The expression of cell cycle related proteins PCNA, Ki67, p27 and p57 in normal and preeclamptic human placentas

Tissue and Cell

Volumn 46, Issue 3, 2014, Pages 198-205

  Unek, Gozde ^a   Ozmen, Asli ^a   Mendilcioglu, Inanc ^a   Simsek, Mehmet ^a   Korgun, Emin Turkay ^a  

^a AKDENIZ UNIVERSITY   (Turkey)

Author keywords

Cell cycle; Human placenta; Immunohistochemistry; Preeclampsia

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 1C; CYCLINE; CYTOKERATIN 7; CYTOKERATIN ANTIBODY; KI 67 ANTIGEN; PROTEIN P27; VIMENTIN; CDKN1C PROTEIN, HUMAN; P27 ANTIGEN;

ADULT; ARTICLE; CELLULAR DISTRIBUTION; CHORION VILLUS; CONTROLLED STUDY; CYTOTROPHOBLAST; DISEASE ASSOCIATION; DOWN REGULATION; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOLOCALIZATION; IMMUNOREACTIVITY; ISOLATED ORGAN; MICROSCOPY; PLACENTA; PREECLAMPSIA; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; SPATIOTEMPORAL ANALYSIS; STAINING; TISSUE DISTRIBUTION; UPREGULATION; CELL CYCLE; FETUS; METABOLISM; PHYSIOLOGY; PREGNANCY; TERM BIRTH; TROPHOBLAST;

ADULT; CELL CYCLE; CYCLIN-DEPENDENT KINASE INHIBITOR P57; FEMALE; FETUS; HUMANS; KI-67 ANTIGEN; PLACENTA; PRE-ECLAMPSIA; PREGNANCY; PROLIFERATING CELL NUCLEAR ANTIGEN; TERM BIRTH; TROPHOBLASTS;

EID: 84901845243     PISSN: 00408166     EISSN: 15323072     Source Type: Journal    
DOI: 10.1016/j.tice.2014.04.003     Document Type: Article

References (46)

