Physico-chemical characterization and stability study of glassy simvastatin

Drug Development and Industrial Pharmacy

Volumn 31, Issue 9, 2005, Pages 895-899

  Ambike, Anshuman A ^a   Mahadik, K R ^a   Paradkar, Anant ^a  

^a BHARATI VIDYAPEETH DEEMED UNIVERSITY   (India)

Author keywords

Amorphous; Enthalpy relaxation; Simvastatin; Stability

Indexed keywords

SIMVASTATIN;

ARTICLE; DIFFERENTIAL SCANNING CALORIMETRY; DRUG STABILITY; DRUG STRUCTURE; ENTHALPY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROGEN BOND; INFRARED SPECTROSCOPY; PHYSICAL CHEMISTRY; X RAY POWDER DIFFRACTION;

ANTICHOLESTEREMIC AGENTS; CALORIMETRY, DIFFERENTIAL SCANNING; CHEMISTRY, PHYSICAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CRYSTALLIZATION; DRUG STABILITY; SIMVASTATIN; SPECTROPHOTOMETRY, INFRARED; THERMODYNAMICS; X-RAY DIFFRACTION;

EID: 27544511407     PISSN: 03639045     EISSN: 15205762     Source Type: Journal    
DOI: 10.1080/03639040500272025     Document Type: Article

References (9)

1. Ambike, A. A., Mahadik, K. R., & Paradkar, A. (2004). Stability study of amorphous valdecoxib. International Journal of Pharmaceutics, 282, 151-162.
2. Hancock, B. C., & Zografi, G. (1994). The relationship between the glass transition temperature and the water content of amorphous pharmaceutical solids. Pharmaceutical Research, 11, 471-477.
3. Hancock, B. C., & Zografi, G. (1997). Characteristics and significance of the amorphous state in pharmaceutical systems. Journal of Pharmaceutical Sciences, 86, 1-12.
4. Hilden, L. R., & Morris, K. R. (2004). Physics of amorphous solids. Journal of Pharmaceutical Sciences, 93, 3-12.
5. Lian, Y. (2001). Amorphous pharmaceutical solids: preparation, characterization and stabilization. Advanced Drug Delivery Reviews, 48, 27-42.
6. Matsumoto, T., & Zografi, G. (1999). Physical properties of solid molecular dispersions of indomethacin with poly(vinylpyrrolidone) and poly(vinylpyrrolidone-co-vinyl-acetate) in relation to indomethacin crystallization. Pharmaceutical Research, 16(11), 1722-1728.
7. Shalaev, E. Y., & Zografi, G. (1996). How does residual water affect the solid-state degradation of drugs in the amorphous state? Journal of Pharmaceutical Sciences, 85, 1137-1141.
8. Shamblin, S. L., & Zografi, G. (1998). Enthalpy relaxation in binary amorphous mixtures containing sucrose. Pharmaceutical Research, 15(12), 1828-1834.
9. Zografi, G. (1988). States of water associated with solids. Drug Development and Industrial Pharmacy, 14, 1905-1926.