): 407-9.
    • (2010) J Hepatobiliary Pancreat Sci , vol.17 , Issue.4 , pp. 407-409
    • Matsui, O.1    Miyayama, S.2    Sanada, J.3
  • 85
    • 0020534533 scopus 로고
    • Hepatic artery embolization in 120 patients with unresectable hepatoma
    • Yamada R, Sato M, Kawabata M, et al. Hepatic artery embolization in 120 patients with unresectable hepatoma. Radiology 1983; 148(2): 397-401.
    • (1983) Radiology , vol.148 , Issue.2 , pp. 397-401
    • Yamada, R.1    Sato, M.2    Kawabata, M.3
  • 86
    • 84859260030 scopus 로고    scopus 로고
    • Transarterial chemoembolization for hepatocellular carcinoma over three decades: current progress and perspective
    • Takayasu K. Transarterial chemoembolization for hepatocellular carcinoma over three decades: current progress and perspective. Jpn J Clin Oncol 2012; 42(4): 247-55.
    • (2012) Jpn J Clin Oncol , vol.42 , Issue.4 , pp. 247-255
    • Takayasu, K.1
  • 87
    • 84858702846 scopus 로고    scopus 로고
    • Superselective transarterial chemoembolization for hepatocellular carcinoma, Validation of treatment algorithm proposed by Japanese guidelines
    • Takayasu K, Arii S, Kudo M, et al. Superselective transarterial chemoembolization for hepatocellular carcinoma. Validation of treatment algorithm proposed by Japanese guidelines. J Hepatol 2012; 56(4): 886-92.
    • (2012) J Hepatol , vol.56 , Issue.4 , pp. 886-892
    • Takayasu, K.1    Arii, S.2    Kudo, M.3
  • 88
    • 0026095001 scopus 로고
    • Effect of repeated transcatheter arterial embolization on the survival time in patients with hepatocellular carcinoma. An analysis by the Cox proportional hazard model
    • Ikeda K, Kumada H, Saitoh S, et al. Effect of repeated transcatheter arterial embolization on the survival time in patients with hepatocellular carcinoma. An analysis by the Cox proportional hazard model. Cancer 1991; 68 (10): 2150-4.
    • (1991) Cancer , vol.68 , Issue.10 , pp. 2150-2154
    • Ikeda, K.1    Kumada, H.2    Saitoh, S.3
  • 89
    • 0028295731 scopus 로고
    • Transarterial oily chemoembolization for the treatment of hepatocellular carcinoma: a multivariate analysis of prognostic factors
    • Mondazzi L, Bottelli R, Brambilla G, et al. Transarterial oily chemoembolization for the treatment of hepatocellular carcinoma: a multivariate analysis of prognostic factors. Hepatology. 1994; 19(5): 1115-23.
    • (1994) Hepatology , vol.19 , Issue.5 , pp. 1115-1123
    • Mondazzi, L.1    Bottelli, R.2    Brambilla, G.3
  • 90
    • 84884418790 scopus 로고    scopus 로고
    • Comparison of the survival and tolerability of radioembolization in elderly versus younger patients with unresectable hepatocellular carcinoma
    • doi:10.1016/j.jhep.2013.05.025
    • Golfieri R, Bilbao JI, Carpanese L, et al. Comparison of the survival and tolerability of radioembolization in elderly versus younger patients with unresectable hepatocellular carcinoma. J Hepatol. 2013; doi:10.1016/j.jhep.2013.05.025.
    • (2013) J Hepatol.
    • Golfieri, R.1    Bilbao, J.I.2    Carpanese, L.3
  • 91
    • 84859082653 scopus 로고    scopus 로고
    • Hepatic Arterial Infusion Chemotherapy for Advanced Hepatocellular Carcinoma in Japan
    • Nishikawa H, Osaki Y, Kita R, et al. Hepatic Arterial Infusion Chemotherapy for Advanced Hepatocellular Carcinoma in Japan. Cancers 2012; 4: 165-83.
    • (2012) Cancers , vol.4 , pp. 165-183
    • Nishikawa, H.1    Osaki, Y.2    Kita, R.3
  • 92
    • 47949116252 scopus 로고    scopus 로고
    • Sorafenib in advanced hepatocellular carcinoma
    • SHARP Investigators Study Group
    • Llovet JM, Ricci S, Mazzaferro V, et al; SHARP Investigators Study Group. Sorafenib in advanced hepatocellular carcinoma. N Engl J Med 2008; 359: 378-90.
