Down-Regulated miR-30a in Clear Cell Renal Cell Carcinoma Correlated with Tumor Hematogenous Metastasis by Targeting Angiogenesis-Specific DLL4

PLoS ONE

Volumn 8, Issue 6, 2013, Pages

  Huang, Qing Bo ^a   Ma, Xin ^a   Zhang, Xu ^a   Liu, Shang Wen ^b   Ai, Qing ^a   Shi, Tao Ping ^a   Zhang, Yu ^a   Gao, Yu ^a   Fan, Yang ^a   Ni, Dong ^a   Wang, Bao Jun ^a   Li, Hong Zhao ^a   Zheng, Tao ^a  

^a CHINESE PLA GENERAL HOSPITAL   (China)

^b The 303rd Hospital of PLA   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOGENIC PROTEIN; DLL4 PROTEIN; MICRORNA; MICRORNA 30A; UNCLASSIFIED DRUG; DLL4 PROTEIN, HUMAN; MIRN30 MICRORNA, HUMAN; SIGNAL PEPTIDE; TUMOR MARKER;

ADULT; ARTICLE; BIOINFORMATICS; CANCER RISK; CAPILLARY DENSITY; CLEAR CELL CARCINOMA; DISEASE ASSOCIATION; ENDOTHELIUM CELL; FEMALE; GENE EXPRESSION; HEMATOGENOUS METASTASIS; HUMAN; HUMAN TISSUE; KIDNEY CARCINOMA; MAJOR CLINICAL STUDY; MALE; METASTASIS; METASTASIS FREE SURVIVAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN TARGETING; REAL TIME POLYMERASE CHAIN REACTION; TUMOR VASCULARIZATION; VALIDATION PROCESS; BIOLOGY; CELL MOTION; CELL PROLIFERATION; DISEASE FREE SURVIVAL; GENE EXPRESSION REGULATION; KIDNEY TUMOR; METABOLISM; MICROVASCULATURE; MIDDLE AGED; NEOVASCULARIZATION (PATHOLOGY); PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; PROGNOSIS; RENAL CELL CARCINOMA; UMBILICAL VEIN ENDOTHELIAL CELL;

ADULT; BIOMARKERS, TUMOR; CARCINOMA, RENAL CELL; CELL MOVEMENT; CELL PROLIFERATION; COMPUTATIONAL BIOLOGY; DISEASE-FREE SURVIVAL; ENDOTHELIAL CELLS; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; KIDNEY NEOPLASMS; MALE; MICRORNAS; MICROVESSELS; MIDDLE AGED; NEOPLASM METASTASIS; NEOVASCULARIZATION, PATHOLOGIC; PROGNOSIS;

EID: 84879535255     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0067294     Document Type: Article

References (45)

