A randomized double-blind placebo-controlled trial of the effect of homocysteine-lowering therapy with folic acid on endothelial function in patients with coronary artery disease

Journal of the American College of Cardiology

Volumn 37, Issue 7, 2001, Pages 1858-1863

  Thambyrajah, Jeetendra ^a,c   Landray, Martin J ^a   Jones, Heather J ^a   McGlynn, Fiona J ^b   Wheeler, David C ^b   Townend, Jonathan N ^a  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^b QUEEN ELIZABETH HOSPITAL   (United Kingdom)

^c UNIVERSITY HOSPITALS BIRMINGHAM NHS FOUNDATION TRUST   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

FOLIC ACID; HOMOCYSTEINE; NITRATE; NITRITE; PLACEBO; VON WILLEBRAND FACTOR;

ADULT; AGED; AMINO ACID BLOOD LEVEL; ARTERY DILATATION; ARTERY ENDOTHELIUM; ARTICLE; ATHEROSCLEROSIS; BRACHIAL ARTERY; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORONARY ARTERY DISEASE; DOUBLE BLIND PROCEDURE; FEMALE; HUMAN; HYPERHOMOCYSTEINEMIA; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RISK FACTOR;

AGED; CORONARY DISEASE; DOUBLE-BLIND METHOD; ENDOTHELIUM, VASCULAR; FEMALE; FOLIC ACID; HOMOCYSTEINE; HUMANS; MALE; MIDDLE AGED; NITRATES; NITRITES; REGIONAL BLOOD FLOW; VON WILLEBRAND FACTOR;

EID: 0035369470     PISSN: 07351097     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0735-1097(01)01235-9     Document Type: Article

References (40)

1. Vascular pathology of homocysteinaemia: Implications for the pathogenesis of arteriosclerosis
2. Can lowering homocysteine levels reduce cardiovascular risk?
3. A prospective study of plasma homocyst(e)ine and risk of myocardial infarction in US physicians
4. Serum total homocysteine and coronary heart disease
5. Prospective study of coronary heart disease incidence in relation to fasting total homocysteine, related genetic polymorphisms, and B vitamins: The Atherosclerosis Risk in Communities (ARIC) study
6. Homocysteine and ischaemic heart disease in the Caerphilly cohort
7. Plasma homocysteine and coronary heart disease: Systematic review of published epidemiological studies
8. Lowering blood homocysteine with folic acid based supplements: Meta-analysis of randomized trials. Homocysteine Lowering Trialists' Collaboration
9. Homocysteine and atherothrombosis: Mechanisms for injury
10. The pathogenesis of atherosclerosis: A perspective for the 1990s
11. Does folic acid decrease plasma homocysteine and improve endothelial function in patients with pre-dialysis renal failure?
12. Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis
13. Nitrite and nitrate determinations in plasma: A critical evaluation
14. Letter: Factor-VIII complex and endothelial damage
15. Prediction of creatinine clearance from serum creatinine
16. Plasma total homocysteine measurement by ion-paired reversed-phase HPLC with electrochemical detection
17. Nitric oxide is responsible for flow-dependent dilation of human peripheral conduit arteries in vivo
18. Beneficial effects of cholesterol-lowering therapy on the coronary endothelium in patients with coronary artery disease
19. Angiotensin-converting enzyme inhibition with quinapril improves endothelial vasomotor dysfunction in patients with coronary artery disease. The TREND (Trial on Reversing Endothelial Dysfunction) Study
20. Non-invasive measurement of human endothelium dependent arterial responses: Accuracy and reproducibility
21. Close relation of endothelial function in the human coronary and peripheral circulations
22. Endothelium-dependent dilation in the systemic arteries of asymptomatic subjects relates to coronary risk factors and their interaction
23. Factor VIII, ABO blood group and the incidence of ischaemic heart disease
24. The vascular endothelium in chronic renal failure
25. Simvastatin, an HMG-coenzyme A reductase inhibitor, improves endothelial function within 1 month
26. Common methylenetetrahydrofolate reductase gene mutation leads to hyperhomocysteinemia but not to vascular disease: The result of a meta-analysis
27. An alternative view of homocysteine
28. Homocysteine-induced endothelial cell injury in vitro: A model for the study of vascular injury
29. Homocysteine-induced arteriosclerosis. The role of endothelial cell injury and platelet response in its genesis
30. Hyperhomocyst(e)inemia is a risk factor for endothelial dysfunction in humans
31. Hyperhomocysteinemia after an oral methionine load acutely impairs endothelial function in healthy adults
32. Effects of folate supplementation in hyperhomocysteinemic pigs
33. Improved vascular endothelial function after oral B vitamins an effect mediated through reduced concentrations of free plasma homocysteine
34. Effect of folic acid and antioxidants vitamins on endothelial dysfunction in patients with coronary artery disease
35. Endothelial dysfunction by acute hyperhomocyst(e)inaemia: Restoration by folic acid
36. Folic acid improves arterial endothelial function in adults with hyperhomocystinemia
37. Effect of homocysteine-lowering treatment with folic acid plus vitamin B6 on progression of subclinical atherosclerosis: A randomized placebo-controlled trial
38. Endpoints for homocysteine-lowering trials
39. No change in impaired endothelial function after long-term folic acid therapy of hyperhomocysteinaemia in haemodialysis patients
40. Folic acid treatment of hyperhomocysteinemia in peritoneal dialysis patients: No change in endothelial function after long-term therapy