Theophylline inhibits the cough reflex through a novel mechanism of action

Journal of Allergy and Clinical Immunology

Volumn 133, Issue 6, 2014, Pages 1588-1598

  Dubuis, Eric ^a   Wortley, Michael A ^a   Grace, Megan S ^a   Maher, Sarah A ^a   Adcock, John J ^a   Birrell, Mark A ^a   Belvisi, Maria G ^a  

^a NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

Author keywords

capsaicin; cough; ion channels; Sensory nerves; vagus

Indexed keywords

ANTITUSSIVE AGENT; CALCIUM ACTIVATED POTASSIUM CHANNEL; CAPSAICIN; THEOPHYLLINE; CIGARETTE SMOKE; POTASSIUM CHANNEL BLOCKING AGENT;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTITUSSIVE ACTIVITY; ARTICLE; ASTHMA; CALCIUM TRANSPORT; CHANNEL GATING; CHRONIC OBSTRUCTIVE LUNG DISEASE; CONTROLLED STUDY; COUGH REFLEX; COUGHING; DEPOLARIZATION; DRUG ACTIVITY; DRUG MECHANISM; EXPERIMENTAL MODEL; HUMAN; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; MALE; NERVE CELL; NERVE EXCITABILITY; NONHUMAN; PATCH CLAMP TECHNIQUE; PRIORITY JOURNAL; SENSORY NERVE; SMOKE; VAGUS NERVE; ANIMAL CELL; ANIMAL MODEL; FIBER; GUINEA PIG MODEL; MEMBRANE STEADY POTENTIAL; REFLEX; SENSORY NERVE CELL; SENSORY NERVE CONDUCTION;

CAPSAICIN; COUGH; ION CHANNELS; SENSORY NERVES; VAGUS;

ACTION POTENTIALS; ANIMALS; ANTITUSSIVE AGENTS; CALCIUM; CAPSAICIN; COUGH; DISEASE MODELS, ANIMAL; GANGLIA, SENSORY; GUINEA PIGS; HUMANS; INTERMEDIATE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS; MALE; NERVE FIBERS, UNMYELINATED; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS, CALCIUM-ACTIVATED; REFLEX; SENSORY RECEPTOR CELLS; SMALL-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS; THEOPHYLLINE; VAGUS NERVE;

EID: 84901776488     PISSN: 00916749     EISSN: 10976825     Source Type: Journal    
DOI: 10.1016/j.jaci.2013.11.017     Document Type: Article

References (51)

