메뉴 건너뛰기




Volumn 26, Issue 4, 2014, Pages 371-376

Relevance of the gut/joint axis for the management of spondyloarthritis in daily clinical practice

Author keywords

microscopic gut inflammation; risk stratification; spondyloarthritis; therapeutic implications

Indexed keywords

ABATACEPT; ADALIMUMAB; CERTOLIZUMAB PEGOL; ETANERCEPT; GOLIMUMAB; INFLIXIMAB; INTERLEUKIN 17; INTERLEUKIN 23; INTERLEUKIN 23 RECEPTOR; NONSTEROID ANTIINFLAMMATORY AGENT; PROBIOTIC AGENT; RITUXIMAB; SECUKINUMAB; TOCILIZUMAB; TUMOR NECROSIS FACTOR INHIBITOR; USTEKINUMAB;

EID: 84901834415     PISSN: 10408711     EISSN: 15316963     Source Type: Journal    
DOI: 10.1097/BOR.0000000000000070     Document Type: Review
Times cited : (17)

References (47)
  • 1
    • 67649831600 scopus 로고    scopus 로고
    • The Assessment of Spondylo-Arthritis International Society (ASAS) handbook: A guide to assess spondylo-arthritis
    • Sieper J, Rudwaleit M, Baraliakos X, et al. The Assessment of Spondylo-Arthritis International Society (ASAS) handbook: a guide to assess spondylo-arthritis. Ann Rheum Dis 2009; 68:1-44.
    • (2009) Ann Rheum Dis , vol.68 , pp. 1-44
    • Sieper, J.1    Rudwaleit, M.2    Baraliakos, X.3
  • 2
    • 0029951347 scopus 로고    scopus 로고
    • Long-term evolution of gut inflammation in patients with spondyloarthropathy
    • DOI 10.1053/gast.1996.v110.pm8964393
    • De Vos M, Mielants H, Cuvelier C, et al. Long-term evolution of gut inflammation in patients with spondyloarthropathy. Gastroenterology 1996; 110:1696-1703. (Pubitemid 26169205)
    • (1996) Gastroenterology , vol.110 , Issue.6 , pp. 1696-1703
    • De Vos, M.1    Mielants, H.2    Cuvelier, C.3    Elewaut, A.4    Veys, E.5
  • 4
    • 84879691837 scopus 로고    scopus 로고
    • Identification of multiple risk variants for ankylosing spondylitis through high-density genotyping of immune-related loci
    • Cortes A, Hadler J, Pointon JP, et al. Identification of multiple risk variants for ankylosing spondylitis through high-density genotyping of immune-related loci. Nature Genet 2013; 45:730-740.
    • (2013) Nature Genet , vol.45 , pp. 730-740
    • Cortes, A.1    Hadler, J.2    Pointon, J.P.3
  • 5
    • 84887323708 scopus 로고    scopus 로고
    • Expansion of intestinal Prevotella copri correlates with enhanced susceptibility to arthritis
    • Scher JU, Sczesnak A, Longman RS, et al. Expansion of intestinal Prevotella copri correlates with enhanced susceptibility to arthritis. eLife 2013; 2:e01202.
    • (2013) ELife , vol.2
    • Scher, J.U.1    Sczesnak, A.2    Longman, R.S.3
  • 8
    • 77950251400 scopus 로고    scopus 로고
    • A human gut microbial gene catalogue established by metagenomic sequencing
    • Qin J, Li R, Raes J, et al. A human gut microbial gene catalogue established by metagenomic sequencing. Nature 2010; 464:59-65.
    • (2010) Nature , vol.464 , pp. 59-65
    • Qin, J.1    Li, R.2    Raes, J.3
  • 9
    • 65549129496 scopus 로고    scopus 로고
    • Commensal bacteria, traditional and opportunistic pathogens, dysbiosis and bacterial killing in inflammatory bowel diseases
    • Packey CD, Sartor RB. Commensal bacteria, traditional and opportunistic pathogens, dysbiosis and bacterial killing in inflammatory bowel diseases. Curr Opin Infect Dis 2009; 22:292-301.
