Vitamin D receptor agonists: Suitable candidates as novel therapeutic options in autoimmune inflammatory myopathy

BioMed Research International

Volumn 2014, Issue , 2014, Pages

  Crescioli, Clara ^a  

^a UNIVERSITY OF ROME FORO ITALICO   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA CHEMOKINE; CELL SURFACE RECEPTOR; CHEMOKINE RECEPTOR CXCR3; GAMMA INTERFERON; GAMMA INTERFERON INDUCIBLE PROTEIN 10; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 12P40; INTERLEUKIN 15; INTERLEUKIN 17; INTERLEUKIN 17F; INTERLEUKIN 2; INTERLEUKIN 22; INTERLEUKIN 4; INTERLEUKIN 6; INTERLEUKIN 8; MITOGEN ACTIVATED PROTEIN KINASE; MONOCYTE CHEMOTACTIC PROTEIN 1; PROTEIN C JUN; RANTES; TRANSCRIPTION FACTOR NFAT; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; VITAMIN D RECEPTOR; VITAMIN D RECEPTOR AGONIST; CALCITRIOL RECEPTOR;

ADAPTIVE IMMUNITY; ANTIINFLAMMATORY ACTIVITY; AUTOIMMUNE DISEASE; CELL VIABILITY; CYTOKINE PRODUCTION; DERMATOMYOSITIS; ENZYME PHOSPHORYLATION; HUMAN; IMMUNOCOMPETENCE; IMMUNOSUPPRESSIVE TREATMENT; INCLUSION BODY MYOSITIS; INNATE IMMUNITY; MEMORY T LYMPHOCYTE; MUSCLE FUNCTION; MYOSITIS; NONHUMAN; PROTEIN EXPRESSION; PROTEIN TARGETING; REVIEW; SKELETAL MUSCLE; TH1 CELL; TH2 CELL; VITAMIN SUPPLEMENTATION; AGONISTS; ANIMAL; AUTOIMMUNE DISEASES; BIOLOGICAL MODEL; IMMUNOLOGICAL TOLERANCE; IMMUNOLOGY; METABOLISM; PATHOLOGY;

ANIMALS; AUTOIMMUNE DISEASES; HUMANS; IMMUNE TOLERANCE; MODELS, IMMUNOLOGICAL; MUSCLE, SKELETAL; MYOSITIS; RECEPTORS, CALCITRIOL;

EID: 84901771020     PISSN: 23146133     EISSN: 23146141     Source Type: Journal    
DOI: 10.1155/2014/949730     Document Type: Review

References (129)

1. Girgis C. M., Clifton-Bligh R. J., Hamrick M. W., Holick M. F., Gunton J. E., The roles of vitamin D in skeletal muscle: form, function, and metabolism. Endocrine Review 2013 34 33 83
2. Ceglia L., Vitamin D and its role in skeletal muscle. Current Opinion in Clinical Nutrition and Metabolic Care 2009 12 6 628 633 2-s2.0-70350133616 10.1097/MCO.0b013e328331c707
3. Giovannucci E., Expanding roles of vitamin D. The Journal of Clinical Endocrinology and Metabolism 2009 94 2 418 420 2-s2.0-59749097195 10.1210/jc.2008-2695
4. Pfeifer M., Begerow B., Minne H. W., Suppan K., Fahrleitner-Pammer A., Dobnig H., Effects of a long-term vitamin D and calcium supplementation on falls and parameters of muscle function in community-dwelling older individuals. Osteoporosis International 2009 20 2 315 322 2-s2.0-58149473095 10.1007/s00198-008-0662-7
5. Flicker L., MacInnis R. J., Stein M. S., Scherer S. C., Mead K. E., Nowson C. A., Thomas J., Lowndes C., Hopper J. L., Wark J. D., Should older people in residential care receive vitamin D to prevent falls? Results of a randomized trial. Journal of the American Geriatrics Society 2005 53 11 1881 1888 2-s2.0-29244461700 10.1111/j.1532-5415.2005.00468.x (Pubitemid 41826064)
6. Bischoff-Ferrari H. A., Dawson-Hughes B., Willett W. C., Staehelin H. B., Bazemore M. G., Zee R. Y., Wong J. B., Effect of vitamin D on falls: a meta-analysis. The Journal of the American Medical Association 2004 291 16 1999 2006 2-s2.0-2142713080 10.1001/jama.291.16.1999 (Pubitemid 38544282)
7. Burne T. H. J., McGrath J. J., Eyles D. W., Mackay-Sim A., Behavioural characterization of vitamin D receptor knockout mice. Behavioural Brain Research 2005 157 2 299 308 2-s2.0-11444253492 10.1016/j.bbr.2004.07.008 (Pubitemid 40082573)
8. Endo I., Inoue D., Mitsui T., Umaki Y., Akaike M., Yoshizawa T., Kato S., Matsumoto T., Deletion of vitamin D receptor gene in mice results in abnormal skeletal muscle development with deregulated expression of myoregulatory transcription factors. Endocrinology 2003 144 12 5138 5144 2-s2.0-0344943235 10.1210/en.2003-0502 (Pubitemid 37476038)