1. P.J. Barnes Theophylline Am J Respir Crit Care Med 188 2013 901 906
2. P.J. Barnes, and R.A. Pauwels Theophylline in asthma: time for reappraisal? Eur Respir J 7 1994 579 591
3. S.V. Culpitt, C. de Matos, R.E. Russell, L.E. Donnelly, D.F. Rogers, and P.J. Barnes Effect of theophylline on induced sputum inflammatory indices and neutrophil chemotaxis in COPD Am J Respir Crit Care Med 165 2002 1371 1376 (Pubitemid 34522939)
4. S. Lim, K. Tomita, G. Carramori, A. Jatakanon, B. Oliver, and A. Keller et al. Low-dose theophylline reduces eosinophilic inflammation but not exhaled nitric oxide in mild asthma Am J Respir Crit Care Med 164 2001 273 276 (Pubitemid 34001294)
5. J. Mokry, G. Nosalova, and D. Mokra Influence of xanthine derivatives on cough and airway reactivity in guinea pigs J Physiol Pharmacol 60 2008 87 91
6. O.S. Usmani, M.G. Belvisi, and H.J. Patel Theobromine inhibits sensory nerve activation and cough FASEB J 19 2005 231 233 (Pubitemid 40189265)
7. B. Bose, J.I. Cater, and R.A. Clark A once daily theophylline preparation in prevention of nocturnal symptoms in childhood asthma Eur J Pediatr 146 1987 524 527 (Pubitemid 18053160)
8. R.S. Irvin, M.H. Baumann, D.C. Bolser, L.-P. Boulet, S.S. Braman, and C.E. Brightling Diagnosis and management of cough executive summary: ACCP evidence based clinical practice guidelines Chest 129 Suppl 2006 1S 23S (Pubitemid 43265198)
9. M. Cazzola, M.G. Matera, G. Liccardi, F. De Prisco, G. D'Amato, and F. Rossi Theophylline in the inhibition of angiotensin-converting enzyme inhibitor-induced cough Respiration 60 1993 212 215 (Pubitemid 23323758)
10. J.G. Widdicombe Neurophysiology of the cough reflex Eur Respir J 8 1995 1193 1202
11. D.K. Cherry, C.W. Burt, and D.A. Woodwell National ambulatory medical care survey: 2001 summary Adv Data 337 2003 1 44
12. F. O'Connell, V.E. Thomas, N.B. Pride, and R.W. Fuller Capsaicin cough sensitivity decreases with successful treatment of chronic cough Am J Respir Crit Care Med 150 1994 374 380 (Pubitemid 24252346)
13. R.A. Haque, O.S. Usmani, and P.J. Barnes Chronic idiopathic cough: A discrete clinical entity? Chest 127 2005 1710 1713 (Pubitemid 46218799)
14. M.D. Kogan, G.R. Alexander, M. Kotelchuck, D.A. Nagey, and B.W. Jack Over-the-counter medication use among US preschool-age children JAMA 272 1994 1025 1030 (Pubitemid 24294653)
15. K. Schroeder, and T. Fahey Systematic review of randomised controlled trials of over the counter cough medicines for acute cough in adults BMJ 324 2002 329 331 (Pubitemid 34142752)
16. M.A. Birrell, M.G. Belvisi, M. Grace, L. Sadofsky, S. Faruqi, and D.J. Hele et al. TRPA1 agonists evoke coughing in guinea pig and human volunteers Am J Respir Crit Care Med 180 2009 1042 1047
17. S.A. Maher, M.A. Birrell, and M.G. Belvisi Prostaglandin E2 mediates cough via the EP3 receptor: implications for future disease therapy Am J Respir Crit Care Med 180 2009 923 928
18. J.J. Adcock, G.J. Douglas, M. Garabette, M. Gascoigne, G. Beatch, and M. Walker et al. RSD931, a novel anti-tussive agent acting on airway sensory nerves Br J Pharmacol 138 2003 407 416 (Pubitemid 36269481)
19. M.G. Belvisi, H.J. Patel, V. Freund-Michel, D.J. Hele, N. Crispino, and M.A. Birrell Inhibitory activity of the novel CB2 receptor agonist, GW833972A, on guinea-pig and human sensory nerve function in the airways Br J Pharmacol 155 2008 547 557
20. M.A. Birrell, N. Crispino, D.J. Hele, H.J. Patel, M.H. Yacoub, and P.J. Barnes et al. Effect of dopamine receptor agonists on sensory nerve activity: possible therapeutic targets for the treatment of asthma and COPD Br J Pharmacol 136 2002 620 628 (Pubitemid 34717707)
21. 2 and bradykinin Thorax 67 2012 891 900
22. S. Eltom, C.S. Stevenson, J. Rastrick, N. Dale, K. Raemdonck, and S. Wong et al. P2X7 receptor and caspase 1 activation are central to airway inflammation observed after exposure to tobacco smoke PLoS One 6 2011 e24097
23. V.C. Freund-Michel, M.A. Birrell, M.A. Giembycz, D.J. Hele, S. Haj-Yahia, and M.G. Belvisi Beta(2)-agonists block tussive responses in guinea pigs via an atypical cAMP-dependent pathway Eur Respir J 35 2010 647 654
24. R.L. ZuWallack, D.A. Mahler, D. Reilly, N. Church, A. Emmett, and K. Rickard et al. Salmeterol plus theophylline combination therapy in the treatment of COPD Chest 119 2001 1661 1670 (Pubitemid 32744919)
25. F.S. Ram, P.W. Jones, A.A. Castro, J.A. De Brito, A.N. Atallah, and Y. Lacasse et al. Oral theophylline for chronic obstructive pulmonary disease Cochrane Database Syst Rev 4 2002 CD003902
26. D.K. Kirsten, R.E. Wegner, R.A. Jorres, and H. Magnussen Effects of theophylline withdrawal in severe chronic obstructive pulmonary disease Chest 104 1993 1101 1107 (Pubitemid 23306061)
27. V. Saano, E. Minker, S. Joki, P. Virta, J. Nuutinen, and D. Korbonits Influence of chinoin-170, a novel antitussive, on the mucociliary activity in respiratory airways of rats, rabbits, guinea-pigs and man J Pharm Pharmacol 45 1993 799 802 (Pubitemid 23272542)
