Clinical features, developmental course, and psychiatric comorbidity of adult autism spectrum disorders

CNS Spectrums

Volumn 19, Issue 2, 2014, Pages 157-164

  Vannucchi, Giulia ^a   Masi, Gabriele ^b   Toni, Cristina ^c   Dell'Osso, Liliana ^a   Marazziti, Donatella ^a   Perugi, Giulio ^a,c  

^a UNIVERSITY OF PISA   (Italy)

^b DEPARTMENT OF DEVELOPMENTAL NEUROSCIENCE   (Italy)

^c G DE LISIO INSTITUTE OF BEHAVIOURAL SCIENCES   (Italy)

Author keywords

Adult autistic spectrum disorders; mood disorders; personality disorders; psychiatric comorbidity; schizophrenia

Indexed keywords

MOOD STABILIZER; PSYCHOTROPIC AGENT; SEROTONIN UPTAKE INHIBITOR; TRICYCLIC ANTIDEPRESSANT AGENT; ANTICONVULSIVE AGENT; ARIPIPRAZOLE; LITHIUM SALT; NEUROLEPTIC AGENT; RISPERIDONE; VALPROIC ACID;

ADULTHOOD; ANXIETY DISORDER; ATTENTION DEFICIT DISORDER; AUTISM; BEHAVIOR DISORDER; BIPOLAR DISORDER; CLINICAL FEATURE; COMMUNICATION DISORDER; COMORBIDITY; DISEASE ASSOCIATION; GENERALIZED ANXIETY DISORDER; HUMAN; MOOD DISORDER; OBSESSIVE COMPULSIVE DISORDER; PERSONALITY DISORDER; PRIORITY JOURNAL; REVIEW; SCHIZOPHRENIA; SCREENING TEST; SOCIAL INTERACTION; TREATMENT INDICATION; MENTAL DISEASE; PSYCHOLOGICAL ASPECT; PSYCHOLOGICAL RATING SCALE; DISEASE COURSE; DRUG EFFICACY; DRUG RESPONSE; DRUG SAFETY; MAJOR DEPRESSION; PREVALENCE; PSYCHOSIS; SOCIAL ADAPTATION;

CHILD DEVELOPMENT DISORDERS, PERVASIVE; COMORBIDITY; HUMANS; MENTAL DISORDERS; PSYCHIATRIC STATUS RATING SCALES;

EID: 84901723398     PISSN: 10928529     EISSN: None     Source Type: Journal    
DOI: 10.1017/S1092852913000941     Document Type: Review

References (84)

