Engineering of arteries in vitro

Cellular and Molecular Life Sciences

Volumn 71, Issue 11, 2014, Pages 2103-2118

  Huang, Angela H ^a   Niklason, Laura E ^a,b  

^a Yale University   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Axial stretching; Biomaterials; Bioreactor; Collagen remodeling; Engineered vessel; Mechanical conditioning; Tissue engineering; Vascular grafts

Indexed keywords

COLLAGEN; FIBRIN; POLYMER; TISSUE SCAFFOLD;

ANGIOGENESIS; ARTERY; ARTERY GRAFT; BIOMECHANICS; BIOMIMETICS; BIOREACTOR; BLOOD VESSEL WALL; ELECTROSPINNING; EMBRYO DEVELOPMENT; ENDOTHELIUM CELL; GEL; HUMAN; IN VITRO STUDY; NONHUMAN; REVIEW; SHEAR STRESS; SMOOTH MUSCLE FIBER; TISSUE ENGINEERING; TISSUE REGENERATION; VASCULAR BIOLOGY;

ARTERIES; BIOCOMPATIBLE MATERIALS; BIOMECHANICAL PHENOMENA; BIOREACTORS; BLOOD VESSEL PROSTHESIS; COLLAGEN; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; EXTRACELLULAR MATRIX; FIBRIN; GRAFT SURVIVAL; HUMANS; MECHANOTRANSDUCTION, CELLULAR; TISSUE CULTURE TECHNIQUES; TISSUE ENGINEERING; TISSUE SCAFFOLDS;

EID: 84901649277     PISSN: 1420682X     EISSN: 14209071     Source Type: Journal    
DOI: 10.1007/s00018-013-1546-3     Document Type: Review

References (150)