1. Jemal A, Bray F, (2011) Center MM, Ferlay J, Ward E, et al (2011) Global cancer statistics. CA Cancer J Clin 61: 69-90.
2. Bukowski RM, (1997) Natural history and therapy of metastatic renal cell carcinoma: the role of interleukin-2. Cancer 80: 1198-1220.
3. Gupta K, Miller JD, Li JZ, Russell MW, Charbonneau C, (2008) Epidemiologic and socioeconomic burden of metastatic renal cell carcinoma (mRCC): a literature review. Cancer Treat Rev 34: 193-205.
4. Motzer RJ, Bacik J, Schwartz LH, Reuter V, Russo P, et al. (2004) Prognostic factors for survival in previously treated patients with metastatic renal cell carcinoma. J Clin Oncol 22: 454-463.
5. Folkman J, (2002) Role of angiogenesis in tumor growth and metastasis. Semin Oncol 29: 15-18.
6. Folkman J, (1990) What is the evidence that tumors are angiogenesis dependent? J Natl Cancer Inst 82: 4-6.
7. Carmeliet P, (2005) VEGF as a key mediator of angiogenesis in cancer. Oncology 69Suppl 3: 4-10.
8. Yan M, Plowman GD, (2007) Delta-like 4/Notch signaling and its therapeutic implications. Clin Cancer Res 13: 7243-7246.
9. Williams CK, Li JL, Murga M, Harris AL, Tosato G, (2006) Up-regulation of the Notch ligand Delta-like 4 inhibits VEGF-induced endothelial cell function. Blood 107: 931-939.
10. Li JL, Harris AL, (2009) Crosstalk of VEGF and Notch pathways in tumour angiogenesis: therapeutic implications. Front Biosci 14: 3094-3110.
11. Noguera-Troise I, Daly C, Papadopoulos NJ, Coetzee S, Boland P, et al. (2006) Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesis. Nature 444: 1032-1037.
12. Santarpia L, Nicoloso M, Calin GA, (2010) MicroRNAs: a complex regulatory network drives the acquisition of malignant cell phenotype. Endocr Relat Cancer 17: F51-75.
13. White NM, Khella HW, Grigull J, Adzovic S, Youssef YM, et al. (2011) miRNA profiling in metastatic renal cell carcinoma reveals a tumour-suppressor effect for miR-215. Br J Cancer 105: 1741-1749.
14. Huang ZM, Yang J, Shen XY, Zhang XY, Meng FS, et al. (2009) MicroRNA expression profile in non-cancerous colonic tissue associated with lymph node metastasis of colon cancer. J Dig Dis 10: 188-194.
15. Le XF, Merchant O, Bast RC, Calin GA, (2010) The Roles of MicroRNAs in the Cancer Invasion-Metastasis Cascade. Cancer Microenviron 3: 137-147.
16. Zhang C, Yao Z, Zhu M, Ma X, Shi T, et al. (2012) Inhibitory effects of microRNA-34a on cell migration and invasion of invasive urothelial bladder carcinoma by targeting Notch1. J Huazhong Univ Sci Technolog Med Sci 32: 375-382.
17. Ai Q, Ma X, Huang Q, Liu S, Shi T, et al. (2012) High-level expression of Notch1 increased the risk of metastasis in T1 stage clear cell renal cell carcinoma. PLoS One 7: e35022.
18. Liu S, Ma X, Ai Q, Huang Q, Shi T, et al. (2011) NOTCH1 functions as an oncogene by regulating the PTEN/PI3K/AKT pathway in clear cell renal cell carcinoma. Urol Oncol.
19. Jung M, Mollenkopf HJ, Grimm C, Wagner I, Albrecht M, et al. (2009) MicroRNA profiling of clear cell renal cell cancer identifies a robust signature to define renal malignancy. J Cell Mol Med 13: 3918-3928.
20. Yi Z, Fu Y, Zhao S, Zhang X, Ma C, (2010) Differential expression of miRNA patterns in renal cell carcinoma and nontumorous tissues. J Cancer Res Clin Oncol 136: 855-862.
21. Wu X, Weng L, Li X, Guo C, Pal SK, et al. (2012) Identification of a 4-microRNA signature for clear cell renal cell carcinoma metastasis and prognosis. PLoS One 7: e35661.
22. Patel NS, Li JL, Generali D, Poulsom R, Cranston DW, et al. (2005) Up-regulation of delta-like 4 ligand in human tumor vasculature and the role of basal expression in endothelial cell function. Cancer Res 65: 8690-8697.
23. Hainaud P, Contreres JO, Villemain A, Liu LX, Plouet J, et al. (2006) The role of the vascular endothelial growth factor-Delta-like 4 ligand/Notch4-ephrin B2 cascade in tumor vessel remodeling and endothelial cell functions. Cancer Res 66: 8501-8510.
