메뉴 건너뛰기




Volumn 19, Issue 3, 2014, Pages 190-204

Controversies regarding the new oral anticoagulants for stroke prevention in patients with atrial fibrillation

Author keywords

atrial fibrillation; oral anticoagulants; stroke prevention

Indexed keywords

ANTIDOTE; APIXABAN; DABIGATRAN; EDOXABAN; RIVAROXABAN; WARFARIN;

EID: 84901817404     PISSN: 1358863X     EISSN: 14770377     Source Type: Journal    
DOI: 10.1177/1358863X14532869     Document Type: Review
Times cited : (9)

References (87)
  • 1
    • 84859603846 scopus 로고    scopus 로고
    • New oral anticoagulants in atrial fibrillation and acute coronary syndromes: ESC Working Group on Thrombosis-Task Force on Anticoagulants in Heart Disease position paper
    • De Caterina R, Husted S, Wallentin L, et al. New oral anticoagulants in atrial fibrillation and acute coronary syndromes: ESC Working Group on Thrombosis-Task Force on Anticoagulants in Heart Disease position paper. J Am Coll Cardiol. 2012 ; 59: 1413-1425
    • (2012) J Am Coll Cardiol , vol.59 , pp. 1413-1425
    • De Caterina, R.1    Husted, S.2    Wallentin, L.3
  • 2
    • 33645470121 scopus 로고    scopus 로고
    • Prevalence, incidence and lifetime risk of atrial fibrillation: The Rotterdam study
    • Heeringa J, van der Kuip DA, Hofman A, et al. Prevalence, incidence and lifetime risk of atrial fibrillation: The Rotterdam study. Eur Heart J. 2006 ; 27: 949-953
    • (2006) Eur Heart J , vol.27 , pp. 949-953
    • Heeringa, J.1    Van Der Kuip, D.A.2    Hofman, A.3
  • 3
    • 34347394385 scopus 로고    scopus 로고
    • Meta-analysis: Antithrombotic therapy to prevent stroke in patients who have nonvalvular atrial fibrillation
    • Hart RG, Pearce LA, Aguilar MI. Meta-analysis: antithrombotic therapy to prevent stroke in patients who have nonvalvular atrial fibrillation. Ann Intern Med. 2007 ; 146: 857-867
    • (2007) Ann Intern Med , vol.146 , pp. 857-867
    • Hart, R.G.1    Pearce, L.A.2    Aguilar, M.I.3
  • 4
    • 77952304296 scopus 로고    scopus 로고
    • New oral anticoagulants for thromboprophylaxis after total hip or knee arthroplasty
    • Friedman RJ. New oral anticoagulants for thromboprophylaxis after total hip or knee arthroplasty. Orthopedics. 2009 ; 32: 79-84
    • (2009) Orthopedics , vol.32 , pp. 79-84
    • Friedman, R.J.1
  • 6
    • 17644400166 scopus 로고    scopus 로고
    • Pharmacokinetic profile of the oral direct thrombin inhibitor dabigatran etexilate in healthy volunteers and patients undergoing total hip replacement
    • Stangier J, Eriksson BI, Dahl OE, et al. Pharmacokinetic profile of the oral direct thrombin inhibitor dabigatran etexilate in healthy volunteers and patients undergoing total hip replacement. J Clin Pharmacol. 2005 ; 45: 555-563
    • (2005) J Clin Pharmacol , vol.45 , pp. 555-563
    • Stangier, J.1    Eriksson, B.I.2    Dahl, O.E.3
  • 7
    • 13244266944 scopus 로고    scopus 로고
    • Dose escalating safety study of a new oral direct thrombin inhibitor, dabigatran etexilate, in patients undergoing total hip replacement: BISTRO i
    • Eriksson BI, Dahl OE, Ahnfelt L, et al. Dose escalating safety study of a new oral direct thrombin inhibitor, dabigatran etexilate, in patients undergoing total hip replacement: BISTRO I. J Thromb Haemost. 2004 ; 2: 1573-1580
    • (2004) J Thromb Haemost , vol.2 , pp. 1573-1580
    • Eriksson, B.I.1    Dahl, O.E.2    Ahnfelt, L.3
  • 8
    • 84864769237 scopus 로고    scopus 로고
    • Pharmacokinetic and clinical implications of dabigatran use in severe renal impairment for stroke prevention in nonvalvular atrial fibrillation
    • Mack DR, Kim JJ. Pharmacokinetic and clinical implications of dabigatran use in severe renal impairment for stroke prevention in nonvalvular atrial fibrillation. Ann Pharmacother. 2012 ; 46: 1105-1110
    • (2012) Ann Pharmacother , vol.46 , pp. 1105-1110
    • MacK, D.R.1    Kim, J.J.2
  • 9
    • 74249121331 scopus 로고    scopus 로고
    • Safety, pharmacokinetics and pharmacodynamics of single doses of rivaroxaban - An oral, direct factor Xa inhibitor - In elderly Chinese subjects
    • Jiang J, Hu Y, Zhang J, et al. Safety, pharmacokinetics and pharmacodynamics of single doses of rivaroxaban - an oral, direct factor Xa inhibitor - in elderly Chinese subjects. Thromb Haemost. 2010 ; 103: 234-241
    • (2010) Thromb Haemost , vol.103 , pp. 234-241
    • Jiang, J.1    Hu, Y.2    Zhang, J.3
  • 10
    • 84872260247 scopus 로고    scopus 로고
    • Apixaban, an oral, direct factor Xa inhibitor: Single dose safety, pharmacokinetics, pharmacodynamics and food effect in healthy subjects
    • Frost C, Wang J, Nepal S, et al. Apixaban, an oral, direct factor Xa inhibitor: single dose safety, pharmacokinetics, pharmacodynamics and food effect in healthy subjects. Br J Clin Pharmacol. 2013 ; 75: 476-487
