Allosteric modulation of M1 muscarinic acetylcholine receptor internalization and subcellular trafficking

Journal of Biological Chemistry

Volumn 289, Issue 22, 2014, Pages 15856-15866

  Yeatman, Holly R ^a   Lane, J Robert ^a   Choy, Kwok Ho Christopher ^a   Lambert, Nevin A ^b   Sexton, Patrick M ^a   Christopoulos, Arthur ^a   Canals, Meritxell ^a  

^a MONASH UNIVERSITY   (Australia)

^b MEDICAL COLLEGE OF GEORGIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; BIOLOGY;

ALLOSTERIC MODULATION; ALLOSTERIC MODULATORS; ARRESTINS; G PROTEIN COUPLED RECEPTORS; MUSCARINIC ACETYLCHOLINE RECEPTORS; RECEPTOR TRAFFICKING; SUBCELLULAR TRAFFICKING;

LIGANDS;

BENZYL QUINOLONE CARBOXYLIC ACID; BETA ARRESTIN 1; BETA ARRESTIN 2; G PROTEIN COUPLED RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; MUSCARINIC M1 RECEPTOR; REGULATOR PROTEIN; UNCLASSIFIED DRUG; ADRBK1 PROTEIN, HUMAN; BETA ARRESTIN; G PROTEIN COUPLED RECEPTOR KINASE 2; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; LIGAND; RETINA S ANTIGEN;

ALLOSTERISM; ARTICLE; BIOLUMINESCENCE RESONANCE ENERGY TRANSFER; CHO CELL LINE; CONTROLLED STUDY; ENDOCYTOSIS; ENDOSOME; HEK293 CELL LINE; INTERNALIZATION; INTRACELLULAR SIGNALING; INTRACELLULAR TRANSPORT; LIGAND BINDING; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN TRANSPORT; RECEPTOR AFFINITY; ALLOSTERIC MODULATOR; ANIMAL; CHEMICAL ACCIDENT; CHEMISTRY; CRICETULUS; G PROTEIN-COUPLED RECEPTOR (GPCR); GPCR REGULATION; HUMAN; METABOLISM; PHYSIOLOGY; RECEPTOR ENDOCYTOSIS; SIGNAL TRANSDUCTION; TRAFFICKING;

ALLOSTERIC MODULATOR; ALLOSTERIC REGULATION; ARRESTIN; G PROTEIN-COUPLED RECEPTOR (GPCR); GPCR REGULATION; RECEPTOR ENDOCYTOSIS; TRAFFICKING;

ALLOSTERIC REGULATION; ANIMALS; ARRESTINS; CHEMICAL HAZARD RELEASE; CHO CELLS; CRICETULUS; ENDOCYTOSIS; ENDOSOMES; G-PROTEIN-COUPLED RECEPTOR KINASE 2; GTP-BINDING PROTEIN ALPHA SUBUNITS, GQ-G11; HEK293 CELLS; HUMANS; LIGANDS; PROTEIN TRANSPORT; RECEPTOR, MUSCARINIC M1; RECEPTORS, G-PROTEIN-COUPLED; SIGNAL TRANSDUCTION;

EID: 84901708225     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.536672     Document Type: Article

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