24. Liu ZJ, Shirakawa T, Li Y, Soma A, Oka M, et al. (2003) Regulation of Notch1 and Dll4 by vascular endothelial growth factor in arterial endothelial cells: implications for modulating arteriogenesis and angiogenesis. Mol Cell Biol 23: 14-25.
25. Mailhos C, Modlich U, Lewis J, Harris A, Bicknell R, et al. (2001) Delta4, an endothelial specific notch ligand expressed at sites of physiological and tumor angiogenesis. Differentiation 69: 135-144.
26. Yan M, Callahan CA, Beyer JC, Allamneni KP, Zhang G, et al. (2010) Chronic DLL4 blockade induces vascular neoplasms. Nature 463: E6-7.
27. Jones-Rhoades MW, Bartel DP, Bartel B, (2006) MicroRNAS and their regulatory roles in plants. Annu Rev Plant Biol 57: 19-53.
28. Bartel DP, (2009) MicroRNAs: target recognition and regulatory functions. Cell 136: 215-233.
29. Wightman B, Ha I, Ruvkun G, (1993) Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans. Cell 75: 855-862.
30. Bridge G, Monteiro R, Henderson S, Emuss V, Lagos D, et al. (2012) The microRNA-30 family targets DLL4 to modulate endothelial cell behavior during angiogenesis. Blood 120: 5063-5072.
31. Guo H, Ingolia NT, Weissman JS, Bartel DP, (2010) Mammalian microRNAs predominantly act to decrease target mRNA levels. Nature 466: 835-840.
32. Lim LP, Lau NC, Garrett-Engele P, Grimson A, Schelter JM, et al. (2005) Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs. Nature 433: 769-773.
33. Krutzfeldt J, Rajewsky N, Braich R, Rajeev KG, Tuschl T, et al. (2005) Silencing of microRNAs in vivo with 'antagomirs'. Nature 438: 685-689.
34. Giraldez AJ, Mishima Y, Rihel J, Grocock RJ, Van Dongen S, et al. (2006) Zebrafish MiR-430 promotes deadenylation and clearance of maternal mRNAs. Science 312: 75-79.
35. Cho WC, (2010) MicroRNAs: potential biomarkers for cancer diagnosis, prognosis and targets for therapy. Int J Biochem Cell Biol 42: 1273-1281.
36. Zhou L, Chen J, Li Z, Li X, Hu X, et al. (2010) Integrated profiling of microRNAs and mRNAs: microRNAs located on Xq27.3 associate with clear cell renal cell carcinoma. PLoS One 5: e15224.
37. Agrawal R, Tran U, Wessely O, (2009) The miR-30 miRNA family regulates Xenopus pronephros development and targets the transcription factor Xlim1/Lhx1. Development 136: 3927-3936.
38. Wu C, Jin B, Chen L, Zhuo D, Zhang Z, et al. (2013) MiR-30d induces apoptosis and is regulated by the Akt/FOXO pathway in renal cell carcinoma. Cell Signal 25: 1212-1221.
39. Heinzelmann J, Henning B, Sanjmyatav J, Posorski N, Steiner T, et al. (2011) Specific miRNA signatures are associated with metastasis and poor prognosis in clear cell renal cell carcinoma. World J Urol 29: 367-373.
40. Fang JH, Zhou HC, Zeng C, Yang J, Liu Y, et al. (2011) MicroRNA-29b suppresses tumor angiogenesis, invasion, and metastasis by regulating matrix metalloproteinase 2 expression. Hepatology 54: 1729-1740.
41. Grange C, Tapparo M, Collino F, Vitillo L, Damasco C, et al. (2011) Microvesicles released from human renal cancer stem cells stimulate angiogenesis and formation of lung premetastatic niche. Cancer Res 71: 5346-5356.
42. Daubman S, (2010) MicroRNAs in angiogenesis and vascular smooth muscle cell function. Circ Res 106: 423-425.
43. Cocucci E, Racchetti G, Meldolesi J, (2009) Shedding microvesicles: artefacts no more. Trends Cell Biol 19: 43-51.
44. Quesenberry PJ, Aliotta JM, (2008) The paradoxical dynamism of marrow stem cells: considerations of stem cells, niches, and microvesicles. Stem Cell Rev 4: 137-147.
45. Ratajczak J, Wysoczynski M, Hayek F, Janowska-Wieczorek A, Ratajczak MZ, (2006) Membrane-derived microvesicles: important and underappreciated mediators of cell-to-cell communication. Leukemia 20: 1487-1495.