    • (2013) Br J Clin Pharmacol , vol.75 , pp. 476-487
    • Frost, C.1    Wang, J.2    Nepal, S.3
  • 11
    • 57449094606 scopus 로고    scopus 로고
    • Comparative pharmacodynamics and pharmacokinetics of oral direct thrombin and factor xa inhibitors in development
    • Eriksson BI, Quinlan DJ, Weitz JI. Comparative pharmacodynamics and pharmacokinetics of oral direct thrombin and factor xa inhibitors in development. Clin Pharmacokinet. 2009 ; 48: 1-22
    • (2009) Clin Pharmacokinet , vol.48 , pp. 1-22
    • Eriksson, B.I.1    Quinlan, D.J.2    Weitz, J.I.3
  • 12
    • 49849099533 scopus 로고    scopus 로고
    • DU-176b, a potent and orally active factor Xa inhibitor: In vitro and in vivo pharmacological profiles
    • Furugohri T, Isobe K, Honda Y, et al. DU-176b, a potent and orally active factor Xa inhibitor: in vitro and in vivo pharmacological profiles. J Thromb Haemost. 2008 ; 6: 1542-1549
    • (2008) J Thromb Haemost , vol.6 , pp. 1542-1549
    • Furugohri, T.1    Isobe, K.2    Honda, Y.3
  • 14
    • 84888362796 scopus 로고    scopus 로고
    • Edoxaban versus warfarin in patients with atrial fibrillation
    • Giugliano RP, Ruff CT, Braunwald E, et al. Edoxaban versus warfarin in patients with atrial fibrillation. N Engl J Med. 2013 ; 369: 2093-2104
    • (2013) N Engl J Med , vol.369 , pp. 2093-2104
    • Giugliano, R.P.1    Ruff, C.T.2    Braunwald, E.3
  • 15
    • 70349306707 scopus 로고    scopus 로고
    • Dabigatran versus warfarin in patients with atrial fibrillation
    • Connolly SJ, Ezekowitz MD, Yusuf S, et al. Dabigatran versus warfarin in patients with atrial fibrillation. N Engl J Med. 2009 ; 361: 1139-1151
    • (2009) N Engl J Med , vol.361 , pp. 1139-1151
    • Connolly, S.J.1    Ezekowitz, M.D.2    Yusuf, S.3
  • 17
    • 84875780959 scopus 로고    scopus 로고
    • Dabigatran and postmarketing reports of bleeding
    • Southworth MR, Reichman ME, Unger EF. Dabigatran and postmarketing reports of bleeding. N Engl J Med. 2013 ; 368: 1272-1274
    • (2013) N Engl J Med , vol.368 , pp. 1272-1274
    • Southworth, M.R.1    Reichman, M.E.2    Unger, E.F.3
  • 18
    • 80052592404 scopus 로고    scopus 로고
    • Rivaroxaban versus warfarin in nonvalvular atrial fibrillation
    • Patel MR, Mahaffey KW, Garg J, et al. Rivaroxaban versus warfarin in nonvalvular atrial fibrillation. N Engl J Med. 2011 ; 365: 883-891
    • (2011) N Engl J Med , vol.365 , pp. 883-891
    • Patel, M.R.1    Mahaffey, K.W.2    Garg, J.3
  • 19
    • 84878652588 scopus 로고    scopus 로고
    • Incidence and outcomes of gastrointestinal hemorrhage in patients with atrial fibrillation treated with rivaroxaban or warfarin: Results from the ROCKET AF Trial
    • Nessel C, Mahaffey KW, Piccini JP, et al. Incidence and outcomes of gastrointestinal hemorrhage in patients with atrial fibrillation treated with rivaroxaban or warfarin: results from the ROCKET AF Trial. Chest. 2012 ; 142 :
    • (2012) Chest , vol.142
    • Nessel, C.1    Mahaffey, K.W.2    Piccini, J.P.3
  • 20
    • 0004084146 scopus 로고    scopus 로고
    • London: ;
    • Press Release. London: ; 2012 :
    • (2012) Press Release
  • 21
    • 79952301326 scopus 로고    scopus 로고
    • Apixaban in patients with atrial fibrillation
    • Connolly SJ, Eikelboom J, Joyner C, et al. Apixaban in patients with atrial fibrillation. N Engl J Med. 2011 ; 364: 806-817
    • (2011) N Engl J Med , vol.364 , pp. 806-817
    • Connolly, S.J.1    Eikelboom, J.2    Joyner, C.3
  • 22
    • 80052825103 scopus 로고    scopus 로고
    • Apixaban versus warfarin in patients with atrial fibrillation
    • Granger CB, Alexander JH, McMurray JJ, et al. Apixaban versus warfarin in patients with atrial fibrillation. N Engl J Med. 2011 ; 365: 981-992
    • (2011) N Engl J Med , vol.365 , pp. 981-992
    • Granger, C.B.1    Alexander, J.H.2    McMurray, J.J.3
  • 23
    • 84869083231 scopus 로고    scopus 로고
    • Efficacy and safety of apixaban compared with warfarin according to patient risk of stroke and of bleeding in atrial fibrillation: A secondary analysis of a randomised controlled trial
    • Lopes RD, Al-Khatib SM, Wallentin L, et al. Efficacy and safety of apixaban compared with warfarin according to patient risk of stroke and of bleeding in atrial fibrillation: a secondary analysis of a randomised controlled trial. Lancet. 2013 ; 380: 1749-1758
    • (2013) Lancet , vol.380 , pp. 1749-1758
    • Lopes, R.D.1    Al-Khatib, S.M.2    Wallentin, L.3
  • 24
    • 84878535107 scopus 로고    scopus 로고
    • Efficacy and safety of apixaban compared with warfarin at different levels of predicted international normalized ratio control for stroke prevention in atrial fibrillation
