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Volumn 66, Issue 6, 2014, Pages 1421-1431

Prediction of therapeutic responses to tocilizumab in patients with rheumatoid arthritis: Biomarkers identified by analysis of gene expression in peripheral blood mononuclear cells using genome-wide dna microarray

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; TOCILIZUMAB;

EID: 84901611446     PISSN: 23265191     EISSN: 23265205     Source Type: Journal    
DOI: 10.1002/art.38400     Document Type: Article
Times cited : (85)

References (53)
  • 1
    • 0021212076 scopus 로고
    • Severe functional declines, work disability, and increased mortality in seventy-five rheumatoid arthritis patients studied over nine years
    • Pincus T, Callahan LF, Sale WG, Brooks AL, Payne LE, Vaughn WK,. Severe functional declines, work disability, and increased mortality in seventy-five rheumatoid arthritis patients studied over nine years. Arthritis Rheum 1984; 27: 864-72.
    • (1984) Arthritis Rheum , vol.27 , pp. 864-872
    • Pincus, T.1    Callahan, L.F.2    Sale, W.G.3    Brooks, A.L.4    Payne, L.E.5    Vaughn, W.K.6
  • 3
    • 0035056003 scopus 로고    scopus 로고
    • Anti-TNFα therapy of rheumatoid arthritis: What have we learned?
    • Feldmann M, Maini RN,. Anti-TNFα therapy of rheumatoid arthritis: what have we learned? Annu Rev Immunol 2001; 19: 163-96.
    • (2001) Annu Rev Immunol , vol.19 , pp. 163-196
    • Feldmann, M.1    Maini, R.N.2
  • 5
    • 84855172814 scopus 로고    scopus 로고
    • The pathogenesis of rheumatoid arthritis
    • McInnes IB, Schett G,. The pathogenesis of rheumatoid arthritis. N Engl J Med 2011; 365: 2205-19.
    • (2011) N Engl J Med , vol.365 , pp. 2205-2219
    • McInnes, I.B.1    Schett, G.2
  • 7
    • 77953701245 scopus 로고    scopus 로고
    • Tumour necrosis factor α -308G→A polymorphism is not associated with response to TNFα blockers in Caucasian patients with rheumatoid arthritis: Systematic review and meta-analysis
    • et al.
    • Pavy S, Toonen EJ, Miceli-Richard C, Barrera P, van Riel PL, Criswell LA, et al. Tumour necrosis factor α -308G→A polymorphism is not associated with response to TNFα blockers in Caucasian patients with rheumatoid arthritis: systematic review and meta-analysis. Ann Rheum Dis 2010; 69: 1022-8.
    • (2010) Ann Rheum Dis , vol.69 , pp. 1022-1028
    • Pavy, S.1    Toonen, E.J.2    Miceli-Richard, C.3    Barrera, P.4    Van Riel, P.L.5    Criswell, L.A.6
  • 8
    • 58349103900 scopus 로고    scopus 로고
    • Association of rheumatoid factor and anti-cyclic citrullinated peptide positivity, but not carriage of shared epitope or PTPN22 susceptibility variants, with anti-tumour necrosis factor response in rheumatoid arthritis
    • et al.
    • Potter C, Hyrich KL, Tracey A, Lunt M, Plant D, Symmons DP, et al. Association of rheumatoid factor and anti-cyclic citrullinated peptide positivity, but not carriage of shared epitope or PTPN22 susceptibility variants, with anti-tumour necrosis factor response in rheumatoid arthritis. Ann Rheum Dis 2009; 68: 69-74.
    • (2009) Ann Rheum Dis , vol.68 , pp. 69-74
    • Potter, C.1    Hyrich, K.L.2    Tracey, A.3    Lunt, M.4    Plant, D.5    Symmons, D.P.6
  • 10
    • 44849130695 scopus 로고    scopus 로고
    • Messenger ribonucleic acid expression profile in peripheral blood cells from RA patients following treatment with an anti-TNF-α monoclonal antibody, infliximab
    • et al.