9. Li Y. C., Pirro A. E., Amling M., Delling G., Baron R., Bronson R., Demay M. B., Targeted ablation of the vitamin D receptor: an animal model of vitamin D-dependent rickets type II with alopecia. Proceedings of the National Academy of Sciences of the United States of America 1997 94 18 9831 9835 2-s2.0-0030610422
10. Windelinckx A., de Mars G., Beunen G., Aerssens J., Delecluse C., Lefevre J., Thomis M. A. I., Polymorphisms in the vitamin D receptor gene are associated with muscle strength in men and women. Osteoporosis International 2007 18 9 1235 1242 2-s2.0-34548120652 10.1007/s00198-007-0374-4 (Pubitemid 47300281)
11. Girgis C. M., Clifton-Bligh R. J., Mokbel N., Cheng K., Gunton J. E., Vitamin D signaling regulates proliferation, differentiation and myotube size in C2C12 skeletal muscle cells. Endocrinology 2014 155 347 357
12. Prineas J. W., Mason A. S., Henson R. A., Myopathy in metabolic bone disease. British Medical Journal 1965 1 1034 1036
13. Dalakas M. C., Immunotherapy of myositis: issues, concerns and future prospects. Nature Reviews Rheumatology 2010 6 3 129 137 2-s2.0-77949269483 10.1038/nrrheum.2010.2
14. Miller F. W., New approaches to the assessment and treatment of the idiopathic inflammatory myopathies. Annals of the Rheumatic Diseases 2012 71 2 i82 i85 2-s2.0-84859506374 10.1136/annrheumdis-2011-200587
15. Ernste F. C., Reed A. M., Idiopathic inflammatory myopathies: current trends in pathogenesis, clinical features, and up-to-date treatment recommendations. Mayo Clinical Proceeding 2013 88 83 105
16. Hamilton B., Vitamin D and human skeletal muscle. Scandinavian Journal of Medicine and Science in Sports 2010 20 2 182 190 2-s2.0-77951661110 10.1111/j.1600-0838.2009.01016.x
17. Bouillon R., Bischoff-Ferrari H., Willett W., Vitamin D and health: perspectives from mice and man. Journal of Bone and Mineral Research 2008 23 7 974 979 2-s2.0-46249092610 10.1359/jbmr.080420 (Pubitemid 351915717)
18. Glueck C. J., Conrad B., Severe vitamin D deficiency, myopathy and rhabdomyolysis. North American Journal of Medical Sciences 2013 5 494 495
19. Arnson Y., Amital H., Shoenfeld Y., Vitamin D and autoimmunity: new aetiological and therapeutic considerations. Annals of the Rheumatic Diseases 2007 66 9 1137 1142 2-s2.0-34548150136 10.1136/ard.2007.069831 (Pubitemid 47309727)
20. Borgogni E., Sarchielli E., Sottili M., Santarlasci V., Cosmi L., Gelmini S., Lombardi A., Cantini G., Perigli G., Luconi M., Vannelli G. B., Annunziato F., Adorini L., Serio M., Crescioli C., Elocalcitol inhibits inflammatory responses in human thyroid cells and T cells. Endocrinology 2008 149 7 3626 3634 2-s2.0-46349105011 10.1210/en.2008-0078 (Pubitemid 351919622)
21. Sottili M., Cosmi L., Borgogni E., Sarchielli E., Maggi L., Francalanci M., Vannelli G. B., Ronconi E., Adorini L., Annunziato F., Romagnani P., Serio M., Crescioli C., Immunomodulatory effects of BXL-01-0029, a less hypercalcemic vitamin D analogue, in human cardiomyocytes and T cells. Experimental Cell Research 2009 315 2 264 273 2-s2.0-57749205602 10.1016/j.yexcr.2008.10.025
22. Dalakas M. C., Medical progress: polymyositis, dermatomyositis, and inclusion-body myositis. The New England Journal of Medicine 1991 325 21 1487 1498 2-s2.0-0026429550
23. Dalakas M. C., Pathophysiology of inflammatory and autoimmune myopathies. Presse Medicale 2011 40 4 e237 e247 2-s2.0-79953768705 10.1016/j.lpm.2011.01. 005
24. Mantegazza R., Bernasconi P., Confalonieri P., Cornelio F., Inflammatory myopathies and systemic disorders: a review of immunopathogenetic mechanisms and clinical features. Journal of Neurology 1997 244 5 277 287 2-s2.0-0030976227 10.1007/s004150050087 (Pubitemid 27212239)
25. Grundtman C., Malmström V., Lundberg I. E., Immune mechanisms in the pathogenesis of idiopathic inflammatory myopathies. Arthritis Research and Therapy 2007 9 2, article 208 2-s2.0-34748918923 10.1186/ar2139 (Pubitemid 47471314)
