-
1
-
-
33847314539
-
The phosphatidyl inositol 3-kinase signaling network: Implications for human breast cancer
-
DOI 10.1038/sj.onc.1210202, PII 1210202
-
Dillon RL, White DE, Muller WJ (2007) The phosphatidyl inositol 3-kinase signaling network: implications for human breast cancer. Oncogene 26(9):1338-1345 (Pubitemid 46328463)
-
(2007)
Oncogene
, vol.26
, Issue.9
, pp. 1338-1345
-
-
Dillon, R.L.1
White, D.E.2
Muller, W.J.3
-
2
-
-
7444250290
-
Mutation of the PIK3CA gene in ovarian and breast cancer
-
DOI 10.1158/0008-5472.CAN-04-2933
-
Campbell IG et al (2004) Mutation of the PIK3CA gene in ovarian and breast cancer. Cancer Res 64(21):7678-7681 (Pubitemid 39446895)
-
(2004)
Cancer Research
, vol.64
, Issue.21
, pp. 7678-7681
-
-
Campbell, I.G.1
Russell, S.E.2
Choong, D.Y.H.3
Montgomery, K.G.4
Ciavarella, M.L.5
Hooi, C.S.F.6
Cristiano, B.E.7
Pearson, R.B.8
Phillips, W.A.9
-
3
-
-
33645224005
-
PIK3CA mutations in breast cancer are associated with poor outcome
-
1:CAS:528:DC%2BD28XivVensbk%3D 16317585 10.1007/s10549-005-9048-0
-
Li SY et al (2006) PIK3CA mutations in breast cancer are associated with poor outcome. Breast Cancer Res Treat 96(1):91-95
-
(2006)
Breast Cancer Res Treat
, vol.96
, Issue.1
, pp. 91-95
-
-
Li, S.Y.1
-
4
-
-
69349105634
-
PIK3CA mutation associates with improved outcome in breast cancer
-
1:CAS:528:DC%2BD1MXpvFeis78%3D 19671852 10.1158/1078-0432.CCR-09-0632
-
Kalinsky K et al (2009) PIK3CA mutation associates with improved outcome in breast cancer. Clin Cancer Res 15(16):5049-5059
-
(2009)
Clin Cancer Res
, vol.15
, Issue.16
, pp. 5049-5059
-
-
Kalinsky, K.1
-
5
-
-
84856767715
-
PIK3CA mutation impact on survival in breast cancer patients and in ERalpha, PR and ERBB2-based subgroups
-
1:CAS:528:DC%2BC38XnvFWktLs%3D 3496146 22330809 10.1186/bcr3113
-
Cizkova M et al (2012) PIK3CA mutation impact on survival in breast cancer patients and in ERalpha, PR and ERBB2-based subgroups. Breast Cancer Res 14(1):R28
-
(2012)
Breast Cancer Res
, vol.14
, Issue.1
, pp. 28
-
-
Cizkova, M.1
-
6
-
-
80755127903
-
Mutations in the phosphatidylinositol 3-kinase pathway: Role in tumor progression and therapeutic implications in breast cancer
-
1:CAS:528:DC%2BC38Xms1Cmuw%3D%3D 3315683 22114931 10.1186/bcr3039
-
Miller TW et al (2011) Mutations in the phosphatidylinositol 3-kinase pathway: role in tumor progression and therapeutic implications in breast cancer. Breast Cancer Res 13(6):224
-
(2011)
Breast Cancer Res
, vol.13
, Issue.6
, pp. 224
-
-
Miller, T.W.1
-
8
-
-
84863338519
-
PI3K/AKT/mTOR inhibitors in patients with breast and gynecologic malignancies harboring PIK3CA mutations
-