    • Wallentin L, Lopes RD, Hanna M, et al. Efficacy and safety of apixaban compared with warfarin at different levels of predicted international normalized ratio control for stroke prevention in atrial fibrillation. Circulation. 2013 ; 127: 2166-2176
    • (2013) Circulation , vol.127 , pp. 2166-2176
    • Wallentin, L.1    Lopes, R.D.2    Hanna, M.3
  • 25
    • 84885129987 scopus 로고    scopus 로고
    • Drug-drug interaction studies of cardiovascular drugs involving P-glycoprotein, an efflux transporter, on the pharmacokinetics of edoxaban, an oral factor Xa inhibitor
    • Mendell J, Zahir H, Matsushima N, et al. Drug-drug interaction studies of cardiovascular drugs involving P-glycoprotein, an efflux transporter, on the pharmacokinetics of edoxaban, an oral factor Xa inhibitor. Am J Cardiovasc Drugs. 2013 ; 13: 331-342
    • (2013) Am J Cardiovasc Drugs , vol.13 , pp. 331-342
    • Mendell, J.1    Zahir, H.2    Matsushima, N.3
  • 26
    • 52449129321 scopus 로고    scopus 로고
    • Warfarin for atrial fibrillation in community-based practise
    • Rose AJ, Ozonoff A, Henault LE, Hylek EM. Warfarin for atrial fibrillation in community-based practise. J Thromb Haemost. 2008 ; 6: 1647-1654
    • (2008) J Thromb Haemost , vol.6 , pp. 1647-1654
    • Rose, A.J.1    Ozonoff, A.2    Henault, L.E.3    Hylek, E.M.4
  • 27
    • 84870480675 scopus 로고    scopus 로고
    • Persistence with therapy among patients treated with warfarin for atrial fibrillation
    • Gomes T, Mamdani MM, Holbrook AM, Paterson JM, Juurlink DN. Persistence with therapy among patients treated with warfarin for atrial fibrillation. Arch Intern Med. 2012 ; 172: 1687-1689
    • (2012) Arch Intern Med , vol.172 , pp. 1687-1689
    • Gomes, T.1    Mamdani, M.M.2    Holbrook, A.M.3    Paterson, J.M.4    Juurlink, D.N.5
  • 28
    • 77956977472 scopus 로고    scopus 로고
    • Efficacy and safety of dabigatran compared with warfarin at different levels of international normalised ratio control for stroke prevention in atrial fibrillation: An analysis of the RE-LY trial
    • Wallentin L, Yusuf S, Ezekowitz MD, et al. Efficacy and safety of dabigatran compared with warfarin at different levels of international normalised ratio control for stroke prevention in atrial fibrillation: an analysis of the RE-LY trial. Lancet. 2010 ; 376: 975-983
    • (2010) Lancet , vol.376 , pp. 975-983
    • Wallentin, L.1    Yusuf, S.2    Ezekowitz, M.D.3
  • 29
    • 84863608998 scopus 로고    scopus 로고
    • New oral anticoagulants for atrial fibrillation
    • Spinler SA, Shafir V. New oral anticoagulants for atrial fibrillation. Circulation. 2012 ; 126: 133-137
    • (2012) Circulation , vol.126 , pp. 133-137
    • Spinler, S.A.1    Shafir, V.2
  • 30
    • 84869236631 scopus 로고    scopus 로고
    • Efficacy and safety of the novel oral anticoagulants in atrial fibrillation: A systematic review and meta-analysis of the literature
    • Dentali F, Riva N, Crowther M, Turpie AG, Lip GY, Ageno W. Efficacy and safety of the novel oral anticoagulants in atrial fibrillation: a systematic review and meta-analysis of the literature. Circulation. 2012 ; 126: 2381-2391
    • (2012) Circulation , vol.126 , pp. 2381-2391
    • Dentali, F.1    Riva, N.2    Crowther, M.3    Turpie, A.G.4    Lip, G.Y.5    Ageno, W.6
  • 31
    • 84878292470 scopus 로고    scopus 로고
    • Efficacy and safety of dabigatran etexilate and warfarin in 'real-world' patients with atrial fibrillation: A prospective nationwide cohort study
    • Larsen TB, Rasmussen LH, Skjoth F, et al. Efficacy and safety of dabigatran etexilate and warfarin in 'real-world' patients with atrial fibrillation: a prospective nationwide cohort study. J Am Coll Cardiol. 2013 ; 61: 2264-2273
    • (2013) J Am Coll Cardiol , vol.61 , pp. 2264-2273
    • Larsen, T.B.1    Rasmussen, L.H.2    Skjoth, F.3
  • 32
    • 84896117299 scopus 로고    scopus 로고
    • Comparison of the efficacy and safety of new oral anticoagulants with warfarin in patients with atrial fibrillation: A meta-analysis of randomised trials
    • Ruff CT, Giugliano RP, Braunwald E, et al. Comparison of the efficacy and safety of new oral anticoagulants with warfarin in patients with atrial fibrillation: a meta-analysis of randomised trials. Lancet. 2014 ; 383: 955-962
    • (2014) Lancet , vol.383 , pp. 955-962
    • Ruff, C.T.1    Giugliano, R.P.2    Braunwald, E.3
  • 33
    • 44649185707 scopus 로고    scopus 로고
    • Warfarin-induced bleeding complications - Clinical presentation and therapeutic options
    • Wiedermann CJ, Stockner I. Warfarin-induced bleeding complications - clinical presentation and therapeutic options. Thromb Res. 2008 ; 122: S13-18
