Plasma homocysteine, dietary B vitamins, betaine, and choline andrisk of peripheral artery disease

Atherosclerosis

Volumn 235, Issue 1, 2014, Pages 94-101

  Bertoia, Monica L ^a,b   Pai, Jennifer K ^b,c   Cooke, John P ^d   Joosten, Michel M ^a,b,e,f   Mittleman, Murray A ^a,b   Rimm, Eric B ^b,c   Mukamal, Kenneth J ^a,b  

^a BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^b HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d HOUSTON METHODIST RESEARCH INSTITUTE   (United States)

^e TOP INSTITUTE FOOD AND NUTRITION   (Netherlands)

^f UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

Author keywords

Betaine; Choline; Folate; Homocysteine; Peripheral artery disease; Riboflavin; Vitamin B12; Vitamin B6

Indexed keywords

BETAINE; CHOLINE; CYANOCOBALAMIN; CYSTATIN C; FOLIC ACID; HEMOGLOBIN A1C; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HOMOCYSTEINE; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PYRIDOXINE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; RIBOFLAVIN; VITAMIN B GROUP; VITAMIN B COMPLEX;

ADULT; ALCOHOL CONSUMPTION; AMINO ACID BLOOD LEVEL; ARTICLE; BLOOD SAMPLING; BODY MASS; CARDIOVASCULAR RISK; CEREBROVASCULAR ACCIDENT; COHORT ANALYSIS; CONTROLLED STUDY; DIABETES MELLITUS; DIETARY INTAKE; DISEASE ASSOCIATION; DISEASE COURSE; FEMALE; FOLLOW UP; FOOD FREQUENCY QUESTIONNAIRE; HUMAN; HUMAN TISSUE; HYPERCHOLESTEROLEMIA; HYPERTENSION; MAJOR CLINICAL STUDY; MALE; PERIPHERAL OCCLUSIVE ARTERY DISEASE; PHYSICAL ACTIVITY; POSTMENOPAUSE; PRIORITY JOURNAL; SEX DIFFERENCE; SMOKING; VITAMIN SUPPLEMENTATION; AGED; BLOOD; CASE CONTROL STUDY; CHEMISTRY; DIET; DIETARY SUPPLEMENT; MIDDLE AGED; PERIPHERAL ARTERIAL DISEASE; PROPORTIONAL HAZARDS MODEL; QUESTIONNAIRE; RISK FACTOR;

ADULT; AGED; BETAINE; CASE-CONTROL STUDIES; CHOLINE; COHORT STUDIES; DIET; DIETARY SUPPLEMENTS; FEMALE; FOLIC ACID; FOLLOW-UP STUDIES; HOMOCYSTEINE; HUMANS; MALE; MIDDLE AGED; PERIPHERAL ARTERIAL DISEASE; PROPORTIONAL HAZARDS MODELS; RIBOFLAVIN; RISK FACTORS; SURVEYS AND QUESTIONNAIRES; VITAMIN B COMPLEX;

EID: 84901820782     PISSN: 00219150     EISSN: 18791484     Source Type: Journal    
DOI: 10.1016/j.atherosclerosis.2014.04.010     Document Type: Article

References (58)