    • Sekiguchi N, Kawauchi S, Furuya T, Inaba N, Matsuda K, Ando S, et al. Messenger ribonucleic acid expression profile in peripheral blood cells from RA patients following treatment with an anti-TNF-α monoclonal antibody, infliximab. Rheumatology (Oxford) 2008; 47: 780-8.
    • (2008) Rheumatology (Oxford) , vol.47 , pp. 780-788
    • Sekiguchi, N.1    Kawauchi, S.2    Furuya, T.3    Inaba, N.4    Matsuda, K.5    Ando, S.6
  • 11
    • 67949101911 scopus 로고    scopus 로고
    • Prediction of efficacy of anti-TNF biologic agent, infliximab, for rheumatoid arthritis patients using a comprehensive transcriptome analysis of white blood cells
    • et al.
    • Tanino M, Matoba R, Nakamura S, Kameda H, Amano K, Okayama T, et al. Prediction of efficacy of anti-TNF biologic agent, infliximab, for rheumatoid arthritis patients using a comprehensive transcriptome analysis of white blood cells. Biochem Biophys Res Commun 2009; 387: 261-5.
    • (2009) Biochem Biophys Res Commun , vol.387 , pp. 261-265
    • Tanino, M.1    Matoba, R.2    Nakamura, S.3    Kameda, H.4    Amano, K.5    Okayama, T.6
  • 12
    • 77955332298 scopus 로고    scopus 로고
    • The gene expression profile in the synovium as a predictor of the clinical response to infliximab treatment in rheumatoid arthritis
    • et al.
    • Lindberg J, Wijbrandts CA, van Baarsen LG, Nader G, Klareskog L, Catrina A, et al. The gene expression profile in the synovium as a predictor of the clinical response to infliximab treatment in rheumatoid arthritis. PLoS One 2010; 5: e11310.
    • (2010) PLoS One , vol.5
    • Lindberg, J.1    Wijbrandts, C.A.2    Van Baarsen, L.G.3    Nader, G.4    Klareskog, L.5    Catrina, A.6
  • 13
    • 84860215051 scopus 로고    scopus 로고
    • The interferon type i signature towards prediction of non-response to rituximab in rheumatoid arthritis patients
    • et al.
    • Raterman HG, Vosslamber S, de Ridder S, Nurmohamed MT, Lems WF, Boers M, et al. The interferon type I signature towards prediction of non-response to rituximab in rheumatoid arthritis patients. Arthritis Res Ther 2012; 14: R95.
    • (2012) Arthritis Res Ther , vol.14
    • Raterman, H.G.1    Vosslamber, S.2    De Ridder, S.3    Nurmohamed, M.T.4    Lems, W.F.5    Boers, M.6
  • 14
    • 34447300492 scopus 로고    scopus 로고
    • Study of Active controlled Monotherapy Used for Rheumatoid Arthritis, an IL-6 inhibitor (SAMURAI): Evidence of clinical and radiographic benefit from an x ray reader-blinded randomised controlled trial of tocilizumab
    • et al.
    • Nishimoto N, Hashimoto J, Miyasaka N, Yamamoto K, Kawai S, Takeuchi T, et al. Study of Active controlled Monotherapy Used for Rheumatoid Arthritis, an IL-6 inhibitor (SAMURAI): evidence of clinical and radiographic benefit from an x ray reader-blinded randomised controlled trial of tocilizumab. Ann Rheum Dis 2007; 66: 1162-7.
    • (2007) Ann Rheum Dis , vol.66 , pp. 1162-1167
    • Nishimoto, N.1    Hashimoto, J.2    Miyasaka, N.3    Yamamoto, K.4    Kawai, S.5    Takeuchi, T.6
  • 15
    • 54949150604 scopus 로고    scopus 로고
    • Interleukin-6 receptor inhibition with tocilizumab reduces disease activity in rheumatoid arthritis with inadequate response to disease-modifying antirheumatic drugs: The Tocilizumab in Combination with Traditional Disease-Modifying Antirheumatic Drug Therapy Study
    • et al.