1. Dahl SLM et al (2003) Decellularized native and engineered arterial scaffolds for transplantation. Cell Transpl 12(6):659-666
2. Opitz F et al (2004) Tissue engineering of ovine aortic blood vessel substitutes using applied shear stress and enzymatically derived vascular smooth muscle cells. Ann Biomed Eng 32(2):212-222
3. Conte MS (1998) The ideal small arterial substitute: a search for the Holy Grail? FASEB J 12(1):43-45
4. Kannan RY et al (2005) Current status of prosthetic bypass grafts: a review. J Biomed Mater Res Part B Appl Biomater 74B(1):570-581
5. Pasic M et al (1995) Seeding with omental cells prevents late neointimal hyperplasia in small-diameter Dacron grafts. Circulation 92(9):2605-2616
6. Graham LM et al (1989) Effects of thromboxane synthetase inhibition on patency and anastomotic hyperplasia of vascular grafts. J Surg Res 46(6):611-615
7. Lucitti JL et al (2007) Vascular remodeling of the mouse yolk sac requires hemodynamic force. Development 134(18):3317-3326
8. Adamo L et al (2009) Biomechanical forces promote embryonic haematopoiesis. Nature 459(7250):1131-1135
9. Jones EAV (2011) Mechanical factors in the development of the vascular bed. Respir Physiol Neurobiol 178(1):59-65
10. Culver JC, Dickinson ME (2010) The effects of hemodynamic force on embryonic development. Microcirculation 17(3):164-178
11. Obi S et al (2009) Fluid shear stress induces arterial differentiation of endothelial progenitor cells. J Appl Physiol 106(1):203-211
12. Chapman WB (1918) The effect of the heart-beat upon the development of the vascular system in the chick. Am J Anat 23(1):175-203
13. Wakimoto K et al (2000) Targeted disruption of Na+/Ca2+ exchanger gene leads to cardiomyocyte apoptosis and defects in heartbeat. J Biol Chem 275(47):36991-36998
14. Hierck BP et al (2008) Fluid shear stress and inner curvature remodeling of the embryonic heart. Choosing the right lane! ScientificWorldJournal 8:212-222
15. Huang CQ et al (2003) Embryonic atrial function is essential for mouse embryogenesis, cardiac morphogenesis and angiogenesis. Development 130(24):6111-6119
16. Clark ER (1918) Studies on the growth of blood-vessels in the tail of the frog larva - by observation and experiment on the living animal. Am J Anat 23(1):37-88
17. Wagenseil JE, Mecham RP (2009) Vascular extracellular matrix and arterial mechanics. Physiol Rev 89(3):957-989
18. Gerrity RG, Cliff WJ (1975) The aortic tunica media of the developing rat. I. Quantitative stereologic and biochemical analysis. Lab Invest 32(5):585-600
19. Olivetti G et al (1980) Morphometric study of early postnatal development of the thoracic aorta in the rat. Circ Res 47(3):417-424
20. Berry CL, Looker T, Germain J (1972) The growth and development of the rat aorta. I. Morphological aspects. J Anat 113(Pt 1):1-16
21. Lucitti JL et al (2006) Increased arterial load alters aortic structural and functional properties during embryogenesis. Am J Physiol Heart Circ Physiol 291(4):H1919-H1926
22. Lucitti JL, Tobita K, Keller BB (2005) Arterial hemodynamics and mechanical properties after circulatory intervention in the chick embryo. J Exp Biol 208(10):1877-1885
23. Freed LE et al (2006) Advanced tools for tissue engineering: scaffolds, bioreactors, and signaling. Tissue Eng 12(12):3285-3305
24. Valdez-Jasso D et al (2011) Linear and nonlinear viscoelastic modeling of aorta and carotid pressure-area dynamics under in vivo and ex vivo conditions. Ann Biomed Eng 39(5):1438-1456
25. Cheng J, Wagenseil J (2012) Extracellular matrix and the mechanics of large artery development. Biomech Model Mechanobiol 11(8):1169-1186
26. Silver FH, Horvath I, Foran DJ (2001) Viscoelasticity of the vessel wall: the role of collagen and elastic fibers. Crit Rev Biomed Eng 29(3):279-301
27. Barra JG et al (1993) Assessment of smooth muscle contribution to descending thoracic aortic elastic mechanics in conscious dogs. Circ Res 73(6):1040-1050
28. Dahl SLM, Vaughn ME, Niklason LE (2007) An ultrastructural analysis of collagen in tissue engineered arteries. Ann Biomed Eng 35:1749-1755
29. Canham PB, Finlay HM, Boughner DR (1997) Contrasting structure of the saphenous vein and internal mammary artery used as coronary bypass vessels. Cardiovasc Res 34(3):557-567
30. Canham PB et al (1991) Medial collagen organization in human arteries of the heart and brain by polarized light microscopy. Connect Tissue Res 26(1-2):121-134
31. Bou-Gharios G et al (2004) Extra-cellular matrix in vascular networks. Cell Prolif 37(3):207-220
