-
1
-
-
79952232216
-
Global cancer statistics
-
Jemal A, Bray F, Center MM, Ferlay J, Ward E and Forman D. Global cancer statistics. CA Cancer J Clin. 2011; 61(2):69-90.
-
(2011)
CA Cancer J Clin
, vol.61
, Issue.2
, pp. 69-90
-
-
Jemal, A.1
Bray, F.2
Center, M.M.3
Ferlay, J.4
Ward, E.5
Forman, D.6
-
2
-
-
0030931682
-
Natural history and therapy of metastatic renal cell carcinoma: the role of interleukin-2
-
Bukowski RM. Natural history and therapy of metastatic renal cell carcinoma: the role of interleukin-2. Cancer. 1997; 80(7):1198-1220.
-
(1997)
Cancer
, vol.80
, Issue.7
, pp. 1198-1220
-
-
Bukowski, R.M.1
-
3
-
-
0036984640
-
Role of angiogenesis in tumor growth and metastasis
-
Folkman J. Role of angiogenesis in tumor growth and metastasis. Semin Oncol. 2002; 29(6 Suppl 16):15-18.
-
(2002)
Semin Oncol
, vol.29
, Issue.6 SUPPL. 16
, pp. 15-18
-
-
Folkman, J.1
-
4
-
-
85013312416
-
Tumor angiogenesis: therapeutic implications
-
Folkman J. Tumor angiogenesis: therapeutic implications. N Engl J Med. 1971; 285(21):1182-1186.
-
(1971)
N Engl J Med
, vol.285
, Issue.21
, pp. 1182-1186
-
-
Folkman, J.1
-
5
-
-
0025141337
-
What is the evidence that tumors are angiogenesis dependent?
-
Folkman J. What is the evidence that tumors are angiogenesis dependent? J Natl Cancer Inst. 1990; 82(1):4-6.
-
(1990)
J Natl Cancer Inst
, vol.82
, Issue.1
, pp. 4-6
-
-
Folkman, J.1
-
6
-
-
81255189734
-
Microvessel density as a prognostic factor in penile squamous cell carcinoma
-
Al-Najar A, Al-Sanabani S, Korda JB, Hegele A, Bolenz C, Herbst H, Junemann KP and Naumann CM. Microvessel density as a prognostic factor in penile squamous cell carcinoma. Urol Oncol. 2010.
-
(2010)
Urol Oncol
-
-
Al-Najar, A.1
Al-Sanabani, S.2
Korda, J.B.3
Hegele, A.4
Bolenz, C.5
Herbst, H.6
Junemann, K.P.7
Naumann, C.M.8
-
7
-
-
37549030522
-
Delta-like 4/Notch signaling and its therapeutic implications
-
Yan M and Plowman GD. Delta-like 4/Notch signaling and its therapeutic implications. Clin Cancer Res. 2007; 13(24):7243-7246.
-
(2007)
Clin Cancer Res
, vol.13
, Issue.24
, pp. 7243-7246
-
-
Yan, M.1
Plowman, G.D.2
-
8
-
-
31544448010
-
Up-regulation of the Notch ligand Delta-like 4 inhibits VEGF-induced endothelial cell function
-
Williams CK, Li JL, Murga M, Harris AL and Tosato G. Up-regulation of the Notch ligand Delta-like 4 inhibits VEGF-induced endothelial cell function. Blood. 2006; 107(3):931-939.
-
(2006)
Blood
, vol.107
, Issue.3
, pp. 931-939
-
-
Williams, C.K.1
Li, J.L.2
Murga, M.3
Harris, A.L.4
Tosato, G.5
-
9
-
-
33847046849
-
Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis
-
Hellstrom M, Phng LK, Hofmann JJ, Wallgard E, Coultas L, Lindblom P, Alva J, Nilsson AK, Karlsson L, Gaiano N, Yoon K, Rossant J, Iruela-Arispe ML, Kalen M, Gerhardt H and Betsholtz C. Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis. Nature. 2007; 445(7129):776-780.
-
(2007)
Nature
, vol.445
, Issue.7129
, pp. 776-780
-
-
Hellstrom, M.1
Phng, L.K.2
Hofmann, J.J.3
Wallgard, E.4
Coultas, L.5
Lindblom, P.6
Alva, J.7
Nilsson, A.K.8
Karlsson, L.9
Gaiano, N.10
Yoon, K.11
Rossant, J.12
Iruela-Arispe, M.L.13
Kalen, M.14
Gerhardt, H.15
Betsholtz, C.16
-
10
-
-
64249172203
-
The canonical Notch signaling pathway: unfolding the activation mechanism
-
Kopan R and Ilagan MX. The canonical Notch signaling pathway: unfolding the activation mechanism. Cell. 2009; 137(2):216-233.