1. Bleuler E. Dementia Praecox oder Gruppe der Schizophrenien. In: Aschaffenburg GE, ed. Handbuch der Psychiatrie. Leipzig, Germany: Deuticke; 1911.
2. Kanner L. Autistic disturbances of affective contact. Nervous Child. 1943; 2: 217-250.
3. Asperger H. Die autistischen Psychopathen im Kindersalter. Arch Psychiatr Nervenkr. 1944; 117: 76-136.
4. Volkmar FR, Cohen DJ. Debate and argument: The utility of the term pervasive developmental disorder. J Child Psychol Psychiatry. 1991; 32(7): 1171-1172.
5. Newschaffer CJ, Falb MD, Gurney JG. National autism prevalence trends from United States special education data. Pediatrics. 2005; 115(3): e277-282. (Pubitemid 43373010)
6. Billstedt E, Gillberg IC, Gillberg C. Autism in adults: symptom patterns and early childhood predictors. Use of the DISCO in a community sample followed from childhood. J Child Psychol Psychiatry. 2007; 48(11): 1102-1110.
7. Howlin P, Goode S, Hutton J, Rutter M. Adult outcome for children with autism. J Child Psychol Psychiatry. 2004; 45(2): 212-229. (Pubitemid 38240270)
8. Shattuck PT, Seltzer MM, Greenberg JS, et al. Change in autism symptoms and maladaptive behaviors in adolescents and adults with an autism spectrum disorder. J Autism Dev Disord. 2007; 37(9): 1735-1747. (Pubitemid 47476598)
9. Lai MC, Lombardo MV, Pasco G, et al. A behavioral comparison of male and female adults with high functioning autism spectrum conditions. PLoS One. 2011; 6(6): e20835.
10. Kobayashi R, Murata T. Setback phenomenon in autism and longterm prognosis. Acta Psychiatr Scand. 1998; 98(4): 296-303. (Pubitemid 28481425)
11. Taylor JL, Seltzer MM. Changes in the autism behavioral phenotype during the transition to adulthood. J Autism Dev Disord. 2010; 40(12): 1431-1446.
12. Bishop SL, Richler J, Lord C. Association between restricted and repetitive behaviors and nonverbal IQ in children with autism spectrum disorders. Child Neuropsychol. 2006; 12(4-5): 247-267. (Pubitemid 44266807)
13. Seltzer MM, Shattuck P, Abbeduto L, Greenberg JS. Trajectory of development in adolescents and adults with autism. Ment Retard Dev Disabil Res Rev. 2004; 10(4): 234-247. (Pubitemid 40209457)
14. Esbensen AJ, Seltzer MM, Lam KS, Bodfish JW. Age-related differences in restricted repetitive behaviors in autism spectrum disorders. J Autism Dev Disord. 2009; 39(1): 57-66.
15. Hoekstra RA, Bartels M, Verweij CJ, Boomsma DI. Heritability of autistic traits in the general population. Arch Pediatr Adolesc Med. 2007; 161(4): 372-377. (Pubitemid 46556368)
16. Whitehouse AJ, Coon H, Miller J, Salisbury B, Bishop DV. Narrowing the broader autism phenotype: A study using the Communication Checklist-Adult Version (CC-A). Autism. 2010; 14(6): 559-574.
17. Attwood T, ed. The Pattern of Abilities and Development of Girls with Asperger's Syndrome: Asperger's and Girls. Arlington, TX: Future Horisons, Inc.; 2006.
18. Gillberg C, ed. A Guide to Asperger Syndrome. Cambridge, UK: Cambridge University Press; 2002.
19. Roy M, Dillo W, Emrich HM, Ohlmeier MD. Asperger's syndrome in adulthood. Dtsch Arztebl Int. 2009; 106(5): 59-64.
20. Bakken TL, Helverschou SB, Eilertsen DE, Heggelund T, Myrbakk E, Martinsen H. Psychiatric disorders in adolescents and adults with autism and intellectual disability: A representative study in one county in Norway. Res Dev Disabil. 2010; 31(6): 1669-1677.
21. Clarke D, Baxter M, Perry D, Prasher V. The diagnosis of affective and psychotic disorders in adults with autism: seven case reports. Autism. 1999; 3: 149-164. (Pubitemid 29286870)
22. Ghazziuddin M, Zafar S. Psychiatric comorbidity of adults with autism spectrum disorders. Clinical Neuropsychiatry. 2008; 5(1): 9-12.
23. Dossetor DR. ''All that glitters is not gold'': misdiagnosis of psychosis in pervasive developmental disorders-A case series. Clin Child Psychol Psychiatry. 2007; 12(4): 537-548. (Pubitemid 47622914)