1. Splaver A., Lamas G.A., Hennekens C.H. Homocysteine and cardiovascular disease: biological mechanisms, observational epidemiology, and the need for randomized trials. Am Heart J Jul 2004, 148(1):34-40.
2. Criqui M.H. Peripheral arterial disease-epidemiological aspects. Vasc Med 2001, 6(3 Suppl.):3-7.
3. Strain J.J., Dowey L., Ward M., Pentieva K., McNulty H. B-vitamins, homocysteine metabolism and CVD. Proc Nutr Soc Nov 2004, 63(4):597-603.
4. Boushey C.J., Beresford S.A., Omenn G.S., Motulsky A.G. Aquantitative assessment of plasma homocysteine as a risk factor for vascular disease. Probable benefits of increasing folic acid intakes. JAm Med Assoc Oct 4 1995, 274(13):1049-1057.
5. Clarke R., Halsey J., Lewington S., Lonn E., Armitage J., Manson J.E., et al. Effects of lowering homocysteine levels with B vitamins on cardiovascular disease, cancer, and cause-specific mortality: meta-analysis of 8 randomized trials involving 37 485 individuals. Arch Intern Med Oct 11 2010, 170(18):1622-1631.
6. Wang X., Qin X., Demirtas H., Li J., Mao G., Huo Y., et al. Efficacy of folic acid supplementation in stroke prevention: a meta-analysis. Lancet Jun 2 2007, 369(9576):1876-1882.
7. Bleys J., Miller E.R., Pastor-Barriuso R., Appel L.J., Guallar E. Vitamin-mineral supplementation and the progression of atherosclerosis: a meta-analysis of randomized controlled trials. Am J Clin Nutr Oct 2006, 84(4):880-887. quiz 954-885.
8. Allison M.A., Cushman M., Solomon C., Aboyans V., McDermott M.M., Goff D.C., et al. Ethnicity and risk factors for change in the ankle-brachial index: the Multi-Ethnic Study of Atherosclerosis. JVasc Surg Nov 2009, 50(5):1049-1056.
9. Ridker P.M., Stampfer M.J., Rifai N. Novel risk factors for systemic atherosclerosis: a comparison of C-reactive protein, fibrinogen, homocysteine, lipoprotein(a), and standard cholesterol screening as predictors of peripheral arterial disease. JAm Med Assoc May 16 2001, 285(19):2481-2485.
10. Pradhan A.D., Shrivastava S., Cook N.R., Rifai N., Creager M.A., Ridker P.M. Symptomatic peripheral arterial disease in women: nontraditional biomarkers of elevated risk. Circulation Feb 12 2008, 117(6):823-831.
11. Durga J., Bots M.L., Schouten E.G., Grobbee D.E., Kok F.J., Verhoef P. Effect of 3 y of folic acid supplementation on the progression of carotid intima-media thickness and carotid arterial stiffness in older adults. Am J Clin Nutr May 2011, 93(5):941-949.
12. Vermeulen E.G., Stehouwer C.D., Twisk J.W., van den Berg M., de Jong S.C., Mackaay A.J., et al. Effect of homocysteine-lowering treatment with folic acid plus vitamin B6 on progression of subclinical atherosclerosis: a randomised, placebo-controlled trial. Lancet Feb 12 2000, 355(9203):517-522.
13. Khandanpour N., Armon M.P., Jennings B., Finglas P.M., Willis G., Clark A., et al. Randomized clinical trial of folate supplementation in patients with peripheral arterial disease. Br J Surg Sep 2009, 96(9):990-998.
14. Willett W.C., Stampfer M.J., Colditz G.A., Rosner B.A., Hennekens C.H., Speizer F.E. Dietary fat and the risk of breast cancer. NEngl J Med Jan 1 1987, 316(1):22-28.
15. Rimm E.B., Giovannucci E.L., Willett W.C., Colditz G.A., Ascherio A., Rosner B., et al. Prospective study of alcohol consumption and risk of coronary disease in men. Lancet Aug 24 1991, 338(8765):464-468.
16. Pischon T., Girman C.J., Hotamisligil G.S., Rifai N., Hu F.B., Rimm E.B. Plasma adiponectin levels and risk of myocardial infarction in men. JAm Med Assoc Apr 14 2004, 291(14):1730-1737.
17. Wei E.K., Ma J., Pollak M.N., Rifai N., Fuchs C.S., Hankinson S.E., et al. Aprospective study of C-peptide, insulin-like growth factor-I, insulin-like growth factor binding protein-1, and the risk of colorectal cancer in women. Cancer Epidemiol Biomarkers Prev Apr 2005, 14(4):850-855.
18. Rimm E.B., Giovannucci E.L., Stampfer M.J., Colditz G.A., Litin L.B., Willett W.C. Reproducibility and validity of an expanded self-administered semiquantitative food frequency questionnaire among male health professionals. Am J Epidemiol May 15 1992, 135(10):1114-1126. discussion 1127-1136.
19. Selhub J., Jacques P.F., Wilson P.W., Rush D., Rosenberg I.H. Vitamin status and intake as primary determinants of homocysteinemia in an elderly population. JAm Med Assoc Dec 8 1993, 270(22):2693-2698.
