Immunoglobulin somatic hypermutation by APOBEC3/Rfv3 during retroviral infection

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 21, 2014, Pages 7759-7764

  Halemano, Kalani ^a,b   Guo, Kejun ^a   Heilman, Karl J ^a   Barrett, Bradley S ^a   Smith, Diana S ^a   Hasenkrug, Kim J ^c   Santiago, Mario L ^a,b  

^a UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF COLORADO   (United States)

^c NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

Affinity maturation; Antibody repertoire profiling; Friend retrovirus; Humoral immunity; Restriction factor

Indexed keywords

APOBEC 3 PROTEIN; COMPLEMENT; COMPLEMENTARY DNA; DINUCLEOTIDE; IMMUNOGLOBULIN; IMMUNOGLOBULIN HEAVY CHAIN; MONOCLONAL ANTIBODY; NEUTRALIZING ANTIBODY; PROTEIN; RECOVERY FROM FRIEND VIRUS 3 PROTEIN; TRINUCLEOTIDE; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; AMPLICON; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY AFFINITY; ANTIBODY RESPONSE; ARTICLE; B LYMPHOCYTE; CELL SELECTION; COMPARATIVE STUDY; COMPLEMENTARITY DETERMINING REGION; CONTROLLED STUDY; GENE MUTATION; GERMINAL CENTER; HYBRIDOMA; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; ROTAVIRUS INFECTION; SOMATIC HYPERMUTATION; VIRION; WILD TYPE;

AFFINITY MATURATION; ANTIBODY REPERTOIRE PROFILING; FRIEND RETROVIRUS; HUMORAL IMMUNITY; RESTRICTION FACTOR;

ANIMALS; ANTIBODIES, NEUTRALIZING; ANTIBODIES, VIRAL; B-LYMPHOCYTES; BASE SEQUENCE; CYTIDINE DEAMINASE; GERMINAL CENTER; MICE; MOLECULAR SEQUENCE DATA; RETROVIRIDAE INFECTIONS; SEQUENCE ANALYSIS, DNA; SOMATIC HYPERMUTATION, IMMUNOGLOBULIN; SPLEEN;

EID: 84901649814     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1403361111     Document Type: Article

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