Unraveling the structure-activity relationship of tomatidine, a steroid alkaloid with unique antibiotic properties against persistent forms of Staphylococcus aureus

European Journal of Medicinal Chemistry

Volumn 80, Issue , 2014, Pages 605-620

  Chagnon, Félix ^a   Guay, Isabelle ^b   Bonin, Marc André ^a   Mitchell, Gabriel ^b   Bouarab, Kamal ^b   Malouin, François ^b   Marsault, Éric ^a  

^a UNIVERSITÉ DE SHERBROOKE   (Canada)

^b UNIVERSITÉ DE SHERBROOKE   (Canada)

Author keywords

Aminoglycoside potentiation; Antibiotic; Small colony variants; Staphylococcus aureus; Steroid alkaloid; Structure activity relationship; Tomatidine

Indexed keywords

26 ACETYLAMINO 3BETA HYDROXY 5A FUROST 20(22) ENE; 26 ACETYLAMINO 3BETA HYDROXY 5A FUROSTANE; 26 ACETYLAMINO 3BETA,16BETA DIACETOXY 22 HYDROXY 5A CHOLESTANE; 26 ACETYLAMINO 3BETA,16BETA DIACETOXY 5A CHOLEST 22 ONE; 26 ACETYLAMINO 3BETA,16BETA,20 TRIHYDROXY 5A CHOLESTANE; 26 AMINO 3BETA ,16BETA DIHYDROXY 5A CHOLESTANO 22,26 PIPERIDINE; 26 AMINO 3BETA,16BETA ACETOXY N ACETYL 5A CHOLEST 22 ENO 22,26 PIPERIDINE; 3 (N AMINOBUTYL) AMINOTOMATIDINE HYDROCHLORIDE; 3 (N AMINOETHYL) AMINOTOMATIDINE HYDROCHLORIDE; 3 (N AMINOHEXYL) AMINOTOMATIDINE HYDROCHLORIDE; 3 ALPHA ACETOXY N FORMYL TOMATIDINE; 3 ALPHA HYDROXYTOMATIDINE HYDROCHLORIDE; 3 AMINOTOMATIDINE HYDROCHLORIDE; 3 BETA ALLYLOXY N FORMYLTOMATIDINE; 3 BETA ALLYLOXYTOMATIDINE HYDROCHLORIDE; 3 OXOTOMATIDINE HYDROCHLORIDE; 3ALPHA ACETOXY N ACETYLTOMATIDINE; 3BETA ACETOXY 27 ACETYLAMINO 5A FUROST 20(22) ENE; AMINOGLYCOSIDE ANTIBIOTIC AGENT; GENTAMICIN; N FORMYL 3 (AMINOHEXYL)AMINOTOMATIDINE; N FORMYL 3 (N BOC AMINOBUTYL)AMINOTOMATIDINE; N FORMYL 3 (N BOC AMINOETHYL)AMINOTOMATIDINE; N FORMYL 3 AMINOTOMATIDINE; N FORMYL 3 OXOTOMATIDINE; N FORMYLTOMATIDINE; PIPERIDINE DERIVATIVE; PLANT EXTRACT; TOMATIDINE; UNCLASSIFIED DRUG; UNINDEXED DRUG; ANTIINFECTIVE AGENT; TOMATINE;

ANTIMICROBIAL ACTIVITY; ARTICLE; BACTERIAL VIRULENCE; BIOLOGICAL ACTIVITY; CARBON NUCLEAR MAGNETIC RESONANCE; DRUG POTENTIATION; DRUG STRUCTURE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROGENATION; INFRARED SPECTROSCOPY; MASS SPECTROMETRY; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; STAPHYLOCOCCUS AUREUS; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION; TOMATO; X RAY CRYSTALLOGRAPHY; ANALOGS AND DERIVATIVES; ANTIBIOTIC RESISTANCE; CHEMISTRY; DRUG EFFECTS; GROWTH, DEVELOPMENT AND AGING; MICROBIAL SENSITIVITY TEST;

ANTI-BACTERIAL AGENTS; DRUG RESISTANCE, BACTERIAL; MICROBIAL SENSITIVITY TESTS; STAPHYLOCOCCUS AUREUS; STRUCTURE-ACTIVITY RELATIONSHIP; TOMATINE;

EID: 84901917714     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2013.11.019     Document Type: Article

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