24. Hutton J, Goode S, Murphy M, Le Couteur A, Rutter M. New-onset psychiatric disorders in individuals with autism. Autism. 2008; 12(4): 373-390. (Pubitemid 351911186)
25. Cooper SA, Smiley E, Morrison J, et al. Psychosis and adults with intellectual disabilities: prevalence, incidence, and related factors. Soc Psychiatry Psychiatr Epidemiol. 2007; 42(7): 530-536. (Pubitemid 47062662)
26. Tsiouris JA, Kim SY, Brown WT, Cohen IL. Association of aggressive behaviours with psychiatric disorders, age, sex and degree of intellectual disability: A large-scale survey. J Intellect Disabil Res. 2011; 55(7): 636-649.
27. Mouridsen SE, Rich B, Isager T. Psychiatric disorders in adults diagnosed as children with atypical autism: A case control study. J Neural Transm. 2008; 115(1): 135-138.
28. Konstantareas MM, Hewitt T. Autistic disorder and schizophrenia: diagnostic overlaps. J Autism Dev Disord. 2001; 31(1): 19-28.
29. Ghaziuddin M. A family history study of Asperger syndrome. J Autism Dev Disord. 2005; 35(2): 177-182. (Pubitemid 40569140)
30. Nylander L, Gillberg C. Screening for autism spectrum disorders in adult psychiatric out-patients: A preliminary report. Acta Psychiatr Scand. 2001; 103(6): 428-434. (Pubitemid 32473034)
31. Sheitman BB, Kraus JE, Bodfish JW, Carmel H. Are the negative symptoms of schizophrenia consistent with an autistic spectrum illness? Schizophr Res. 2004; 69(1): 119-120. (Pubitemid 38625765)
32. Goldstein G, Minshew NJ, Allen DN, Seaton BE. High-functioning autism and schizophrenia: A comparison of an early and late onset neurodevelopmental disorder. Arch Clin Neuropsychol. 2002; 17(5): 461-475. (Pubitemid 34626386)
33. Rinehart NJ, Bradshaw JL, Brereton AV, Tonge BJ. Movement preparation in high-functioning autism and Asperger disorder: A serial choice reaction time task involving motor reprogramming. J Autism Dev Disord. 2001; 31(1): 79-88.
34. Mayes SD, Calhoun SL. Ability profiles in children with autism: Influence of age and IQ. Autism. 2003; 7(1): 65-80. (Pubitemid 36305234)
35. Bagner DM, Melinder MR, Barch DM. Language comprehension and working memory language comprehension and working memory deficits in patients with schizophrenia. Schizophr Res. 2003; 60(2-3): 299-309. (Pubitemid 36184717)
36. Bellack AS, Morrison RL, Wixted JT, Mueser KT. An analysis of social competence in schizophrenia. Br J Psychiatry. 1990; 156(6): 809-818. (Pubitemid 20207091)
37. Barneveld PS, Pieterse J, de Sonneville L, et al. Overlap of autistic and schizotypal traits in adolescents with autism spectrum disorders. Schizophr Res. 2011; 126(1-3): 231-236.
38. Esterberg ML, Trotman HD, Brasfield JL, Compton MT, Walker EF. Childhood and current autistic features in adolescents with schizotypal personality disorder. Schizophr Res. 2008; 104(1-3): 265-273.
39. Rutter M. Autistic children: Infancy to adulthood. Semin Psychiatry. 1970; 2(4): 435-450.
40. Lainhart JE. Psychiatric problems in individuals with autism, their parents, and siblings. Int Rev Psychiatry. 1999; 11(4): 278-298.
41. Perry DW, Marston GM, Hinder SA, Munden AC, Roy A. The phenomenology of depressive illness in people with a learning disability and autism. Autism. 2001; 5(3): 265-275. (Pubitemid 32780830)
42. de Bruin EI, Ferdinand RF, Meester S, de Nijs PF, Verheij F. High rates of psychiatric co-morbidity in PDD-NOS. J Autism Dev Disord. 2007; 37(5): 877-886. (Pubitemid 46790785)
43. Ghaziuddin M, Ghazziuddin N, Greden J. Depression in adults with autism: Implications for research and clinical care. J Autism Dev Disord. 2002; 32: 299-306. (Pubitemid 37490179)
44. Munesue T, Ono Y, Mutoh K, et al. High prevalence of bipolar disorder comorbidity in adolescents and young adults with high-functioning autism spectrum disorder: A preliminary study of 44 outpatients. J Affect Disord. 2008; 111(2-3): 170-175.