    • (2008) Thromb Res , vol.122 , pp. 13-18
    • Wiedermann, C.J.1    Stockner, I.2
  • 34
    • 84861173947 scopus 로고    scopus 로고
    • Reversal of drug-induced anticoagulation: Old solutions and new problems
    • Dzik WS. Reversal of drug-induced anticoagulation: old solutions and new problems. Transfusion. 2012 ; 52: 45S - 55S
    • (2012) Transfusion , vol.52
    • Dzik, W.S.1
  • 35
    • 84856772158 scopus 로고    scopus 로고
    • Evidence-based management of anticoagulant therapy: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines
    • Holbrook A, Schulman S, Witt DM, et al. Evidence-based management of anticoagulant therapy: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest. 2012 ; 141: e152S - e184S
    • (2012) Chest , vol.141
    • Holbrook, A.1    Schulman, S.2    Witt, D.M.3
  • 36
    • 84901795857 scopus 로고    scopus 로고
    • FDA approves Kcentra for the urgent reversal of anticoagulation in adults with major bleeding
    • FDA approves Kcentra for the urgent reversal of anticoagulation in adults with major bleeding. FDA News Release. 2013 ;:
    • (2013) FDA News Release
  • 37
    • 84879754339 scopus 로고    scopus 로고
    • Med Lett Drugs Ther. 2013 ; 55: 53-54
    • (2013) Med Lett Drugs Ther , vol.55 , pp. 53-54
  • 38
    • 84870924316 scopus 로고    scopus 로고
    • Emergency management of bleeding associated with old and new oral anticoagulants
    • Peacock WF, Gearhart MM, Mills RM. Emergency management of bleeding associated with old and new oral anticoagulants. Clin Cardiol. 2012 ; 35: 730-737
    • (2012) Clin Cardiol , vol.35 , pp. 730-737
    • Peacock, W.F.1    Gearhart, M.M.2    Mills, R.M.3
  • 39
    • 84861616750 scopus 로고    scopus 로고
    • Intracranial hemorrhage in atrial fibrillation patients during anticoagulation with warfarin or dabigatran: The RE-LY trial
    • Hart RG, Diener HC, Yang S, et al. Intracranial hemorrhage in atrial fibrillation patients during anticoagulation with warfarin or dabigatran: the RE-LY trial. Stroke. 2012 ; 43: 1511-1517
    • (2012) Stroke , vol.43 , pp. 1511-1517
    • Hart, R.G.1    Diener, H.C.2    Yang, S.3
  • 40
    • 84888197736 scopus 로고    scopus 로고
    • Management and outcomes of major bleeding during treatment with dabigatran or warfarin
    • Majeed A, Hwang HG, Connolly SJ, et al. Management and outcomes of major bleeding during treatment with dabigatran or warfarin. Circulation. 2013 ; 128: 2325-2332
    • (2013) Circulation , vol.128 , pp. 2325-2332
    • Majeed, A.1    Hwang, H.G.2    Connolly, S.J.3
  • 41
    • 84863989146 scopus 로고    scopus 로고
    • Periprocedural bleeding and thromboembolic events with dabigatran compared with warfarin: Results from the Randomized Evaluation of Long-Term Anticoagulation Therapy (RE-LY) randomized trial
    • Healey JS, Eikelboom J, Douketis J, et al. Periprocedural bleeding and thromboembolic events with dabigatran compared with warfarin: results from the Randomized Evaluation of Long-Term Anticoagulation Therapy (RE-LY) randomized trial. Circulation. 2012 ; 126: 343-348
    • (2012) Circulation , vol.126 , pp. 343-348
    • Healey, J.S.1    Eikelboom, J.2    Douketis, J.3
  • 42
    • 0004084146 scopus 로고    scopus 로고
    • South San Francisco, USA: ;
    • Press Release. South San Francisco, USA: ; 2012 :
    • (2012) Press Release
  • 43
    • 84879548455 scopus 로고    scopus 로고
    • A specific antidote for dabigatran: Functional and structural characterization
    • Schiele F, van Ryn J, Canada K, et al. A specific antidote for dabigatran: functional and structural characterization. Blood. 2013 ; 121: 3554-3562
    • (2013) Blood , vol.121 , pp. 3554-3562
    • Schiele, F.1    Van Ryn, J.2    Canada, K.3
  • 44
    • 80052232522 scopus 로고    scopus 로고
    • Dabigatran vs placebo in patients with acute coronary syndromes on dual antiplatelet therapy: A randomized, double-blind, phase II trial
    • Oldgren J, Budaj A, Granger CB, et al. Dabigatran vs. placebo in patients with acute coronary syndromes on dual antiplatelet therapy: a randomized, double-blind, phase II trial. Eur Heart J. 2011 ; 32: 2781-2789
    • (2011) Eur Heart J , vol.32 , pp. 2781-2789
    • Oldgren, J.1    Budaj, A.2    Granger, C.B.3
  • 45
    • 67649562905 scopus 로고    scopus 로고
    • Rivaroxaban versus placebo in patients with acute coronary syndromes (ATLAS ACS-TIMI 46): A randomised, double-blind, phase II trial
    • Mega JL, Braunwald E, Mohanavelu S, et al. Rivaroxaban versus placebo in patients with acute coronary syndromes (ATLAS ACS-TIMI 46): a randomised, double-blind, phase II trial. Lancet. 2009 ; 374: 29-38
    • (2009) Lancet , vol.374 , pp. 29-38
    • Mega, J.L.1    Braunwald, E.2    Mohanavelu, S.3