32. Shadwick RE (1999) Mechanical design in arteries. J Exp Biol 202(23):3305-3313
33. Humphrey JD (2008) Vascular adaptation and mechanical homeostasis at tissue, cellular, and sub-cellular levels. Cell Biochem Biophys 50(2):53-78
34. Gleason RL, Wilson E, Humphrey JD (2007) Biaxial biomechanical adaptations of mouse carotid arteries cultured at altered axial extension. J Biomech 40(4):766-776
35. Jackson ZS, Gotlieb AI, Langille BL (2002) Wall tissue remodeling regulates longitudinal tension in arteries. Circ Res 90(8):918-925
36. Clerin V et al (2003) Tissue engineering of arteries by directed remodeling of intact arterial segments. Tissue Eng 9(3):461-472
37. Lawrence AR, Gooch KJ (2009) Transmural pressure and axial loading interactively regulate arterial remodeling ex vivo. Am J Physiol Heart Circ Physiol 297(1):22
38. Cines DB et al (1998) Endothelial cells in physiology and in the pathophysiology of vascular disorders. Blood 91(10):3527-3561
39. Davies PF (2009) Hemodynamic shear stress and the endothelium in cardiovascular pathophysiology. Nat Clin Pract Cardiovasc Med 6(1):16-26
40. Chien S (2007) Mechanotransduction and endothelial cell homeostasis: the wisdom of the cell. Am J Physiol Heart Circ Physiol 292(3):H1209-H1224
41. Yamamoto K et al (2003) Proliferation, differentiation, and tube formation by endothelial progenitor cells in response to shear stress. J Appl Physiol 95(5):2081-2088
42. Franke RP et al (1984) Induction of human vascular endothelial stress fibres by fluid shear stress. Nature 307(5952):648-649
43. Wechezak AR, Viggers RF, Sauvage LR (1985) Fibronectin and F-actin redistribution in cultured endothelial cells exposed to shear stress. Lab Invest 53(6):639-647
44. Traub O, Berk BC (1998) Laminar shear stress: mechanisms by which endothelial cells transduce an atheroprotective force. Arterioscler Thromb Vasc Biol 18(5):677-685
45. Vanhoutte PM (1989) Endothelium and control of vascular function. State of the art lecture. Hypertension 13(6 Pt 2):658-667
46. Paszkowiak JJ, Dardik A (2003) Arterial wall shear stress: observations from the bench to the bedside. Vasc Endovascular Surg 37(1):47-57
47. Balligand JL, Feron O, Dessy C (2009) eNOS activation by physical forces: from short-term regulation of contraction to chronic remodeling of cardiovascular tissues. Physiol Rev 89(2):481-534
48. Tzima E et al (2006) A mechanosensory complex that mediates the endothelial cell response to fluid shear stress. FASEB J 20(5):A1378-A1378
49. Shaw A, Xu Q (2003) Biomechanical stress-induced signaling in smooth muscle cells: an update. Curr Vasc Pharmacol 1(1):41-58
50. Owens GK (1995) Regulation of differentiation of vascular smooth muscle cells. Physiol Rev 75(3):487-517
51. Stegemann JP, Hong H, Nerem RM (2005) Mechanical, biochemical, and extracellular matrix effects on vascular smooth muscle cell phenotype. J Appl Physiol 98(6):2321-2327
52. Gupta V, Grande-Allen KJ (2006) Effects of static and cyclic loading in regulating extracellular matrix synthesis by cardiovascular cells. Cardiovasc Res 72(3):375-383
53. Tock J et al (2003) Induction of SM-alpha-actin expression by mechanical strain in adult vascular smooth muscle cells is mediated through activation of JNK and p38 MAP kinase. Biochem Biophys Res Commun 301(4):1116-1121
54. Li X et al (2011) Uniaxial mechanical strain modulates the differentiation of neural crest stem cells into smooth muscle lineage on micropatterned surfaces. Plos One 6(10):7
55. Reusch P et al (1996) Mechanical strain increases smooth muscle and decreases nonmuscle myosin expression in rat vascular smooth muscle cells. Circ Res 79(5):1046-1053
56. Leung DY, Glagov S, Mathews MB (1976) Cyclic stretching stimulates synthesis of matrix components by arterial smooth muscle cells in vitro. Science 191(4226):475-477
57. Beamish JA et al (2010) Molecular regulation of contractile smooth muscle cell phenotype: implications for vascular tissue engineering. Tissue Eng Part B Rev 16(5):467-491
58. Carver W et al (1991) Collagen expression in mechanically stimulated cardiac fibroblasts. Circ Res 69(1):116-122
59. Sheidaei A et al (2011) Simulation of abdominal aortic aneurysm growth with updating hemodynamic loads using a realistic geometry. Med Eng Phys 33(1):80-88
60. Rucker RB, Tinker D (1977) Structure and metabolism of arterial elastin. Int Rev Exp Pathol 17:1-47
61. Lefevre M, Rucker RB (1980) Aorta elastin turnover in normal and hypercholesterolemic Japanese quail. Biochim Biophys Acta 630(4):519-529