26. Arahata K., Engel A. G., Monoclonal antibody analysis of mononuclear cells in myopathies. I: quantitation of subsets according to diagnosis and sites of accumulation and demonstration and counts of muscle fibers invaded by T cells. Annals of Neurology 1984 16 2 193 208 2-s2.0-0021176654 (Pubitemid 14062666)
27. Engel A. G., Arahata K., Emslie-Smith A., Immune effector mechanisms in inflammatory myopathies. Research Publications-Association for Research in Nervous and Mental Disease 1990 68 141 157 2-s2.0-0025105445
28. de Paepe B., Creus K. K., de Bleecker J. L., Role of cytokines and chemokines in idiopathic inflammatory myopathies. Current Opinion in Rheumatology 2009 21 6 610 616 2-s2.0-70349789681 10.1097/BOR.0b013e3283317b31
29. Nagaraju K., Update on immunopathogenesis in inflammatory myopathies. Current Opinion in Rheumatology 2001 13 6 461 468 2-s2.0-0035171361 10.1097/00002281-200111000-00002 (Pubitemid 33070961)
30. Choi J.-H., Park Y.-E., Kim S.-I., Kim J.-I., Lee C.-H., Park K.-H., Kim D.-S., Differential Immunohistological features of inflammatory myopathies and dysferlinopathy. Journal of Korean Medical Science 2009 24 6 1015 1023 2-s2.0-75349083088 10.3346/jkms.2009.24.6.1015
31. Tournadre A., Miossec P., Chemokines and dendritic cells in inflammatory myopathies. Annals of the Rheumatic Diseases 2009 68 3 300 304 2-s2.0-61449245620 10.1136/ard.2008.095984
32. Dalakas M. C., Hohlfeld R., Polymyositis and dermatomyositis. The Lancet 2003 362 9388 971 982 2-s2.0-0141651951 10.1016/S0140-6736(03)14368-1 (Pubitemid 37159295)
33. Hohlfeld R., Engel A. G., Goebels N., Behrens L., Cellular immune mechanisms in inflammatory myopathies. Current Opinion in Rheumatology 1997 9 6 520 526 2-s2.0-0030834477 (Pubitemid 27504209)
34. Rayavarapu S., Coley W., Kinder T. B., Nagaraju K., Idiopathic inflammatory myopathies: pathogenic mechanisms of muscle weakness. Skeletal Muscle 2013 3, article 13 10.1186/2044-5040-3-13
35. Brunn A., Zornbach K., Hans V. H., Haupt W. F., Deckert M., Toll-like receptors promote inflammation in idiopathic inflammatory myopathies. Journal of Neuropathology and Experimental Neurology 2012 3 855 867
36. Lundberg I., Brengman J. M., Engel A. G., Analysis of cytokine expression in muscle in inflammatory myopathies, Duchenne dystrophy, and non-weak controls. Journal of Neuroimmunology 1995 63 1 9 16 2-s2.0-0028807858 10.1016/0165-5728(95)00122-0
37. de Paepe B., Creus K. K., de Bleecker J. L., Chemokines in idiopathic inflammatory myopathies. Frontiers in Bioscience 2008 13 7 2548 2577 2-s2.0-38449097099 10.2741/2866 (Pubitemid 351599704)
38. Tews D. S., Goebel Cytokine H. H., Expression profile in idiopathic inflammatory myopathies. Journal of Neuropathology & Experimental Neurology 1996 55 342 347 (Pubitemid 26085583)
39. Scolletta S., Colletti M., di Luigi L., Crescioli C., Vitamin D receptor agonists target CXCL10: new therapeutic tools for resolution of inflammation. Mediators of Inflammation 2013 2013 11 10.1155/2013/876319 876319
40. Romagnani P., Crescioli C., CXCL10: a candidate biomarker in transplantation. Clinica Chimica Acta 2012 413 1364 1373 2-s2.0-84857684486 10.1016/j.cca.2012.02.009
41. Nagaraju K., Raben N., Merritt G., Loeffler L., Kirk K., Plotz P., A variety of cytokines and immunologically relevant surface molecules are expressed by normal human skeletal muscle cells under proinflammatory stimuli. Clinical and Experimental Immunology 1998 113 3 407 414 2-s2.0-0031660980 10.1046/j.1365-2249.1998.00664.x (Pubitemid 28410566)
42. Pedersen B. K., Edward F. Adolph Distinguished Lecture: muscle as an endocrine organ: IL-6 and other myokines. The Journal of Applied Physiology 2009 107 4 1006 1014 2-s2.0-70350159156 10.1152/japplphysiol.00734.2009