  • 46
    • 67649563209 scopus 로고    scopus 로고
    • Apixaban, an oral, direct, selective factor Xa inhibitor, in combination with antiplatelet therapy after acute coronary syndrome: Results of the Apixaban for Prevention of Acute Ischemic and Safety Events (APPRAISE) trial
    • Alexander JH, Becker RC, Bhatt DL, et al. Apixaban, an oral, direct, selective factor Xa inhibitor, in combination with antiplatelet therapy after acute coronary syndrome: results of the Apixaban for Prevention of Acute Ischemic and Safety Events (APPRAISE) trial. Circulation. 2009 ; 119: 2877-2885
    • (2009) Circulation , vol.119 , pp. 2877-2885
    • Alexander, J.H.1    Becker, R.C.2    Bhatt, D.L.3
  • 47
    • 80052162121 scopus 로고    scopus 로고
    • Apixaban with antiplatelet therapy after acute coronary syndrome
    • Alexander JH, Lopes RD, James S, et al. Apixaban with antiplatelet therapy after acute coronary syndrome. N Engl J Med. 2011 ; 365: 699-708
    • (2011) N Engl J Med , vol.365 , pp. 699-708
    • Alexander, J.H.1    Lopes, R.D.2    James, S.3
  • 48
    • 84862907587 scopus 로고    scopus 로고
    • Rivaroxaban in patients with a recent acute coronary syndrome
    • Mega JL, Braunwald E, Wiviott SD, et al. Rivaroxaban in patients with a recent acute coronary syndrome. N Engl J Med. 2012 ; 366: 9-19
    • (2012) N Engl J Med , vol.366 , pp. 9-19
    • Mega, J.L.1    Braunwald, E.2    Wiviott, S.D.3
  • 49
    • 84869131278 scopus 로고    scopus 로고
    • Use of new-generation oral anticoagulant agents in patients receiving antiplatelet therapy after an acute coronary syndrome: Systematic review and meta-analysis of randomized controlled trials
    • Komócsi A, Vorobcsuk A, Kehl D, Aradi D. Use of new-generation oral anticoagulant agents in patients receiving antiplatelet therapy after an acute coronary syndrome: systematic review and meta-analysis of randomized controlled trials. Arch Intern Med. 2012 ; 172: 1537-1545
    • (2012) Arch Intern Med , vol.172 , pp. 1537-1545
    • Komócsi, A.1    Vorobcsuk, A.2    Kehl, D.3    Aradi, D.4
  • 50
    • 84876963408 scopus 로고    scopus 로고
    • Rivaroxaban in patients stabilized after a ST-segment elevation myocardial infarction: Results from the ATLAS ACS-2-TIMI-51 trial (Anti-Xa Therapy to Lower Cardiovascular Events in Addition to Standard Therapy in Subjects with Acute Coronary Syndrome-Thrombolysis in Myocardial Infarction-51)
    • Mega JL, Braunwald E, Murphy SA, et al. Rivaroxaban in patients stabilized after a ST-segment elevation myocardial infarction: results from the ATLAS ACS-2-TIMI-51 trial (Anti-Xa Therapy to Lower Cardiovascular Events in Addition to Standard Therapy in Subjects with Acute Coronary Syndrome-Thrombolysis In Myocardial Infarction-51). J Am Coll Cardiol. 2013 ; 61: 1853-1859
    • (2013) J Am Coll Cardiol , vol.61 , pp. 1853-1859
    • Mega, J.L.1    Braunwald, E.2    Murphy, S.A.3
  • 51
    • 0004084146 scopus 로고    scopus 로고
    • Berlin, DE: ;
    • Press Release. Berlin, DE: ; 2013 :
    • (2013) Press Release
  • 52
    • 84875720372 scopus 로고    scopus 로고
    • Use of clopidogrel with or without aspirin in patients taking oral anticoagulant therapy and undergoing percutaneous coronary intervention: An open-label, randomised, controlled trial
    • Dewilde WJ, Oirbans T, Verheugt FW, et al. Use of clopidogrel with or without aspirin in patients taking oral anticoagulant therapy and undergoing percutaneous coronary intervention: an open-label, randomised, controlled trial. Lancet. 2013 ; 381: 1107-1115
    • (2013) Lancet , vol.381 , pp. 1107-1115
    • Dewilde, W.J.1    Oirbans, T.2    Verheugt, F.W.3
  • 53
    • 84883481368 scopus 로고    scopus 로고
    • Oral anticoagulation and antiplatelets in atrial fibrillation patients after myocardial infarction and coronary intervention
    • Lamberts M, Gislason GH, Olesen JB, et al. Oral anticoagulation and antiplatelets in atrial fibrillation patients after myocardial infarction and coronary intervention. J Am Coll Cardiol. 2013 ; 62: 981-989
    • (2013) J Am Coll Cardiol , vol.62 , pp. 981-989
    • Lamberts, M.1    Gislason, G.H.2    Olesen, J.B.3
  • 56
    • 84884512133 scopus 로고    scopus 로고
    • Dabigatran versus warfarin in patients with mechanical heart valves
    • Eikelboom JW, Connolly SJ, Brueckmann M, et al. Dabigatran versus warfarin in patients with mechanical heart valves. N Engl J Med. 2013 ; 369: 1206-1214
    • (2013) N Engl J Med , vol.369 , pp. 1206-1214
    • Eikelboom, J.W.1    Connolly, S.J.2    Brueckmann, M.3
  • 58
    • 84871044907 scopus 로고    scopus 로고
    • Comparative effectiveness and safety of the novel oral anticoagulants: Do the pivotal clinical trials point to a new paradigm?