    • (2008) N Engl J Med , vol.359 , pp. 378-390
    • Llovet, J.M.1    Ricci, S.2    Mazzaferro, V.3
  • 93
    • 57749189578 scopus 로고    scopus 로고
    • Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: a phase III randomised, double-blind, placebo-controlled trial
    • Cheng AL, Kang YK, Chen Z, et al. Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: a phase III randomised, double-blind, placebo-controlled trial. Lancet Oncol 2009; 10: 25-34.
    • (2009) Lancet Oncol , vol.10 , pp. 25-34
    • Cheng, A.L.1    Kang, Y.K.2    Chen, Z.3
  • 94
    • 84864642779 scopus 로고    scopus 로고
    • Current status of hepatocellular carcinoma treatment in Japan: case study and discussion-voting system
    • Kudo M, Tateishi R, Yamashita T, et al. Current status of hepatocellular carcinoma treatment in Japan: case study and discussion-voting system. Clin Drug Investig 2012; 32 Suppl 2: 37-51.
    • (2012) Clin Drug Investig , vol.32 , Issue.SUPPL. 2 , pp. 37-51
    • Kudo, M.1    Tateishi, R.2    Yamashita, T.3
  • 95
    • 84871822275 scopus 로고    scopus 로고
    • Real-life clinical practice with sorafenib in advanced hepatocellular carcinoma: a single-center experience
    • Kudo M, Ueshima K, Arizumi T. Real-life clinical practice with sorafenib in advanced hepatocellular carcinoma: a single-center experience. Dig Dis 2012; 30(6): 609-16.
    • (2012) Dig Dis , vol.30 , Issue.6 , pp. 609-616
    • Kudo, M.1    Ueshima, K.2    Arizumi, T.3
  • 96
    • 84855175227 scopus 로고    scopus 로고
    • The outcomes and safety of single-agent sorafenib in the treatment of elderly patients with advanced hepatocellular carcinoma (HCC)
    • Wong H, Tang YF, Yao TJ, et al. The outcomes and safety of single-agent sorafenib in the treatment of elderly patients with advanced hepatocellular carcinoma (HCC). Oncologist. 2011; 16(12): 1721-8.
    • (2011) Oncologist , vol.16 , Issue.12 , pp. 1721-1728
    • Wong, H.1    Tang, Y.F.2    Yao, T.J.3
  • 97
    • 84880617574 scopus 로고    scopus 로고
    • Impact of age on toxicity and efficacy of sorafenib-targeted therapy in cirrhotic patients with hepatocellular carcinoma
    • Di Costanzo GG, Tortora R, De Luca M, et al. Impact of age on toxicity and efficacy of sorafenib-targeted therapy in cirrhotic patients with hepatocellular carcinoma. Med Oncol. 2013; 30(1): 446.
    • (2013) Med Oncol. , vol.30 , Issue.1 , pp. 446
    • Di Costanzo, G.G.1    Tortora, R.2    De Luca, M.3
  • 98
    • 84874002381 scopus 로고    scopus 로고
    • Sorafenib in elderly patients with advanced hepatocellular carcinoma: a case series
    • Montella L, Addeo R, Cennamo G, et al. Sorafenib in elderly patients with advanced hepatocellular carcinoma: a case series. Oncology. 2013; 84(5): 265-72.
    • (2013) Oncology , vol.84 , Issue.5 , pp. 265-272
    • Montella, L.1    Addeo, R.2    Cennamo, G.3
  • 99
    • 33749017926 scopus 로고    scopus 로고
    • Phase II study of sorafenib in patients with advanced hepatocellular carcinoma
    • Abou-Alfa GK, Schwartz L, Ricci S, et al. Phase II study of sorafenib in patients with advanced hepatocellular carcinoma. J Clin Oncol 2006; 24: 4293-300.