    • (2009) Curr Opin Infect Dis , vol.22 , pp. 292-301
    • Packey, C.D.1    Sartor, R.B.2
  • 11
    • 77957874781 scopus 로고    scopus 로고
    • Probiotic therapy for the treatment of spondyloarthritis: A randomized controlled trial
    • Jenks K, Stebbings S, Burton J, et al. Probiotic therapy for the treatment of spondyloarthritis: a randomized controlled trial. J Rheumatol 2010; 37:2118-2125.
    • (2010) J Rheumatol , vol.37 , pp. 2118-2125
    • Jenks, K.1    Stebbings, S.2    Burton, J.3
  • 12
    • 84893687483 scopus 로고    scopus 로고
    • Effect of probiotics on inducing remission and maintaining therapy in ulcerative colitis, Crohn's disease, and pouchitis: Meta-analysis of randomized controlled trials
    • Shen J, Zuo ZX, Mao AP. Effect of probiotics on inducing remission and maintaining therapy in ulcerative colitis, Crohn's disease, and pouchitis: meta-analysis of randomized controlled trials. Inflamm Bowel Dis 2014; 20:21-35.
    • (2014) Inflamm Bowel Dis , vol.20 , pp. 21-35
    • Shen, J.1    Zuo, Z.X.2    Mao, A.P.3
  • 13
    • 84895469428 scopus 로고    scopus 로고
    • Probiotic supple-mentation improves inflammatory status in patients with rheumatoid arthritis
    • Vaghef-Mehrabany E, Alipour B, Homayouni-Rad A, et al. Probiotic supple-mentation improves inflammatory status in patients with rheumatoid arthritis. Nutrition 2014; 30:430-435.
    • (2014) Nutrition , vol.30 , pp. 430-435
    • Vaghef-Mehrabany, E.1    Alipour, B.2    Homayouni-Rad, A.3
  • 14
    • 84873725322 scopus 로고    scopus 로고
    • Microscopic gut inflammation in axial spondyloarthritis: A multiparametric predictive model
    • Van Praet L, Van den Bosch FE, Jacques P, et al. Microscopic gut inflammation in axial spondyloarthritis: a multiparametric predictive model. Ann Rheum Dis 2013; 72:414-417.
    • (2013) Ann Rheum Dis , vol.72 , pp. 414-417
    • Van Praet, L.1    Van Den Bosch, F.E.2    Jacques, P.3
  • 15
    • 84899981410 scopus 로고    scopus 로고
    • Degree of bone marrow oedema in sacroiliac joints of patients with axial spondyloarthritis is linked to gut inflammation and male sex: Results from the GIANT cohort
    • 10.1136/annrheumdis-2013-203854. [Epub ahead of print]
    • Van Praet L, Jans L, Carron P, et al. Degree of bone marrow oedema in sacroiliac joints of patients with axial spondyloarthritis is linked to gut inflammation and male sex: results from the GIANT cohort. Ann Rheum Dis 2013; 10.1136/annrheumdis-2013-203854. [Epub ahead of print]
    • (2013) Ann Rheum Dis
    • Van Praet, L.1    Jans, L.2    Carron, P.3
  • 16
    • 54949113223 scopus 로고    scopus 로고
    • Radiographic findings following two years of infliximab therapy in patients with ankylosing spondy-litis
    • Van der Heijde D, Landewe R, Baraliakos X, et al. Radiographic findings following two years of infliximab therapy in patients with ankylosing spondy-litis. Arthritis Rheum 2008; 58:3063-3070.
    • (2008) Arthritis Rheum , vol.58 , pp. 3063-3070
    • Van Der Heijde, D.1    Landewe, R.2    Baraliakos, X.3
  • 18
    • 73349110978 scopus 로고    scopus 로고
    • Assessment of radio-graphic progression in the spines of patients with ankylosing spondylitis treated with adalimumab for up to 2 years
    • Van der Heijde D, Salonen D, Weissman BN, et al. Assessment of radio-graphic progression in the spines of patients with ankylosing spondylitis treated with adalimumab for up to 2 years. Arthritis Res Ther 2009; 11:R127. (This article is online at: http://arthritis-research.com/content/11/4/R127).