-
(2009)
Cell
, vol.137
, Issue.2
, pp. 216-233
-
-
Kopan, R.1
Ilagan, M.X.2
-
12
-
-
84862981221
-
Epigenetic regulation of Delta-Like1 controls Notch1 activation in gastric cancer
-
Piazzi G, Fini L, Selgrad M, Garcia M, Daoud Y, Wex T, Malfertheiner P, Gasbarrini A, Romano M, Meyer RL, Genta RM, Fox JG, Boland CR, Bazzoli F and Ricciardiello L. Epigenetic regulation of Delta-Like1 controls Notch1 activation in gastric cancer. Oncotarget. 2011; 2(12):1291-1301.
-
(2011)
Oncotarget
, vol.2
, Issue.12
, pp. 1291-1301
-
-
Piazzi, G.1
Fini, L.2
Selgrad, M.3
Garcia, M.4
Daoud, Y.5
Wex, T.6
Malfertheiner, P.7
Gasbarrini, A.8
Romano, M.9
Meyer, R.L.10
Genta, R.M.11
Fox, J.G.12
Boland, C.R.13
Bazzoli, F.14
Ricciardiello, L.15
-
13
-
-
85039609174
-
Cross-talk between endothelial cells and tumor via delta-like ligand4/Notch/PTEN signaling inhibits lung cancer growth
-
Ding XY, Ding J, Wu K, Wen W, Liu C, Yan HX, Chen C, Wang S, Tang H, Gao CK, Guo LN, Cao D, Li Z, Feng GS, Wang HY and Xu ZF. Cross-talk between endothelial cells and tumor via delta-like ligand4/Notch/PTEN signaling inhibits lung cancer growth. Oncogene. 2011.
-
(2011)
Oncogene
-
-
Ding, X.Y.1
Ding, J.2
Wu, K.3
Wen, W.4
Liu, C.5
Yan, H.X.6
Chen, C.7
Wang, S.8
Tang, H.9
Gao, C.K.10
Guo, L.N.11
Cao, D.12
Li, Z.13
Feng, G.S.14
Wang, H.Y.15
Xu, Z.F.16
-
14
-
-
84879535255
-
Down-Regulated miR-30a in Clear Cell Renal Cell Carcinoma Correlated with Tumor Hematogenous Metastasis by Targeting Angiogenesis-Specific DLL4
-
Huang QB, Ma X, Zhang X, Liu SW, Ai Q, Shi TP, Zhang Y, Gao Y, Fan Y, Ni D, Wang BJ, Li HZ and Zheng T. Down-Regulated miR-30a in Clear Cell Renal Cell Carcinoma Correlated with Tumor Hematogenous Metastasis by Targeting Angiogenesis-Specific DLL4. PLoS One. 2013; 8(6):e67294.
-
(2013)
PLoS One
, vol.8
, Issue.6
-
-
Huang, Q.B.1
Ma, X.2
Zhang, X.3
Liu, S.W.4
Ai, Q.5
Shi, T.P.6
Zhang, Y.7
Gao, Y.8
Fan, Y.9
Ni, D.10
Wang, B.J.11
Li, H.Z.12
Zheng, T.13
-
15
-
-
25444506836
-
Up-regulation of delta-like 4 ligand in human tumor vasculature and the role of basal expression in endothelial cell function
-
Patel NS, Li JL, Generali D, Poulsom R, Cranston DW and Harris AL. Up-regulation of delta-like 4 ligand in human tumor vasculature and the role of basal expression in endothelial cell function. Cancer Res. 2005; 65(19):8690-8697.
-
(2005)
Cancer Res
, vol.65
, Issue.19
, pp. 8690-8697
-
-
Patel, N.S.1
Li, J.L.2
Generali, D.3
Poulsom, R.4
Cranston, D.W.5
Harris, A.L.6
-
16
-
-
33847635620
-
Delta-like ligand 4 (Dll4) is induced by VEGF as a negative regulator of angiogenic sprouting
-
Lobov IB, Renard RA, Papadopoulos N, Gale NW, Thurston G, Yancopoulos GD and Wiegand SJ. Delta-like ligand 4 (Dll4) is induced by VEGF as a negative regulator of angiogenic sprouting. Proc Natl Acad Sci U S A. 2007; 104(9):3219-3224.
