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Volumn 22, Issue 13, 2014, Pages 3351-3359
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Structure-based efforts to optimize a non-β-lactam inhibitor of AmpC β-lactamase
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Author keywords
Antibiotic resistance; Structure based drug design; X ray crystallography
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Indexed keywords
3 (4 CARBOXYBENZYLSULFAMOYL)THIOPHENE 2 CARBOXYLIC ACID;
3 (4 CARBOXYPHENYLETHYSULFAMOYL)THIOPHENE 2 CARBOXYLIC ACID;
3 (4 CARBOXYPHENYLPROPYLSULFAMOYL)THIOPHENE 2 CARBOXYLIC ACID;
3 [(4 CHLOROANILINO)SULFONYL]THIOPHENE 2 CARBOXYLIC ACID;
AMOXICILLIN;
BENZENE;
BETA LACTAMASE AMPC;
BETA LACTAMASE INHIBITOR;
CARBON;
CARBOXYLIC ACID;
CLAVULANIC ACID;
THIOPHENE;
UNCLASSIFIED DRUG;
3-((4-CHLOROANILINO)SULFONYL)THIOPHENE-2-CARBOXYLIC ACID;
AMPC BETA-LACTAMASES;
ANILINE DERIVATIVE;
BACTERIAL PROTEIN;
BETA LACTAMASE;
ENZYME INHIBITOR;
THIOPHENE DERIVATIVE;
ARTICLE;
COMPLEX FORMATION;
CONTROLLED STUDY;
CRYSTAL STRUCTURE;
DRUG BINDING SITE;
DRUG DESIGN;
DRUG MECHANISM;
DRUG PROTEIN BINDING;
DRUG SYNTHESIS;
ENZYME ACTIVE SITE;
ENZYME INHIBITION;
PROCESS OPTIMIZATION;
STRUCTURE ACTIVITY RELATION;
ANTAGONISTS AND INHIBITORS;
CHEMICAL STRUCTURE;
CHEMISTRY;
DOSE RESPONSE;
METABOLISM;
SYNTHESIS;
X RAY CRYSTALLOGRAPHY;
ANILINE COMPOUNDS;
BACTERIAL PROTEINS;
BETA-LACTAMASES;
CRYSTALLOGRAPHY, X-RAY;
DOSE-RESPONSE RELATIONSHIP, DRUG;
ENZYME INHIBITORS;
MODELS, MOLECULAR;
MOLECULAR STRUCTURE;
STRUCTURE-ACTIVITY RELATIONSHIP;
THIOPHENES;
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EID: 84901925897
PISSN: 09680896
EISSN: 14643391
Source Type: Journal
DOI: 10.1016/j.bmc.2014.04.051 Document Type: Article |
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Times cited : (4)
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References (26)
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