1. Allaire A.D., Ballenger K.A., Wells S.R., McMahon M.J., Lessey B.A. Placental apoptosis in preeclampsia. Obstet. Gynecol. 2000, 96:271-276.
2. Arnholdt H., Meisel F., Fandrey K., Lohrs U. Proliferation of villous trophoblast of the human placenta in normal and abnormal pregnancies. Virchows Arch. B. Cell Pathol. Incl. Mol. Pathol. 1991, 60:365-372.
3. Bacus S., Flowers J.L., Press M.F., Bacus J.W., McCarty K.S. The evaluation of estrogen receptor in primary breast carcinoma by computer-assisted image analysis. Am. J. Clin. Pathol. 1988, 90:233-239.
4. Bamberger A., Sudahl S., Bamberger C.M., Schulte H.M., Loning T. Expression patterns of the cell-cycle inhibitor p27 and the cell-cycle promoter cyclin E in the human placenta throughout gestation: implications for the control of proliferation. Placenta 1999, 20:401-406.
5. Benirschke K., Kaufmann P., Baergen R.N. Pathology of the Human placenta 2006, Springer, New York. 5th ed.
6. Bulmer J.N. Immune aspects of pathology of the placental bed contributing to pregnancy pathology. Baillieres Clin. Obstet. Gynaecol. 1992, 6:461-488.
7. Crocker I.P., Tansinda D.M., Baker P.N. Altered cell kinetics in cultured placental villous explants in pregnancies complicated by pre-eclampsia and intrauterine growth restriction. J. Pathol. 2004, 204:11-18.
8. Danihel L., Gomolcak P., Korbel M., Pruzinec J., Vojtassak J., Janik P., Babal P. Expression of proliferation and apoptotic markers in human placenta during pregnancy. Acta Histochem. 2002, 104:335-338.
9. De Falco M., Fedele V., Cobellis L., Mastrogiacomo A., Giraldi D., Leone S., De Luca L., Laforgia V., De Luca A. Pattern of expression of cyclin D1/CDK4 complex in human placenta during gestation. Cell Tissue Res. 2004, 317:187-194.
10. DiFederico E., Genbacev O., Fisher S.J. Preeclampsia is associated with widespread apoptosis of placental cytotrophoblasts within the uterine wall. Am. J. Pathol. 1999, 155:293-301.
11. Fukunaga M. Immunohistochemical characterization of p57(KIP2) expression in early hydatidiform moles. Hum. Pathol. 2002, 33:1188-1192.
12. Genbacev O., McMaster M.T., Fisher S.J. A repertoire of cell cycle regulators whose expression is coordinated with human cytotrophoblast differentiation. Am. J. Pathol. 2000, 157:1337-1351.
13. Gerdes J., Lemke H., Baisch H., Wacker H.H., Schwab U., Stein H. Cell cycle analysis of a cell proliferation-associated human nuclear antigen defined by the monoclonal antibody Ki-67. J. Immunol. 1984, 133:1710-1715.
14. Heazell A.E., Buttle H.R., Baker P.N., Crocker I.P. Altered expression of regulators of caspase activity within trophoblast of normal pregnancies and pregnancies complicated by preeclampsia. Reprod. Sci. 2008, 15:1034-1043.
15. Huppertz B., Kingdom J.C. Apoptosis in the trophoblast - role of apoptosis in placental morphogenesis. J. Soc. Gynecol. Investig. 2004, 11:353-362.
16. Hustin J., Foidart J.M., Lambotte R. Cellular proliferation in villi of normal and pathological pregnancies. Gynecol. Obstet. Invest. 1984, 17:1-9.
17. Ishihara N., Matsuo H., Murakoshi H., Laoag-Fernandez J.B., Samoto T., Maruo T. Increased apoptosis in the syncytiotrophoblast in human term placentas complicated by either preeclampsia or intrauterine growth retardation. Am. J. Obstet. Gynecol. 2002, 186:158-166.
18. Jeschke U., Schiessl B., Mylonas I., Kunze S., Kuhn C., Schulze S., Friese K., Mayr D. Expression of the proliferation marker Ki-67 and of p53 tumor protein in trophoblastic tissue of preeclamptic, HELLP, and intrauterine growth-restricted pregnancies. Int. J. Gynecol. Pathol. 2006, 25:354-360.
19. Jones C.J., Fox H. An ultrastructural and ultrahistochemical study of the human placenta in maternal pre-eclampsia. Placenta 1980, 1:61-76.
20. Katayose Y., Kim M., Rakkar A.N., Li Z., Cowan K.H., Seth P. Promoting apoptosis: a novel activity associated with the cyclin-dependent kinase inhibitor p27. Cancer Res. 1997, 57:5441-5445.
21. Korgun E.T., Celik-Ozenci C., Acar N., Cayli S., Desoye G., Demir R. Location of cell cycle regulators cyclin B1, cyclin A, PCNA, Ki67 and cell cycle inhibitors p21, p27 and p57 in human first trimester placenta and deciduas. Histochem. Cell Biol. 2006, 125:615-624.