43. Loell I., Lundberg I. E., Can muscle regeneration fail in chronic inflammation: a weakness in inflammatory myopathies? Journal of Internal Medicine 2011 269 3 243 257 2-s2.0-79951688504 10.1111/j.1365-2796.2010.02334.x
44. DeVries M. E., Hosiawa K. A., Cameron C. M., Bosinger S. E., Persad D., Kelvin A. A., Coombs J. C., Wang H., Zhong R., Cameron M. J., Kelvin D. J., The role of chemokines and chemokine receptors in alloantigen-independent and alloantigen-dependent transplantation injury. Seminars in Immunology 2003 15 1 33 48 2-s2.0-12244250731 10.1016/S1044-5323(02)00126-4 (Pubitemid 36092177)
45. de Rossi M., Bernasconi P., Baggi F., de Waal Malefyt R., Mantegazza R., Cytokines and chemokines are both expressed by human myoblasts: possible relevance for the immune pathogenesis of muscle inflammation. International Immunology 2000 12 9 1329 1335 2-s2.0-0033842592 (Pubitemid 30657777)
46. Raju R., Vasconcelos O. M., Semino-Mora C., Granger R. P., Dalakas M. C., Expression of interferon-gamma inducible chemokines in the muscles of patients with inclusion body myositis. Neurology 2002 58 A390
47. Confalonieri P., Bernasconi P., Megna P., Galbiati S., Cornelio F., Mantegazza R., Increased expression of β -chemokines in muscle of patients with inflammatory myopathies. Journal of Neuropathology and Experimental Neurology 2000 59 2 164 169 2-s2.0-0033970327 (Pubitemid 30106472)
48. Crescioli C., Sottili M., Bonini P., Cosmi L., Chiarugi P., Romagnani P., Vannelli G. B., Colletti M., Isidori A. M., Serio M., Lenzi A., Di Luigi L., Inflammatory response in human skeletal muscle cells: CXCL10 as a potential therapeutic target. European Journal of Cell Biology 2012 91 2 139 149 2-s2.0-84855548726 10.1016/j.ejcb.2011.09.011
49. di Luigi L., Sottili M., Antinozzi C., Vannelli G. B., Romanelli F., Riccieri V., Valesini G., Lenzi A., Crescioli C., The vitamin D receptor agonist BXL-01-0029 as a potential new pharmacological tool for the treatment of inflammatory myopathies. PLoS ONE 2013 8 e77745
50. Luster A. D., Ravetch J. V., Biochemical characterization of a γ interferon-inducible cytokine (IP-10). Journal of Experimental Medicine 1987 166 4 1084 1097 2-s2.0-0023604651 (Pubitemid 18024248)
51. Loetscher M., Gerber B., Loetscher P., Jones S. A., Piali L., Clark-Lewis I., Baggiolini M., Moser B., Chemokine receptor specific for IP10 and Mig: structure, function, and expression in activate T-Lymphocytes. Journal of Experimental Medicine 1996 184 3 963 969 2-s2.0-0029829106
52. Loetscher M., Moetscher P., Brass N., Meese E., Moser B., Lymphocyte-specific chemokine receptor CXCR3: regulation, chemokine binding and gene localization. European Journal of Immunology 1998 28 3696 3705 (Pubitemid 28510780)
53. Qin S., Rottman J. B., Myers P., Kassam N., Weinblatt M., Loetscher M., Koch A. E., Moser B., Mackay C. R., The chemokine receptors CXCR3 and CCR5 mark subsets of T cells associated with certain inflammatory reactions. The Journal of Clinical Investigation 1998 101 4 746 754 2-s2.0-0032519405 (Pubitemid 28096070)
54. Campbell J. D., Gangur V., Simons F. E. R., HayGlass K. T., Allergic humans are hyporesponsive to a CXCR3 ligand-mediated Th1 immunity-promoting loop. The FASEB Journal 2004 18 2 329 331 2-s2.0-1442314709
55. Figarella-Branger D., Civatte M., Bartoli C., Pellissier J.-F., Cytokines, chemokines, and cell adhesion molecules in inflammatory myopathies. Muscle and Nerve 2003 28 6 659 682 2-s2.0-0344875464 10.1002/mus.10462 (Pubitemid 37484828)
56. Frasca L., Nasso M., Spensieri F., Fedele G., Palazzo R., Malavasi F., Ausiello C. M., IFN- γ arms human dendritic cells to perform multiple effector functions. Journal of Immunology 2008 180 3 1471 1481 2-s2.0-40749136284
57. Forsgren S., Renström L., Purdam C., Gaida J. E., TNF-alpha in the locomotor system beyond joints: high degree of involvement in myositis in a rabbit model. International Journal of Rheumatology 2012 2012 11 2-s2.0-84859724492 10.1155/2012/637452 637452