62. Shapiro SD (1998) Matrix metalloproteinase degradation of extracellular matrix: biological consequences. Curr Opin Cell Biol 10(5):602-608
63. Solan A et al (2003) Effect of pulse rate on collagen deposition in the tissue-engineered blood vessel. Tissue Eng 9(4):579-586
64. Asanuma K et al (2003) Uniaxial strain upregulates matrix-degrading enzymes produced by human vascular smooth muscle cells. Am J Physiol Heart Circ Physiol 284(5):H1778-H1784
65. Weinberg CB, Bell E (1986) A blood vessel model constructed from collagen and cultured vascular cells. Science 231(4736):397-400
66. Clark RA et al (1995) Collagen matrices attenuate the collagen-synthetic response of cultured fibroblasts to TGF-beta. J Cell Sci 108(Pt 3):1251-1261
67. Thie M et al (1991) Aortic smooth muscle cells in collagen lattice culture: effects on ultrastructure, proliferation and collagen synthesis. Eur J Cell Biol 55(2):295-304
68. Schmidt CE, Baier JM (2000) Acellular vascular tissues: natural biomaterials for tissue repair and tissue engineering. Biomaterials 21(22):2215-2231
69. Payne JW (1973) Polymerization of proteins with glutaraldehyde. Soluble molecular-weight markers. Biochem J 135(4):867-873
70. Charulatha V, Rajaram A (2003) Influence of different crosslinking treatments on the physical properties of collagen membranes. Biomaterials 24(5):759-767
71. Elbjeirami WM et al (2003) Enhancing mechanical properties of tissue-engineered constructs via lysyl oxidase crosslinking activity. J Biomed Mater Res Part A 66A(3):513-521
72. Orban JM et al (2004) Crosslinking of collagen gels by transglutaminase. J Biomed Mater Res Part A 68A(4):756-762
73. Brinkman WT et al (2003) Photo-cross-linking of type I collagen gels in the presence of smooth muscle cells: mechanical properties, cell viability, and function. Biomacromolecules 4(4):890-895
74. Ibusuki S et al (2007) Photochemically cross-linked collagen gels as three-dimensional scaffolds for tissue engineering. Tissue Eng 13(8):1995-2001
75. Mi SL et al (2011) Photochemical cross-linking of plastically compressed collagen gel produces an optimal scaffold for corneal tissue engineering. J Biomed Mater Res Part A 99A(1):1-8
76. Seliktar D et al (2000) Dynamic mechanical conditioning of collagen-gel blood vessel constructs induces remodeling in vitro. Ann Biomed Eng 28(4):351-362
77. Dahl SL, Rhim C, Song YC, Niklason LE (2007) Mechanical properties and compositions of tissue engineered and native arteries. Ann Biomed Eng 35(3):348-355
78. Shaikh FM et al (2008) Fibrin: a natural biodegradable scaffold in vascular tissue engineering. Cells Tissues Organs 188(4):333-346
79. Grassl ED, Oegema TR, Tranquillo RT (2002) Fibrin as an alternative biopolymer to type-I collagen for the fabrication of a media equivalent. J Biomed Mater Res 60(4):607-612
80. Long JL, Tranquillo RT (2003) Elastic fiber production in cardiovascular tissue-equivalents. Matrix Biol 22(4):339-350
81. Grassl ED, Oegema TR, Tranquillo RT (2003) A fibrin-based arterial media equivalent. J Biomed Mater Res Part A 66A(3):550-561
82. Swartz DD, Russell JA, Andreadis ST (2005) Engineering of fibrin-based functional and implantable small-diameter blood vessels. Am J Physiol Heart Circ Physiol 288(3):H1451-H1460
83. L'Heureux N et al (1993) In vitro construction of a human blood vessel from cultured vascular cells: a morphologic study. J Vasc Surg 17(3):499-509
84. Konig G et al (2009) Mechanical properties of completely autologous human tissue engineered blood vessels compared to human saphenous vein and mammary artery. Biomaterials 30(8):1542-1550
85. McAllister TN et al (2009) Effectiveness of haemodialysis access with an autologous tissue-engineered vascular graft: a multicentre cohort study. Lancet 373(9673):1440-1446
86. Garrido SA et al (2009) Haemodialysis access via tissue-engineered vascular graft Authors' reply. Lancet 374(9685):201
87. Wystrychowski W et al (2013) First human use of an allogeneic tissue-engineered vascular graft for hemodialysis access. J Vasc Surg 5(13):01530-01539
88. Pham QP, Sharma U, Mikos AG (2006) Electrospinning of polymeric nanofibers for tissue engineering applications: a review. Tissue Eng 12(5):1197-1211
89. Sill TJ, von Recum HA (2008) Electro spinning: applications in drug delivery and tissue engineering. Biomaterials 29(13):1989-2006
90. Mikos AG et al (1993) Prevascularization of porous biodegradable polymers. Biotechnol Bioeng 42(6):716-723
91. Kwon IK, Matsuda T (2005) Co-electrospun nanofiber fabrics of poly(l-lactide-co-epsilon-caprolactone) with type I collagen or heparin. Biomacromolecules 6(4):2096-2105
