ClC-2 voltage-gated channels constitute part of the background conductance and assist chloride extrusion

Journal of Neuroscience

Volumn 30, Issue 13, 2010, Pages 4776-4786

  Rinke, Ilka ^a   Artmann, Judith ^a,b   Stein, Valentin ^a  

^a MAX PLANCK INSTITUTE OF NEUROBIOLOGY   (Germany)

^b ETH ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID RECEPTOR; CHLORIDE; CHLORIDE CHANNEL; UNCLASSIFIED DRUG; VOLTAGE GATED CHANNEL FORMING PROTEIN; VOLTAGE GATED CHANNEL FORMING PROTEIN C1C 2;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EXCITATORY POSTSYNAPTIC POTENTIAL; FEMALE; HIPPOCAMPUS; INTERNEURON; MALE; MOUSE; NERVE CELL EXCITABILITY; NERVE CELL INHIBITION; NERVE CELL MEMBRANE CONDUCTANCE; NERVE CONDUCTION; NONHUMAN; PRIORITY JOURNAL; PYRAMIDAL NERVE CELL; SYNAPTIC TRANSMISSION;

ANIMALS; CHLORIDE CHANNELS; CHLORIDES; ELECTRIC CONDUCTIVITY; EXCITATORY POSTSYNAPTIC POTENTIALS; GAMMA-AMINOBUTYRIC ACID; HIPPOCAMPUS; INHIBITORY POSTSYNAPTIC POTENTIALS; INTERNEURONS; MEMBRANE POTENTIALS; MICE; MICE, KNOCKOUT; MINIATURE POSTSYNAPTIC POTENTIALS; PATCH-CLAMP TECHNIQUES; PYRAMIDAL CELLS; SYNAPTIC TRANSMISSION;

EID: 77950646639     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.6299-09.2010     Document Type: Article

References (40)

