Lysine-specific gingipain promotes lipopolysaccharide- and active-vitamin D3-induced osteoclast differentiation by degrading osteoprotegerin

Biochemical Journal

Volumn 419, Issue 1, 2009, Pages 159-166

  Yasuhara, Rika ^a   Miyamoto, Yoichi ^a   Takami, Masamichi ^a   Imamura, Takahisa ^b   Potempa, Jan ^c   Yoshimura, Kentaro ^a   Kamijo, Ryutaro ^a  

^a SHOWA UNIVERSITY   (Japan)

^b KUMAMOTO UNIVERSITY   (Japan)

^c JAGIELLONIAN UNIVERSITY   (Poland)

Author keywords

Bacterial lysine specific gingipain; Bone resorption; Osteoclastogenesis; Periodontitis; Vitamin D

Indexed keywords

BONE; DISEASES; ENZYME ACTIVITY; OSTEOBLASTS; RECOMBINANT PROTEINS;

BACTERIAL LYSINE-SPECIFIC GINGIPAIN; BONE RESORPTION; OSTEOCLASTOGENESIS; PERIODONTITIS; VITAMIN-D;

AMINO ACIDS;

CALCITRIOL; COLECALCIFEROL; CYSTEINE PROTEINASE; LIPOPOLYSACCHARIDE; LYSINE SPECIFIC GINGIPAIN; OSTEOPROTEGERIN; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG; ADHESIN; ARGINGIPAIN, PORPHYROMONAS GINGIVALIS;

ANIMAL CELL; ARTICLE; BONE MARROW CELL; CELL DIFFERENTIATION; COCULTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CULTURE MEDIUM; DENTIN; ENZYME ACTIVITY; ENZYME ANALYSIS; MOUSE; MULTINUCLEAR CELL; NEWBORN; NONHUMAN; OSTEOCLAST; OSTEOLYSIS; PERIODONTITIS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DEPLETION; ANIMAL; CELL CULTURE; CYTOLOGY; DRUG EFFECT; METABOLISM; MOUSE MUTANT; PROTEIN STABILITY;

BACTERIA (MICROORGANISMS); PORPHYROMONAS GINGIVALIS;

ADHESINS, BACTERIAL; ANIMALS; CELL DIFFERENTIATION; CELLS, CULTURED; CHOLECALCIFEROL; CYSTEINE ENDOPEPTIDASES; LIPOPOLYSACCHARIDES; MICE; MICE, MUTANT STRAINS; OSTEOCLASTS; OSTEOPROTEGERIN; PROTEIN STABILITY;

EID: 62749204368     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20081469     Document Type: Article

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