Novel benzimidazole derivatives as phosphodiesterase 10A (PDE10A) inhibitors with improved metabolic stability

Bioorganic and Medicinal Chemistry

Volumn 22, Issue 13, 2014, Pages 3515-3526

  Chino, Ayaka ^a   Masuda, Naoyuki ^a   Amano, Yasushi ^a   Honbou, Kazuya ^a   Mihara, Takuma ^a   Yamazaki, Mayako ^a   Tomishima, Masaki ^a  

^a ASTELLAS PHARMA INC   (Japan)

Author keywords

Benzimidazole; Imidazopyridine; Metabolic stability; PDE10A inhibitor; Schizophrenia

Indexed keywords

1 METHYL 3 [2 (5 METHYL 1 PHENYL 1H BENZIMIDAZOL 2 YL)ETHYL] 1 METHYL 1,3 DIHYDRO 2H IMIDAZO[4,5 B]PYRIDIN 2 ONE; 2 CHLORO 4 METHYL 3 NITROPYRIDINE; 3 (1 METHYL 2 OXO 1,2 DIHYDRO 3H IMIDAZO[4,5 B]PYRIDIN 3 YL)PROPANOIC ACID; 3 METHOXY 2 NITRO N PHENYLANILINE; 3 METHOXY N1 PHENYLBENZENE 1,2 DIAMINE; 3 NITROPYRIDINE 2 AMINE; 3 [2 (4 METHOXY 1 PHENYL 1H BENZIMIDAZOL 2 YL)ETHYL] 1 METHYL 1,3 DIHYDRO 2H IMIDAZO[4,5 B]PYRIDIN 2 ONE; 3,7 DIMETHYLIMIDAZO[4,5 B]PYRIDIN 2 ONE; 4 METHOXY 2 NITRO N PHENYLANILINE; 4 METHOXY N1 (PYRIDIN 2 YL)BENZENE 1,2 DIAMINE; 4 METHOXY N1 (PYRIDIN 3 YL)BENZENE 1,2 DIAMINE; 4 METHOXY N1 (PYRIDIN 4 YL)BENZENE 1,2 DIAMINE; 4 METHOXY N1 PHENYLBENZENE 1,2 DIAMINE; 4 METHYL N1 PHENYLBENZENE 1,2 DIAMINE; BENZIMIDAZOLE DERIVATIVE; CARBOXYLIC ACID; CYTOCHROME P450 3A4; DIAMINOPYRIDINE; ETHYL 3 (1 METHYL 2 OXO 1,2 DIHYDRO 3H IMIDAZO[4,5 B]PYRIDIN 3 YL)PROPANOATE; IMIDAZOPYRIDINE DERIVATIVE; IMIDAZOPYRIDINONE; N (4 METHOXY 2 NITROPHENYL)PYRIDIN 2 AMINE; N (4 METHOXY 2 NITROPHENYL)PYRIDIN 3 AMINE; N (4 METHOXY 2 NITROPHENYL)PYRIDIN 4 AMINE; NEW DRUG; PHOSPHODIESTERASE; PHOSPHODIESTERASE 10A INHIBITOR DERIVATIVE; PHOSPHODIESTERASE INHIBITOR; PYRIDINE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG; BENZIMIDAZOLE; PDE10A PROTEIN, HUMAN; RECOMBINANT PROTEIN;

AMIDATION; AQUEOUS SOLUTION; ARTICLE; CATALYSIS; CHEMICAL INTERACTION; CONTROLLED STUDY; CRYSTAL STRUCTURE; CYCLIZATION; DRUG DETERMINATION; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; ENZYME INHIBITION; HIGH THROUGHPUT SCREENING; HYDROGENATION; HYDROLYSIS; LIPOPHILICITY; METABOLISM; METHYLATION; PROCESS OPTIMIZATION; SOLVENT EFFECT; STRUCTURE ACTIVITY RELATION; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; HUMAN; SYNTHESIS;

BENZIMIDAZOLES; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PHOSPHODIESTERASE INHIBITORS; PHOSPHORIC DIESTER HYDROLASES; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84901918212     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2014.04.023     Document Type: Article

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