45. Bolton PF, Pickles A, Murphy M, Rutter M. Autism, affective and other psychiatric disorders: patterns of familial aggregation. Psychol Med. 1998; 28(2): 385-395. (Pubitemid 28197553)
46. Ghaziuddin M, Greden J. Depression in children with autism/ pervasive developmental disorders: A case-control family history study. J Autism Dev Disord. 1998; 28(2): 111-115. (Pubitemid 28194011)
47. Piven J, Palmer P. Psychiatric disorder and the broad autism phenotype: evidence from a family study of multiple-incidence autism families. Am J Psychiatry. 1999; 156(4): 557-563. (Pubitemid 29162976)
48. Sterling L, Dawson G, Estes A, Greenson J. Characteristics associated with presence of depressive symptoms in adults with autism spectrum disorder. J Autism Dev Disord. 2008; 38(6): 1011-1018.
49. Raja M, Azzoni A. Comorbidity of Asperger's syndrome and bipolar disorder. Clin Pract Epidemiol Ment Health. 2008; 4: 26.
50. McElroy SL. Diagnosing and treating comorbid (complicated) bipolar disorder. J Clin Psychiatry. 2004; 65(Suppl 15): 35-44.
51. Stahlberg O, Soderstrom H, Rastam M, Gillberg C. Bipolar disorder, schizophrenia, and other psychotic disorders in adults with childhood onset AD/HD and/or autism spectrum disorders. J Neural Transm. 2004; 111(7): 891-902. (Pubitemid 38916282)
52. Kerbeshian J, Burd L. Case study: comorbidity among Tourette's syndrome, autistic disorder, and bipolar disorder. J Am Acad Child Adolesc Psychiatry. 1996; 35(5): 681-685. (Pubitemid 26134807)
53. Tantam D. Asperger syndrome in adulthood. In: Frith U, ed. Autism and Asperger Syndrome. Cambridge, UK: Cambridge University Press; 1991: 147-183.
54. Lugnegard T, Hallerback MU, Gillberg C. Psychiatric comorbidity in young adults with a clinical diagnosis of Asperger syndrome. Res Dev Disabil. 2011; 32(5): 1910-1917.
55. DeLong GR, Dwyer JT. Correlation of family history with specific autistic subgroups: Asperger's syndrome and bipolar affective disease. J Autism Dev Disord. 1988; 18(4): 593-600. (Pubitemid 19025243)
56. Gillberg IC, Gillberg C. Asperger syndrome-some epidemiological considerations: A research note. J Child Psychol Psychiatry. 1989; 30(4): 631-638. (Pubitemid 19209098)
57. DeLong R. Children with autism spectrum disorder and a family history of affective disorder. Dev Med Child Neurol. 1994; 36(8): 674-687.
58. Mattila ML, Hurtig T, Haapsamo H, et al. Comorbid psychiatric disorders associated with Asperger syndrome/high-functioning autism: A community- and clinic-based study. J Autism Dev Disord. 2010; 40(9): 1080-1093.
59. Leyfer OT, Folstein SE, Bacalman S, et al. Comorbid psychiatric disorders in children with autism: Interview development and rates of disorders. J Autism Dev Disord. 2006; 36(7): 849-861. (Pubitemid 44440104)
60. Ivarsson T, Melin K. Autism spectrum traits in children and adolescents with obsessive-compulsive disorder (OCD). J Anxiety Disord. 2008; 22(6): 969-978. (Pubitemid 351927271)
61. Bejerot S, Nylander L, Lindstrom E. Autistic traits in obsessivecompulsive disorder. Nord J Psychiatry. 2001; 55(3): 169-176.
62. Russell AJ, Mataix-Cols D, Anson M, Murphy DG. Obsessions and compulsions in Asperger syndrome and high-functioning autism. Br J Psychiatry. 2005; 186(6): 525-528. (Pubitemid 40834873)
63. McDougle CJ, Kresch LE, Goodman WK, et al. A case-controlled study of repetitive thoughts and behavior in adults with autistic disorder and obsessive-compulsive disorder. Am J Psychiatry. 1995; 152(5): 772-777.
64. Hollander E, King A, Delaney K, Smith CJ, Silverman JM. Obsessive-compulsive behaviors in parents of multiplex autism families. Psychiatry Res. 2003; 117(1): 11-16. (Pubitemid 36173772)
65. Abramson RK, Ravan SA, Wright HH, et al. The relationship between restrictive and repetitive behaviors in individuals with autism and obsessive compulsive symptoms in parents. Child Psychiatry Hum Dev. 2005; 36(2): 155-165. (Pubitemid 41446578)
