Paeoniflorin suppress NF-κB activation through modulation of IκBα and enhances 5-fluorouracil-induced apoptosis in human gastric carcinoma cells

Biomedicine and Pharmacotherapy

Volumn 62, Issue 9, 2008, Pages 659-666

  Wu, Hao ^a   Li, Wei ^a   Wang, Tongshan ^a   Shu, Yongqian ^a   Liu, Ping ^a  

^a NANJING MEDICAL UNIVERSITY   (China)

Author keywords

Apoptosis; Gastric carcinoma cells; I B ; NF B; Paeoniflorin

Indexed keywords

FLUOROURACIL; I KAPPA B ALPHA; I KAPPA B KINASE ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PAEONIFLORIN;

APOPTOSIS; ARTICLE; CARCINOMA CELL; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; STOMACH CARCINOMA;

ACTIVE TRANSPORT, CELL NUCLEUS; ANTINEOPLASTIC AGENTS; APOPTOSIS; BENZOIC ACIDS; BRIDGED COMPOUNDS; CELL LINE, TUMOR; CELL NUCLEUS; FLUOROURACIL; GLUCOSIDES; HUMANS; I-KAPPA B PROTEINS; NF-KAPPA B; PHOSPHORYLATION; STOMACH NEOPLASMS;

EID: 54049146611     PISSN: 07533322     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biopha.2008.08.002     Document Type: Article

References (35)