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, Issue.9
, pp. 3219-3224
-
-
Lobov, I.B.1
Renard, R.A.2
Papadopoulos, N.3
Gale, N.W.4
Thurston, G.5
Yancopoulos, G.D.6
Wiegand, S.J.7
-
17
-
-
33845907380
-
Inhibition of Dll4 signalling inhibits tumour growth by deregulating angiogenesis
-
Ridgway J, Zhang G, Wu Y, Stawicki S, Liang WC, Chanthery Y, Kowalski J, Watts RJ, Callahan C, Kasman I, Singh M, Chien M, Tan C, Hongo JA, de Sauvage F, Plowman G, et al. Inhibition of Dll4 signalling inhibits tumour growth by deregulating angiogenesis. Nature. 2006; 444(7122):1083-1087.
-
(2006)
Nature
, vol.444
, Issue.7122
, pp. 1083-1087
-
-
Ridgway, J.1
Zhang, G.2
Wu, Y.3
Stawicki, S.4
Liang, W.C.5
Chanthery, Y.6
Kowalski, J.7
Watts, R.J.8
Callahan, C.9
Kasman, I.10
Singh, M.11
Chien, M.12
Tan, C.13
Hongo, J.A.14
de Sauvage, F.15
Plowman, G.16
-
18
-
-
33845877157
-
Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesis
-
Noguera-Troise I, Daly C, Papadopoulos NJ, Coetzee S, Boland P, Gale NW, Lin HC, Yancopoulos GD and Thurston G. Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesis. Nature. 2006; 444(7122):1032-1037.
-
(2006)
Nature
, vol.444
, Issue.7122
, pp. 1032-1037
-
-
Noguera-Troise, I.1
Daly, C.2
Papadopoulos, N.J.3
Coetzee, S.4
Boland, P.5
Gale, N.W.6
Lin, H.C.7
Yancopoulos, G.D.8
Thurston, G.9
-
19
-
-
34247539127
-
The Delta paradox: DLL4 blockade leads to more tumour vessels but less tumour growth
-
Thurston G, Noguera-Troise I and Yancopoulos GD. The Delta paradox: DLL4 blockade leads to more tumour vessels but less tumour growth. Nat Rev Cancer. 2007; 7(5):327-331.
-
(2007)
Nat Rev Cancer
, vol.7
, Issue.5
, pp. 327-331
-
-
Thurston, G.1
Noguera-Troise, I.2
Yancopoulos, G.D.3
-
20
-
-
85039621913
-
Lung cancer neovascularisation: Cellular and molecular interaction between endothelial and lung cancer cells
-
Kaessmeyer S, Bhoola K, Baltic S, Thompson P and Plendl J. Lung cancer neovascularisation: Cellular and molecular interaction between endothelial and lung cancer cells. Immunobiology. 2013.
-
(2013)
Immunobiology
-
-
Kaessmeyer, S.1
Bhoola, K.2
Baltic, S.3
Thompson, P.4
Plendl, J.5
-
21
-
-
79957987225
-
Tie2/TEK modulates the interaction of glioma and brain tumor stem cells with endothelial cells and promotes an invasive phenotype
-
Liu D, Martin V, Fueyo J, Lee OH, Xu J, Cortes-Santiago N, Alonso MM, Aldape K, Colman H and Gomez-Manzano C. Tie2/TEK modulates the interaction of glioma and brain tumor stem cells with endothelial cells and promotes an invasive phenotype. Oncotarget. 2010; 1(8):700-709.
-
(2010)
Oncotarget
, vol.1
, Issue.8
, pp. 700-709
-
-
Liu, D.1
Martin, V.2
Fueyo, J.3
Lee, O.H.4
Xu, J.5
Cortes-Santiago, N.6
Alonso, M.M.7
Aldape, K.8
Colman, H.9
Gomez-Manzano, C.10
-
22
-
-
60549117358
-
Cross-talk between tumor and endothelial cells involving the Notch3-Dll4 interaction marks escape from tumor dormancy
-
Indraccolo S, Minuzzo S, Masiero M, Pusceddu I, Persano L, Moserle L, Reboldi A, Favaro E, Mecarozzi M, Di Mario G, Screpanti I, Ponzoni M, Doglioni C and Amadori A. Cross-talk between tumor and endothelial cells involving the Notch3-Dll4 interaction marks escape from tumor dormancy. Cancer Res. 2009; 69(4):1314-1323.