    • Genovese MC, McKay JD, Nasonov EL, Mysler EF, da Silva NA, Alecock E, et al. Interleukin-6 receptor inhibition with tocilizumab reduces disease activity in rheumatoid arthritis with inadequate response to disease-modifying antirheumatic drugs: the Tocilizumab in Combination with Traditional Disease-Modifying Antirheumatic Drug Therapy Study. Arthritis Rheum 2008; 58: 2968-80.
    • (2008) Arthritis Rheum , vol.58 , pp. 2968-2980
    • Genovese, M.C.1    McKay, J.D.2    Nasonov, E.L.3    Mysler, E.F.4    Da Silva, N.A.5    Alecock, E.6
  • 16
    • 84877275257 scopus 로고    scopus 로고
    • Tocilizumab monotherapy versus adalimumab monotherapy for treatment of rheumatoid arthritis (ADACTA): A randomised, double-blind, controlled phase 4 trial
    • et al.
    • Gabay C, Emery P, van Vollenhoven R, Dikranian A, Alten R, Pavelka K, et al. Tocilizumab monotherapy versus adalimumab monotherapy for treatment of rheumatoid arthritis (ADACTA): a randomised, double-blind, controlled phase 4 trial. Lancet 2013; 381: 1541-50.
    • (2013) Lancet , vol.381 , pp. 1541-1550
    • Gabay, C.1    Emery, P.2    Van Vollenhoven, R.3    Dikranian, A.4    Alten, R.5    Pavelka, K.6
  • 17
    • 0023945481 scopus 로고
    • The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis
    • et al.
    • Arnett FC, Edworthy SM, Bloch DA, McShane DJ, Fries JF, Cooper NS, et al. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 1988; 31: 315-24.
    • (1988) Arthritis Rheum , vol.31 , pp. 315-324
    • Arnett, F.C.1    Edworthy, S.M.2    Bloch, D.A.3    McShane, D.J.4    Fries, J.F.5    Cooper, N.S.6
  • 19
    • 0029044362 scopus 로고
    • American College of Rheumatology preliminary definition of improvement in rheumatoid arthritis
    • et al.
    • Felson DT, Anderson JJ, Boers M, Bombardier C, Furst D, Goldsmith C, et al. American College of Rheumatology preliminary definition of improvement in rheumatoid arthritis. Arthritis Rheum 1995; 38: 727-35.
    • (1995) Arthritis Rheum , vol.38 , pp. 727-735
    • Felson, D.T.1    Anderson, J.J.2    Boers, M.3    Bombardier, C.4    Furst, D.5    Goldsmith, C.6
  • 20
    • 0030068817 scopus 로고    scopus 로고
    • Development and validation of the European League Against Rheumatism response criteria for rheumatoid arthritis: Comparison with the preliminary American College of Rheumatology and the World Health Organization/ International League Against Rheumatism criteria
    • Van Gestel AM, Prevoo ML, van't Hof MA, van Rijswijk MH, van de Putte LB, van Riel PL,. Development and validation of the European League Against Rheumatism response criteria for rheumatoid arthritis: comparison with the preliminary American College of Rheumatology and the World Health Organization/ International League Against Rheumatism criteria. Arthritis Rheum 1996; 39: 34-40.
    • (1996) Arthritis Rheum , vol.39 , pp. 34-40
    • Van Gestel, A.M.1    Prevoo, M.L.2    Van'T Hof, M.A.3    Van Rijswijk, M.H.4    Van De Putte, L.B.5    Van Riel, P.L.6
  • 21
    • 33644804877 scopus 로고    scopus 로고
    • The Simplified Disease Activity Index (SDAI) and the Clinical Disease Activity Index (CDAI): A review of their usefulness and validity in rheumatoid arthritis
    • Aletaha D, Smolen J,. The Simplified Disease Activity Index (SDAI) and the Clinical Disease Activity Index (CDAI): a review of their usefulness and validity in rheumatoid arthritis. Clin Exp Rheumatol 2005; 23: S100-8.