    • (2006) J Clin Oncol , vol.24 , pp. 4293-4300
    • Abou-Alfa, G.K.1    Schwartz, L.2    Ricci, S.3
  • 100
    • 79959421984 scopus 로고    scopus 로고
    • Prognostic Factors in Patients with Advanced Hepatocellular Carcinoma treated with Sorafenib: A Retrospective Comparison with Previously Known Prognostic Models
    • Baek KK, Kim JH, Uhm JE, et al. Prognostic Factors in Patients with Advanced Hepatocellular Carcinoma treated with Sorafenib: A Retrospective Comparison with Previously Known Prognostic Models. Oncology 2011; 80: 167-74.
    • (2011) Oncology , vol.80 , pp. 167-174
    • Baek, K.K.1    Kim, J.H.2    Uhm, J.E.3
  • 101
    • 84859880607 scopus 로고    scopus 로고
    • Plasma Biomarkers as Predictors of Outcome in Patients with Advanced Hepatocellular Carcinoma
    • On behalf of the SHARP Investigators Study Group
    • Llovet JM, Peña CE, Lathia CD, et al; on behalf of the SHARP Investigators Study Group: Plasma Biomarkers as Predictors of Outcome in Patients with Advanced Hepatocellular Carcinoma. Clin Cancer Res 2012; 18: 2290-300.
    • (2012) Clin Cancer Res , vol.18 , pp. 2290-2300
    • Llovet, J.M.1    Peña, C.E.2    Lathia, C.D.3
  • 102
    • 84876290448 scopus 로고    scopus 로고
    • Sorafenib-induced acute interstitial pneumonia in patients with advanced hepatocellular carcinoma: report of three cases
    • Takeda H, Nishikawa H, Iguchi E, et al. Sorafenib-induced acute interstitial pneumonia in patients with advanced hepatocellular carcinoma: report of three cases. Clin J Gastroenterol 2012; 5: 407-12.
    • (2012) Clin J Gastroenterol , vol.5 , pp. 407-412
    • Takeda, H.1    Nishikawa, H.2    Iguchi, E.3
  • 103
    • 84875900781 scopus 로고    scopus 로고
    • Impact of pretreatment serum cholinesterase level in unresectable advanced hepatocellular carcinoma patients treated with sorafenib
    • Takeda H, Nishikawa H, Iguchi E, et al. Impact of pretreatment serum cholinesterase level in unresectable advanced hepatocellular carcinoma patients treated with sorafenib. Mol and Clin Oncol 2013; 1: 241-48.
    • (2013) Mol and Clin Oncol , vol.1 , pp. 241-248
    • Takeda, H.1    Nishikawa, H.2    Iguchi, E.3
  • 104
    • 84863946325 scopus 로고    scopus 로고
    • Comparison of the efficacy of transcatheter arterialchemoembolization and sorafenib for advanced hepatocellular carcinoma
    • Nishikawa H, Osaki Y, Iguchi E, et al. Comparison of the efficacy of transcatheter arterialchemoembolization and sorafenib for advanced hepatocellular carcinoma. Exp Ther Med 2012; 4(3): 381-6.
    • (2012) Exp Ther Med , vol.4 , Issue.3 , pp. 381-386
    • Nishikawa, H.1    Osaki, Y.2    Iguchi, E.3
  • 105
    • 84901387672 scopus 로고    scopus 로고
    • Efficacy of sorafenib in patients with hepatocellular carcinoma refractory to transcatheter arterial chemoembolization
    • [Epub ahead of print]
    • Ikeda M, Mitsunaga S, Shimizu S, et al. Efficacy of sorafenib in patients with hepatocellular carcinoma refractory to transcatheter arterial chemoembolization. J Gastroenterol. 2013; [Epub ahead of print]
    • (2013) J Gastroenterol.
    • Ikeda, M.1    Mitsunaga, S.2    Shimizu, S.3
  • 106
    • 79952823438 scopus 로고    scopus 로고
    • Higher discontinuation and lower survival rates are likely in elderly Japanese patients with advanced hepatocellular carcinoma receiving sorafenib
    • Morimoto M, Numata K, Kondo M, et al. Higher discontinuation and lower survival rates are likely in elderly Japanese patients with advanced hepatocellular carcinoma receiving sorafenib. Hepatol Res. 2011; 41(4): 296-302.
    • (2011) Hepatol Res. , vol.41 , Issue.4 , pp. 296-302
    • Morimoto, M.1    Numata, K.2    Kondo, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.