Unexplained reduced microbiological efficacy of intramuscular benzathine penicillin G and of oral penicillin V in eradication of group A streptococci from children with acute pharyngitis

Pediatrics

Volumn 108, Issue 5, 2001, Pages 1180-1186

  Kaplan, Edward L ^a   Johnson, Dwight R ^a  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

Author keywords

Benzathine penicillin G; Ceftriaxone; Penicillin V; Streptococcal carrier; Streptococcal pharyngitis

Indexed keywords

BENZATHINE PENICILLIN; PENICILLIN V;

ARTICLE; BACTERIUM ISOLATION; CHILD; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFICACY; FEMALE; HEALTH CARE POLICY; HUMAN; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; PHARYNGITIS; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SINGLE BLIND PROCEDURE; STREPTOCOCCUS GROUP A; THROAT CULTURE; TREATMENT FAILURE;

ACUTE DISEASE; ADMINISTRATION, ORAL; CARRIER STATE; CHILD; CHILD, PRESCHOOL; HUMANS; INJECTIONS, INTRAMUSCULAR; PENICILLIN G, BENZATHINE; PENICILLIN V; PENICILLINS; PHARYNGITIS; SINGLE-BLIND METHOD; STREPTOCOCCAL INFECTIONS; STREPTOCOCCUS PYOGENES; TREATMENT FAILURE;

EID: 0034765377     PISSN: 00314005     EISSN: None     Source Type: Journal    
DOI: 10.1542/peds.108.5.1180     Document Type: Article

References (35)

1. Prevention of rheumatic fever: A statement for health professionals by the Committee on Rheumatic Fever, Endocarditis and Kawasaki Disease of the Council on Cardiovascular Disease in the Young, the American Heart Association
2. Diagnosis and management of group A streptococcal pharyngitis: A practice guideline
3. Failure of penicillin to eradicate group A streptococci during an outbreak of pharyngitis
4. Pharmacokinetics of benzathine penicillin G: Serum levels during the 28 days after intramuscular injection of 1,200;000 units
5. Differences in serum penicillin concentrations following intramuscular injection of benzathine penicillin G from different manufacturers
6. Adherence to physician's instructions as a factor in managing streptococcal pharyngitis
7. Prophylaxis of acute rheumatic fever by treatment of the preceding streptococcal infection with various amounts of depot penicillin
8. General guidelines for the evaluation of new anti-infective drugs for the treatment of respiratory tract infections
9. Diagnosis of streptococcal pharyngitis: Differentiation of active infection from the carrier state in the symptomatic child
10. Streptococcal pharyngitis: The case for penicillin therapy
11. Symposium on rheumatic heart disease: The role of the streptococcus in the pathogenesis of rheumatic fever
12. Susceptibility of group A beta hemolytic streptococci to thirteen antibiotics: Examination of 301 strains isolated in the United States between 1994 and 1997
13. Pharmacokinetic (PK) variability explains the high microbiological failure rate for single dose ceftriaxone (CTX) for group A streptococcal pharyngitis (GSP)
14. Benzathine penicillin G for treatment of group A streptococcal pharyngitis: A reappraisal in 1985
15. Are the currently recommended doses of benzathine penicillin G adequate for secondary prophylaxis of rheumatic fever?
16. Studies of the continuing susceptibility of group A streptococcal strains to penicillin during eight decades
17. The role of the carrier in treatment failures after antibiotic therapy for group A streptococci in the upper respiratory tract
18. Streptococcal pharyngitis: Placebo controlled double-blind evaluation of clinical response to penicillin therapy
19. The effect of penicillin therapy on the symptoms and signs of streptococcal pharyngitis
20. Effect of penicillin and Aureomycin on the natural course of streptococcal tonsillitis and pharyngitis
21. Group A streptococcal carriers and contacts: (When) is retreatment necessary?
22. Group A streptococci efficiently invade human respiratory epithelial cells
23. Persistence of Streptococcus pyogenes within cultured human respiratory cells
24. Potential mechanisms for failure to eradicate group A streptococci from the pharynx
25. The group A streptococcal upper respiratory tract carrier state: An enigma
26. Perplexity and precision in the diagnosis of streptococcal pharyngitis
27. Diagnosis of pharyngitis. Clinical and epidemiologic features
28. Comparative effects of penicillin, aureomycin, and terramycin on streptococcal tonsillitis and pharyngitis
29. Serum penicillin concentrations after intramuscular administration of benzathine penicillin G in children
30. Serum levels of penicillin in basic trainees in the US Army who received intramuscular penicillin G benzathine
31. Prophylaxis against group A streptococcal infections in rheumatic fever patients