1:CAS:528:DC%2BC38XntV2lsLc%3D 3295566 22271473 10.1200/JCO.2011.36.1196
-
Janku F et al (2012) PI3K/AKT/mTOR inhibitors in patients with breast and gynecologic malignancies harboring PIK3CA mutations. J Clin Oncol 30(8):777-782
-
(2012)
J Clin Oncol
, vol.30
, Issue.8
, pp. 777-782
-
-
Janku, F.1
-
9
-
-
79951834210
-
PIK3CA mutations may be discordant between primary and corresponding metastatic disease in breast cancer
-
10.1158/1078-0432.CCR-10-1133
-
Jensen DJ et al (2011) PIK3CA mutations may be discordant between primary and corresponding metastatic disease in breast cancer. Clin Cancer Res 17(4):667-677
-
(2011)
Clin Cancer Res
, vol.17
, Issue.4
, pp. 667-677
-
-
Jensen, D.J.1
-
10
-
-
28244479028
-
Breast cancer-associated PIK3CA mutations are oncogenic in mammary epithelial cells
-
DOI 10.1158/0008-5472.CAN-05-2612
-
Isakoff SJ et al (2005) Breast cancer-associated PIK3CA mutations are oncogenic in mammary epithelial cells. Cancer Res 65(23):10992-11000 (Pubitemid 41713369)
-
(2005)
Cancer Research
, vol.65
, Issue.23
, pp. 10992-11000
-
-
Isakoff, S.J.1
Engelman, J.A.2
Irie, H.Y.3
Luo, J.4
Brachmann, S.M.5
Pearline, R.V.6
Cantley, L.C.7
Brugge, J.S.8
-
11
-
-
51849128358
-
Class i PI3K in oncogenic cellular transformation
-
1:CAS:528:DC%2BD1cXhtFWiur%2FP 2757120 18794883 10.1038/onc.2008.244
-
Zhao L, Vogt PK (2008) Class I PI3K in oncogenic cellular transformation. Oncogene 27(41):5486-5496
-
(2008)
Oncogene
, vol.27
, Issue.41
, pp. 5486-5496
-
-
Zhao, L.1
Vogt, P.K.2
-
12
-
-
84872823067
-
Frequency of mesenchymal-epithelial transition factor gene (MET) and the catalytic subunit of phosphoinositide-3-kinase (PIK3CA) copy number elevation and correlation with outcome in patients with early stage breast cancer
-
1:CAS:528:DC%2BC38XhvVyntrvN 3461089 22736407 10.1002/cncr.27608
-
Gonzalez-Angulo AM et al (2013) Frequency of mesenchymal-epithelial transition factor gene (MET) and the catalytic subunit of phosphoinositide-3- kinase (PIK3CA) copy number elevation and correlation with outcome in patients with early stage breast cancer. Cancer 119(1):7-15
-
(2013)
Cancer
, vol.119
, Issue.1
, pp. 7-15
-
-
Gonzalez-Angulo, A.M.1
-
13
-
-
34250749822
-
PIK3CA mutations and PTEN loss correlate with similar prognostic factors and are not mutually exclusive in breast cancer
-
DOI 10.1158/1078-0432.CCR-06-1609
-
Perez-Tenorio G et al (2007) PIK3CA mutations and PTEN loss correlate with similar prognostic factors and are not mutually exclusive in breast cancer. Clin Cancer Res 13(12):3577-3584 (Pubitemid 46955118)
-
(2007)
Clinical Cancer Research
, vol.13
, Issue.12
, pp. 3577-3584
-
-
Perez-Tenorio, G.1
Alkhori, L.2
Olsson, B.3
Waltersson, M.A.4
