The effect of homocysteine-lowering therapy with folic acid on flow-mediated vasodilation in patients with coronary artery disease: Ameta-analysis of randomized controlled trials

Atherosclerosis

Volumn 235, Issue 1, 2014, Pages 31-35

  Liu, Yaxin ^a   Tian, Tao ^a   Zhang, Huijun ^b   Gao, Linggen ^b   Zhou, Xianliang ^a  

^a FUWAI HOSPITAL   (China)

^b CHINESE PLA GENERAL HOSPITAL   (China)

Author keywords

Flow mediated vasodilation; Folic acid; Homocysteine

Indexed keywords

CYANOCOBALAMIN; FOLIC ACID; HOMOCYSTEINE; PYRIDOXINE;

ARTERY DILATATION; BRACHIAL ARTERY; CORONARY ARTERY DISEASE; ENDOTHELIAL DYSFUNCTION; FLOW MEDIATED VASODILATION; HUMAN; META ANALYSIS; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; SUPPLEMENTATION; SYSTEMATIC REVIEW; AGED; ATHEROSCLEROSIS; BLOOD; CHEMISTRY; DIETARY SUPPLEMENT; FEMALE; MALE; MIDDLE AGED; PATHOLOGY; PATHOPHYSIOLOGY; VASCULAR ENDOTHELIUM; VASODILATATION;

AGED; ATHEROSCLEROSIS; BRACHIAL ARTERY; CORONARY ARTERY DISEASE; DIETARY SUPPLEMENTS; ENDOTHELIUM, VASCULAR; FEMALE; FOLIC ACID; HOMOCYSTEINE; HUMANS; MALE; MIDDLE AGED; RANDOMIZED CONTROLLED TRIALS AS TOPIC; VASODILATION;

EID: 84901841469     PISSN: 00219150     EISSN: 18791484     Source Type: Journal    
DOI: 10.1016/j.atherosclerosis.2014.03.032     Document Type: Review

References (31)