58. Chinoy H., Salway F., John S., Fertig N., Tait B. D., Oddis C. V., Ollier W. E. R., Cooper R. G., Tumour necrosis factor- α single nucleotide polymorphisms are not independent of HLA class I in UK Caucasians with adult onset idiopathic inflammatory myopathies. Rheumatology 2007 46 9 1411 1416 2-s2.0-34548242316 10.1093/rheumatology/kem145 (Pubitemid 47317085)
59. Keller C. W., Fokken C., Turville S. G., Lünemann A., Schmidt J., Münz C., Lünemann J. D., TNF- α induces macroautophagy and regulates MHC class II expression in human skeletal muscle cells. The Journal of Biological Chemistry 2011 286 5 3970 3980 2-s2.0-79952800563 10.1074/jbc.M110.159392
60. Baudy A. R., Saxena N., Gordish H., Hoffman E. P., Nagaraju K., A robust in vitro screening assay to identify NF- B inhibitors for inflammatory muscle diseases. International Immunopharmacology 2009 9 10 1209 1214 2-s2.0-68949175349 10.1016/j.intimp.2009.07.001
61. Sugihara T., Okiyama N., Watanabe N., Miyasaka N., Kohsaka H., Interleukin-1 and tumor necrosis factor α blockade treatment of experimental polymyositis in mice. Arthritis and Reumatism 2012 64 2655 2662
62. Tournadre A., Dubost J.-J., Soubrier M., Treatment of inflammatory muscle disease in adults. Joint Bone Spine 2010 77 5 390 394 2-s2.0-77957877047 10.1016/j.jbspin.2010.04.007
63. Hodgetts S., Radley H., Davies M., Grounds M. D., Reduced necrosis of dystrophic muscle by depletion of host neutrophils, or blocking TNF α function with Etanercept in mdx mice. Neuromuscular Disorders 2006 16 9-10 591 602 2-s2.0-33748519220 10.1016/j.nmd.2006.06.011 (Pubitemid 44374323)
64. Efthimiou P., Tumor necrosis factor- α in inflammatory myopathies: pathophysiology and therapeutic implications. Seminars in Arthritis and Rheumatism 2006 36 3 168 172 2-s2.0-33750622608 10.1016/j.semarthrit.2006.07.003 (Pubitemid 44691885)
65. Dold S., Justiniano M. E., Marquez J., Espinoza L. R., Treatment of early and refractory dermatomyositis with infliximab: a report of two cases. Clinical Rheumatology 2007 26 7 1186 1188 2-s2.0-34249914757 10.1007/s10067-006-0325-z (Pubitemid 46863976)
66. Hehlgans T., Pfeffer K., The intriguing biology of the tumour necrosis factor/tumour necrosis factor receptor superfamily: players, rules and the games. Immunology 2005 115 1 1 20 2-s2.0-17944371991 10.1111/j.1365-2567.2005. 02143.x (Pubitemid 40598088)
67. 35-55-induced experimental autoimmune encephalomyelitis. Cellular Immunology 2000 205 1 24 33 2-s2.0-0034633542 10.1006/cimm.2000.1706
68. Abu-Amer Y., Bar-Shavit Z., Impaired bone marrow-derived macrophage differentiation in vitamin D deficiency. Cellular Immunology 1993 151 2 356 368 2-s2.0-0027368236 10.1006/cimm.1993.1245 (Pubitemid 23325458)
69. 3 by normal human macrophages. Biochemical and Biophysical Research Communications 1985 127 2 596 603 2-s2.0-0022359881 (Pubitemid 16217468)
70. 3 metabolism by lipopolysaccharide-stimulated normal human macrophages. The Journal of Clinical Endocrinology and Metabolism 1987 64 1 1 9 2-s2.0-0023164973 (Pubitemid 17015869)
71. 3 down-regulates intracellular Toll-like receptor 9 expression and Toll-like receptor 9-induced IL-6 production in human monocytes. Rheumatology 2010 49 8 1466 1471 2-s2.0-77954703735 10.1093/rheumatology/keq124
72. 3 down-regulates monocyte TLR expression and triggers hyporesponsiveness to pathogen-associated molecular patterns. European Journal of Immunology 2006 36 2 361 370 2-s2.0-32944464959 10.1002/eji.200425995 (Pubitemid 43257459)
73. 3 receptors in human leukocytes. Science 1983 221 4616 1181 1183 2-s2.0-0020517536 (Pubitemid 13001231)
74. 3 in the immune system. The Journal of Steroid Biochemistry and Molecular Biology 2010 121 1-2 221 227 2-s2.0-77954763264 10.1016/j.jsbmb.2010. 03.037
