Dual thermoresponsive and pH-responsive self-assembled micellar nanogel for anticancer drug delivery

Drug Delivery

Volumn 21, Issue 4, 2014, Pages 258-264

  Chen, Daquan ^a   Yu, Hongyun ^a,b   Sun, Kaoxiang ^a,b   Liu, Wanhui ^a,b   Wang, Hongbo ^a,b  

^a YANTAI UNIVERSITY   (China)

^b State Key Laboratory of Long acting Extended Release and Targeting Drug Delivery Systems   (China)

Author keywords

Micellar nanogel; MPEG IS (PI); PH responsive micelles; PTX delivery; Thermoresponsive

Indexed keywords

ACETAL DERIVATIVE; DRUG CARRIER; ISOPROPYLIDENEGLYCEROL; MACROGOL 2000; PACLITAXEL; POLYMER; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; MACROGOL DERIVATIVE; MICELLE; NANOGEL; POLYETHYLENEIMINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; BIOCOMPATIBILITY; BODY TEMPERATURE; CANCER INHIBITION; CANCER THERAPY; CONTROLLED DRUG RELEASE; CONTROLLED STUDY; DEGRADATION; DRUG CYTOTOXICITY; DRUG DELIVERY SYSTEM; DRUG EFFICACY; DRUG SOLUBILITY; DRUG STABILITY; HEAT SENSITIVITY; HUMAN; HUMAN CELL; HYDROGEL; HYDROPHILICITY; HYDROPHOBICITY; IN VITRO STUDY; MOUSE; NANOENCAPSULATION; NONHUMAN; PARTICLE SIZE; PH; PHASE TRANSITION; PRIORITY JOURNAL; SELF ASSEMBLED MICELLAR NANOGEL; ANIMAL; BAGG ALBINO MOUSE; CARCINOMA, HEPATOCELLULAR; CHEMISTRY; DRUG SCREENING; HEK293 CELL LINE; MICELLE; PATHOLOGY; PROCEDURES; TEMPERATURE; TUMOR CELL LINE;

ANIMALS; ANTINEOPLASTIC AGENTS; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; HEK293 CELLS; HUMANS; HYDROGEN-ION CONCENTRATION; MICE; MICE, INBRED BALB C; MICELLES; PACLITAXEL; POLYETHYLENE GLYCOLS; POLYETHYLENEIMINE; TEMPERATURE; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84901939665     PISSN: 10717544     EISSN: 15210464     Source Type: Journal    
DOI: 10.3109/10717544.2013.838717     Document Type: Article

References (25)

