Disrupting MLC1 and GlialCAM and ClC-2 interactions in leukodystrophy entails glial chloride channel dysfunction

Nature Communications

Volumn 5, Issue , 2014, Pages

  Hoegg Beiler, Maja B ^a,b   Sirisi, Sònia ^c,d   Orozco, Ian J ^a,b   Ferrer, Isidre ^e   Hohensee, Svea ^a   Auberson, Muriel ^a,b,h   Gödde, Kathrin ^a,b   Vilches, Clara ^d   De Heredia, Miguel López ^d,f   Nunes, Virginia ^c,d,f   Estévez, Raúl ^c,f   Jentsch, Thomas J ^a,b,g  

^a LEIBNIZ INSTITUT FÜR MOLEKULARE PHARMAKOLOGIE   (Germany)

^b MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^c UNIVERSITY OF BARCELONA   (Spain)

^d BELLVITGE BIOMEDICAL RESEARCH INSTITUTE IDIBELL   (Spain)

^e HOSPITAL UNIVERSITARI DE BELLVITGE   (Spain)

^f CENTRO DE INVESTIGACIÓN BIOMÉDICA EN RED DE ENFERMEDADES RARAS CIBERER   (Spain)

^g CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^h UNIVERSITY OF LAUSANNE   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CELL ADHESION MOLECULE; CHLORIDE CHANNEL; CLC 2 PROTEIN; GLIALCAM PROTEIN; MEMBRANE PROTEIN; MLC1 PROTEIN; MYELIN; UNCLASSIFIED DRUG; CLC-2 CHLORIDE CHANNELS; GLIALCAM PROTEIN, MOUSE; MLC1 PROTEIN, MOUSE; NERVE CELL ADHESION MOLECULE; NERVE PROTEIN;

BIOPHYSICS; CELL ORGANELLE; CHLORIDE; CYST; MEMBRANE; PATHOGEN; PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD VESSEL; CELL VACUOLE; CEREBELLUM; CHLORIDE CHANNELOPATHY; CHLORIDE CURRENT; CONTROLLED STUDY; GLIA; HUMAN; HUMAN CELL; IN VIVO STUDY; LEUKODYSTROPHY; LOSS OF FUNCTION MUTATION; MOUSE; MOUSE MODEL; NONHUMAN; OLIGODENDROGLIA; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING; ANIMAL; ASTROCYTE; BRAIN; C57BL MOUSE; CONFOCAL MICROSCOPY; DISEASE MODEL; ELECTRON MICROSCOPY; FEMALE; GENETICS; HEK293 CELL LINE; HELA CELL LINE; KNOCKOUT MOUSE; LEUKOENCEPHALOPATHY; MEMBRANE POTENTIAL; METABOLISM; PATCH CLAMP TECHNIQUE; PATHOLOGY; ULTRASTRUCTURE; WESTERN BLOTTING;

ANIMALS; ASTROCYTES; BLOTTING, WESTERN; BRAIN; CELL ADHESION MOLECULES; CELL ADHESION MOLECULES, NEURON-GLIA; CEREBELLUM; CHLORIDE CHANNELS; DISEASE MODELS, ANIMAL; FEMALE; HEK293 CELLS; HELA CELLS; HUMANS; LEUKOENCEPHALOPATHIES; MEMBRANE POTENTIALS; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICROSCOPY, CONFOCAL; MICROSCOPY, ELECTRON; NERVE TISSUE PROTEINS; OLIGODENDROGLIA; PATCH-CLAMP TECHNIQUES;

EID: 84901924901     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms4475     Document Type: Article

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