Group A streptococcus inhibitors by high-throughput virtual screening

European Journal of Medicinal Chemistry

Volumn 82, Issue , 2014, Pages 120-126

  Hu, Haipeng ^a   Mao, Shuli ^a   Bugrysheva, Julia V ^b   Pruett, Sarah ^a   Liotta, Dennis C ^a   Scott, June R ^b   Snyder, James P ^a  

^a EMORY UNIVERSITY   (United States)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Group A streptococcus; High throughput virtual screening (HTVS); Homology model; RNase J1 J2

Indexed keywords

ANTIBIOTIC AGENT; COMPOUND 18; COMPOUND 78; COMPOUND 8; COMPOUND 82; COMPOUND 83; COMPOUND 84; COMPOUND 85; RIBONUCLEASE INHIBITOR; RNASE J1 INHIBITOR; RNASE J2 INHIBITOR; UNCLASSIFIED DRUG; ANTIINFECTIVE AGENT; ENZYME INHIBITOR; MOLECULAR LIBRARY; RIBONUCLEASE;

ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL GROWTH; BIOASSAY; CELL ASSAY; DATA BASE; GROWTH INHIBITION; HIGH THROUGHPUT SCREENING; HIGH THROUGHPUT VIRTUAL SCREENING; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR LIBRARY; NONHUMAN; NUCLEOTIDE SEQUENCE; STREPTOCOCCUS GROUP A; STRUCTURE ACTIVITY RELATION; VIRTUAL REALITY; ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; CHEMISTRY; CONFORMATION; CYTOLOGY; DOSE RESPONSE; DRUG EFFECTS; ENZYMOLOGY; METABOLISM; MICROBIAL SENSITIVITY TEST; PHARMACOLOGY; STREPTOCOCCUS PYOGENES; THERMUS THERMOPHILUS;

ANTI-BACTERIAL AGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; HIGH-THROUGHPUT SCREENING ASSAYS; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; RIBONUCLEASES; SMALL MOLECULE LIBRARIES; STREPTOCOCCUS PYOGENES; STRUCTURE-ACTIVITY RELATIONSHIP; THERMUS THERMOPHILUS;

EID: 84901935191     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2014.05.006     Document Type: Article

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