    • (2005) Clin Exp Rheumatol , vol.23
    • Aletaha, D.1    Smolen, J.2
  • 22
    • 77956055481 scopus 로고    scopus 로고
    • 2010 rheumatoid arthritis classification criteria: An American College of Rheumatology/European League Against Rheumatism collaborative initiative
    • et al.
    • Aletaha D, Neogi T, Silman AJ, Funovits J, Felson DT, Bingham CO III, et al. 2010 rheumatoid arthritis classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative. Arthritis Rheum 2010; 62: 2569-81.
    • (2010) Arthritis Rheum , vol.62 , pp. 2569-2581
    • Aletaha, D.1    Neogi, T.2    Silman, A.J.3    Funovits, J.4    Felson, D.T.5    Bingham III, C.O.6
  • 24
    • 34249712937 scopus 로고    scopus 로고
    • Rheumatoid arthritis subtypes identified by genomic profiling of peripheral blood cells: Assignment of a type i interferon signature in a subpopulation of patients
    • et al.
    • Van der Pouw Kraan TC, Wijbrandts CA, van Baarsen LG, Voskuyl AE, Rustenburg F, Baggen JM, et al. Rheumatoid arthritis subtypes identified by genomic profiling of peripheral blood cells: assignment of a type I interferon signature in a subpopulation of patients. Ann Rheum Dis 2007; 66: 1008-14.
    • (2007) Ann Rheum Dis , vol.66 , pp. 1008-1014
    • Van Der Pouw Kraan, T.C.1    Wijbrandts, C.A.2    Van Baarsen, L.G.3    Voskuyl, A.E.4    Rustenburg, F.5    Baggen, J.M.6
  • 25
    • 75749084066 scopus 로고    scopus 로고
    • Association of the response to tumor necrosis factor antagonists with plasma type i interferon activity and interferon-β/α ratios in rheumatoid arthritis patients: A post hoc analysis of a predominantly Hispanic cohort
    • Mavragani CP, La DT, Stohl W, Crow MK,. Association of the response to tumor necrosis factor antagonists with plasma type I interferon activity and interferon-β/α ratios in rheumatoid arthritis patients: a post hoc analysis of a predominantly Hispanic cohort. Arthritis Rheum 2010; 62: 392-401.
    • (2010) Arthritis Rheum , vol.62 , pp. 392-401
    • Mavragani, C.P.1    La, D.T.2    Stohl, W.3    Crow, M.K.4
  • 26
    • 78650063161 scopus 로고    scopus 로고
    • Relationship between the type i interferon signature and the response to rituximab in rheumatoid arthritis patients
    • et al.
    • Thurlings RM, Boumans M, Tekstra J, van Roon JA, Vos K, van Westing DM, et al. Relationship between the type I interferon signature and the response to rituximab in rheumatoid arthritis patients. Arthritis Rheum 2010; 62: 3607-14.
    • (2010) Arthritis Rheum , vol.62 , pp. 3607-3614
    • Thurlings, R.M.1    Boumans, M.2    Tekstra, J.3    Van Roon, J.A.4    Vos, K.5    Van Westing, D.M.6
  • 27
    • 80053495592 scopus 로고    scopus 로고
    • Patients with systemic lupus erythematosus, myositis, rheumatoid arthritis and scleroderma share activation of a common type i interferon pathway
    • et al.
    • Higgs BW, Liu Z, White B, Zhu W, White WI, Morehouse C, et al. Patients with systemic lupus erythematosus, myositis, rheumatoid arthritis and scleroderma share activation of a common type I interferon pathway. Ann Rheum Dis 2011; 70: 2029-36.
