Knockdown of Hnrnpa0, a del(5q) gene, alters myeloid cell fate in murine cells through regulation of AU-rich transcripts

Haematologica

Volumn 99, Issue 6, 2014, Pages 1032-1040

  Young, David J ^a   Stoddart, Angela ^b   Nakitandwe, Joy ^c   Chen, Shann Ching ^c   Qian, Zhijian ^d   Downing, James R ^c   Le Beau, Michelle M ^b  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF CHICAGO   (United States)

^c ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^d UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN; RNA BINDING PROTEIN; SMALL INTERFERING RNA; HNRNPA0 PROTEIN, HUMAN;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; CELL DIFFERENTIATION; CHROMOSOME 5; CHROMOSOME ANALYSIS; CHROMOSOME DELETION; CLINICAL ARTICLE; GENE; GENE EXPRESSION; GRANULOCYTE; HAPLOINSUFFICIENCY; HEMATOPOIESIS; HNRNP A0 GENE; HUMAN; LEUKEMOGENESIS; MICROARRAY ANALYSIS; MONOCYTE; MOUSE; NEOPLASM; NONHUMAN; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA INTERFERENCE; THERAPY RELATED MYELOID NEOPLASM; ANIMAL; AT RICH SEQUENCE; BONE MARROW CELL; CELL LINE; CELL TRANSDIFFERENTIATION; CYTOLOGY; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE SILENCING; GENETIC TRANSCRIPTION; GENETICS; KNOCKOUT MOUSE; METABOLISM; MYELOID LEUKEMIA; SECOND CANCER;

ANIMALS; AT RICH SEQUENCE; CELL LINE; CELL TRANSDIFFERENTIATION; CHROMOSOME DELETION; CHROMOSOMES, HUMAN, PAIR 5; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE KNOCKDOWN TECHNIQUES; GRANULOCYTES; HEMATOPOIESIS; HETEROGENEOUS-NUCLEAR RIBONUCLEOPROTEINS; HUMANS; LEUKEMIA, MYELOID; MICE; MICE, KNOCKOUT; MONOCYTES; MYELOID CELLS; NEOPLASMS, SECOND PRIMARY; TRANSCRIPTION, GENETIC;

EID: 84901723353     PISSN: 03906078     EISSN: 15928721     Source Type: Journal    
DOI: 10.3324/haematol.2013.098657     Document Type: Article

References (40)

