Tiotropium in asthma: A systematic review

Journal of Asthma and Allergy

Volumn , Issue 7, 2014, Pages 11-21

  Befekadu, Elizabeth ^a   Onofrei, Claudia ^a   Colice, Gene L ^a,b  

^a WASHINGTON HOSPITAL CENTER   (United States)

^b GEORGE WASHINGTON UNIVERSITY SCHOOL OF MEDICINE AND HEALTH SCIENCES   (United States)

Author keywords

Asthma; Inflammation; Inhaled corticosteroid; LABA; LAMA; Lung; Tiotropium

Indexed keywords

BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; CORTICOSTEROID; FLUTICASONE; PLACEBO; SALMETEROL; TIOTROPIUM BROMIDE;

ADD ON THERAPY; ALLERGIC RHINITIS; ASTHMA; CLINICAL EFFECTIVENESS; DISEASE DURATION; DISEASE EXACERBATION; DISEASE SEVERITY; DRUG DOSE REDUCTION; DRUG EFFICACY; DRUG SAFETY; EVENING DOSAGE; FORCED EXPIRATORY VOLUME; HUMAN; MORNING DOSAGE; OUTCOME ASSESSMENT; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; STUDY DESIGN; SYSTEMATIC REVIEW; XEROSTOMIA;

EID: 84901664430     PISSN: 11786965     EISSN: None     Source Type: Journal    
DOI: 10.2147/JAA.S38841     Document Type: Review

References (32)

1. Fanta CH. Asthma. N Eng J Med. 2009;360:1002-1014.
2. Akinbami LJ, Moorman JE, Bailey C, etal. Trends in Asthma Prevalence, Health Care Use, and Mortality in the United States, 2001-2010. Available from: http://www.cdc.gov/nchs/data/databriefs/db94.htm. Accessed January 16, 2014.
3. National Asthma Education and Prevention Program. Expert Panel Report III. Guidelines for the Diagnosis and Management of Asthma (EPR-3). Bethesda, MD: National Heart, Lung, and Blood Institute, 2007. NIH publication No 08-4051. Available from: http://www.nhlbi.nih.gov/guidelines/asthma/. Accessed January 16, 2014.
4. Global Initiative for Asthma. Global Strategy for Asthma Management and Prevention. Update 2012. Available from: http://www.ginasthma.org/documents/4. Accessed January 16, 2014.
5. Olivieri D, Chetta A, Del Donno M, etal. Effect of short-term treatment with low-dose inhaled fluticasone propionate on airway inflammation and remodeling in mild asthma. Am J Respir Crit Care Med. 1997;155: 1864-1871.
6. Trigg CJ, Manolitsas ND, Wang J, etal. Placebo-controlled immunopathologic study of four months of inhaled corticosteroids in asthma. Am J Respir Crit Care Med. 1994;150:17-22.
7. Bateman ED, Boushey HA, Bousquet J, etal. Can guideline-defined asthma control be achieved? Am J Resp Crit Care Med. 2004;170: 836-844.
8. Price D, Musgrave SD, Shepstone L, etal. Leukotriene antagonists as first-line or add-on asthma-controller therapy. N Engl J Med. 2011;364: 1695-1707.
9. Scullion JE. The development of anticholinergics in the management of COPD. Int J COPD. 2007;2:33-40.
10. Tashkin DP, Celli B, Senn S, etal. A 4-year trial of tiotropium in chronic obstructive pulmonary disease. N Engl J Med. 2008;359:1543-1554.
11. Vogelmeier C, Hederer B, Glaab T, etal. Tiotropium versus salmeterol for the prevention of exacerbations of COPD. N Engl J Med. 2011;364: 1093-1103.
12. Gosens R, Bos IS, Zaagsma J, Meurs H. Protective effects of tiotropium bromide in the progression of airway smooth muscle remodeling. Am J Respir Crit Care Med. 2005;171:1096-1102.
13. Kang JY, Rhee CK, Kim JS, etal. Effect of tiotropium bromide on airway remodeling in a chronic asthma model. Ann Allergy Asthma Immunol. 2012;109:29-35.
14. Terzano C, Petroianni A, Ricci A, etal. Early protective effects of tiotropium bromide in patients with airways hyperresponsiveness. Eur Rev Med Pharmacol Sci. 2004;8:259-264.
15. Magnussen H, Bugnas B, van Noord J, etal. Improvements with tiotropium in COPD patients with concomitant asthma. Respir Med. 2008;102:50-56.
16. Yoshida M, Nakano T, Fukuyama S, etal. Effects of tiotropium on lung function in severe asthmatics with or without emphysematous changes. Pulm Pharmacol Ther. 2013;26:159-166.
17. Moher D, Liberati A, Tetzlaff J, etal. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA Statement. Ann Intern Med. 2009;151:264-269.
18. Schulz KF, Altman DG, Moher D, etal. CONSORT 2010 Statement: updated guidelines for reporting parallel group randomized trials. Ann Intern Med. 2010;152:726-732.
19. Fardon T, Haggart K, Lee DK, Lipworth BJ. A proof of concept study to evaluate stepping down the dose of fluticasone in combination with salmeterol and tiotripium in severe persistent asthma. Respir Med. 2007;101:1218-1228.
20. Peters SP, Kunselman SJ, Icitovic N, etal. Tiotropium bromide step-up therapy for adults with uncontrolled asthma. NEMJ. 2010;363: 1715-1726.
21. Kerstjens HAM, Disse B, Schroder-Babo W, etal. Tiotropium improves lung function in patients with severe uncontrolled asthma: a randomized controlled trial. J Allergy Clin Immunol. 2011;128:308-314.
22. Bateman ED, Kornamann O, Schmidt P, etal. Tiotropium is noninferior to salmeterol in maintaining improved lung function in B16-Arg/Arg patients with asthma. J Allergy Clin Immunol. 2011;128:315-322.
23. Kerstjens HA, Engle M, Dahl R, etal. Tiotropium in asthma poorly controlled with standard combination therapy. NEMJ. 2012;367: 1257-1259.
24. Iwamoto H, Yokoyama A, Shiota N, etal. Tiotropium bromide is effective for severe asthma with noneosinophilic phenotype. Eur Respir J. 2008;31:1379-1382.
25. Park HW, Yang MS, Park CS, etal. Additive role of tiotropium in severe asthmatics and Arg16Gly in ADRB2 as a potential marker to predict response. Allergy. 2009;64:778-783.
26. Product information. Spiriva (tiotropium), Ridgefield. CT: Boehringer Ingleheim Pharmacetuticals, Inc., Mar 2012.
27. Verner HA. Status asthmaticus in children: a review. Chest. 2001;119: 1913-1929.
28. Gosens R, Zaagsma J, Meurs H, Halayko AJ. Muscarinic receptor signaling in the pathophysiology of asthma and COPD. Respir Res. 2006;7:73.
29. Bateman ED, Rennard S, Barnes PJ, etal. Alternative mechanisms for tiotropium. Pulm Pharmacol Ther. 2009;22:533-542.
30. Verhamme KM, Afonso A, Romio S, etal. Use of tiotropium Respimat Soft Mist Inhaler versus HandiHaler and mortality in patients with COPD. Eur Respir J. 2013;42:606-615.
31. Wise R, Anzueto A, Cotton D, etal. Tiotropium Respimat inhaler and the risk of death in COPD. N Engl J Med. 2013;369:1491-1501.
32. Peters SP, Bleecker ER, Kunselman SJ, etal. Predictors of response to tiotropium versus salmeterol in asthmatic adults. J Allergy Clin Immunol. 2013;132:1068-1074.