66. Sverd J. Tourette syndrome and autistic disorder: A significant relationship. Am J Med Genet. 1991; 39(2): 173-179.
67. Kano Y, Ohta M, Nagai Y, Yokota K, Shimizu Y. Tourette's disorder coupled with infantile autism: A prospective study of two boys. Jpn J Psychiatry Neurol. 1988; 42(1): 49-57.
68. Miller JN, Ozonoff S. Did Asperger's cases have Asperger disorder? A research note. J Child Psychol Psychiatry. 1997; 38(2): 247-251. (Pubitemid 27095888)
69. Tantam D. Lifelong eccentricity and social isolation. II: Asperger's syndrome or schizoid personality disorder? Br J Psychiatry. Dec 1988; 153(6): 783-791. (Pubitemid 19008665)
70. Hurst RM, Nelson-Gray RO, Mitchell JT, Kwapil TR. The relationship of Asperger's characteristics and schizotypal personality traits in a non-clinical adult sample. J Autism Dev Disord. 2007; 37(9): 1711-1720. (Pubitemid 47476594)
71. Lugnegard T, Hallerback MU, Gillberg C. Personality disorders and autism spectrum disorders: what are the connections? Compr Psychiatry. 2012; 53(4): 333-340.
72. Sucksmith E, Roth I, Hoekstra RA. Autistic traits below the clinical threshold: re-examining the broader autism phenotype in the 21st century. Neuropsychol Rev. 2011; 21(4): 360-389.
73. Dawson G, Estes A, Munson J, et al. Quantitative assessment of autism symptom-related traits in probands and parents: Broader Phenotype Autism Symptom Scale. J Autism Dev Disord. 2007; 37(3): 523-536. (Pubitemid 46355987)
74. Losh M, Childress D, Lam K, Piven J. Defining key features of the broad autism phenotype: A comparison across parents of multiple- and single-incidence autism families. Am J Med Genet B Neuropsychiatr Genet. 2008; 147B(4): 424-433. (Pubitemid 351830798)
75. Smith CJ, Lang CM, Kryzak L, et al. Familial associations of intense preoccupations, an empirical factor of the restricted, repetitive behaviors and interests domain of autism. J Child Psychol Psychiatry. 2009; 50(8): 982-990.
76. Baron-Cohen S, Wheelwright S, Skinner R, Martin J, Clubley E. The autism-spectrum quotient (AQ): evidence from Asperger syndrome/high-functioning autism, males and females, scientists and mathematicians. J Autism Dev Disord. 2001; 31(1): 5-17.
77. Constantino JN, Lajonchere C, Lutz M, et al. Autistic social impairment in the siblings of children with pervasive developmental disorders. Am J Psychiatry. 2006; 163(2): 294-296. (Pubitemid 44480850)
78. McDougle CJ, Scahill L, McCracken JT, et al. Research Units on Pediatric Psychopharmacology (RUPP) Autism Network: background and rationale for an initial controlled study of risperidone. Child Adolesc Psychiatr Clin N Am. 2000; 9(1): 201-224. (Pubitemid 30261725)
79. Zuddas A, Zanni R, Usala T. Second generation antipsychotics (SGAs) for non-psychotic disorders in children and adolescents: A review of the randomized controlled studies. Eur Neuropsychopharmacol. 2011; 21(8): 600-620.
80. Hollander E, Dolgoff-Kaspar R, Cartwright C, Rawitt R, Novotny S. An open trial of divalproex sodium in autism spectrum disorders. J Clin Psychiatry. 2001; 62(7): 530-534. (Pubitemid 32703092)
81. Piven J, Chase GA, Landa R, et al. Psychiatric disorders in the parents of autistic individuals. J Am Acad Child Adolesc Psychiatry. 1991; 30(3): 471-478.
82. Kerbeshian J, Burd L, Fisher W. Lithium carbonate in the treatment of two patients with infantile autism and atypical bipolar symptomatology. J Clin Psychopharmacol. 1987; 7(6): 401-405. (Pubitemid 18006087)
83. Tantam D, Girgis S. Recognition and treatment of Asperger syndrome in the community. Br Med Bull. 2009; 89(1): 41-62.
84. Henry CA, Steingard R, Venter J, et al. Treatment outcome and outcome associations in children with pervasive developmental disorders treated with selective serotonin reuptake inhibitors: A chart review. J Child Adolesc Psychopharmacol. 2006; 16(1-2): 187-195.