92. Pham QP, Sharma U, Mikos AG (2006) Electrospun poly(epsilon-caprolactone) microfiber and multilayer nanofiber/microfiber scaffolds: characterization of scaffolds and measurement of cellular infiltration. Biomacromolecules 7(10):2796-2805
93. Bergmeister H et al (2012) Electrospun small-diameter polyurethane vascular grafts: ingrowth and differentiation of vascular-specific host cells. Artif Organs 36(1):54-61
94. Shin'oka T et al (2005) Midterm clinical result of tissue-engineered vascular autografts seeded with autologous bone marrow cells. J Thorac Cardiovasc Surg 129(6):1330-1338
95. Hibino N et al (2010) Late-term results of tissue-engineered vascular grafts in humans. J Thorac Cardiovasc Surg 139(2):431-436
96. Roh JD et al (2010) Tissue-engineered vascular grafts transform into mature blood vessels via an inflammation-mediated process of vascular remodeling. Proc Natl Acad Sci USA 107(10):4669-4674
97. Wu W, Allen RA, Wang Y (2012) Fast-degrading elastomer enables rapid remodeling of a cell-free synthetic graft into a neoartery. Nat Med 18(7):1148-1153
98. Fiddler GI et al (1983) Calcification of glutaraldehyde-preserved porcine and bovine xenograft valves in young children. Ann Thorac Surg 35(3):257-261
99. Rose AG, Forman R, Bowen RM (1978) Calcification of glutaraldehyde-fixed porcine xenograft. Thorax 33(1):111-114
100. Jernigan TW et al (2004) Small intestinal submucosa for vascular reconstruction in the presence of gastrointestinal contamination. Ann Surg 239(5):733-738
101. Lantz GC et al (1990) Small intestinal submucosa as a small-diameter arterial graft in the dog. J Invest Surg 3(3):217-227
102. Kennealey PT et al (2011) A prospective, randomized comparison of bovine carotid artery and expanded polytetrafluoroethylene for permanent hemodialysis vascular access. J Vasc Surg 53(6):1640-1648
103. Crapo PM, Gilbert TW, Badylak SF (2011) An overview of tissue and whole organ decellularization processes. Biomaterials 32(12):3233-3243
104. Cho SW et al (2005) Small-diameter blood vessels engineered with bone marrow-derived cells. Ann Surg 241(3):506-515
105. Brown KE et al (2009) Arterial reconstruction with cryopreserved human allografts in the setting of infection: a single-center experience with midterm follow-up. J Vasc Surg 49(3):660-666
106. Gui L et al (2009) Development of decellularized human umbilical arteries as small-diameter vascular grafts. Tissue Eng Part A 15(9):2665-2676
107. Schaner PJ et al (2004) Decellularized vein as a potential scaffold for vascular tissue engineering. J Vasc Surg 40(1):146-153
108. Bonetti PO, Lerman LO, Lerman A (2003) Endothelial dysfunction: a marker of atherosclerotic risk. Arterioscler Thromb Vasc Biol 23(2):168-175
109. Li S, Henry JJ (2011) Nonthrombogenic approaches to cardiovascular bioengineering. Annu Rev Biomed Eng 13:451-475
110. Chien S (2008) Effects of disturbed flow on endothelial cells. Ann Biomed Eng 36(4):554-562
111. Cicha I et al (2008) Endothelial dysfunction and monocyte recruitment in cells exposed to non-uniform shear stress. Clin Hemorheol Microcirc 39(1-4):113-119
112. Chiu J-J, Usami S, Chien S (2009) Vascular endothelial responses to altered shear stress: pathologic implications for atherosclerosis. Ann Med 41(1):19-28
113. Stanley JC et al (1982) Enhanced patency of small-diameter, externally supported Dacron iliofemoral grafts seeded with endothelial cells. Surgery 92(6):994-1005
114. Schneider PA et al (1988) Preformed confluent endothelial cell monolayers prevent early platelet deposition on vascular prostheses in baboons. J Vasc Surg 8(3):229-235
115. Williams SK et al (1991) Formation of a functional endothelium on vascular grafts. J Electron Microsc Tech 19(4):439-451
116. Pasic M et al (1993) Long-term results in the dog carotid artery with small lumen vascular prostheses with microvascular endothelial cells. Helv Chir Acta 60(3):381-385
117. Rosenman JE et al (1985) Kinetics of endothelial cell seeding. J Vasc Surg 2(6):778-784
118. Miyata T et al (1991) Delayed exposure to pulsatile shear stress improves retention of human saphenous vein endothelial cells on seeded ePTFE grafts. J Surg Res 50(5):485-493
119. Ott MJ, Ballermann BJ (1995) Shear stress-conditioned, endothelial cell-seeded vascular grafts: improved cell adherence in response to in vitro shear stress. Surgery 117(3):334-339
120. Inoguchi H et al (2007) The effect of gradually graded shear stress on the morphological integrity of a huvec-seeded compliant small-diameter vascular graft. Biomaterials 28(3):486-495