1. Bartos M, Vida I, Jonas P (2007) Synaptic mechanisms of synchronized gamma oscillations in inhibitory interneuron networks. Nat Rev Neurosci 8:45-56. (Pubitemid 46011998)
2. Ben-Ari Y (2002) Excitatory actions of gaba during development: the nature of the nurture. Nat Rev Neurosci 3:728-739. (Pubitemid 135706678)
3. Blanz J, Schweizer M, Auberson M., Maier H, Muenscher A, Hübner CA, Jentsch TJ (2007) Leukoencephalopathy upon disruption of the chloride channel ClC-2. J Neurosci 27:6581-6589. (Pubitemid 46920373)
4. Bösl MR, Stein V, Hübner C, Zdebik AA, Jordt SE, Mukhopadhyay AK, Davidoff MS, Holstein AF, Jentsch TJ (2001) Male germ cells and photoreceptors, both dependent on close cell-cell interactions, degenerate upon ClC-2 Cl(-) channel disruption. EMBO J 20:1289-1299. (Pubitemid 32233969)
5. A signaling in neonatal neurons. J Neurosci 28:1301-1312.
6. Carvalho TP, Buonomano DV (2009) Differential effects of excitatory and inhibitory plasticity on synaptically driven neuronal input-output functions. Neuron 61:774-785.
7. Chenoy-Marchais D (1982) A Cl- conductance activated by hyperpolarization in Aplysia neurones. Nature 299:359-361.
8. Chesnoy-Marchais D (1983) Characterization of a chloride conductance activated by hyperpolarization in Aplysia neurones. J Physiol 342:277-308.
9. Combi R, Grioni D, Contri M, Redaelli S, Redaelli F, Bassi MT, Barisani D, Lavitrano ML, Tredici G, Tenchini ML, Bertolini M, Dalprà L (2009) Clinical and genetic familial study of a large cohort of Italian children with idiopathic epilepsy. Brain Res Bull 79:89-96.
10. D'AgostinoD,BertelliM,GalloS,CecchinS,AlbieroE,GarofaloPG,GambardellaA, StHilaireJM,KwiecinskiH,AndermannE,PandolfbM(2004) MutationsandpolymorphismsoftheCLCN2geneinidiopathicepilepsy.Neurology63: 1500-1502.(Pubitemid39426290)
11. Daoudal G, Debanne D (2003) Long-term plasticity of intrinsic excitability: learning rules and mechanisms. Learn Mem 10:456-465. (Pubitemid 37499775)
12. Everett K, Chioza B, Aicardi J, Aschauer H, Brouwer O, Callenbach P, Covanis A, Dooley J, Dulac O, Durncr M, Eeg-Olofsson O, Feucht M., Friis M, Guerrini R, Heils A, Kjeldsen M, Nabbout R, Sander T, Wirrell E, McKeigue P, Robinson R, Taske N, Gardiner M (2007) Linkage and mutational analysis of CLCN2 in childhood absence epilepsy. Epilepsy Res 75:145-153. (Pubitemid 47048657)
13. Goldstein SA, Bockenhauer D, O'Kelly I, Zilberberg N (2001) Potassium leak channels and the KCNK family of two-P-domain subunits. Nat Rev Neurosci 2:175-184. (Pubitemid 33673370)
14. Gründer S, Thiemann A, Pusch M, Jentsch TJ (1992) Regions involved in the opening of CIC-2 chloride channel by voltage and cell volume. Nature 360:759-762. (Pubitemid 23012277)
15. Haug K, Warnstedt M, Alekov AK, Sander T, Ramirez A, Poser B, Maljevic S, Hebeisen S, Kubisch C, Rebstock J, Horvath S, Hallmann K, Dullinger JS, Rau B, Haverkamp F, Beyenburg S, Schulz H, Janz D, Giese B, MüllerNewen G, Propping P, Elger CE, Fahlke C, Lerche H (2009) Retraction: Mutations in CLCN2 encoding a voltage-gated chloride channel are associated with idiopathic generalized epilepsies. Nat Genet 41:1043.
16. Honoré E (2007) The neuronal background K2P channels: focus on TREK1. Nat Rev Neurosci 8:251-261.
17. Huguenard JR, Alger BE (1986) Whole-cell voltage-clamp study of the fading of GABA-activated currents in acutely dissociated hippocampal neurons. J Neurophysiol 56:1-18.
18. JentschTJ,SteinV,WeinreichF,ZdebikAA(2002) Molecularstructureandphysiologicalfunctionofchloridechannels.PhysiolRev82: 503-568.(Pubitemid34654460)
19. Jordt SE, Jentsch TJ (1997) Molecular dissection of gating in the ClC-2 chloride channel. EMBO J 16:1582-1592. (Pubitemid 27151953)
20. Klausberger T, Somogyi P (2008) Neuronal diversity and temporal dynamics: the unity of hippocampal circuit operations. Science 321:53-57. (Pubitemid 351956237)
21. Ling DS, Benardo LS (1995) Activity-dependent depression of monosynaptic fast IPSCs in hippocampus: contributions from reductions in chloride driving force and conductance. Brain Res 670:142-146.