-
(2009)
Cancer Res
, vol.69
, Issue.4
, pp. 1314-1323
-
-
Indraccolo, S.1
Minuzzo, S.2
Masiero, M.3
Pusceddu, I.4
Persano, L.5
Moserle, L.6
Reboldi, A.7
Favaro, E.8
Mecarozzi, M.9
Di Mario, G.10
Screpanti, I.11
Ponzoni, M.12
Doglioni, C.13
Amadori, A.14
-
23
-
-
33746851956
-
Tumor metastasis: mechanistic insights and clinical challenges
-
Steeg PS. Tumor metastasis: mechanistic insights and clinical challenges. Nat Med. 2006; 12(8):895-904.
-
(2006)
Nat Med
, vol.12
, Issue.8
, pp. 895-904
-
-
Steeg, P.S.1
-
25
-
-
34147155343
-
Tumor size predicts synchronous metastatic renal cell carcinoma: implications for surveillance of small renal masses
-
discussion 1697
-
Kunkle DA, Crispen PL, Li T and Uzzo RG. Tumor size predicts synchronous metastatic renal cell carcinoma: implications for surveillance of small renal masses. J Urol. 2007; 177(5):1692-1696; discussion 1697.
-
(2007)
J Urol
, vol.177
, Issue.5
, pp. 1692-1696
-
-
Kunkle, D.A.1
Crispen, P.L.2
Li, T.3
Uzzo, R.G.4
-
26
-
-
67349202279
-
Metastatic renal cell carcinoma risk according to tumor size
-
Thompson RH, Hill JR, Babayev Y, Cronin A, Kaag M, Kundu S, Bernstein M, Coleman J, Dalbagni G, Touijer K and Russo P. Metastatic renal cell carcinoma risk according to tumor size. J Urol. 2009; 182(1):41-45.
-
(2009)
J Urol
, vol.182
, Issue.1
, pp. 41-45
-
-
Thompson, R.H.1
Hill, J.R.2
Babayev, Y.3
Cronin, A.4
Kaag, M.5
Kundu, S.6
Bernstein, M.7
Coleman, J.8
Dalbagni, G.9
Touijer, K.10
Russo, P.11
-
27
-
-
0036512208
-
New functions for the matrix metalloproteinases in cancer progression
-
Egeblad M and Werb Z. New functions for the matrix metalloproteinases in cancer progression. Nat Rev Cancer. 2002; 2(3):161-174.
-
(2002)
Nat Rev Cancer
, vol.2
, Issue.3
, pp. 161-174
-
-
Egeblad, M.1
Werb, Z.2
-
28
-
-
0142166718
-
Increased expression of matrix metalloproteinase 9 correlates with poor prognostic variables in renal cell carcinoma
-
Cho NH, Shim HS, Rha SY, Kang SH, Hong SH, Choi YD, Hong SJ and Cho SH. Increased expression of matrix metalloproteinase 9 correlates with poor prognostic variables in renal cell carcinoma. Eur Urol. 2003; 44(5):560-566.
-
(2003)
Eur Urol
, vol.44
, Issue.5
, pp. 560-566
-
-
Cho, N.H.1
Shim, H.S.2
Rha, S.Y.3
Kang, S.H.4
Hong, S.H.5
Choi, Y.D.6
Hong, S.J.7
Cho, S.H.8
-
29
-
-
0034798212
-
Increased expression of matrix metalloproteinases 2 and 9 and tissue inhibitors of metalloproteinases 1 and 2 correlate with poor prognostic variables in renal cell carcinoma
-
Kallakury BV, Karikehalli S, Haholu A, Sheehan CE, Azumi N and Ross JS. Increased expression of matrix metalloproteinases 2 and 9 and tissue inhibitors of metalloproteinases 1 and 2 correlate with poor prognostic variables in renal cell carcinoma. Clin Cancer Res. 2001; 7(10):3113-3119.
-
(2001)
Clin Cancer Res
, vol.7
, Issue.10
, pp. 3113-3119
-
-
Kallakury, B.V.1
Karikehalli, S.2
Haholu, A.3
Sheehan, C.E.4
Azumi, N.5
Ross, J.S.6
-
30
-
-
0035131552
-
Expression levels of genes that regulate metastasis and angiogenesis correlate with advanced pathological stage of renal cell carcinoma
-
Slaton JW, Inoue K, Perrotte P, El-Naggar AK, Swanson DA, Fidler IJ and Dinney CP. Expression levels of genes that regulate metastasis and angiogenesis correlate with advanced pathological stage of renal cell carcinoma. Am J Pathol. 2001; 158(2):735-743.