75. 3 inhibits antigen-induced T cell activation. Journal of Immunology 1984 133 4 1748 1754 2-s2.0-0021213827 (Pubitemid 14035260)
76. 3: preferential inhibition of Th1 functions. The Journal of Nutrition 1995 125 6 1704S 1708S 2-s2.0-0029018309
77. 3 European Journal of Immunology 2000 30 498 508 (Pubitemid 30098842)
78. 3: direct inhibition of NFATp/AP-1 complex formation by a nuclear hormone receptor. Molecular and Cellular Biology 1995 15 10 5789 5799 2-s2.0-0029149894
79. 3-mediated effects. Journal of Immunology 1998 160 1 209 218 2-s2.0-0031883711 (Pubitemid 28116731)
80. 3: a transcriptional modulator of the interferon-gamma gene. European Journal of Immunology 1998 28 3017 3030 (Pubitemid 28470247)
81. 3 is a positive regulator for the two anti- encephalitogenic cytokines TGF- β 1 and IL-4. Journal of Immunology 1998 160 11 5314 5319 2-s2.0-0032103001 (Pubitemid 28267819)
82. Griffin M. D., Xing N., Kumar R., Vitamin D and its analogs as regulators of immune activation and antigen presentation. Annual Review of Nutrition 2003 23 117 145 2-s2.0-0041864252 10.1146/annurev.nutr.23.011702.073114 (Pubitemid 37059719)
83. Li Q., Verma I. M., NF- B regulation in the immune system. Nature Reviews Immunology 2002 2 10 725 734 2-s2.0-0036781052 10.1038/nri910 (Pubitemid 37328713)
84. Hyppönen E., Läärä E., Reunanen A., Järvelin M.-R., Virtanen S. M., Intake of vitamin D and risk of type 1 diabetes: a birth-cohort study. The Lancet 2001 358 9292 1500 1503 2-s2.0-0035802695 10.1016/S0140-6736(01)06580-1 (Pubitemid 33055701)
85. 3 Journal of Neuroimmunology 1995 61 2 151 160 2-s2.0-0028812632 10.1016/0165-5728(95)00076-E
86. Racke M. K., Dhib-Jalbut S., Cannella B., Albert P. S., Raine C. S., McFarlin D. E., Prevention and treatment of chronic relapsing experimental allergic encephalomyelitis by transforming growth factor- β 1. Journal of Immunology 1991 146 9 3012 3017 2-s2.0-0025892475
87. 3 and mycophenolate mofetil treatment mediate transplantation tolerance. Journal of Immunology 2001 167 4 1945 1953 2-s2.0-0035881234 (Pubitemid 32747499)
88. 3 and its analogs: a vitamin D receptor-dependent pathway that promotes a persistent state of immaturity in vitro and in vivo. Proceedings of the National Academy of Sciences of the United States of America 2001 98 12 6800 6805 2-s2.0-0035811015 10.1073/pnas.121172198 (Pubitemid 32538297)
89. Wang J., Nuite M., McAlindon T. E., Association of estrogen and aromatase gene polymorphisms with systemic lupus erythematosus. Lupus 2010 19 6 734 740 2-s2.0-77951232178 10.1177/0961203309359517
90. Souberbielle J.-C., Body J.-J., Lappe J. M., Plebani M., Shoenfeld Y., Wang T. J., Bischoff-Ferrari H. A., Cavalier E., Ebeling P. R., Fardellone P., Gandini S., Gruson D., Guérin A. P., Heickendorff L., Hollis B. W., Ish-Shalom S., Jean G., von Landenberg P., Largura A., Olsson T., Pierrot-Deseilligny C., Pilz S., Tincani A., Valcour A., Zittermann A., Vitamin D and musculoskeletal health, cardiovascular disease, autoimmunity and cancer: recommendations for clinical practice. Autoimmunity Reviews 2010 9 11 709 715 2-s2.0-77956182419 10.1016/j.autrev.2010.06.009
91. 3 modulates Th17 polarization and interleukin-22 expression by memory T cells from patients with early rheumatoid arthritis. Arthritis and Rheumatism 2010 62 1 132 142 2-s2.0-74849095189 10.1002/art.25043
92. + T cells to enhance the development of Th2 cells. Journal of Immunology 2001 167 9 4974 4980 2-s2.0-0035497752 (Pubitemid 33009728)
93. 3: basic concepts. The Journal of Steroid Biochemistry and Molecular Biology 2005 97 1-2 93 101 2-s2.0-27544499686 10.1016/j.jsbmb.2005.06.002 (Pubitemid 41546218)
94. 3-modified regulatory dendritic cells. Clinical and Experimental Immunology 2009 157 1 48 59 2-s2.0-66849106716 10.1111/j.1365-2249.2009.03961.x
