Porphyromonas gingivalis-derived lysine gingipain enhances osteoclast differentiation induced by tumor necrosis factor-α and interleukin-1β but suppresses that by interleukin-17A: Importance of proteolytic degradation of osteoprotegerin by lysine gingipain

Journal of Biological Chemistry

Volumn 289, Issue 22, 2014, Pages 15621-15630

  Akiyama, Tomohito ^a   Miyamoto, Yoichi ^a   Yoshimura, Kentaro ^a   Yamada, Atsushi ^a   Takami, Masamichi ^a   Suzawa, Tetsuo ^a   Hoshino, Marie ^a   Imamura, Takahisa ^b   Akiyama, Chie ^a   Yasuhara, Rika ^a   Mishima, Kenji ^b   Maruyama, Toshifumi ^a   Kohda, Chikara ^a   Tanaka, Kazuo ^a   Potempa, Jan ^c,d   Yasuda, Hisataka ^e   Baba, Kazuyoshi ^a   Kamijo, Ryutaro ^a  

^a SHOWA UNIVERSITY   (Japan)

^b KUMAMOTO UNIVERSITY   (Japan)

^c JAGIELLONIAN UNIVERSITY   (Poland)

^d UNIVERSITY OF LOUISVILLE SCHOOL OF MEDICINE   (United States)

^e Oriental Yeast Co Ltd   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCOPROTEINS; MACROPHAGES;

CYTOKINES; INTERLEUKIN-1; OSTEOCLAST DIFFERENTIATION; OSTEOCLASTOGENESIS; OSTEOLYSIS; OSTEOPROTEGERIN; PROTEOLYTIC DEGRADATION; TUMOR NECROSIS FACTORS;

AMINO ACIDS;

CYTOKINE; GINGIPAIN R; INTERLEUKIN 17; INTERLEUKIN 1BETA; LYSINE GINGIPAIN; MEMBRANE PROTEIN; OSTEOCLAST DIFFERENTIATION FACTOR; OSTEOPROTEGERIN; RECEPTOR ACTIVATOR OF NUCLEAR FACTOR KAPPA B; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BONE MARROW CELL; CELL DIFFERENTIATION; CELL FREE SYSTEM; CELL SURFACE; CONTROLLED STUDY; ENZYME REPRESSION; IN VITRO STUDY; MALE; MOUSE; NEWBORN; NONHUMAN; OSTEOBLAST; OSTEOCLASTOGENESIS; OSTEOLYSIS; PERIODONTITIS; PORPHYROMONAS GINGIVALIS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CLEAVAGE; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION;

CELL DIFFERENTIATION; CYTOKINE; GINGIPAIN; INFLAMMATION; OSTEOCLAST; OSTEOPROTEGERIN; PROTEOLYTIC ENZYME;

ADHESINS, BACTERIAL; AMINO ACID SEQUENCE; ANIMALS; ANIMALS, OUTBRED STRAINS; BACTEROIDACEAE INFECTIONS; BONE MARROW CELLS; CELL DIFFERENTIATION; CELLS, CULTURED; CYSTEINE ENDOPEPTIDASES; HUMANS; INTERLEUKIN-17; INTERLEUKIN-1BETA; MICE; MOLECULAR SEQUENCE DATA; OSTEOBLASTS; OSTEOCLASTS; OSTEOPROTEGERIN; PERIODONTITIS; PORPHYROMONAS GINGIVALIS; RANK LIGAND; RECEPTOR ACTIVATOR OF NUCLEAR FACTOR-KAPPA B; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84901699728     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.520510     Document Type: Article

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