    • Spyropoulos AC, Goldenberg NA, Kessler CM, et al. Comparative effectiveness and safety of the novel oral anticoagulants: do the pivotal clinical trials point to a new paradigm?. J Thromb Haemost. 2012 ; 10: 2621-2624
    • (2012) J Thromb Haemost , vol.10 , pp. 2621-2624
    • Spyropoulos, A.C.1    Goldenberg, N.A.2    Kessler, C.M.3
  • 59
    • 79951820739 scopus 로고    scopus 로고
    • Improving academic leadership and oversight in large industry-sponsored clinical trials: The ARO-CRO model
    • Goldenberg NA, Spyropoulos AC, Halperin JL, et al. Improving academic leadership and oversight in large industry-sponsored clinical trials: the ARO-CRO model. Blood. 2011 ; 117: 2089-2092
    • (2011) Blood , vol.117 , pp. 2089-2092
    • Goldenberg, N.A.1    Spyropoulos, A.C.2    Halperin, J.L.3
  • 60
    • 84864968277 scopus 로고    scopus 로고
    • Dabigatran etexilate: A pharmacoeconomic review of its use in the prevention of stroke and systemic embolism in patients with atrial fibrillation
    • McKeage K. Dabigatran etexilate: a pharmacoeconomic review of its use in the prevention of stroke and systemic embolism in patients with atrial fibrillation. Pharmacoeconomics. 2012 ; 30: 841-855
    • (2012) Pharmacoeconomics , vol.30 , pp. 841-855
    • McKeage, K.1
  • 61
    • 0004084146 scopus 로고    scopus 로고
    • Montreal, QC: ;
    • Press Release. Montreal, QC: ; 2012 :
    • (2012) Press Release
  • 62
    • 79952444246 scopus 로고    scopus 로고
    • Forecasting the future of cardiovascular disease in the United States: A policy statement from the American Heart Association
    • Heidenreich PA, Trogdon JG, Khavjou OA, et al. Forecasting the future of cardiovascular disease in the United States: a policy statement from the American Heart Association. Circulation. 2011 ; 123: 933-944
    • (2011) Circulation , vol.123 , pp. 933-944
    • Heidenreich, P.A.1    Trogdon, J.G.2    Khavjou, O.A.3
  • 63
    • 76749085604 scopus 로고    scopus 로고
    • Cost of atrial fibrillation in United States managed care organizations
    • Kim MH, Lin J, Hussein M, Kreilick C, Battleman D. Cost of atrial fibrillation in United States managed care organizations. Adv Ther. 2009 ; 26: 847-857
    • (2009) Adv Ther , vol.26 , pp. 847-857
    • Kim, M.H.1    Lin, J.2    Hussein, M.3    Kreilick, C.4    Battleman, D.5
  • 64
    • 79551589662 scopus 로고    scopus 로고
    • Cost-effectiveness of dabigatran compared with warfarin for stroke prevention in atrial fibrillation
    • Freeman JV, Zhu RP, Owens DK, et al. Cost-effectiveness of dabigatran compared with warfarin for stroke prevention in atrial fibrillation. Ann Intern Med. 2011 ; 154: 1-11
    • (2011) Ann Intern Med , vol.154 , pp. 1-11
    • Freeman, J.V.1    Zhu, R.P.2    Owens, D.K.3
  • 65
    • 79955774273 scopus 로고    scopus 로고
    • Cost-effectiveness of dabigatran etexilate for the prevention of stroke and systemic embolism in atrial fibrillation: A Canadian payer perspective
    • Sorensen SV, Kansal AR, Connolly S, et al. Cost-effectiveness of dabigatran etexilate for the prevention of stroke and systemic embolism in atrial fibrillation: a Canadian payer perspective. Thromb Haemost. 2011 ; 105: 908-919
    • (2011) Thromb Haemost , vol.105 , pp. 908-919
    • Sorensen, S.V.1    Kansal, A.R.2    Connolly, S.3
  • 66
    • 84858598110 scopus 로고    scopus 로고
    • Cost-effectiveness of dabigatran etexilate for the prevention of stroke and systemic embolism in UK patients with atrial fibrillation
    • Kansal AR, Sorensen SV, Gani R, et al. Cost-effectiveness of dabigatran etexilate for the prevention of stroke and systemic embolism in UK patients with atrial fibrillation. Heart. 2012 ; 98: 573-578
    • (2012) Heart , vol.98 , pp. 573-578
    • Kansal, A.R.1    Sorensen, S.V.2    Gani, R.3
  • 67
    • 79958813704 scopus 로고    scopus 로고
    • Cost-effectiveness of dabigatran for stroke prophylaxis in atrial fibrillation
    • Shah SV, Gage BF. Cost-effectiveness of dabigatran for stroke prophylaxis in atrial fibrillation. Circulation. 2011 ; 123: 2562-2570
    • (2011) Circulation , vol.123 , pp. 2562-2570
    • Shah, S.V.1    Gage, B.F.2
  • 68
    • 84862549811 scopus 로고    scopus 로고
    • Medical cost reductions associated with the usage of novel oral anticoagulants vs warfarin among atrial fibrillation patients, based on the RE-LY, ROCKET-AF, and ARISTOTLE trials
    • Deitelzweig S, Amin A, Jing Y, et al. Medical cost reductions associated with the usage of novel oral anticoagulants vs warfarin among atrial fibrillation patients, based on the RE-LY, ROCKET-AF, and ARISTOTLE trials. J Med Econ. 2012 ; 15: 776-785
    • (2012) J Med Econ , vol.15 , pp. 776-785
    • Deitelzweig, S.1    Amin, A.2    Jing, Y.3
  • 69
    • 84863874413 scopus 로고    scopus 로고
    • Prescribing trends for dabigatran etexilate in primary care