Nordenskjold, B.5
Rutqvist, L.E.6
Skoog, L.7
Stal, O.8
-
14
-
-
84880230412
-
Somatic mutation profiling and associations with prognosis and trastuzumab benefit in early breast cancer
-
1:CAS:528:DC%2BC3sXhtFSisbvO 23739063 10.1093/jnci/djt121
-
Loi S et al (2013) Somatic mutation profiling and associations with prognosis and trastuzumab benefit in early breast cancer. J Natl Cancer Inst 105(13):960-967
-
(2013)
J Natl Cancer Inst
, vol.105
, Issue.13
, pp. 960-967
-
-
Loi, S.1
-
15
-
-
20144387695
-
PIK3CA mutations correlate with hormone receptors, node metastasis, and ERBB2, and are mutually exclusive with PTEN loss in human breast carcinoma
-
DOI 10.1158/0008-5472-CAN-04-3913
-
Saal LH et al (2005) PIK3CA mutations correlate with hormone receptors, node metastasis, and ERBB2, and are mutually exclusive with PTEN loss in human breast carcinoma. Cancer Res 65(7):2554-2559 (Pubitemid 40490050)
-
(2005)
Cancer Research
, vol.65
, Issue.7
, pp. 2554-2559
-
-
Saal, L.H.1
Holm, K.2
Maurer, M.3
Memeo, L.4
Su, T.5
Wang, X.6
Yu, J.S.7
Malmstrom, P.-O.8
Mansukhani, M.9
Enoksson, J.10
Hibshoosh, H.11
Borg, A.12
Parsons, R.13
-
16
-
-
84864395175
-
The favorable impact of PIK3CA mutations on survival: An analysis of 2587 patients with breast cancer
-
1:CAS:528:DC%2BC38XhtlCrsLnK 3777497 22640628 10.5732/cjc.012.10032
-
Dumont AG, Dumont SN, Trent JC (2012) The favorable impact of PIK3CA mutations on survival: An analysis of 2587 patients with breast cancer. Chin J Cancer 31(7):327-334
-
(2012)
Chin J Cancer
, vol.31
, Issue.7
, pp. 327-334
-
-
Dumont, A.G.1
Dumont, S.N.2
Trent, J.C.3
-
17
-
-
81755162797
-
Phosphatidylinositol 3-kinase and antiestrogen resistance in breast cancer
-
1:CAS:528:DC%2BC38Xns1Sgug%3D%3D 3221526 22010023 10.1200/JCO.2010.34. 4879
-
Miller TW, Balko JM, Arteaga CL (2011) Phosphatidylinositol 3-kinase and antiestrogen resistance in breast cancer. J Clin Oncol 29(33):4452-4461
-
(2011)
J Clin Oncol
, vol.29
, Issue.33
, pp. 4452-4461
-
-
Miller, T.W.1
Balko, J.M.2
Arteaga, C.L.3
-
18
-
-
0035971181
-
Phosphatidylinositol 3-kinase/AKT-mediated activation of estrogen receptor alpha: A new model for anti-estrogen resistance
-
1:CAS:528:DC%2BD3MXis1Olu7k%3D 11139588 10.1074/jbc.M010840200
-
Campbell RA et al (2001) Phosphatidylinositol 3-kinase/AKT-mediated activation of estrogen receptor alpha: A new model for anti-estrogen resistance. J Biol Chem 276(13):9817-9824
-
(2001)
J Biol Chem
, vol.276
, Issue.13
, pp. 9817-9824
-
-
Campbell, R.A.1
-
19
-
-
35148885729
-
A Functional Genetic Approach Identifies the PI3K Pathway as a Major Determinant of Trastuzumab Resistance in Breast Cancer
-