28. E.G. Mikus, J. Revesz, E. Minker, D. Korbonits, V. Saano, and M. Pascal et al. Experimental studies on the antitussive properties of the new xanthine derivative 1H-purine-2,6-dione, 3,7-dihydro-3-methyl-7[(5-methyl-1,2,4- oxadiazol-3-yl)methyl]. 1st communication: in vivo demonstration of the effects on animal models of cough and of mucociliary clearance Arzneimittelforschung 47 1997 395 400 (Pubitemid 27207311)
29. E.A. Laude, K.S. Higgins, and A.H. Morice A comparative study of the effects of citric acid, capsaicin and resiniferatoxin on the cough challenge in guinea-pig and man Pulm Pharmacol 6 1993 171 175 (Pubitemid 23270144)
30. C.A. Smith, D.L. Adamson, N.B. Choudry, and R.W. Fuller The effect of altering airway tone on the sensitivity of the cough reflex in normal volunteers Eur Respir J 4 1991 1078 1079
31. H.J. Patel, M.A. Birrell, N. Crispino, D.J. Hele, P. Venkatesan, and P.J. Barnes et al. Inhibition of guinea-pig and human sensory nerve activity and the cough reflex in guinea-pigs by cannabinoid (CB2) receptor activation Br J Pharmacol 140 2003 261 268 (Pubitemid 37249185)
32. J. Mokry, D. Mokra, G. Nosalova, M. Beharkova, and Z. Feherova Influence of selective inhibitors of phosphodiesterase 3 and 4 on cough and airway reactivity J Physiol Pharmacol 59 Suppl 6 2008 473 482
33. J. Mokry, and G. Nosalova The influence of the PDE inhibitors on cough reflex in guinea pigs Bratisl Lek Listy 112 2011 131 135
34. H.J. Lü, Z.M. Qiu, W.L. Wei, L. Yu, R.L. Liu, and M. Zhang Effects of phosphodiesterase 4 inhibitor on cough response in guinea pigs sensitized and challenged with ovalbumin Chin Med J (Engl) 117 2004 1620 1624 (Pubitemid 39619235)
35. J. Mokry, M. Joskova, D. Mokra, I. Christensen, and G. Nosalova Effects of selective inhibition of PDE4 and PDE7 on airway reactivity and cough in healthy and ovalbumin-sensitized guinea pigs Adv Exp Med Biol 56 2013 57 64
36. M. Fujimura, and Q. Liu Selective inhibitors for phosphodiesterase 3 and 4 in antigen-induced increase of cough reflex sensitivity in guinea pigs Pulm Pharmacol Ther 20 2007 543 548 (Pubitemid 47077645)
37. C. Schudt, S. Winder, B. Müller, and D. Ukena Zardaverine as a selective inhibitor of phosphodiesterase isozyme Biochem Pharmacol 42 1991 153 162
38. J. Cortijo, J. Bou, J. Beleta, I. Cardelús, J. Llenas, and E. Morcillo et al. Investigation into the role of phosphodiesterase IV in bronchorelaxation, including studies with human bronchus Br J Pharmacol 108 1993 562 568 (Pubitemid 23032571)
39. A. Hatzelmann, H. Tenor, and C. Schudt Differential effects of non-selective and selective phosphodiesterase inhibitors on human eosinophil functions Br J Pharmacol 114 1995 821 831
40. B. Chuaychoo, M.G. Lee, M. Kollarik, R. Pullmann Jr., and B.J. Undem Evidence for both adenosine A1 and A2A receptors activating single vagal sensory C-fibres in guinea pig lungs J Physiol 575 2006 481 490 (Pubitemid 44270176)
41. E.S. Faber, and P. Sah Calcium-activated potassium channels: multiple contributions to neuronal function Neuroscientist 9 2003 181 194 (Pubitemid 36605447)
42. M.K. Boettger, S. Till, M.X. Chen, U. Anand, W.R. Otto, and C. Plumpton et al. Calcium-activated potassium channel SK1- and IK1-like immunoreactivity in injured human sensory neurones and its regulation by neurotrophic factors Brain 125 2002 252 263 (Pubitemid 34127428)
43. R.L. Schroder, B.S. Jensen, D. Strobaek, S.P. Olesen, and P. Christophersen Activation of the human, intermediate-conductance, Ca2+-activated K+ channel by methylxanthines Pflugers Arch 440 2000 809 818
44. J. Cui, D.H. Cox, and R.W. Aldrich Intrinsic voltage dependence and Ca2+ regulation of mslo large conductance Ca-activated K+ channels J Gen Physiol 109 1997 647 673 (Pubitemid 27212383)
45. S. Dai, D.D. Hall, and J.W. Hell Supramolecular assemblies and localized regulation of voltage-gated ion channels Physiol Rev 89 2009 411 452
46. K.L. Weatherall, S.J. Goodchild, D.E. Jane, and N.V. Marrion Small conductance calcium-activated potassium channels: from structure to function Prog Neurobiol 91 2010 242 255
47. A.C. Riegel, and J.T. Williams CRF facilitates calcium release from intracellular stores in midbrain dopamine neurons Neuron 57 2008 559 570 (Pubitemid 351273995)
48. A.C. Gerlach, N.N. Gangopadhyay, and D.C. Devor Kinase-dependent regulation of the intermediate conductance, calcium-dependent potassium channel, hIK1 J Biol Chem 275 2000 585 598 (Pubitemid 30039022)
49. A.C. Gerlach, C.A. Syme, L.A. Giltinan, J.P. Adelman, and D.C. Devor ATP-dependent activation of the intermediate conductance, Ca2+-activated K+ channel, hIK1, is conferred by a C-terminal domain J Biol Chem 276 2001 10963 10970 (Pubitemid 38089275)
50. F.X. Blanc, P. Macedo, M. Hew, and K.F. Chung Capsaicin cough sensitivity in smokers with and without airflow obstruction Respir Med 103 2009 786 790
51. M.J. Doherty, R. Mister, M.G. Pearson, and P.M. Calverley Capsaicin responsiveness and cough in asthma and chronic obstructive pulmonary disease Thorax 55 2000 643 649 (Pubitemid 30468218)