    • McCullagh L, Barry M. Prescribing trends for dabigatran etexilate in primary care. Ir Med J. 2012 ; 105: 134-136
    • (2012) Ir Med J , vol.105 , pp. 134-136
    • McCullagh, L.1    Barry, M.2
  • 70
    • 84885022750 scopus 로고    scopus 로고
    • Factors influencing doctors' selection of dabigatran in non-valvular atrial fibrillation
    • Huang C, Siu M, Vu L, Wong S, Shin J. Factors influencing doctors' selection of dabigatran in non-valvular atrial fibrillation. J Eval Clin Pract. 2013 ; 19: 938-943
    • (2013) J Eval Clin Pract , vol.19 , pp. 938-943
    • Huang, C.1    Siu, M.2    Vu, L.3    Wong, S.4    Shin, J.5
  • 71
    • 84877276344 scopus 로고    scopus 로고
    • Outcomes after cardioversion and atrial fibrillation ablation in patients treated with rivaroxaban and warfarin in the ROCKET AF Trial
    • Piccini JP, Stevens SR, Lokhnygina Y, et al. Outcomes after cardioversion and atrial fibrillation ablation in patients treated with rivaroxaban and warfarin in the ROCKET AF Trial. J Am Coll Cardiol. 2013 ; 61: 1998-2006
    • (2013) J Am Coll Cardiol , vol.61 , pp. 1998-2006
    • Piccini, J.P.1    Stevens, S.R.2    Lokhnygina, Y.3
  • 72
    • 84875753938 scopus 로고    scopus 로고
    • Dabigatran vs warfarin for radiofrequency catheter ablation of atrial fibrillation
    • Kim JS, She F, Jongnarangsin K, et al. Dabigatran vs warfarin for radiofrequency catheter ablation of atrial fibrillation. Heart Rhythm. 2013 ; 10: 483-489
    • (2013) Heart Rhythm , vol.10 , pp. 483-489
    • Kim, J.S.1    She, F.2    Jongnarangsin, K.3
  • 73
    • 84858709300 scopus 로고    scopus 로고
    • Feasibility and safety of dabigatran versus warfarin for periprocedural anticoagulation in patients undergoing radiofrequency ablation for atrial fibrillation: Results from a multicenter prospective registry
    • Lakkireddy D, Reddy YM, Di Biase L, et al. Feasibility and safety of dabigatran versus warfarin for periprocedural anticoagulation in patients undergoing radiofrequency ablation for atrial fibrillation: results from a multicenter prospective registry. J Am Coll Cardiol. 2012 ; 59: 1168-1174
    • (2012) J Am Coll Cardiol , vol.59 , pp. 1168-1174
    • Lakkireddy, D.1    Reddy, Y.M.2    Di Biase, L.3
  • 74
    • 84882251208 scopus 로고    scopus 로고
    • Use of dabigatran for periprocedural anticoagulation in patients undergoing catheter ablation for atrial fibrillation
    • Bassiouny M, Saliba W, Rickard J, et al. Use of dabigatran for periprocedural anticoagulation in patients undergoing catheter ablation for atrial fibrillation. Circ Arrhythm Electrophysiol. 2013 ; 6: 460-466
    • (2013) Circ Arrhythm Electrophysiol , vol.6 , pp. 460-466
    • Bassiouny, M.1    Saliba, W.2    Rickard, J.3
  • 75
    • 84893518420 scopus 로고    scopus 로고
    • Safety and efficacy of dabigatran versus warfarin in patients undergoing catheter ablation of atrial fibrillation: A systematic review and meta-analysis
    • Providência R, Albenque JP, Combes S, et al. Safety and efficacy of dabigatran versus warfarin in patients undergoing catheter ablation of atrial fibrillation: a systematic review and meta-analysis. Heart. 2014 ; 100: 324-335
    • (2014) Heart , vol.100 , pp. 324-335
    • Providência, R.1    Albenque, J.P.2    Combes, S.3
  • 76
    • 84901796921 scopus 로고    scopus 로고
    • Abstract 18024: The efficacy and safety of rivaroxaban vs warfarin in patients undergoing atrial fibrillation ablation: A meta-analysis. Scientific Sessions 2013 - American Heart Association
    • Gangireddy SR, Koh AP, Bockstall KE, et al. Abstract 18024: The efficacy and safety of rivaroxaban vs warfarin in patients undergoing atrial fibrillation ablation: a meta-analysis. Scientific Sessions 2013 - American Heart Association. Circulation. 2013 ; 128: A18024
    • (2013) Circulation , vol.128 , pp. 18024
    • Gangireddy, S.R.1    Koh, A.P.2    Bockstall, K.E.3
  • 77
    • 84863142762 scopus 로고    scopus 로고
    • Myocardial ischemic events in patients with atrial fibrillation treated with dabigatran or warfarin in the RE-LY (Randomized Evaluation of Long-Term Anticoagulation Therapy) trial
    • Hohnloser SH, Oldgren J, Yang S, et al. Myocardial ischemic events in patients with atrial fibrillation treated with dabigatran or warfarin in the RE-LY (Randomized Evaluation of Long-Term Anticoagulation Therapy) trial. Circulation. 2012 ; 125: 669-676
    • (2012) Circulation , vol.125 , pp. 669-676
    • Hohnloser, S.H.1    Oldgren, J.2    Yang, S.3
  • 78
    • 64349107688 scopus 로고    scopus 로고
    • Rationale and design of RE-LY: Randomized evaluation of long-term anticoagulant therapy, warfarin, compared with dabigatran
    • Ezekowitz MD, Connolly S, Parekh A, et al. Rationale and design of RE-LY: randomized evaluation of long-term anticoagulant therapy, warfarin, compared with dabigatran. Am Heart J. 2009 ; 157: 805-810
    • (2009) Am Heart J , vol.157 , pp. 805-810