-
(2001)
Am J Pathol
, vol.158
, Issue.2
, pp. 735-743
-
-
Slaton, J.W.1
Inoue, K.2
Perrotte, P.3
El-Naggar, A.K.4
Swanson, D.A.5
Fidler, I.J.6
Dinney, C.P.7
-
31
-
-
80052803473
-
DLL4-Notch signaling mediates tumor resistance to anti-VEGF therapy in vivo
-
Li JL, Sainson RC, Oon CE, Turley H, Leek R, Sheldon H, Bridges E, Shi W, Snell C, Bowden ET, Wu H, Chowdhury PS, Russell AJ, Montgomery CP, Poulsom R and Harris AL. DLL4-Notch signaling mediates tumor resistance to anti-VEGF therapy in vivo. Cancer Res. 2011.
-
(2011)
Cancer Res
-
-
Li, J.L.1
Sainson, R.C.2
Oon, C.E.3
Turley, H.4
Leek, R.5
Sheldon, H.6
Bridges, E.7
Shi, W.8
Snell, C.9
Bowden, E.T.10
Wu, H.11
Chowdhury, P.S.12
Russell, A.J.13
Montgomery, C.P.14
Poulsom, R.15
Harris, A.L.16
-
32
-
-
84902085631
-
A multiple-ascending-dose study of the safety and tolerability of REGN421 in patients with advanced solid malignancies
-
ClinicalTrials.gov.
-
ClinicalTrials.gov. A multiple-ascending-dose study of the safety and tolerability of REGN421 in patients with advanced solid malignancies. http://clinicaltrialsgov/ct2/show/NCT00871559. 2010.
-
(2010)
-
-
-
33
-
-
84902081721
-
A phase 1 dose escalation study of OMP-21M18 in subjects with solid tumors
-
ClinicalTrials.gov.
-
ClinicalTrials.gov. A phase 1 dose escalation study of OMP-21M18 in subjects with solid tumors. http://clinicaltrialsgov/ct2/show/NCT00744562. 2010.
-
(2010)
-
-
-
34
-
-
63849310246
-
Crosstalk of VEGF and Notch pathways in tumour angiogenesis: therapeutic implications
-
Li JL and Harris AL. Crosstalk of VEGF and Notch pathways in tumour angiogenesis: therapeutic implications. Front Biosci. 2009; 14:3094-3110.
-
(2009)
Front Biosci
, vol.14
, pp. 3094-3110
-
-
Li, J.L.1
Harris, A.L.2
-
35
-
-
0034594628
-
New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada.
-
Therasse P, Arbuck SG, Eisenhauer EA, Wanders J, Kaplan RS, Rubinstein L, Verweij J, Van Glabbeke M, van Oosterom AT, Christian MC and Gwyther SG. New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada. J Natl Cancer Inst. 2000; 92(3):205-216.
-
(2000)
J Natl Cancer Inst
, vol.92
, Issue.3
, pp. 205-216
-
-
Therasse, P.1
Arbuck, S.G.2
Eisenhauer, E.A.3
Wanders, J.4
Kaplan, R.S.5
Rubinstein, L.6
Verweij, J.7
Van Glabbeke, M.8
van Oosterom, A.T.9
Christian, M.C.10
Gwyther, S.G.11
-
36
-
-
84859578343
-
High-level expression of Notch1 increased the risk of metastasis in T1 stage clear cell renal cell carcinoma
-
Ai Q, Ma X, Huang Q, Liu S, Shi T, Zhang C, Zhu M, Zhang Y, Wang B, Ni D, Li H, Zheng T and Zhang X. High-level expression of Notch1 increased the risk of metastasis in T1 stage clear cell renal cell carcinoma. PLoS One. 2012; 7(4):e35022.
-
(2012)
PLoS One
, vol.7
, Issue.4
-
-
Ai, Q.1
Ma, X.2
Huang, Q.3
Liu, S.4
Shi, T.5
Zhang, C.6
Zhu, M.7
Zhang, Y.8
Wang, B.9
Ni, D.10
Li, H.11
Zheng, T.12
Zhang, X.13
|