1. Godley LA, Le Beau MM. Therapy-related AML. In: Karp JE, ed. Acute myelogenous leukemia. Totowa, NJ: Humana Press, Inc.; 2007:71-95.
2. Godley LA, Larson RA. Therapy-related myeloid leukemia. Semin Oncol. 2008; 35(4):418-29.
3. Smith SM, Le Beau MM, Huo D, Karrison T, Sobecks RM, Anastasi J, et al. Clinical-cytogenetic associations in 306 patients with therapy-related myelodysplasia and myeloid leukemia: the University of Chicago series. Blood. 2003;102(1):43-52.
4. Le Beau MM, Espinosa R 3rd, Neuman WL, Stock W, Roulston D, Larson RA, et al. Cytogenetic and molecular delineation of the smallest commonly deleted region of chromosome 5 in malignant myeloid diseases. Proc Natl Acad Sci USA. 1993;90(12): 5484-8.
5. Pedersen-Bjergaard J, Andersen MK, Andersen MT, Christiansen DH. Genetics of therapy-related myelodysplasia and acute myeloid leukemia. Leukemia. 2008;22(2): 240-8.
6. Lai F, Godley LA, Joslin J, Fernald AA, Liu J, Espinosa R 3rd, et al. Transcript map and comparative analysis of the 1.5-Mb commonly deleted segment of human 5q31 in malignant myeloid diseases with a del(5q). Genomics. 2001;71(2):235-45.
7. Saitoh T, Katoh M. Molecular cloning and characterization of human WNT8A. Int J Oncol. 2001;19(1):123-27.
8. Myer VE, Steitz JA. Isolation and characterization of a novel, low abundance hnRNP protein: A0. RNA. 1995;1:171-82.
9. Reinhardt HC, Hasskamp P, Schmedding I, Morandell S, van Vugt MA, Wang X, et al. DNA damage activates a spatially distinct late cytoplasmic cell-cycle checkpoint network controlled by MK2-mediated RNA stabilization. Mol Cell. 2010;40(1):34-49.
10. Rousseau S, Morrice N, Peggie M, Campbell DG, Gaestel M, Cohen P. Inhibition of SAPK2a/p38 prevents hnRNP A0 phosphorylation by MAPKAP-K2 and its interaction with cytokine mRNAs. The EMBO Journal. 2002;21(23):6505-14.
11. Pellagatti A, Cazzola M, Giagounidis AA, Malcovati L, Porta MG, Killick S, et al. Gene expression profiles of CD34+ cells in myelodysplastic syndromes: involvement of interferon-stimulated genes and correlation to FAB subtype and karyotype. Blood. 2006;108(1):337-45.
12. Khabar KS. The AU-rich transcriptome: more than interferons and cytokines, and its role in disease. J Interferon Cytokine Res. 2005;25(1):1-10.
13. Baou M, Norton JD, Murphy JJ. AU-rich RNA binding proteins in hematopoiesis and leukemogenesis. Blood. 2011; 118(22):5732-40.
14. von Roretz C, Gallouzi IE. Decoding AREmediated decay: is microRNA part of the equation? J Cell Biol. 2008;181(2):189-94.
15. Audic Y, Hartley RS. Post-transcriptional regulation in cancer. Biol Cell. 2004;96(7): 479-98.
16. Wang S, Zhang J, Zhang Y, Kern S, Danner RL. Nitric oxide-p38 MAPK signaling stabilizes mRNA through AU-rich elementdependent and-independent mechanisms. J Leukoc Biol. 2008;83(4):982-90.
17. Reschly EJ, Spaulding C, Vilimas T, Graham WV, Brumbaugh RL, Aifantis I, et al. Notch1 promotes survival of E2A-deficient T cell lymphomas through pre-T cell receptordependent and-independent mechanisms. Blood. 2006;107(10):4115-21.
18. Novershtern N, Subramanian A, Lawton LN, Mak RH, Haining WN, McConkey ME, et al. Densely interconnected transcriptional circuits control cell states in human hematopoiesis. Cell. 2011;144(2):296-309.
19. Laslo P, Spooner CJ, Warmflash A, Lancki DW, Lee HJ, Sciammas R, et al. Multilineage transcriptional priming and determination of alternate hematopoietic cell fates. Cell. 2006;126(4):755-66.
20. Dahl R, Iyer SR, Owens KS, Cuylear DD, Simon MC. The transcriptional repressor GFI-1 antagonizes PU.1 activity through protein-protein interaction. J Biol Chem. 2007;282(9):6473-83.
21. Laslo P, Pongubala JM, Lancki DW, Singh H. Gene regulatory networks directing myeloid and lymphoid cell fates within the immune system. Semin Immunol. 2008; 20(4):228-35.
22. Rosmarin AG, Yang Z, Resendes KK. Transcriptional regulation in myelopoiesis: Hematopoietic fate choice, myeloid differentiation, and leukemogenesis. Exp Hematol. 2005;33(2):131-43.
23. Frevel MA, Bakheet T, Silva AM, Hissong JG, Khabar KS, Williams BR. p38 Mitogenactivated protein kinase-dependent and-independent signaling of mRNA stability of AU-rich element-containing transcripts. Mol Cell Biol. 2003;23(2):425-36.
24. Lin NY, Lin CT, Chang CJ. Modulation of immediate early gene expression by tristetraprolin in the differentiation of 3T3-L1 cells. Biochem Biophys Res Commun. 2008; 365(1):69-74.
25. Chen CY, Shyu AB. Selective degradation of early-response-gene mRNAs: functional analyses of sequence features of the AU-rich elements. Mol Cell Biol. 1994; 14(12):8471-82.
26. Bakheet T, Williams BR, Khabar KS. ARED 3.0: the large and diverse AU-rich transcriptome. Nucleic Acids Res. 2006;34(Database issue):D111-14.
27. Subramanian A, Kuehn H, Gould J, Tamayo P, Mesirov JP. GSEA-P: a desktop application for Gene Set Enrichment Analysis. Bioinformatics. 2007;23(23):3251-3.
28. Kundu M, Chen A, Anderson S, Kirby M, Xu L, Castilla LH, et al. Role of Cbfb in hematopoiesis and perturbations resulting from expression of the leukemogenic fusion gene Cbfb-MYH11. Blood. 2002;100(7): 2449-56.
29. Van Loo PF, Bouwman P, Ling KW, Middendorp S, Suske G, Grosveld F, et al. Impaired hematopoiesis in mice lacking the transcription factor Sp3. Blood. 2003;102(3): 858-66.
30. Huang da W, Sherman BT, Lempicki RA. Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc. 2009;4(1):44-57.
31. Huang da W, Sherman BT, Lempicki RA. Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists. Nucleic Acids Res. 2009;37(1):1-13.
32. Geest CR, Coffer PJ. MAPK signaling pathways in the regulation of hematopoiesis. J Leukoc Biol. 2009;86(2):237-50.
33. Stoddart A, McNerney ME, Bartom E, Bergerson R, Young DJ, Qian Z, et al. Genetic pathways leading to therapy-related myeloid neoplasms. Mediterr J Hematol Infect Dis. 2011;3(1):e2011019.
34. Karsunky H, Zeng H, Schmidt T, Zevnik B, Kluge R, Schmid KW, et al. Inflammatory reactions and severe neutropenia in mice lacking the transcriptional repressor Gfi1. Nat Genet. 2002;30(3):295-300.
35. Krishnaraju K, Hoffman B, Liebermann DA. Early growth response gene 1 stimulates development of hematopoietic progenitor cells along the macrophage lineage at the expense of the granulocyte and erythroid lineages. Blood. 2001;97(5):1298-305.
36. Nguyen HQ, Hoffman-Liebermann B, Liebermann DA. The zinc finger transcription factor Egr-1 is essential for and restricts differentiation along the macrophage lineage. Cell. 1993;72(2):197-209.
37. Ross SE, Radomska HS, Wu B, Zhang P, Winnay JN, Bajnok L, et al. Phosphorylation of C/EBPalpha inhibits granulopoiesis. Mol Cell Biol. 2004; 24(2):675-86.
38. Barreau C, Paillard L, Osborne HB. AU-rich elements and associated factors: are there unifying principles? Nucleic Acids Res. 2005;33(22):7138-50.
39. Beisang D, Bohjanen PR. Perspectives on the ARE as it turns 25 years old. Wiley Interdiscip Rev RNA. 2012;3(5):719-31.
40. Wilusz CJ, Wormington M, Peltz SW. The cap-to-tail guide to mRNA turnover. Nat Rev Mol Cell Biol. 2001;2(4):237-46.