    • Ezekowitz, M.D.1    Connolly, S.2    Parekh, A.3
  • 79
    • 77649249878 scopus 로고    scopus 로고
    • Apixaban for reduction in stroke and other ThromboemboLic events in atrial fibrillation (ARISTOTLE) trial: Design and rationale
    • Lopes RD, Alexander JH, Al-Khatib SM, et al. Apixaban for reduction in stroke and other ThromboemboLic events in atrial fibrillation (ARISTOTLE) trial: design and rationale. Am Heart J. 2010 ; 159: 331-339
    • (2010) Am Heart J , vol.159 , pp. 331-339
    • Lopes, R.D.1    Alexander, J.H.2    Al-Khatib, S.M.3
  • 80
    • 85058721877 scopus 로고    scopus 로고
    • Rivaroxaban-once daily, oral, direct factor Xa inhibition compared with vitamin K antagonism for prevention of stroke and Embolism Trial in Atrial Fibrillation: Rationale and design of the ROCKET AF study
    • Rivaroxaban-once daily, oral, direct factor Xa inhibition compared with vitamin K antagonism for prevention of stroke and Embolism Trial in Atrial Fibrillation: rationale and design of the ROCKET AF study. Am Heart J. 2010 ; 159: 340-347.e1
    • (2010) Am Heart J , vol.159
  • 81
    • 84876681725 scopus 로고    scopus 로고
    • Reversal of novel oral anticoagulants in patients with major bleeding
    • Siegal DM, Cuker A. Reversal of novel oral anticoagulants in patients with major bleeding. J Thromb Thrombolysis. 2013 ; 35: 391-398
    • (2013) J Thromb Thrombolysis , vol.35 , pp. 391-398
    • Siegal, D.M.1    Cuker, A.2
  • 82
    • 84884354180 scopus 로고    scopus 로고
    • Efficacy and safety of a 4-factor prothrombin complex concentrate in patients on vitamin K antagonists presenting with major bleeding: A randomized, plasma-controlled, phase IIIb study
    • Sarode R, Milling TJ, Refaai MA, et al. Efficacy and safety of a 4-factor prothrombin complex concentrate in patients on vitamin K antagonists presenting with major bleeding: a randomized, plasma-controlled, phase IIIb study. Circulation. 2013 ; 128: 1234-1243
    • (2013) Circulation , vol.128 , pp. 1234-1243
    • Sarode, R.1    Milling, T.J.2    Ma, R.3
  • 83
    • 84877301336 scopus 로고    scopus 로고
    • European Heart Rhythm Association Practical Guide on the use of new oral anticoagulants in patients with non-valvular atrial fibrillation
    • Heidbuchel H, Verhamme P, Alings M, et al. European Heart Rhythm Association Practical Guide on the use of new oral anticoagulants in patients with non-valvular atrial fibrillation. Europace. 2013 ; 15: 625-651
    • (2013) Europace , vol.15 , pp. 625-651
    • Heidbuchel, H.1    Verhamme, P.2    Alings, M.3
  • 84
    • 84873378766 scopus 로고    scopus 로고
    • Outcomes of discontinuing rivaroxaban compared with warfarin in patients with nonvalvular atrial fibrillation: Analysis from the ROCKET AF trial (Rivaroxaban Once-Daily, Oral, Direct Factor Xa Inhibition Compared with Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in Atrial Fibrillation)
    • Patel MR, Hellkamp AS, Lokhnygina Y, et al. Outcomes of discontinuing rivaroxaban compared with warfarin in patients with nonvalvular atrial fibrillation: analysis from the ROCKET AF trial (Rivaroxaban Once-Daily, Oral, Direct Factor Xa Inhibition Compared With Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in Atrial Fibrillation). J Am Coll Cardiol. 2013 ; 61: 651-658
    • (2013) J Am Coll Cardiol , vol.61 , pp. 651-658
    • Patel, M.R.1    Hellkamp, A.S.2    Lokhnygina, Y.3
  • 85
    • 84878451205 scopus 로고    scopus 로고
    • Dabigatran use in Danish atrial fibrillation patients in 2011: A nationwide study
    • Sorensen R, Gislason G, Torp-Pedersen C, et al. Dabigatran use in Danish atrial fibrillation patients in 2011: a nationwide study. BMJ Open. 2013 ;: 3
    • (2013) BMJ Open , pp. 3
    • Sorensen, R.1    Gislason, G.2    Torp-Pedersen, C.3
  • 86
    • 84884492931 scopus 로고    scopus 로고
    • End of study transition from study drug to open-label vitamin K antagonist therapy: The ROCKET AF Experience
    • Mahaffey KW, Hellkamp AS, Patel MR, et al. End of study transition from study drug to open-label vitamin K antagonist therapy: The ROCKET AF Experience. Circ Cardiovasc Qual Outcomes. 2013 ; 6: 470-478
    • (2013) Circ Cardiovasc Qual Outcomes , vol.6 , pp. 470-478
    • Mahaffey, K.W.1    Hellkamp, A.S.2    Patel, M.R.3
  • 87
    • 84869100588 scopus 로고    scopus 로고
    • Efficacy of apixaban when compared with warfarin in relation to renal function in patients with atrial fibrillation: Insights from the ARISTOTLE trial
    • Hohnloser SH, Hijazi Z, Thomas L, et al. Efficacy of apixaban when compared with warfarin in relation to renal function in patients with atrial fibrillation: insights from the ARISTOTLE trial. Eur Heart J. 2012 ; 33: 2821-2830
    • (2012) Eur Heart J , vol.33 , pp. 2821-2830
    • Hohnloser, S.H.1    Hijazi, Z.2    Thomas, L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.