    • (2011) Ann Rheum Dis , vol.70 , pp. 2029-2036
    • Higgs, B.W.1    Liu, Z.2    White, B.3    Zhu, W.4    White, W.I.5    Morehouse, C.6
  • 28
    • 79955109537 scopus 로고    scopus 로고
    • Gene expression profiles from discordant monozygotic twins suggest that molecular pathways are shared among multiple systemic autoimmune diseases
    • et al.
    • O'Hanlon TP, Rider LG, Gan L, Fannin R, Paules RS, Umbach DM, et al. Gene expression profiles from discordant monozygotic twins suggest that molecular pathways are shared among multiple systemic autoimmune diseases. Arthritis Res Ther 2011; 13: R69.
    • (2011) Arthritis Res Ther , vol.13
    • O'Hanlon, T.P.1    Rider, L.G.2    Gan, L.3    Fannin, R.4    Paules, R.S.5    Umbach, D.M.6
  • 29
    • 79955823796 scopus 로고    scopus 로고
    • Pharmacological induction of interferon type i activity following treatment with rituximab determines clinical response in rheumatoid arthritis
    • et al.
    • Vosslamber S, Raterman HG, van der Pouw Kraan TC, Schreurs MW, von Blomberg BM, Nurmohamed MT, et al. Pharmacological induction of interferon type I activity following treatment with rituximab determines clinical response in rheumatoid arthritis. Ann Rheum Dis 2011; 70: 1153-9.
    • (2011) Ann Rheum Dis , vol.70 , pp. 1153-1159
    • Vosslamber, S.1    Raterman, H.G.2    Van Der Pouw Kraan, T.C.3    Schreurs, M.W.4    Von Blomberg, B.M.5    Nurmohamed, M.T.6
  • 30
    • 77649289297 scopus 로고    scopus 로고
    • Regulation of IFN response gene activity during infliximab treatment in rheumatoid arthritis is associated with clinical response to treatment
    • et al.
    • Van Baarsen LG, Wijbrandts CA, Rustenburg F, Cantaert T, van der Pouw Kraan TC, Baeten DL, et al. Regulation of IFN response gene activity during infliximab treatment in rheumatoid arthritis is associated with clinical response to treatment. Arthritis Res Ther 2010; 12: R11.
    • (2010) Arthritis Res Ther , vol.12
    • Van Baarsen, L.G.1    Wijbrandts, C.A.2    Rustenburg, F.3    Cantaert, T.4    Van Der Pouw Kraan, T.C.5    Baeten, D.L.6
  • 31
    • 84867398434 scopus 로고    scopus 로고
    • Pretreatment synovial transcriptional profile is associated with early and late clinical response in rheumatoid arthritis patients treated with rituximab
    • et al.
    • Hogan VE, Holweg CT, Choy DF, Kummerfeld SK, Hackney JA, Teng YK, et al. Pretreatment synovial transcriptional profile is associated with early and late clinical response in rheumatoid arthritis patients treated with rituximab. Ann Rheum Dis 2012; 71: 1888-94.
    • (2012) Ann Rheum Dis , vol.71 , pp. 1888-1894
    • Hogan, V.E.1    Holweg, C.T.2    Choy, D.F.3    Kummerfeld, S.K.4    Hackney, J.A.5    Teng, Y.K.6
  • 32
    • 85027930906 scopus 로고    scopus 로고
    • Inhibition of plasma IL-6 in addition to maintenance of an efficacious trough level of infliximab associated with clinical remission in patients with rheumatoid arthritis: Analysis of the RISING Study
    • et al.
    • Takeuchi T, Miyasaka N, Tatsuki Y, Yano T, Yoshinari T, Abe T, et al. Inhibition of plasma IL-6 in addition to maintenance of an efficacious trough level of infliximab associated with clinical remission in patients with rheumatoid arthritis: analysis of the RISING Study. Ann Rheum Dis 2012; 71: 1583-5.
