BIG3 inhibits insulin granule biogenesis and insulin secretion

EMBO Reports

Volumn 15, Issue 6, 2014, Pages 714-722

  Li, Hongyu ^a,b   Wei, Shunhui ^b   Cheng, Kenneth ^c,d   Gounko, Natalia V ^a,e   Ericksen, Russell E ^b   Xu, Aimin ^c,d   Hong, Wanjin ^a   Han, Weiping ^b  

^a INSTITUTE OF MOLECULAR AND CELL BIOLOGY   (Singapore)

^b AGENCY FOR SCIENCE   (Singapore)

^c UNIVERSITY OF HONG KONG   (Hong Kong)

^d UNIVERSITY OF HONG KONG   (Hong Kong)

^e AGENCY FOR SCIENCE   (Singapore)

Author keywords

insulin granule biogenesis; insulin resistance; insulin secretion; metabolism; proinsulin processing

Indexed keywords

BIG3 PROTEIN; CHROMOGRANIN A; INSULIN; PROINSULIN; PROTEIN; UNCLASSIFIED DRUG; GLUCOSE; WDR5 PROTEIN, MOUSE;

ANIMAL TISSUE; ARTICLE; BIOGENESIS; CONTROLLED STUDY; GLUCOSE HOMEOSTASIS; HYPERGLYCEMIA; HYPERINSULINEMIA; IMPAIRED GLUCOSE TOLERANCE; INSULIN RELEASE; INSULIN RESISTANCE; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SECRETORY GRANULE; TRANS GOLGI NETWORK; ANIMAL; CHEMISTRY; GENETICS; HOMEOSTASIS; INDIRECT CALORIMETRY; KNOCKOUT MOUSE; METABOLISM; PHYSIOLOGY; SECRETION (PROCESS); SECRETORY VESICLE;

ANIMALS; CALORIMETRY, INDIRECT; GLUCOSE; HOMEOSTASIS; HYPERGLYCEMIA; INSULIN; INSULIN RESISTANCE; INSULIN-SECRETING CELLS; MICE; MICE, KNOCKOUT; PROTEINS; SECRETORY VESICLES; TRANS-GOLGI NETWORK;

EID: 84901783915     PISSN: 1469221X     EISSN: 14693178     Source Type: Journal    
DOI: 10.1002/embr.201338181     Document Type: Article

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