20. Tucker K.L., Mahnken B., Wilson P.W., Jacques P., Selhub J. Folic acid fortification of the food supply. Potential benefits and risks for the elderly population. JAm Med Assoc Dec 18 1996, 276(23):1879-1885.
21. Chiuve S.E., Giovannucci E.L., Hankinson S.E., Hunter D.J., Stampfer M.J., Willett W.C., et al. Alcohol intake and methylenetetrahydrofolate reductase polymorphism modify the relation of folate intake to plasma homocysteine. Am J Clin Nutr Jul 2005, 82(1):155-162.
22. Chasan-Taber S., Rimm E.B., Stampfer M.J., Spiegelman D., Colditz G.A., Giovannucci E., et al. Reproducibility and validity of a self-administered physical activity questionnaire for male health professionals. Epidemiology Jan 1996, 7(1):81-86.
23. Rimm E.B., Stampfer M.J., Colditz G.A., Chute C.G., Litin L.B., Willett W.C. Validity of self-reported waist and hip circumferences in men and women. Epidemiology Nov 1990, 1(6):466-473.
24. Wolf A.M., Hunter D.J., Colditz G.A., Manson J.E., Stampfer M.J., Corsano K.A., et al. Reproducibility and validity of a self-administered physical activity questionnaire. Int J Epidemiol Oct 1994, 23(5):991-999.
25. Rothman K.J., Greenland S., Lash T.L. Modern epidemiology 2008, Lippincott Williams & Wilkins, Philadelphia, PA. 3rd ed.
26. Willett W.C. Nutritional epidemiology 1998, Oxford University Press, Inc, New York, NY. 2nd ed.
27. Khandanpour N., Loke Y.K., Meyer F.J., Jennings B., Armon M.P. Homocysteine and peripheral arterial disease: systematic review and meta-analysis. Eur J Vasc Endovasc Surg Sep 2009, 38(3):316-322.
28. Merchant A.T., Hu F.B., Spiegelman D., Willett W.C., Rimm E.B., Ascherio A. The use of B vitamin supplements and peripheral arterial disease risk in men are inversely related. JNutr Sep 2003, 133(9):2863-2867.
29. Aboyans V., Criqui M.H., Denenberg J.O., Knoke J.D., Ridker P.M., Fronek A. Risk factors for progression of peripheral arterial disease in large and small vessels. Circulation Jun 6 2006, 113(22):2623-2629.
30. Taylor L.M., Moneta G.L., Sexton G.J., Schuff R.A., Porter J.M. Prospective blinded study of the relationship between plasma homocysteine and progression of symptomatic peripheral arterial disease. JVasc Surg Jan 1999, 29(1):8-19. discussion 19-21.
31. Dierkes J., Jeckel A., Ambrosch A., Westphal S., Luley C., Boeing H. Factors explaining the difference of total homocysteine between men and women in the European Investigation into Cancer and Nutrition Potsdam Study. Metabolism Jun 2001, 50(6):640-645.
32. Fukagawa N.K., Martin J.M., Wurthmann A., Prue A.H., Ebenstein D., O'Rourke B. Sex-related differences in methionine metabolism and plasma homocysteine concentrations. Am J Clin Nutr Jul 2000, 72(1):22-29.
33. Mijatovic V., Kenemans P., Jakobs C., van Baal W.M., Peters-Muller E.R., van der Mooren M.J. Arandomized controlled study of the effects of 17beta-estradiol-dydrogesterone on plasma homocysteine in postmenopausal women. Obstet Gynecol Mar 1998, 91(3):432-436.
34. Sader M.A., Celermajer D.S. Endothelial function, vascular reactivity and gender differences in the cardiovascular system. Cardiovasc Res Feb 15 2002, 53(3):597-604.
35. Mendelsohn M.E., Karas R.H. The protective effects of estrogen on the cardiovascular system. NEngl J Med Jun 10 1999, 340(23):1801-1811.
36. Gerhard M., Walsh B.W., Tawakol A., Haley E.A., Creager S.J., Seely E.W., et al. Estradiol therapy combined with progesterone and endothelium-dependent vasodilation in postmenopausal women. Circulation Sep 22 1998, 98(12):1158-1163.
37. Guallar E., Silbergeld E.K., Navas-Acien A., Malhotra S., Astor B.C., Sharrett A.R., et al. Confounding of the relation between homocysteine and peripheral arterial disease by lead, cadmium, and renal function. Am J Epidemiol Apr 15 2006, 163(8):700-708.
38. Vasan R.S., Beiser A., D'Agostino R.B., Levy D., Selhub J., Jacques P.F., et al. Plasma homocysteine and risk for congestive heart failure in adults without prior myocardial infarction. JAm Med Assoc Mar 12 2003, 289(10):1251-1257.
39. Nygard O., Nordrehaug J.E., Refsum H., Ueland P.M., Farstad M., Vollset S.E. Plasma homocysteine levels and mortality in patients with coronary artery disease. NEngl J Med Jul 24 1997, 337(4):230-236.