    • (2009) Arthritis Res Ther , vol.11
    • Van Der Heijde, D.1    Salonen, D.2    Weissman, B.N.3
  • 19
    • 85027939037 scopus 로고    scopus 로고
    • Suppression of inflammation and effects on new bone formation in ankylosing spondylitis: Evidence for a window of opportunity in disease modification
    • Maksymowych WP, Morency N, Conner-Spady B, Lambert RG. Suppression of inflammation and effects on new bone formation in ankylosing spondylitis: evidence for a window of opportunity in disease modification. Ann Rheum Dis 2013; 72:23-28.
    • (2013) Ann Rheum Dis , vol.72 , pp. 23-28
    • Maksymowych, W.P.1    Morency, N.2    Conner-Spady, B.3    Lambert, R.G.4
  • 20
    • 84895490291 scopus 로고    scopus 로고
    • Continuous long-term anti-TNF therapy does not lead to an increase in the rate of new bone formation over 8 years in patients with ankylosing spondylitis
    • Baraliakos X, Haibel H, Listing J, et al. Continuous long-term anti-TNF therapy does not lead to an increase in the rate of new bone formation over 8 years in patients with ankylosing spondylitis. Ann Rheum Dis 2014; 73:710-715.
    • (2014) Ann Rheum Dis , vol.73 , pp. 710-715
    • Baraliakos, X.1    Haibel, H.2    Listing, J.3
  • 21
    • 84885126123 scopus 로고    scopus 로고
    • The impact of tumor necrosis factor alpha inhibitors on radiographic progression in ankylosing spondylitis
    • Haroon N, Inman RD, Learch TJ, et al. The impact of tumor necrosis factor alpha inhibitors on radiographic progression in ankylosing spondylitis. Arthritis Rheum 2013; 65:2645-2654.
    • (2013) Arthritis Rheum , vol.65 , pp. 2645-2654
    • Haroon, N.1    Inman, R.D.2    Learch, T.J.3
  • 23
    • 75449114677 scopus 로고    scopus 로고
    • Mucosal healing predicts sustained clinical remission in patients with early-stage Crohn's disease
    • Baert F, Moortgat L, Van Assche G, et al. Mucosal healing predicts sustained clinical remission in patients with early-stage Crohn's disease. Gastroenter-ology 2010; 138:463-468.
    • (2010) Gastroenter-ology , vol.138 , pp. 463-468
    • Baert, F.1    Moortgat, L.2    Van Assche, G.3
  • 24
    • 84879890395 scopus 로고    scopus 로고
    • Treatment of spondyloarthropathy: The potential for agents other than TNF inhibitors
    • Her M, Kavanaugh A. Treatment of spondyloarthropathy: the potential for agents other than TNF inhibitors. Curr Opin Rheumatol 2013; 25:455-459.
    • (2013) Curr Opin Rheumatol , vol.25 , pp. 455-459
    • Her, M.1    Kavanaugh, A.2
  • 25
    • 85027933537 scopus 로고    scopus 로고
    • Continuous NSAID use reverts the effects of inflammation on radiographic progression in patients with ankylosing spondylitis
    • Kroon F, Landewe R, Dougados M, van der Heijde D. Continuous NSAID use reverts the effects of inflammation on radiographic progression in patients with ankylosing spondylitis. Ann Rheum Dis 2012; 71:1623-1629.
    • (2012) Ann Rheum Dis , vol.71 , pp. 1623-1629
    • Kroon, F.1    Landewe, R.2    Dougados, M.3    Van Der Heijde, D.4
  • 26
    • 70349651858 scopus 로고    scopus 로고
    • Present status and strategy of NSAIDs-induced small bowel injury
    • Higuchi K, Umegaki E, Watanabe T, et al. Present status and strategy of NSAIDs-induced small bowel injury. J Gastroenterol 2009; 44:879-888.