22. Madison DV, Malenka RC, Nicoll RA (1986) Phorbol esters block a voltage-sensitive chloride current in hippocampal pyramidal cells. Nature 321:695-697.
23. Marder CP, Buonomano DV (2003) Differential effects of short-and longterm potentiation on cell firing in the CA1 region of the hippocampus. J Neurosci 23:112-121.
24. McCarrenM,AlgerBE(1985)Use- dependentdepressionofIPSPsinrathippocampalpyramidalcellsinvitro.JNeurophysiol53: 557-571.(Pubitemid15134965)
25. Mladinić M, Becchetti A, Didelon F, Bradbury A, Cherubini E (1999) Low expression of the ClC-2 chloride channel during postnatal development: a mechanism for the paradoxical depolarizing action of GABA and glycine in the hippocampus. Proc Biol Sci 266:1207-1213. (Pubitemid 29319389)
26. - current in salivary acinar cells from Clcn2 knockout mice. J Biol Chem 277:23604-23611.
27. Obata K, Oide M, Tanaka H (1978) Excitatory and inhibitory actions of GABA and glycine on embryonic chick spinal neurons in culture. Brain Res 144:179-184. (Pubitemid 8297921)
28. Saint-Martin C, Gauvain G, Teodorescu G, Gourfinkel-An I, Fedirko E, Weber YG, Maljevic S, Ernst JP, Garck-Olivares J, Fahlke C, Nabbout R, LeGuern E, Lerche H, Poncer JC, Depienne C (2009) Two novel CLCN2 mutations accelerating chloride channel deactivation are associated with idiopathic generalized epilepsy. Hum Mutat 30:397-405.
29. Sik A, Smith RL, Freund TF (2000) Distribution of chloride channel-2immunoreactive neuronal and astrocytic processes in the hippocampus. Neuroscience 101:51-65.
30. Smith RL, Clayton GH, Wilcox CL, Escudero KW, Staley KJ (1995) Differential expression of an inwardly rectifying chloride conductance in rat brain neurons: a potential mechanism for cell-specific modulation of postsynaptic inhibition. J Neurosci 15:4057-4067.
31. Staff NP, Spruston N (2003) Intracellular correlate of EPSP-spike potentia-tion in CA1 pyramidal neurons is controlled by GABAergic modulation. Hippocampus 13:801-805.
32. StaleyK(1994) Theroleofaninwardlyrectifyingchlorideconductanceinpostsynapticinhibition. JNeurophysiol72:273-284.(Pubitemid24233650)
33. Staley K, Smith R, Schaack J, Wilcox C, Jentsch TJ (1996) Alteration of GABAA receptor function following gene transfer of the CLC-2 chloride channel. Neuron 17:543-551. (Pubitemid 26322225)
34. Stein V, Hermans-Borgmeyer I, Jentsch TJ, Hübner CA (2004) Expression of the KCl cotransporter KCC2 parallels neuronal maturation and the emergence of low intracellular chloride. J Comp Neurol 468:57-64. (Pubitemid 37531643)
35. Stobrawa SM, Breiderhoff T, Takamori S, Engel D, Schweizer M, Zdebik AA, Bosi MR, Ruether K, Jahn H, Draguhn A, Jahn R, Jentsch TJ (2001) Disruption of ClC-3, a chloride channel expressed on synaptic vesicles, leads to a loss of the hippocampus. Neuron 29:185-196. (Pubitemid 32108731)
36. Stogmann E, Lichtner P, Baumgartner C, Schmied M, Hotzy C, Asmus F, Leutmezer F, Bonelli S, Assem-Hilger E, Vass K, Hatala K, Strom TM, Meitinger T, Zimprich F, Zimprich A (2006) Mutations in the CLCN2 gene are a rare cause of idiopathic generalized epilepsy syndromes. Neurogenetics 7:265-268. (Pubitemid 44584080)
37. Thiemann A, Gründer S, Pusch M, Jentsch TJ (1992) A chloride channel widely expressed in epithelial and non-epithelial cells. Nature 356:57-60.
38. Thompson SM, Gähwiler BH (1989) Activity-dependent disinhibition. I. Repetitive stimulation reduces IPSP driving force and conductance in the hippocampus in vitro. J Neurophysiol 61:501-511.
39. Tyzio R, Minlebaev M, Rheims S, Ivanov A, Jorquera I, Holmes GL, Zilberter Y, Ben-Ari Y, Khazipov R (2008) Postnatal changes in somatic gammaaminobutyric acid signalling in the rat hippocampus. Eur J Neurosci 27:2515-2528. (Pubitemid 351781675)
40. Zúñiga L, Niemeyer MI, Varela D, Catalán M, Cid LP, Sepúlveda FV (2004) The voltage-dependent ClC-2 chloride channel has a dual gating mechanism. J Physiol 555:671-682.