40. Bots M.L., Launer L.J., Lindemans J., Hoes A.W., Hofman A., Witteman J.C., et al. Homocysteine and short-term risk of myocardial infarction and stroke in the elderly: the Rotterdam Study. Arch Intern Med Jan 11 1999, 159(1):38-44.
41. Alfthan G., Pekkanen J., Jauhiainen M., Pitkaniemi J., Karvonen M., Tuomilehto J., et al. Relation of serum homocysteine and lipoprotein(a) concentrations to atherosclerotic disease in a prospective Finnish population based study. Atherosclerosis Mar 1994, 106(1):9-19.
42. Morrison H.I., Schaubel D., Desmeules M., Wigle D.T. Serum folate and risk of fatal coronary heart disease. JAm Med Assoc Jun 26 1996, 275(24):1893-1896.
43. Giles W.H., Kittner S.J., Anda R.F., Croft J.B., Casper M.L. Serum folate and risk for ischemic stroke. First National Health and Nutrition Examination Survey epidemiologic follow-up study. Stroke Jul 1995, 26(7):1166-1170.
44. Vollset S.E., Refsum H., Tverdal A., Nygard O., Nordrehaug J.E., Tell G.S., et al. Plasma total homocysteine and cardiovascular and noncardiovascular mortality: the Hordaland Homocysteine Study. Am J Clin Nutr Jul 2001, 74(1):130-136.
45. Folsom A.R., Nieto F.J., McGovern P.G., Tsai M.Y., Malinow M.R., Eckfeldt J.H., et al. Prospective study of coronary heart disease incidence in relation to fasting total homocysteine, related genetic polymorphisms, and B vitamins: the Atherosclerosis Risk in Communities (ARIC) Study. Circulation Jul 21 1998, 98(3):204-210.
46. Khandanpour N., Willis G., Meyer F.J., Armon M.P., Loke Y.K., Wright A.J., et al. Peripheral arterial disease and methylenetetrahydrofolate reductase (MTHFR) C677T mutations: a case-control study and meta-analysis. JVasc Surg Mar 2009, 49(3):711-718.
47. Henning S.M., Swendseid M.E., Ivandic B.T., Liao F. Vitamins C, E and A and heme oxygenase in rats fed methyl/folate-deficient diets. Free Radic Biol Med 1997, 23(6):936-942.
48. Moat S.J., Lang D., McDowell I.F., Clarke Z.L., Madhavan A.K., Lewis M.J., et al. Folate, homocysteine, endothelial function and cardiovascular disease. JNutr Biochem Feb 2004, 15(2):64-79.
49. Bunout D., Garrido A., Suazo M., Kauffman R., Venegas P., de la Maza P., et al. Effects of supplementation with folic acid and antioxidant vitamins on homocysteine levels and LDL oxidation in coronary patients. Nutrition Feb 2000, 16(2):107-110.
50. Schnyder G., Roffi M., Pin R., Flammer Y., Lange H., Eberli F.R., et al. Decreased rate of coronary restenosis after lowering of plasma homocysteine levels. NEngl J Med Nov 29 2001, 345(22):1593-1600.
51. McNulty H., Dowey le R.C., Strain J.J., Dunne A., Ward M., Molloy A.M., et al. Riboflavin lowers homocysteine in individuals homozygous for the MTHFR 677C->T polymorphism. Circulation Jan 3 2006, 113(1):74-80.
52. Araki R., Maruyama C., Igarashi S., Yoshida M., Maruyama T., Satoh T., et al. Effects of short-term folic acid and/or riboflavin supplementation on serum folate and plasma total homocysteine concentrations in young Japanese male subjects. Eur J Clin Nutr May 2006, 60(5):573-579.
53. McKinley M.C., McNulty H., McPartlin J., Strain J.J., Scott J.M. Effect of riboflavin supplementation on plasma homocysteine in elderly people with low riboflavin status. Eur J Clin Nutr Sep 2002, 56(9):850-856.
54. Hackam D.G., Anand S.S. Emerging risk factors for atherosclerotic vascular disease: a critical review of the evidence. JAm Med Assoc Aug 20 2003, 290(7):932-940.
55. Dudman N.P., Guo X.W., Gordon R.B., Dawson P.A., Wilcken D.E. Human homocysteine catabolism: three major pathways and their relevance to development of arterial occlusive disease. JNutr Apr 1996, 126(4 Suppl.):1295S-1300S.
56. Atkinson W., Slow S., Elmslie J., Lever M., Chambers S.T., George P.M. Dietary and supplementary betaine: effects on betaine and homocysteine concentrations in males. Nutr Metab Cardiovasc Dis Dec 2009, 19(11):767-773.
57. Atkinson W., Elmslie J., Lever M., Chambers S.T., George P.M. Dietary and supplementary betaine: acute effects on plasma betaine and homocysteine concentrations under standard and postmethionine load conditions in healthy male subjects. Am J Clin Nutr Mar 2008, 87(3):577-585.
58. Honein M.A., Paulozzi L.J., Mathews T.J., Erickson J.D., Wong L.Y. Impact of folic acid fortification of the US food supply on the occurrence of neural tube defects. JAm Med Assoc Jun 20 2001, 285(23):2981-2986.