1. Ross R. The pathogenesis of atherosclerosis: a perspective for the 1990s. Nature 1993, 362:801-809.
2. Homocysteine Lowering Trialists' Collaboration Dose-dependent effects of folic acid on blood concentrations of homocysteine: a meta-analysis of the randomized trials. Am J Clin Nutr 2005, 82:806-812.
3. Title L.M., Cummings P.M., Giddens K., Genest J.J., Nassar B.A. Effect of folic acid and antioxidant vitamins on endothelial dysfunction in patients with coronary artery disease. JAm Coll Cardiol 2000, 36:758-765.
4. Doshi S.N., McDowell I.F., Moat S.J., Lang D., Newcombe R.G., Kredan M.B., et al. Folate improves endothelial function in coronary artery disease: an effect mediated by reduction of intracellular superoxide?. Arterioscler Thromb Vasc Biol 2001, 21(7):1196-1202.
5. Doshi S.N., McDowell I.F., Moat S.J., Payne N., Durrant H.J., Lewis M.J., et al. Folic acid improves endothelial function in coronary artery disease via mechanisms largely independent of homocysteine lowering. Circulation 2002, 105:22-26.
6. Lekakis J.P., Papamichael C.M., Papaioannou T.G., Dagre A.D., Stamatelopoulos K.S., Tryfonopoulos D., et al. Oral folic acid enhances endothelial function in patients with hypercholesterolaemia receiving statins. Eur J Cardiovasc Prev Rehabil 2004, 11:416-420.
7. Thambyrajah J., Landray M.J., Jones H.J., McGlynn F.J., Wheeler D.C., Townend J.N. Arandomized double-blind placebo controlled trial of the effect of homocysteine-lowering therapy with folic acid on endothelial function in patients with coronary artery disease. JAm Coll Cardiol 2001, 37:1858-1863.
8. Dinckal M.H., Aksoy N., Aksoy M., Davutoglu V., Soydinc S., Kirilmaz A., et al. Effect of homocysteine-lowering therapy on vascular endothelial function and exercise performance in coronary patients with hyperhomocysteinaemia. Acta Cardiol 2003, 58:389-396.
9. Chambers J.C., Ueland P.M., Obeid O.A., Wrigley J., Refsum H., Kooner J.S. Improved vascular endothelial function after oral B vitamins: an effect mediated through reduced concentrations of free plasma homocysteine. Circulation 2000, 102:2479-2483.
10. Moens A.L., Claeys M.J., Wuyts F.L., Goovaerts I., Van Hertbruggen E., Wendelen L.C., et al. Effect of folic acid on endothelial function following acute myocardial infarction. Am J Cardiol 2007, 99:476-481.
11. Tawakol A., Migrino R.Q., Aziz K.S., Waitkowska J., Holmvang G., Alpert N.M., et al. High-dose folic acid acutely improves coronary vasodilator function in patients with coronary artery disease. JAm Coll Cardiol 2005, 45:1580-1584.
12. Higgins J.P., White I.R., Wood A.M. Imputation methods for missing outcome data in meta-analysis of clinical trials. Clin Trials 2008, 5:225-239.
13. Verhagen A.P., de Vet H.C., de Bie R.A., Kessels A.G., Boers M., Bouter L.M., et al. The Delphi list: a criteria list for quality assessment of randomized clinical trials for conducting systematic reviews developed by Delphi consensus. JClin Epidemiol 1998, 51:1235-1241.
14. Egger M., Davey Smith G., Schneider M., Minder C. Bias in metaanalysis detected by a simple, graphical test. BMJ 1997, 315:629-634.
15. Mheid I.A., Quyyumi A.A. Allometric scaling of endothelium-dependent vasodilation: brachial artery flow-mediated dilation coming of age?. Vasc Med 2013, 18(6):368-371.
16. Ozkor M.A., Murrow J.R., Rahman A.M., Kavtaradze N., Lin J., Manatunga A., et al. Endothelium derived hyperpolarizing factor determines resting and stimulated forearm vasodilator tone in health and in disease. Circulation 2011, 123:2244-2253.
17. Quyyumi A.A., Ozkor M. Vasodilation by hyperpolarization: beyond NO. Hypertension 2006, 48:1023-1025.
18. Wald D.S., Bishop L., Wald N.J., Law M., Hennessy E., Weir D., et al. Randomized trial of folic acid supplementation and serum homocysteine levels. Arch Intern Med 2001, 161:695-700.
19. Bonaa K.H., Njolstad I., Ueland P.M., Schirmer H., Tverdal A., Steigen T., et al. Homocysteine lowering and cardiovascular events after acute myocardial infarction. NEngl J Med 2006, 354:1578-1588.
20. Rafeq Z., Roh J.D., Guarino P., Kaufman J., Joseph J. Adverse myocardial effects of B-vitamin therapy in subjects with chronic kidney disease and hyperhomocysteinaemia. Nutr Metab Cardiovasc Dis 2013, 23:836-842.
21. Lange H., Suryapranata H., de Luca G., Börner C., Dille J., Kallmayer K., et al. Folate therapy and in-stent restenosis after coronary stenting. NEngl J Med 2004, 350:2673-2681.
22. Loland K.H., Bleie O., Blix A.J., Strand E., Ueland P.M., Refsum H., et al. Effect of homocysteine-lowering B vitamin treatment on angiographic progression of coronary artery disease: a western Norway B vitamin intervention trial (WENBIT) substudy. Am J Cardiol 2010, 105:1577-1584.
23. Ebbing M., Bonaa K.H., Arnesen E., Ueland P.M., Nordrehaug J.E., Rasmussen K., et al. Combined analyses and extended follow-up of two randomized controlled homocysteine-lowering B-vitamin trials. JIntern Med 2010, 268:367-382.
24. Gori T., Burstein J.M., Ahmed S., Miner S.E., Al-Hesayen A., Kelly S., et al. Folic acid prevents nitroglycerin-induced nitric oxide synthase dysfunction and nitrate tolerance: a human invivo study. Circulation 2001, 104:1119-1123.
25. Verhaar M.C., Wever R.M., Kastelein J.J., van Loon D., Milstien S., Koomans H.A., et al. Effects of oral folic acid supplementation on endothelial function in familial hypercholesterolemia: a randomized placebo-controlled trial. Circulation 1999, 100:335-338.
26. Verhaar M.C., Wever R.M., Kastelein J.J., van Dam T., Koomans H.A., Rabelink T.J. 5-Methyltetrahydrofolate, the active form of folic acid, restores endothelial function in familial hypercholesterolemia. Circulation 1998, 97:237-241.
27. Bellamy M.F., McDowell I.F., Ramsey M.W., Brownlee M., Newcombe R.G., Lewis M.J. Oral folate enhances endothelial function in hyperhomocysteinaemic subjects. Eur J Clin Invest 1999, 29:659-662.
28. Woo K.S., Chook P., Lolin Y.I., Sanderson J.E., Metreweli C., Celermajer D.S. Folic acid improves arterial endothelial function in adults with hyperhomocystinemia. JAm Coll Cardiol 1999, 34:2002-2006.
29. Usui M., Matsuoka H., Miyazaki H., Ueda S., Okuda S., Imaizumi T. Endothelial dysfunction by acute hyperhomocyst(e)inaemia: restoration by folic acid. Clin Sci (Colch) 1999, 96:235-239.
30. Peña A.S., Maftei O., Dowling K., Gent R., Wiltshire E., MacKenzie K., et al. Folate fortification and supplementation do not provide vascular health benefits in type 1 diabetes. JPediatr 2013 Jul, 163(1):255-260.
31. Alian Z., Hashemipour M., Dehkordi E.H., Gent R., Wiltshire E., MacKenzie K., et al. The effects of folic acid on markers of endothelial function in patients with type 1 diabetes mellitus. Med Arh 2012, 66:12-15.