1. Nizamutdinova I.T., Jin Y.C., Kim J.S., Yean M.H., Kang S.S., Kim Y.S., et al. Paeonol and paeoniflorin, the main active principles of Paeonia albiflora, protect the heart from myocardial ischemia/reperfusion injury in rats. Planta Med 74 1 (2008) 14-18
2. Zheng Y.Q., Wei W., Zhu L., and Liu J.X. Effects and mechanisms of paeoniflorin, a bioactive glucoside from paeony root, on adjuvant arthritis in rats. Inflamm Res 56 5 (2007) 182-188
3. Liu D.F., Wei W., and Song L.H. Protective effect of paeoniflorin on immunological liver injury induced by bacillus Calmette-Guerin plus lipopolysaccharide: modulation of tumour necrosis factor-alpha and interleukin-6 MRNA. Clin Exp Pharmacol Physiol 33 4 (2006) 332-339
4. Liu J., Jin D.Z., Xiao L., and Zhu X.Z. Paeoniflorin attenuates chronic cerebral hypoperfusion-induced learning dysfunction and brain damage in rats. Brain Res 1089 1 (2006) 162-170
5. Sun R., Lv L.L., and Liu G.Q. Effects of paeoniflorin on cerebral energy metabolism, nitric oxide and nitric oxide synthase after cerebral ischemia in Mongolia gerbils. Zhongguo Zhong Yao Za Zhi 31 10 (2006) 832-835
6. Hung J.Y., Yang C.J., Tsai Y.M., Huang H.W., and Huang M.S. Antiproliferative activity of paeoniflorin is through cell cycle arrest and the Fas/Fas ligand-mediated apoptotic pathway in human non-small cell lung cancer A549 cells. Clin Exp Pharmacol Physiol 35 2 (2008) 141-147
7. Tsuboi H., Hossain K., Akhand A.A., Takeda K., Du J., Rifai M., et al. Paeoniflorin induces apoptosis of lymphocytes through a redox-linked mechanism. J Cell Biochem 93 1 (2004) 162-172
8. Bonizzi G., and Karin M. The two NF-kappaB activation pathways and their role in innate and adaptive immunity. Trends Immunol 25 6 (2004) 280-288
9. Jobin C., and Sartor R.B. The I kappa B/NF-kappa B system: a key determinant of mucosal inflammation and protection. Am J Physiol Cell Physiol 278 3 (2000) C451-C462
10. Senftleben U., Cao Y., Xiao G., Greten F.R., Krähn G., Bonizzi G., et al. Activation by IKKalpha of a second, evolutionary conserved, NF-kappa B signaling pathway. Science 293 5534 (2001) 1495-1499
11. Hayden M.S., and Ghosh S. Signaling to NF-kappaB. Genes Dev 18 18 (2004) 2195-2224
12. Pikarsky E., Porat R.M., Stein I., Abramovitch R., Amit S., Kasem S., et al. NF-kappaB functions as a tumour promoter in inflammation-associated cancer. Nature 431 7007 (2004) 461-466
13. Luo J.L., Maeda S., Hsu L.C., Yagita H., and Karin M. Inhibition of NF-kappaB in cancer cells converts inflammation-induced tumor growth mediated by TNFalpha to TRAIL-mediated tumor regression. Cancer Cell 6 3 (2004) 297-305
14. Xiao W., Hodge D.R., Wang L., Yang X., Zhang X., Farrar W.L., et al. NF-kappaB activates IL-6 expression through cooperation with c-Jun and IL6-AP1 site, but is independent of its IL6-NFkappaB regulatory site in autocrine human multiple myeloma cells. Cancer Biol Ther 3 10 (2004) 1007-1017
15. Sathe S.S., Sizemore N., Li X., Vithalani K., Commane M., Swiatkowski S.M., et al. Mutant human cells with constitutive activation of NF-kappaB. Proc Natl Acad Sci U S A 101 1 (2004) 192-197
16. Li Q., Yu Y.Y., Zhu Z.G., Ji Y.B., Zhang Y., Liu B.Y., et al. Effect of NF-kappaB constitutive activation on proliferation and apoptosis of gastric cancer cell lines. Eur Surg Res 37 2 (2005) 105-110
17. Shishodia S., Potdar P., Gairola C.G., and Aggarwal B.B. Curcumin (diferuloylmethane) down-regulates cigarette smoke-induced NF-kappaB activation through inhibition of IkappaBalpha kinase in human lung epithelial cells: correlation with suppression of COX-2, MMP-9 and cyclin D1. Carcinogenesis 24 7 (2003) 1269-1279
18. Sandur S.K., Ichikawa H., Sethi G., Ahn K.S., and Aggarwal B.B. Plumbagin (5-hydroxy-2-methyl-1,4-naphthoquinone) suppresses NF-kappaB activation and NF-kappaB-regulated gene products through modulation of p65 and IkappaBalpha kinase activation, leading to potentiation of apoptosis induced by cytokine and chemotherapeutic agents. J Biol Chem 281 25 (2006) 17023-17033
19. Morotti A., Cilloni D., Pautasso M., Messa F., Arruga F., Defilippi I., et al. NF-kB inhibition as a strategy to enhance etoposide-induced apoptosis in K562 cell line. Am J Hematol 81 12 (2006) 938-945
20. Haefner B. NF-kappa B: arresting a major culprit in cancer. Drug Discov Today 7 12 (2002) 653-663
21. Viatour P., Merville M.P., Bours V., and Chariot A. Phosphorylation of NF-kappaB and IkappaB proteins: implications in cancer and inflammation. Trends Biochem Sci 30 1 (2005) 43-52
22. Levidou G., Korkolopoulou P., Nikiteas N., Tzanakis N., Thymara I., Saetta A.A., et al. Expression of nuclear factor kappaB in human gastric carcinoma: relationship with I kappaB a and prognostic significance. Virchows Arch 450 5 (2007) 519-527
23. Nakanishi C., and Toi M. Nuclear factor-kappaB inhibitors as sensitizers to anticancer drugs. Nat Rev Cancer 5 4 (2005) 297-309
24. Li L., Aggarwal B.B., Shishodia S., Abbruzzese J., and Kurzrock R. Nuclear factor-kappaB and IkappaB kinase are constitutively active in human pancreatic cells, and their down-regulation by curcumin (diferuloylmethane) is associated with the suppression of proliferation and the induction of apoptosis. Cancer 101 10 (2004) 2351-2362
25. Belguise K., Guo S., Yang S., Rogers A.E., Seldin D.C., Sherr D.H., et al. Green tea polyphenols reverse cooperation between c-Rel and CK2 that induces the aryl hydrocarbon receptor, slug, and an invasive phenotype. Cancer Res 67 24 (2007) 11742-11750
26. Adhami V.M., Afaq F., and Ahmad N. Suppression of ultraviolet B exposure-mediated activation of NF-kappaB in normal human keratinocytes by resveratrol. Neoplasia 5 1 (2003) 74-82
27. Gupta S., Hastak K., Afaq F., Ahmad N., and Mukhtar H. Essential role of caspases in epigallocatechin-3-gallate-mediated inhibition of nuclear factor kappa B and induction of apoptosis. Oncogene 23 14 (2004) 2507-2522
28. Hsieh T.C., Wijeratne E.K., Liang J.Y., Gunatilaka A.L., and Wu J.M. Differential control of growth, cell cycle progression, and expression of NF-kappaB in human breast cancer cells MCF-7, MCF-10A, and MDA-MB-231 by ponicidin and oridonin, diterpenoids from the Chinese herb Rabdosia rubescens. Biochem Biophys Res Commun 337 1 (2005) 224-231
29. Shishodia S., Koul D., and Aggarwal B.B. Cyclooxygenase (COX)-2 inhibitor celecoxib abrogates TNF-induced NF-kappa B activation through inhibition of activation of I kappa B alpha kinase and Akt in human non-small cell lung carcinoma: correlation with suppression of COX-2 synthesis. J Immunol 173 3 (2004) 2011-2022
30. Wen D., Nong Y., Morgan J.G., Gangurde P., Bielecki A., Dasilva J., et al. A selective small molecule IkappaB Kinase beta inhibitor blocks nuclear factor kappaB-mediated inflammatory responses in human fibroblast-like synoviocytes, chondrocytes, and mast cells. J Pharmacol Exp Ther 317 3 (2006) 989-1001
31. Pierce J.W., Schoenleber R., Jesmok G., Best J., Moore S.A., Collins T., et al. Novel inhibitors of cytokine-induced IkappaBalpha phosphorylation and endothelial cell adhesion molecule expression show anti-inflammatory effects in vivo. J Biol Chem 272 34 (1997) 21096-21103
32. Sartore-Bianchi A., Gasparri F., Galvani A., Nici L., Darnowski J.W., Barbone D., et al. Bortezomib inhibits nuclear factor-kappaB dependent survival and has potent in vivo activity in mesothelioma. Clin Cancer Res 13 19 (2007) 5942-5951
33. Ahn K.S., Sethi G., and Aggarwal B.B. Reversal of chemoresistance and enhancement of apoptosis by statins through down-regulation of the NF-kappaB pathway. Biochem Pharmacol 75 4 (2008) 907-913
34. Perona R., and Sánchez-Pérez I. Signalling pathways involved in clinical responses to chemotherapy. Clin Transl Oncol 9 10 (2007) 625-633
35. Tan C., and Waldmann T.A. Proteasome inhibitor PS-341, a potential therapeutic agent for adult T-cell leukemia. Cancer Res 62 4 (2002) 1083-1086