DOI 10.1016/j.ccr.2007.08.030, PII S1535610807002620
-
Berns K et al (2007) A functional genetic approach identifies the PI3K pathway as a major determinant of trastuzumab resistance in breast cancer. Cancer Cell 12(4):395-402 (Pubitemid 47539306)
-
(2007)
Cancer Cell
, vol.12
, Issue.4
, pp. 395-402
-
-
Berns, K.1
Horlings, H.M.2
Hennessy, B.T.3
Madiredjo, M.4
Hijmans, E.M.5
Beelen, K.6
Linn, S.C.7
Gonzalez-Angulo, A.M.8
Stemke-Hale, K.9
Hauptmann, M.10
Beijersbergen, R.L.11
Mills, G.B.12
Van De Vijver, M.J.13
Bernards, R.14
-
20
-
-
56449111358
-
Phosphatidylinositol 3-kinase hyperactivation results in lapatinib resistance that is reversed by the mTOR/phosphatidylinositol 3-kinase inhibitor NVP-BEZ235
-
1:CAS:528:DC%2BD1cXhtlOmt73F 2587064 19010894 10.1158/0008-5472.CAN-08- 1740
-
Eichhorn PJ et al (2008) Phosphatidylinositol 3-kinase hyperactivation results in lapatinib resistance that is reversed by the mTOR/ phosphatidylinositol 3-kinase inhibitor NVP-BEZ235. Cancer Res 68(22):9221-9230
-
(2008)
Cancer Res
, vol.68
, Issue.22
, pp. 9221-9230
-
-
Eichhorn, P.J.1
-
21
-
-
84878532044
-
Outcome impact of PIK3CA mutations in HER2-positive breast cancer patients treated with trastuzumab
-
1:CAS:528:DC%2BC3sXnvFylsrk%3D 3658522 23612454 10.1038/bjc.2013.164
-
Cizkova M et al (2013) Outcome impact of PIK3CA mutations in HER2-positive breast cancer patients treated with trastuzumab. Br J Cancer 108(9):1807-1809
-
(2013)
Br J Cancer
, vol.108
, Issue.9
, pp. 1807-1809
-
-
Cizkova, M.1
-
22
-
-
84864945212
-
PIK3CA mutations, PTEN, and pHER2 expression and impact on outcome in HER2-positive early-stage breast cancer patients treated with adjuvant chemotherapy and trastuzumab
-
1:STN:280:DC%2BC38zovFSjtA%3D%3D 22172323 10.1093/annonc/mdr546
-
Jensen JD et al (2012) PIK3CA mutations, PTEN, and pHER2 expression and impact on outcome in HER2-positive early-stage breast cancer patients treated with adjuvant chemotherapy and trastuzumab. Ann Oncol 23(8):2034-2042
-
(2012)
Ann Oncol
, vol.23
, Issue.8
, pp. 2034-2042
-
-
Jensen, J.D.1
-
23
-
-
84882962589
-
Biomarker analyses in CLEOPATRA: A phase III, placebo-controlled study of pertuzumab in HER2-positive, first-line metastatic breast cancer (MBC)
-
San Antonio, TX, 4-8 Dec 2012; Cancer. Res. S5-1
-
Baselga, J., et al.,: Biomarker analyses in CLEOPATRA: A phase III, placebo-controlled study of pertuzumab in HER2-positive, first-line metastatic breast cancer (MBC). In: Thirty-fifth annual CTRC-AACR San Antonio Breast Cancer Symposium, San Antonio, TX, 4-8 Dec 2012; Cancer. Res. 72(24 Supplement), S5-1 (2012)
-
(2012)
Thirty-fifth Annual CTRC-AACR San Antonio Breast Cancer Symposium
, vol.72
, Issue.24 SUPPL.