22. Levy R., Smith S.D., Yusuf K., Huettner P.C., Kraus F.T., Sadovsky Y., Nelson D.M. Trophoblast apoptosis from pregnancies complicated by fetal growth restriction is associated with enhanced p53 expression. Am. J. Obstet. Gynecol. 2002, 186:1056-1061.
23. Lyall F., Myatt L. The role of the placenta in pre-eclampsia - a workshop report. Placenta 2002, 23(Suppl. A):S142-S145.
24. Maruo T., Ishihara N., Samoto T., Murakoshi H., Laoag-Fernandez J.B., Matsuo H. Regulation of human trophoblast proliferation and apoptosis during pregnancy. Early Pregnancy 2001, 5:28-29.
25. Matsuoka S., Edwards M.C., Bai C., Parker S., Zhang P., Baldini A., Harper J.W., Elledge S.J. p57KIP2, a structurally distinct member of the p21CIP1 Cdk inhibitor family, is a candidate tumor suppressor gene. Genes Dev. 1995, 9:650-662.
26. Nakayama K. Cip/Kip cyclin-dependent kinase inhibitors: brakes of the cell cycle engine during development. Bioessays 1998, 20:1020-1029.
27. Olvera M., Harris S., Amezcua C.A., McCourty A., Rezk S., Koo C., Felix J.C., Brynes R.K. Immunohistochemical expression of cell cycle proteins E2F-1, Cdk-2, Cyclin E, p27(kip1), and Ki-67 in normal placenta and gestational trophoblastic disease. Mod. Pathol. 2001, 14:1036-1042.
28. Ozbey O., Sahin Z., Ozenci A.M., Acar N., Ustunel I. The effect of systemic corticosteroid treatment on the immunolocalisation of Notch-1, Delta, CD105 and CD166 in rat articular cartilage. Acta Histochem. 2010, 112:424-431.
29. Papageorghiou A.T., Yu C.K., Bindra R., Pandis G., Nicolaides K.H. Multicenter screening for pre-eclampsia and fetal growth restriction by transvaginal uterine artery Doppler at 23 weeks of gestation. Ultrasound Obstet. Gynecol. 2001, 18:441-449.
30. Pollard D., Earnshaw C. Cell Biology 2002, Saunders, Philadelphia. 1st ed.
31. Redline R.W., Patterson P. Pre-eclampsia is associated with an excess of proliferative immature intermediate trophoblast. Hum. Pathol. 1995, 26:594-600.
32. Roberts J.M., Taylor R.N., Musci T.J., Rodgers G.M., Hubel C.A., McLaughlin M.K. Preeclampsia: an endothelial cell disorder. Am. J. Obstet. Gynecol. 1989, 161:1200-1204.
33. Salafia C., Shiverick K. Cigarette smoking and pregnancy II: vascular effects. Placenta 1999, 20:273-279.
34. Samuelsson M.K., Pazirandeh A., Okret S. A pro-apoptotic effect of the CDK inhibitor p57(Kip2) on staurosporine-induced apoptosis in HeLa cells. Biochem. Biophys. Res. Commun. 2002, 296:702-709.
35. Scholzen T., Gerdes J. The Ki-67 protein: from the known and the unknown. J. Cell. Physiol. 2000, 182:311-322.
36. Sherr C.J., Roberts J.M. CDK inhibitors: positive and negative regulators of G1-phase progression. Genes Dev. 1999, 13:1501-1512.
37. Smith S.C., Price E., Hewitt M.J., Symonds E.M., Baker P.N. Cellular proliferation in the placenta in normal human pregnancy and pregnancy complicated by intrauterine growth restriction. J. Soc. Gynecol. Investig. 1998, 5:317-323.
38. Soma H., Yoshida K., Mukaida T., Tabuchi Y. Morphologic changes in the hypertensive placenta. Contrib. Gynecol. Obstet. 1982, 9:58-75.
39. Start R.D., Cross S.S., Clelland C., Silcocks P.B., Rogers K., Smith J.H. Delay in fixation does not affect the immunoreactivity of proliferating cell nuclear antigen (PCNA). J. Pathol. 1992, 168:197-199.
40. Takahashi T., Caviness V.S. PCNA-binding to DNA at the G1/S transition in proliferating cells of the developing cerebral wall. J. Neurocytol. 1993, 22:1096-1102.
41. Teasdale F. Histomorphometry of the human placenta in maternal preeclampsia. Am. J. Obstet. Gynecol. 1985, 152:25-31.
42. Vlachos P., Nyman U., Hajji N., Joseph B. The cell cycle inhibitor p57(Kip2) promotes cell death via the mitochondrial apoptotic pathway. Cell Death Differ. 2007, 14:1497-1507.
43. Weinberg R.A. Tumor suppressor genes. Science 1991, 254:1138-1146.
44. Wu Q., Kirschmeier P., Hockenberry T., Yang T.Y., Brassard D.L., Wang L., McClanahan T., Black S., Rizzi G., Musco M.L., Mirza A., Liu S. Transcriptional regulation during p21WAF1/CIP1-induced apoptosis in human ovarian cancer cells. J. Biol. Chem. 2002, 277:36329-36337.
45. Yoshida Y., Ninomiya K., Hamada H., Noda M. Involvement of the SKP2-p27(KIP1) pathway in suppression of cancer cell proliferation by RECK. Oncogene 2012, 31:4128-4138.
46. Zieske J.D. Expression of cyclin-dependent kinase inhibitors during corneal wound repair. Prog. Retin. Eye Res. 2000, 19:257-270.