121. Ott MJ, Olson JL, Ballermann BJ (1995) Chronic in vitro flow promotes ultrastructural differentiation of endothelial cells. Endothelium 3(1):21-30
122. Ballermann BJ (1998) Adding endothelium to artificial vascular grafts. News Physiol Sci 13:154
123. Kim BS et al (1999) Cyclic mechanical strain regulates the development of engineered smooth muscle tissue. Nat Biotechnol 17(10):979-983
124. Niklason LE et al (1999) Functional arteries grown in vitro. Science 284(5413):489-493
125. Cross KS et al (1994) Long-term human vein graft contractility and morphology: a functional and histopathological study of retrieved coronary vein grafts. Br J Surg 81(5):699-705
126. Niklason LE et al (2001) Morphologic and mechanical characteristics of engineered bovine arteries. J Vasc Surg 33(3):628-638
127. L'Heureux N et al (1998) A completely biological tissue-engineered human blood vessel. FASEB J 12(1):47-56
128. Mironov V et al (2003) Perfusion bioreactor for vascular tissue engineering with capacities for longitudinal stretch. J Craniofac Surg 14(3):340-347
129. Zaucha MT et al (2009) A novel cylindrical biaxial computer-controlled bioreactor and biomechanical testing device for vascular tissue engineering. Tissue Eng Part A 15(11):3331-3340
130. Syedain ZH, Weinberg JS, Tranquillo RT (2008) Cyclic distension of fibrin-based tissue constructs: evidence of adaptation during growth of engineered connective tissue. Proc Natl Acad Sci USA 105(18):6537-6542
131. Syedain ZH et al (2011) Implantable arterial grafts from human fibroblasts and fibrin using a multi-graft pulsed flow-stretch bioreactor with noninvasive strength monitoring. Biomaterials 32(3):714-722
132. Gui L et al (2013) Construction of tissue-engineered small-diameter vascular grafts in fibrin scaffolds in 30 days. Tissue Eng Part A 10:10
133. Tower TT, Neidert MR, Tranquillo RT (2002) Fiber alignment imaging during mechanical testing of soft tissues. Ann Biomed Eng 30(10):1221-1233
134. Driessen NJ et al (2003) Computational analyses of mechanically induced collagen fiber remodeling in the aortic heart valve. J Biomech Eng 125(4):549-557
135. Shadwick RE (1999) Mechanical design in arteries. J Exp Biol 202(Pt 23):3305-3313
136. Cox RH (1978) Differences in mechanics of arterial smooth muscle from hindlimb arteries. Am J Physiol 235(6):H649-H656
137. Niklason LE et al (2010) Enabling tools for engineering collagenous tissues integrating bioreactors, intravital imaging, and biomechanical modeling. Proc Natl Acad Sci USA 107(8):3335-3339
138. Zoumi A et al (2004) Imaging coronary artery microstructure using second-harmonic and two-photon fluorescence microscopy. Biophys J 87(4):2778-2786
139. Ferruzzi J et al (2011) Mechanical assessment of elastin integrity in fibrillin-1-deficient carotid arteries: implications for Marfan syndrome. Cardiovasc Res 92(2):287-295
140. Timmins LH et al (2010) Structural inhomogeneity and fiber orientation in the inner arterial media. Am J Physiol Heart Circ Physiol 298(5):19
141. Steelman SM et al (2010) Perivascular tethering modulates the geometry and biomechanics of cerebral arterioles. J Biomech 43(14):2717-2721
142. Hu JJ, Humphrey JD, Yeh AT (2009) Characterization of engineered tissue development under biaxial stretch using nonlinear optical microscopy. Tissue Eng Part A 15(7):1553-1564
143. Bourget JM et al (2012) Human fibroblast-derived ECM as a scaffold for vascular tissue engineering. Biomaterials 33(36):9205-9213
144. Hasan A et al (2014) Electrospun scaffolds for tissue engineering of vascular grafts. Acta Biomater 10(1):11-25
145. Thomas V et al (2011) Electrospinning of Biosyn((R))-based tubular conduits: structural, morphological, and mechanical characterizations. Acta Biomater 7(5):2070-2079
146. Soletti L et al (2010) A bilayered elastomeric scaffold for tissue engineering of small diameter vascular grafts. Acta Biomater 6(1):110-122
147. Subramanian A, Krishnan UM, Sethuraman S (2011) Fabrication of uniaxially aligned 3D electrospun scaffolds for neural regeneration. Biomed Mater 6(2):1748-6041
148. Zhao Y et al (2010) The development of a tissue-engineered artery using decellularized scaffold and autologous ovine mesenchymal stem cells. Biomaterials 31(2):296-307
149. Dahl SL et al (2011) Readily available tissue-engineered vascular grafts. Sci Transl Med 3(68):3001426
150. Quint C et al (2011) Decellularized tissue-engineered blood vessel as an arterial conduit. Proc Natl Acad Sci USA 108(22):9214-9219