95. 3 ameliorates Th17 autoimmunity via transcriptional modulation of interleukin-17A. Molecular and Cellular Biology 2011 31 17 3653 3669 2-s2.0-80052387833 10.1128/MCB.05020-11
96. Khoo A.-L., Chai L. Y. A., Koenen H. J. P. M., Sweep F. C. G. J., Joosten I., Netea M. G., van der Ven A. J. A. M., Regulation of cytokine responses by seasonality of vitamin D status in healthy individuals. Clinical and Experimental Immunology 2011 164 1 72 79 2-s2.0-79952492953 10.1111/j.1365-2249. 2010.04315.x
97. Fritsche J., Mondal K., Ehrnsperger A., Andreesen R., Kreutz M., Regulation of 25-hydroxyvitamin D3-1 alpha-hydroxylase and production of 1 alpha,25-dihydroxyvitamin D3 by human dendritic cells. Blood 2003 102 9 3314 3316 (Pubitemid 37314772)
98. 3 on human B cell differentiation. Journal of Immunology 2007 179 3 1634 1647 2-s2.0-34548637038
99. 3 impairs NF- B activation in human naïve B cells. Biochemical and Biophysical Research Communications 2011 407 4 699 702 2-s2.0-79955015334 10.1016/j.bbrc.2011.03.078
100. Adorini L., Intervention in autoimmunity: the potential of vitamin D receptor agonists. Cellular Immunology 2005 233 2 115 124 2-s2.0-23044479095 10.1016/j.cellimm.2005.04.013 (Pubitemid 41074064)
101. Sagrinati C., Sottili M., Mazzinghi B., Borgogni E., Adorini L., Serio M., Romagnani P., Crescioli C., Comparison between VDR analogs and current immunosuppressive drugs in relation to CXCL10 secretion by human renal tubular cells. Transplant International 2010 23 9 914 923 2-s2.0-77955265207 10.1111/j.1432-2277.2010.01078.x
102. Crescioli C., Cosmi L., Borgogni E., Santarlasci V., Gelmini S., Sottili M., Sarchielli E., Mazzinghi B., Francalanci M., Pezzatini A., Perigli G., Vannelli G. B., Annunziato F., Serio M., Methimazole inhibits CXC chemokine ligand 10 secretion in human thyrocytes. Journal of Endocrinology 2007 195 1 145 155 2-s2.0-35848971017 10.1677/JOE-07-0240 (Pubitemid 350056008)
103. Crescioli C., Squecco R., Cosmi L., Sottili M., Gelmini S., Borgogni E., Sarchielli E., Scolletta S., Francini F., Annunziato F., Vannelli G. B., Serio M., Immunosuppression in cardiac graft rejection: a human in vitro model to study the potential use of new immunomodulatory drugs. Experimental Cell Research 2008 314 6 1337 1350 2-s2.0-40049087871 10.1016/j.yexcr.2007.12.016
104. 3 via the NF- B pathway. The FASEB Journal 2012 26 11 4400 4407 10.1096/fj.12-210880
105. 3 suppresses inflammation-induced expression of plasminogen activator inhibitor-1 by blocking nuclear factor- B activation. Archives of Biochemistry and Biophysics 2011 507 2 241 247 2-s2.0-79951946021 10.1016/j.abb.2010.12.020
106. Temiz P., Weihl C. C., Pestronk A., Inflammatory myopathies with mitochondrial pathology and protein aggregates. Journal of the Neurological Sciences 2009 278 1-2 25 29 2-s2.0-58749094423 10.1016/j.jns.2008.11.010
107. Schröder J. M., Molnar M., Mitochondrial abnormalities and peripheral neuropathy in inflammatory myopathy, especially inclusion body myositis. Molecular and Cellular Biochemistry 1997 174 1-2 277 281 2-s2.0-0030765112 10.1023/A:1006829129079 (Pubitemid 27404203)
108. Miró Ó., Casademont J., Grau J. M., Jarreta D., Urbano-Márquez Á., Cardellach F., Histological and biochemical assessment of mitochondrial function in dermatomyositis. British Journal of Rheumatology 1998 37 10 1047 1053 2-s2.0-0031754856
109. Alhatou M. I., Sladky J. T., Bagasra O., Glass J. D., Mitochondrial abnormalities in dermatomyositis: characteristic pattern of neuropathology. Journal of Molecular Histology 2004 35 6 615 619 2-s2.0-16644368081 10.1007/s10735-004-2194-6 (Pubitemid 41404647)
110. 3 analog enhances regulatory T-cells and arrests autoimmune diabetes in NOD mice. Diabetes 2002 51 5 1367 1374 2-s2.0-0036020679 (Pubitemid 34826601)