-
-
Baselga, J.1
-
24
-
-
84896071725
-
PI3KCA mutations and correlation with pCR in the NeoALTTO trial (BIG 01-06)
-
Sep 27-Oct 1,2013; Amsterdam. Abstract 1859, 2013
-
Baselga J, M.I., Nuciforo PG et al. (2013) PI3KCA mutations and correlation with pCR in the NeoALTTO trial (BIG 01-06). Presented at European Cancer Congress 2013; Sep 27-Oct 1,2013; Amsterdam. Abstract 1859, 2013
-
(2013)
European Cancer Congress 2013
-
-
Baselga, J.M.I.1
Nuciforo, P.G.2
-
25
-
-
84871968444
-
PIK3CA mutation H1047R is associated with response to PI3K/AKT/mTOR signaling pathway inhibitors in early-phase clinical trials
-
1:CAS:528:DC%2BC3sXjs1WrtQ%3D%3D 3537862 23066039 10.1158/0008-5472.CAN- 12-1726
-
Janku F et al (2013) PIK3CA mutation H1047R is associated with response to PI3K/AKT/mTOR signaling pathway inhibitors in early-phase clinical trials. Cancer Res 73(1):276-284
-
(2013)
Cancer Res
, vol.73
, Issue.1
, pp. 276-284
-
-
Janku, F.1
-
26
-
-
84856071447
-
Phase I, dose-escalation study of BKM120, an oral pan-Class i PI3K inhibitor, in patients with advanced solid tumors
-
1:CAS:528:DC%2BC38XjsFCit70%3D 22162589 10.1200/JCO.2011.36.1360
-
Bendell JC et al (2012) Phase I, dose-escalation study of BKM120, an oral pan-Class I PI3K inhibitor, in patients with advanced solid tumors. J Clin Oncol 30(3):282-290
-
(2012)
J Clin Oncol
, vol.30
, Issue.3
, pp. 282-290
-
-
Bendell, J.C.1
-
27
-
-
70350064529
-
A SNaPshot assay for the rapid and simple detection of four common hotspot codon mutations in the PIK3CA gene
-
2683860 19402901 10.1186/1756-0500-2-66
-
Hurst CD et al (2009) A SNaPshot assay for the rapid and simple detection of four common hotspot codon mutations in the PIK3CA gene. BMC Res Notes 2:66
-
(2009)
BMC Res Notes
, vol.2
, pp. 66
-
-
Hurst, C.D.1
-
28
-
-
78651079558
-
A platform for rapid detection of multiple oncogenic mutations with relevance to targeted therapy in non-small-cell lung cancer
-
1:CAS:528:DC%2BC3MXisVCisb0%3D 3070558 21227397 10.1016/j.jmoldx.2010.11. 010
-
Su Z et al (2011) A platform for rapid detection of multiple oncogenic mutations with relevance to targeted therapy in non-small-cell lung cancer. J Mol Diagn 13(1):74-84
-
(2011)
J Mol Diagn
, vol.13
, Issue.1
, pp. 74-84
-
-
Su, Z.1
-
29
-
-
84859972424
-
Routine multiplex mutational profiling of melanomas enables enrollment in genotype-driven therapeutic trials
-
1:CAS:528:DC%2BC38XmslOktrg%3D 3335021 22536370 10.1371/journal.pone. 0035309
-
Lovly CM et al (2012) Routine multiplex mutational profiling of melanomas enables enrollment in genotype-driven therapeutic trials. PLoS One 7(4):e35309
-
(2012)
PLoS One
, vol.7
, Issue.4
, pp. 35309
-
-
Lovly, C.M.1
-
30
-
-
77954331064
-
American Society of Clinical Oncology/College of American Pathologists guideline recommendations for immunohistochemical testing of estrogen and progesterone receptors in breast cancer (unabridged version)
-
1:CAS:528:DC%2BC3cXpsFShu7k%3D 20586616
-
Hammond ME et al (2010) American Society of Clinical Oncology/College of American Pathologists guideline recommendations for immunohistochemical testing of estrogen and progesterone receptors in breast cancer (unabridged version). Arch Pathol Lab Med 134(7):e48-e72
-
(2010)
Arch Pathol Lab Med
, vol.134
, Issue.7
-
-
Hammond, M.E.1
-
31
-
-
33846568336
-
American Society of Clinical Oncology/College of American Pathologists guideline recommendations for human epidermal growth factor receptor 2 testing in breast cancer
-
Wolff AC et al (2007) American Society of Clinical Oncology/College of American Pathologists guideline recommendations for human epidermal growth factor receptor 2 testing in breast cancer. Arch Pathol Lab Med 131(1):18-43 (Pubitemid 46174133)
-
(2007)
Archives of Pathology and Laboratory Medicine
, vol.131
, Issue.1
, pp. 18-43
-
-
Wolff, A.C.1
Hammond, M.E.H.2
Schwartz, J.N.3
Hagerty, K.L.4
Alfred, D.C.5
Cote, R.J.6
Dowsett, M.7
Fitzgibbons, P.L.8
Hanna, W.M.9
Langer, A.10
McShane, L.M.11
Paik, S.12
Pegram, M.D.13
Perez, E.A.14
Press, M.F.15
Rhodes, A.16
Sturgeon, C.17
Taube, S.E.18
Tubbs, R.19
Vance, G.H.20
Van De Vijver, M.21
Wheeler, T.M.22
Hayes, D.F.23
more..