    • (2009) J Gastroenterol , vol.44 , pp. 879-888
    • Higuchi, K.1    Umegaki, E.2    Watanabe, T.3
  • 27
    • 76849096442 scopus 로고    scopus 로고
    • Do nonsteroidal anti-inflammatory drugs cause exacerbations of inflammatory bowel disease?
    • Feagins LA, Cryer BL. Do nonsteroidal anti-inflammatory drugs cause exacerbations of inflammatory bowel disease? Digest Dis Sci 2010; 55:226-232.
    • (2010) Digest Dis Sci , vol.55 , pp. 226-232
    • Feagins, L.A.1    Cryer, B.L.2
  • 28
    • 33644900228 scopus 로고    scopus 로고
    • The gastrointestinal safety and effect on disease activity of etoricoxib, a selective Cox-2 inhibitor in inflammatory bowel diseases
    • DOI 10.1111/j.1572-0241.2006.00384.x
    • El Miedany Y, Youssef S, Ahmed I, El Gaafary M. The gastrointestinal safety and effect on disease activity of etoricoxib, a selective Cox-2 inhibitor in inflammatory bowel diseases. Am J Gastroenterol 2006; 101:311-317. (Pubitemid 43381673)
    • (2006) American Journal of Gastroenterology , vol.101 , Issue.2 , pp. 311-317
    • El Miedany, Y.1    Youssef, S.2    Ahmed, I.3    El Gaafary, M.4
  • 29
    • 75149161836 scopus 로고    scopus 로고
    • The second European evidence-based consensus on the diagnosis and management of Crohn's disease: Current management
    • Dignass A, Van Assche G, Lindsay JO, et al. The second European evidence-based consensus on the diagnosis and management of Crohn's disease: current management. J Crohns Colitis 2010; 4:28-62.
    • (2010) J Crohns Colitis , vol.4 , pp. 28-62
    • Dignass, A.1    Van Assche, G.2    Lindsay, J.O.3
  • 30
    • 84887910621 scopus 로고    scopus 로고
    • Certolizumab pegol in axial spondyloarthritis
    • Song IH, Rudwaleit M. Certolizumab pegol in axial spondyloarthritis. Exp Rev Clin Immunol 2013; 9:1161-1172.
    • (2013) Exp Rev Clin Immunol , vol.9 , pp. 1161-1172
    • Song, I.H.1    Rudwaleit, M.2
  • 31
    • 84891898217 scopus 로고    scopus 로고
    • Interleukin-17A: A unique pathway in immune-mediated diseases: Psoriasis, psoriatic arthritis and rheumatoid arthritis
    • Kirkham BW, Kavanaugh A, Reich K. Interleukin-17A: a unique pathway in immune-mediated diseases: psoriasis, psoriatic arthritis and rheumatoid arthritis. Immunology 2014; 141:133-142.
    • (2014) Immunology , vol.141 , pp. 133-142
    • Kirkham, B.W.1    Kavanaugh, A.2    Reich, K.3
  • 32
    • 65249152431 scopus 로고    scopus 로고
    • Overexpression of interleukin-23, but not interleukin-17, as an immunologic signature of subdinical intestinal inflammation in ankylosing spondylitis
    • Ciccia F, Bombardieri M, Principato A, et al. Overexpression of interleukin-23, but not interleukin-17, as an immunologic signature of subdinical intestinal inflammation in ankylosing spondylitis. Arthritis Rheum 2009; 60:955-965.
    • (2009) Arthritis Rheum , vol.60 , pp. 955-965
    • Ciccia, F.1    Bombardieri, M.2    Principato, A.3
  • 33
    • 34948840330 scopus 로고    scopus 로고
    • The IL23 axis plays a key role in the pathogenesis of IBD
    • DOI 10.1136/gut.2006.115402
    • McGovern D, Powrie F. The IL23 axis plays a key role in the pathogenesis of IBD. Gut 2007; 56:1333-1336. (Pubitemid 47517817)
    • (2007) Gut , vol.56 , Issue.10 , pp. 1333-1336
    • McGovern, D.1    Powrie, F.2
  • 34
    • 79959207913 scopus 로고    scopus 로고
    • Analysis of IL-17[+) cells in facet joints of patients with spondyloarthritis suggests that the innate immune pathway might be of greater relevance than the Th17-mediated adaptive immune response
    • Appel H, Maier R, Wu P, et al. Analysis of IL-17[+) cells in facet joints of patients with spondyloarthritis suggests that the innate immune pathway might be of greater relevance than the Th17-mediated adaptive immune response. Arthritis Res Ther 2011; 13:R95.
