Amino derivatives of glycyrrhetinic acid as potential inhibitors of cholinesterases

Bioorganic and Medicinal Chemistry

Volumn 22, Issue 13, 2014, Pages 3370-3378

  Schwarz, Stefan ^a   Lucas, Susana Dias ^b   Sommerwerk, Sven ^a   Csuk, René ^a  

^a MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

^b RESEARCH INSTITUTE FOR MEDICINES IMED ULISBOA   (Portugal)

Author keywords

Cholinesterase inhibitors; Docking studies; Ellman's test; Glycyrrhetinic acid

Indexed keywords

ACETYLCHOLINESTERASE; CARBONATE DEHYDRATASE II; CHOLINESTERASE; CHOLINESTERASE INHIBITOR; GLYCYRRHETINIC ACID DERIVATIVE; PAPAIN; SULFORHODAMINE B; TRIACYLGLYCEROL LIPASE; GLYCYRRHETINIC ACID;

3T3 CELL LINE; ANIMAL CELL; ARTICLE; CANDIDA ANTARCTICA; COMPUTER MODEL; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG MECHANISM; ENZYME ASSAY; FIBROBLAST; IC 50; MASS SPECTROMETRY; MOLECULAR DOCKING; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; SPECTROPHOTOMETER; ANIMAL; ANTAGONISTS AND INHIBITORS; BLOOD; CANDIDA; CARICA; CHEMICAL STRUCTURE; CHEMISTRY; CONFORMATION; DOSE RESPONSE; EEL; ENZYMOLOGY; HORSE; KINETICS; METABOLISM; MOUSE; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

CANDIDA ANTARCTICA; MURINAE;

ACETYLCHOLINESTERASE; ANIMALS; BUTYRYLCHOLINESTERASE; CANDIDA; CARICA; CHOLINESTERASE INHIBITORS; DOSE-RESPONSE RELATIONSHIP, DRUG; EELS; GLYCYRRHETINIC ACID; HORSES; KINETICS; LIPASE; MICE; MODELS, MOLECULAR; MOLECULAR CONFORMATION; NIH 3T3 CELLS; PAPAIN; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84901917129     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2014.04.046     Document Type: Article

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