-
32
-
-
40649096375
-
Helical domain and kinase domain mutations in p110α of phosphatidylinositol 3-kinase induce gain of function by different mechanisms
-
DOI 10.1073/pnas.0712169105
-
Zhao L, Vogt PK (2008) Helical domain and kinase domain mutations in p110alpha of phosphatidylinositol 3-kinase induce gain of function by different mechanisms. Proc Natl Acad Sci U S A 105(7):2652-2657 (Pubitemid 351520568)
-
(2008)
Proceedings of the National Academy of Sciences of the United States of America
, vol.105
, Issue.7
, pp. 2652-2657
-
-
Zhao, L.1
Vogt, P.K.2
-
33
-
-
42449154262
-
Multiplexed assays for detection of mutations in PIK3CA
-
DOI 10.1373/clinchem.2007.098376
-
Board RE et al (2008) Multiplexed assays for detection of mutations in PIK3CA. Clin Chem 54(4):757-760 (Pubitemid 351573719)
-
(2008)
Clinical Chemistry
, vol.54
, Issue.4
, pp. 757-760
-
-
Board, R.E.1
Thelwell, N.J.2
Ravetto, P.F.3
Little, S.4
Ranson, M.5
Dive, C.6
Hughes, A.7
Whitcombe, D.8
-
34
-
-
77952536391
-
Two multiplex assays that simultaneously identify 22 possible mutation sites in the KRAS, BRAF, NRAS and PIK3CA genes
-
2809099 20098682 10.1371/journal.pone.0008802
-
Lurkin I et al (2010) Two multiplex assays that simultaneously identify 22 possible mutation sites in the KRAS, BRAF, NRAS and PIK3CA genes. PLoS One 5(1):e8802
-
(2010)
PLoS One
, vol.5
, Issue.1
, pp. 8802
-
-
Lurkin, I.1
-
35
-
-
84877582951
-
Hotspot mutations in PIK3CA associate with first-line treatment outcome for aromatase inhibitors but not for tamoxifen
-
1:CAS:528:DC%2BC3sXnsVWhsL0%3D 23592373 10.1007/s10549-013-2529-7
-
Ramirez-Ardila DE et al (2013) Hotspot mutations in PIK3CA associate with first-line treatment outcome for aromatase inhibitors but not for tamoxifen. Breast Cancer Res Treat 139(1):39-49
-
(2013)
Breast Cancer Res Treat
, vol.139
, Issue.1
, pp. 39-49
-
-
Ramirez-Ardila, D.E.1
-
36
-
-
0017700706
-
Estrogen receptor as an independent prognostic factor for early recurrence in breast cancer
-
1:CAS:528:DyaE1cXkvVOgsw%3D%3D 922747
-
Knight WA et al (1977) Estrogen receptor as an independent prognostic factor for early recurrence in breast cancer. Cancer Res 37(12):4669-4671
-
(1977)
Cancer Res
, vol.37
, Issue.12
, pp. 4669-4671
-
-
Knight, W.A.1
-
37
-
-
0019455672
-
Estrogen receptor protein in breast cancer as a predictor of recurrence
-
DOI 10.1002 /1097-0142 (19810515) 47:10<2364::AID-CNCR2820471007>3. 0.CO;2-S
-
Kinne DW et al (1981) Estrogen receptor protein in breast cancer as a predictor of recurrence. Cancer 47(10):2364-2367 (Pubitemid 11127624)
-
(1981)
Cancer
, vol.47
, Issue.10
, pp. 2364-2367
-
-
Kinne, D.W.1
Ashikari, R.2
Butler, A.3
|