Mutations flanking the carbohydrate binding site of surfactant protein D confer antiviral activity for pandemic influenza A viruses

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 306, Issue 11, 2014, Pages

  Nikolaidis, Nikolaos M ^a   White, Mitchell R ^b   Allen, Kimberly ^c   Tripathi, Shweta ^b   Qi, Li ^d   McDonald, Barbara ^c   Taubenberger, Jeffery ^d   Seaton, Barbara A ^b   McCormack, Francis X ^a   Crouch, Erika C ^c   Hartshorn, Kevan L ^b  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^b BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

Collectin; Innate immunity; Mouse

Indexed keywords

ALANINE; CARBOHYDRATE; GLYCAN; HEMAGGLUTININ; LECTIN; NECK AND CARBOHYDRATE RECOGNITION DOMAIN; PROTEIN; SERINE; SURFACTANT PROTEIN D; UNCLASSIFIED DRUG; VIRUS ENVELOPE PROTEIN;

AMINO ACID SUBSTITUTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIVIRAL ACTIVITY; ARTICLE; BINDING SITE; CONTROLLED STUDY; EPITHELIUM CELL; FEMALE; HUMAN; INFLUENZA VIRUS A; INFLUENZA VIRUS A H1N1; INFLUENZA VIRUS A H3N2; MDCK CELL LINE; MORTALITY; MOUSE; MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN STRUCTURE; VIRAL CLEARANCE; VIRUS LOAD; VIRUS STRAIN;

COLLECTIN; INNATE IMMUNITY; MOUSE;

ANIMALS; BINDING SITES; CHO CELLS; CRICETINAE; CRICETULUS; DISEASE RESISTANCE; DOGS; FEMALE; HOST-PATHOGEN INTERACTIONS; HUMANS; INFLUENZA A VIRUS, H1N1 SUBTYPE; INFLUENZA A VIRUS, H3N2 SUBTYPE; INFLUENZA, HUMAN; MADIN DARBY CANINE KIDNEY CELLS; MICE; MICE, INBRED DBA; MUTATION, MISSENSE; PANDEMICS; PROTEIN BINDING; PULMONARY SURFACTANT-ASSOCIATED PROTEIN D; VIRAL LOAD;

EID: 84901702029     PISSN: 10400605     EISSN: 15221504     Source Type: Journal    
DOI: 10.1152/ajplung.00035.2014     Document Type: Article

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