    • (2011) Arthritis Res Ther , vol.13
    • Appel, H.1    Maier, R.2    Wu, P.3
  • 35
    • 84855291352 scopus 로고    scopus 로고
    • Interleukin-17-positive mast cells contribute to synovial inflammation in spondylarthritis
    • Noordenbos T, Yeremenko N, Gofita I, et al. Interleukin-17-positive mast cells contribute to synovial inflammation in spondylarthritis. Arthritis Rheum 2012; 64:99-109.
    • (2012) Arthritis Rheum , vol.64 , pp. 99-109
    • Noordenbos, T.1    Yeremenko, N.2    Gofita, I.3
  • 36
    • 84878527072 scopus 로고    scopus 로고
    • In situ analysis of interleukin-23-and interleukin-12-positive cells in the spine of patients with ankylosing spondylitis
    • Appel H, Maier R, Bleil J, et al. In situ analysis of interleukin-23-and interleukin-12-positive cells in the spine of patients with ankylosing spondylitis. Arthritis Rheum 2013; 65:1522-1529.
    • (2013) Arthritis Rheum , vol.65 , pp. 1522-1529
    • Appel, H.1    Maier, R.2    Bleil, J.3
  • 38
    • 33747089041 scopus 로고    scopus 로고
    • Differential activity of IL-12 and IL-23 in mucosal and systemic innate immune pathology
    • Uhlig HH, McKenzie BS, Hue S, et al. Differential activity of IL-12 and IL-23 in mucosal and systemic innate immune pathology. Immunity 2006; 25:309-318.
    • (2006) Immunity , vol.25 , pp. 309-318
    • Uhlig, H.H.1    McKenzie, B.S.2    Hue, S.3
  • 40
    • 84903907928 scopus 로고    scopus 로고
    • Evidence that autophagy, but not the unfolded protein response, regulates the expression of IL-23 in the gut of patients with ankylosing spondylitis and subclinical gut inflammation
    • 10.1136/annrheumdis-2012-202925. [Epub ahead of print]
    • Ciccia F, Accardo-Palumbo A, Rizzo A, et al. Evidence that autophagy, but not the unfolded protein response, regulates the expression of IL-23 in the gut of patients with ankylosing spondylitis and subclinical gut inflammation. Ann Rheum Dis 2013; 10.1136/annrheumdis-2012-202925. [Epub ahead of print]
    • (2013) Ann Rheum Dis
    • Ciccia, F.1    Accardo-Palumbo, A.2    Rizzo, A.3
  • 41
    • 84873168729 scopus 로고    scopus 로고
    • Secukinumab induction and maintenance therapy in moderate-to-severe plaque psoriasis: A randomized, double-blind, placebo-controlled, phase II regimen-finding study
    • Rich P, Sigurgeirsson B, Thaci D, et al. Secukinumab induction and maintenance therapy in moderate-to-severe plaque psoriasis: a randomized, double-blind, placebo-controlled, phase II regimen-finding study. Br J Derma-tol 2013; 168:402-411.
    • (2013) Br J Derma-tol , vol.168 , pp. 402-411
    • Rich, P.1    Sigurgeirsson, B.2    Thaci, D.3
  • 42
    • 84891740105 scopus 로고    scopus 로고
    • Efficacy and safety of secukinumab, a fully human antiinterleukin-17A monoclonal antibody, in patients with moderate-to-severe psoriatic arthritis: A 24-week, randomised, double-blind, placebo-controlled, phase II proof-of-concept trial
    • McInnes IB, Sieper J, Braun J, et al. Efficacy and safety of secukinumab, a fully human antiinterleukin-17A monoclonal antibody, in patients with moderate-to-severe psoriatic arthritis: a 24-week, randomised, double-blind, placebo-controlled, phase II proof-of-concept trial. Ann Rheum Dis 2014; 73:349-356.