111. Szodoray P., Alex P., Knowlton N., Centola M., Dozmorov I., Csipo I., Nagy A. T., Constantin T., Ponyi A., Nakken B., Danko K., Idiopathic inflammatory myopathies, signified by distinctive peripheral cytokines, chemokines and the TNF family members B-cell activating factor and a proliferation inducing ligand. Rheumatology 2010 49 10 1867 1877 2-s2.0-77956857329 10.1093/rheumatology/keq151
112. Wang Y., DeLuca H. F., Is the vitamin D receptor found in muscle? Endocrinology 2011 152 2 354 363 2-s2.0-79951646427 10.1210/en.2010-1109
113. 3 receptor in human skeletal muscle tissue. Histochemical Journal 2001 33 1 19 24 2-s2.0-0035061672 10.1023/A:1017535728844 (Pubitemid 32368054)
114. 3 -dependent non-genomic activation of MAPKs, Src and Akt in skeletal muscle cells. Journal of Steroid Biochemistry & Molecular Biology 2013 136 125 130
115. Boland R. L., VDR activation of intracellular signaling pathways in skeletal muscle. Molecular and Cellular Endocrinology 2011 347 1-2 11 16 2-s2.0-82455162445 10.1016/j.mce.2011.05.021
116. 3-MARRS receptor: multiple functional roles in diverse cell systems. Current Medicinal Chemistry 2007 14 10 1087 1093 2-s2.0-34247555889 10.2174/092986707780362871 (Pubitemid 46672627)
117. Menaker R. J., Ceponis P. J. M., Jones N. L., Helicobacter pylori induces apoptosis of macrophages in association with alterations in the mitochondrial pathway. Infection and Immunity 2004 72 5 2889 2898 2-s2.0-2142660753 10.1128/IAI.72.5.2889-2898.2004 (Pubitemid 38542419)
118. Mercer S. E., Ewton D. Z., Deng X., Lim S., Mazur T. R., Friedman E., Mirk/Dyrk1B mediates survival during the differentiation of C2C12 myoblasts. The Journal of Biological Chemistry 2005 280 27 25788 25801 2-s2.0-21844468764 10.1074/jbc.M413594200 (Pubitemid 40962289)
119. Girgis C. M., Clifton-Bligh R. J., Turner N., Lau S. L., Gunton J. E., Effects of vitamin D in skeletal muscle: falls, strength, athletic performance and insulin sensitivity. Clinical Endocrinology 2014 80 169 181
120. Stempfle H.-U., Werner C., Siebert U., Assum T., Wehr U., Rambeck W. A., Meiser B., Theisen K., Gartner R., The role of tacrolimus (FK506)-based immunosuppression on bone mineral density and bone turnover after cardiac transplantation: a prospective, longitudinal, randomized, double-blind trial with calcitriol. Transplantation 2002 73 4 547 552 2-s2.0-0037181121 (Pubitemid 34193613)
121. 3 prolongs graft survival without compromising host resistance to infection or bone mineral density. Transplantation 1998 66 7 828 831 2-s2.0-0032532198 10.1097/00007890-199810150-00003 (Pubitemid 28487453)
122. Picotto G., Liaudat A. C., Bohl L., Talamoni N. T., Molecular aspects of vitamin D anticancer activity. Cancer Investigation 2012 30 604 614
123. Scott L. J., Dunn C. J., Goa K. L., Calcipotriol ointment: a review of its use in the management of psoriasis. American Journal of Clinical Dermatology 2001 2 2 95 120 2-s2.0-0034959697 (Pubitemid 32592528)
124. 3: a helpful immuno-modulator. Immunology 2011 134 2 123 139 2-s2.0-80052458571 10.1111/j.1365-2567.2011.03482.x
125. Endres D. B., Investigation of hypercalcemia. Clinical Biochemistry 2012 45 954 963
126. Takahashi T., Morikawa K., Vitamin D receptor agonists: opportunities and challenges in drug discovery. Current Topics in Medicinal Chemistry 2006 6 12 1303 1316 2-s2.0-33746339987 10.2174/156802606777864917 (Pubitemid 44110919)
127. Steddon S. J., Schroeder N. J., Cunningham J., Vitamin D analogues: how do they differ and what is their clinical role? Nephrology Dialysis Transplantation 2001 16 10 1965 1967 2-s2.0-0034786319 (Pubitemid 32970551)
128. Zhu G. D., Vitamin D analogs currently on the market and in development. Why Does Vitamin D Matter? 2013 26 Bentham Science Publisher 57 82
129. Feldman D., Wesley Pike J., Adams J. S., Vitamin D 2011 3rd London, UK Academic Press