1. Bae Y, Jang WD, Nishiyama N, et al. (2005a). Multifunctional polymeric micelles with folate-mediated cancer cell targeting and pH-triggered drug releasing properties for active intracellular drug delivery. Mol Biosys 1:242-50. (Pubitemid 41442434)
2. Bae Y, Nishiyama N, Fukushima S, et al. (2005b). Preparation and biological characterization of polymeric micelle drug carriers with intracellular pH-triggered drug release property: tumor permeability, controlled subcellular drug distribution, and enhanced in vivo antitumor efficacy. Bioconjug Chem 16:122-30. (Pubitemid 40129685)
3. Chen D, Jiang X, Liu J, et al. (2010a). In vivo evaluation of novel pHsensitive mPEG-Hz-Chol conjugate in liposomes: pharmacokinetics, tissue distribution, efficacy assessment. Artif Cells Blood Substit Immobil Biotechnol 38:136-42.
4. Chen D, Jiang X, Huang Y, et al. (2010b). pH-Sensitive mPEGHz- cholesterol conjugates as a liposome delivery system. J Bioact Compat Polym 25:527-42.
5. Chen D, Liu W, Shen Y, et al. (2011). Effects of a novel pH-sensitive liposome with cleavable esterase-catalyzed and pH-responsive double smart mPEG lipid derivative on ABC phenomenon. Int J Nanomedicine 6:2053-61.
6. Chen D, Sun K, Mu H, et al. (2012). pH and temperature dual-sensitive liposome gel based on novel cleavable mPEG-Hz-CHEMS polymeric vaginal delivery system. Int J Nanomedicine 7:2621-30.
7. Chen D, Hong Y, Hong M, et al. (2013). Novel chitosan derivative for temperature and ultrasound dual-sensitive liposomal microbubble gel. Carbohydrate Polymers 94:17-23.
8. Davis ME, Chen ZG, Shin DM. (2008). Nanoparticle therapeutics: an emerging treatment modality for cancer. Nat Rev Drug Discov 7: 771-82.
9. Fiore VF, Lofton MC, Roser-Page S, et al. (2010). Polyketal microparticles for therapeutic delivery to the lung. Biomaterials 31: 810-17.
10. Ganta S, Devalapally H, Shahiwala A, Amiji M. (2008). A review of stimuli-responsive nanocarriers for drug and gene delivery. J Control Release 126:187-204.
11. Gelderblom H, Verweij J, Nooter K, Sparreboom A. (2001). Cremophor EL: the drawbacks and advantages of vehicle selection for drug formulation. Eur J Cancer 37:1590-8. (Pubitemid 32778603)
12. Heller J, Barr J. (2004). Poly(ortho esters)-from concept to reality. Biomacromolecules 5:1625-32.
13. Heffernan M, Murthy N. (2005). Polyketal nanoparticles: a new pH-sensitive biodegradable drug delivery vehicle. Bioconjug Chem 16:1340-2. (Pubitemid 41681496)
14. Hallaj-Nezhadi S, Dass CR, Lotfipour F. (2013). Intraperitoneal delivery of nanoparticles for cancer gene therapy. Future Oncol 9: 59-68.
15. Mo R, Xiao Y, Sun M, et al. (2011a). Enhancing effect of N-octyl-O-sulfate chitosan on etoposide absorption. Int J Pharm 409:38-45.
16. Mo R, Jin X, Li N, et al. (2011b). The mechanism of enhancement on oral absorption of paclitaxel by N-octyl-O-sulfate chitosan micelles. Biomaterials 32:4609-20.
17. Oh KT, Kim D, You HH, et al. (2009). pH-sensitive properties of surface charge-switched multifunctional polymeric micelle. Int J Pharm 376: 134-40.
18. Park JS, Oh YK, Yoon H, et al. (2002). In situ gelling and mucoadhesive polymer vehicles for controlled intranasal delivery of plasmid DNA. J Biomed Mater Res 59:144-51.
19. Qian WY, Sun DM, Zhu RR, et al. (2012). pH-sensitive strontium carbonate nanoparticles as new anticancer vehicles for controlled etoposide release. Int J Nanomedicine 7:5781-92.
20. Siepmann J, Gopferich A. (2001). Mathematical modeling of bioerodible, polymeric drug delivery systems. Adv Drug Deliv Rev 48: 229-47. (Pubitemid 32434405)
21. Singla AK, Garg A, Aggarwal D. (2002). Paclitaxel and its formulations. Int J Pharm 235:179-92. (Pubitemid 34185449)
22. Szebeni J, Muggia FM, Alving CR. (1998). Complement activation by Cremophor EL as a possible contributor to hypersensitivity to paclitaxel: an in vitro study. J Natl Cancer Inst 90:300-6. (Pubitemid 28182386)
23. von Burkersroda F, Schedl L, Gopferich A. (2002). Why degradable polymers undergo surface erosion or bulk erosion. Biomaterials 23: 4221-31. (Pubitemid 34814991)
24. Yuk SH, Oh KS, Koo H, et al. (2011). Multi-core vesicle nanoparticles based on vesicle fusion for delivery of chemotherapic drugs. Biomaterials 32:7924-31.
25. Zhang JA, Anyarambhatla G, Ma L, et al. (2005). Development and characterization of a novel Cremophor EL free liposome-base paclitaxel (LEP-ETU) formulation. Eur J Pharm Biopharm 59:177-87. (Pubitemid 39573451)