    • (2014) Ann Rheum Dis , vol.73 , pp. 349-356
    • McInnes, I.B.1    Sieper, J.2    Braun, J.3
  • 43
    • 84887992906 scopus 로고    scopus 로고
    • Antiinterleukin-17A monoclonal anti-body secukinumab in treatment of ankylosing spondylitis: A randomised, double-blind, placebo-controlled trial
    • Baeten D, Baraliakos X, Braun J, et al. Antiinterleukin-17A monoclonal anti-body secukinumab in treatment of ankylosing spondylitis: a randomised, double-blind, placebo-controlled trial. Lancet 2013; 382:1705-1713.
    • (2013) Lancet , vol.382 , pp. 1705-1713
    • Baeten, D.1    Baraliakos, X.2    Braun, J.3
  • 44
    • 84868680312 scopus 로고    scopus 로고
    • Secukinumab, a human anti-IL-17A monoclonal antibody, for moderate to severe Crohn's disease: Unexpected results of a randomised, double-blind placebo-controlled trial
    • Hueber W, Sands BE, Lewitzky S, et al. Secukinumab, a human anti-IL-17A monoclonal antibody, for moderate to severe Crohn's disease: unexpected results of a randomised, double-blind placebo-controlled trial. Gut 2012; 61:1693-1700.
    • (2012) Gut , vol.61 , pp. 1693-1700
    • Hueber, W.1    Sands, B.E.2    Lewitzky, S.3
  • 45
    • 84899991797 scopus 로고    scopus 로고
    • Efficacy and safety of the anti-IL-12/23 p40 monoclonal antibody, ustekinumab, in patients with active psoriatic arthritis despite conventional nonbiological and biological antitumour necrosis factor therapy: 6-month and 1-year results of the phase 3, multicentre, double-blind, placebo-controlled, randomised PSUMMIT 2 trial
    • 10.1136/annrheumdis-2013-204655. [Epub ahead of print]
    • Ritchlin C, Rahman P, Kavanaugh A, et al. Efficacy and safety of the anti-IL-12/23 p40 monoclonal antibody, ustekinumab, in patients with active psoriatic arthritis despite conventional nonbiological and biological antitumour necrosis factor therapy: 6-month and 1-year results of the phase 3, multicentre, double-blind, placebo-controlled, randomised PSUMMIT 2 trial. Ann Rheum Dis 2014; 10.1136/annrheumdis-2013-204655. [Epub ahead of print]
    • (2014) Ann Rheum Dis
    • Ritchlin, C.1    Rahman, P.2    Kavanaugh, A.3
  • 46
    • 84871701834 scopus 로고    scopus 로고
    • Ustekinumab induction and main tenance therapy in refractory Crohn's disease
    • Sandborn WJ, Gasink C, Gao LL, et al. Ustekinumab induction and main tenance therapy in refractory Crohn's disease. N Engl J Med 2012; 367:1519-1528.
    • (2012) N Engl J Med , vol.367 , pp. 1519-1528
    • Sandborn, W.J.1    Gasink, C.2    Gao, L.L.3
  • 47
    • 84896810693 scopus 로고    scopus 로고
    • Ustekinumab for the treatment of patients with active ankylosing spondylitis: Results of a 28-week, prospective, open-label, proof-of-concept study (TOPAS)
    • Poddubnyy D, Callhoff J, Listing J, Sieper J. Ustekinumab for the treatment of patients with active ankylosing spondylitis: results of a 28-week, prospective, open-label, proof-of-concept study (TOPAS). Arthritis Rheum 2013; 65:S766-S770.
    • (2013) Arthritis Rheum , vol.65
    • Poddubnyy, D.1    Callhoff, J.2    Listing, J.3    Sieper, J.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.