Artesunate induces apoptosis through caspase-dependent and -independent mitochondrial pathways in human myelodysplastic syndrome SKM-1 cells

Chemico-Biological Interactions

Volumn 219, Issue , 2014, Pages 28-36

  Wang, Ying ^a   Yang, Jingci ^a   Chen, Li ^a   Wang, Jiamin ^a   Wang, Yaqian ^a   Luo, Jianmin ^a   Pan, Ling ^b   Zhang, Xuejun ^a  

^a HEBEI MEDICAL UNIVERSITY   (China)

^b SICHUAN UNIVERSITY   (China)

Author keywords

Apoptosis inducing factor; Artesunate; Caspase 3; Caspase 9; Mitochondrial apoptosis pathways; Myelodysplastic syndrome

Indexed keywords

ARTESUNATE; CASPASE; CASPASE 3; CASPASE 9; CHOLECYSTOKININ OCTAPEPTIDE; FLUORESCENT DYE; JC 1 DYE; LIPOCORTIN 5; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROPIDIUM IODIDE; PROTEIN BAX; PROTEIN BCL 2; UNCLASSIFIED DRUG; APOPTOSIS INDUCING FACTOR; 5,5',6,6'-TETRACHLORO-1,1',3,3'-TETRAETHYLBENZIMIDAZOLOCARBOCYANINE; ARTEMISININ DERIVATIVE; BENZIMIDAZOLE DERIVATIVE; CARBOCYANINE;

APOPTOSIS; ARTICLE; BCL 2 BAX RATIO; BONE MARROW CELL; CELL ASSAY; CELL LEVEL; CELL PROLIFERATION; CELLULAR DISTRIBUTION; CLINICAL ARTICLE; CONTROLLED STUDY; DEPOLARIZATION; ENZYME ACTIVATION; FLUORESCENCE ANALYSIS; HUMAN; HUMAN CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; MOLECULAR DYNAMICS; MONONUCLEAR CELL; MYELODYSPLASTIC SYNDROME; PROTEIN CLEAVAGE; SIGNAL TRANSDUCTION; STROMA CELL; WESTERN BLOTTING; ACUTE GRANULOCYTIC LEUKEMIA; ANTIPROLIFERATIVE ACTIVITY; BONE MARROW DERIVED MONONUCLEAR CELL; BONE MARROW STROMA CELL; CONCENTRATION RESPONSE; IC50; REFRACTORY ANEMIA WITH EXCESS BLASTS; DRUG EFFECTS; METABOLISM; MYELODYSPLASTIC SYNDROMES; PHYSIOLOGY; TUMOR CELL LINE;

APOPTOSIS; ARTEMISININS; BCL-2-ASSOCIATED X PROTEIN; BENZIMIDAZOLES; BLOTTING, WESTERN; BONE MARROW CELLS; CARBOCYANINES; CASPASES; CELL LINE, TUMOR; CELL PROLIFERATION; HUMANS; INHIBITORY CONCENTRATION 50; MEMBRANE POTENTIAL, MITOCHONDRIAL; MYELODYSPLASTIC SYNDROMES; POLY(ADP-RIBOSE) POLYMERASES; PROTO-ONCOGENE PROTEINS C-BCL-2; SINCALIDE;

EID: 84901933842     PISSN: 00092797     EISSN: 18727786     Source Type: Journal    
DOI: 10.1016/j.cbi.2014.03.011     Document Type: Article

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