    • (2012) Ann Rheum Dis , vol.71 , pp. 1583-1585
    • Takeuchi, T.1    Miyasaka, N.2    Tatsuki, Y.3    Yano, T.4    Yoshinari, T.5    Abe, T.6
  • 33
    • 0036922030 scopus 로고    scopus 로고
    • Autoimmune disease complicating antiviral therapy for hepatitis C virus infection
    • Wilson LE, Widman D, Dikman SH, Gorevic PD,. Autoimmune disease complicating antiviral therapy for hepatitis C virus infection. Semin Arthritis Rheum 2002; 32: 163-73.
    • (2002) Semin Arthritis Rheum , vol.32 , pp. 163-173
    • Wilson, L.E.1    Widman, D.2    Dikman, S.H.3    Gorevic, P.D.4
  • 34
    • 77955869446 scopus 로고    scopus 로고
    • Psoriasis during interferon β treatment for multiple sclerosis
    • La Mantia L, Capsoni F,. Psoriasis during interferon β treatment for multiple sclerosis. Neurol Sci 2010; 31: 337-9.
    • (2010) Neurol Sci , vol.31 , pp. 337-339
    • La Mantia, L.1    Capsoni, F.2
  • 35
    • 77955456303 scopus 로고    scopus 로고
    • Interferon β treatment in neuromyelitis optica: Increase in relapses and aquaporin 4 antibody titers
    • Palace J, Leite MI, Nairne A, Vincent A,. Interferon β treatment in neuromyelitis optica: increase in relapses and aquaporin 4 antibody titers. Arch Neurol 2010; 67: 1016-7.
    • (2010) Arch Neurol , vol.67 , pp. 1016-1017
    • Palace, J.1    Leite, M.I.2    Nairne, A.3    Vincent, A.4
  • 36
    • 84886548895 scopus 로고    scopus 로고
    • Rheumatoid arthritis following PEG-interferon-alfa-2a plus ribavirin treatment for chronic hepatitis C: A case report and review of the literature
    • Cacopardo B, Benanti F, Pinzone MR, Nunnari G,. Rheumatoid arthritis following PEG-interferon-alfa-2a plus ribavirin treatment for chronic hepatitis C: a case report and review of the literature. BMC Res Notes 2013; 6: 437.
    • (2013) BMC Res Notes , vol.6 , pp. 437
    • Cacopardo, B.1    Benanti, F.2    Pinzone, M.R.3    Nunnari, G.4
  • 37
    • 84862748323 scopus 로고    scopus 로고
    • Janus-like effects of type i interferon in autoimmune diseases
    • Axtell RC, Raman C,. Janus-like effects of type I interferon in autoimmune diseases. Immunol Rev 2012; 248: 23-35.
    • (2012) Immunol Rev , vol.248 , pp. 23-35
    • Axtell, R.C.1    Raman, C.2
  • 38
    • 84883114740 scopus 로고    scopus 로고
    • Immunopathogenic mechanisms of systemic autoimmune disease
    • Wahren-Herlenius M, Dorner T,. Immunopathogenic mechanisms of systemic autoimmune disease. Lancet 2013; 382: 819-31.
    • (2013) Lancet , vol.382 , pp. 819-831
    • Wahren-Herlenius, M.1    Dorner, T.2
  • 39
    • 77950534540 scopus 로고    scopus 로고
    • T helper type 1 and 17 cells determine efficacy of interferon-β in multiple sclerosis and experimental encephalomyelitis
    • et al.
    • Axtell RC, de Jong BA, Boniface K, van der Voort LF, Bhat R, De Sarno P, et al. T helper type 1 and 17 cells determine efficacy of interferon-β in multiple sclerosis and experimental encephalomyelitis. Nat Med 2010; 16: 406-12.
    • (2010) Nat Med , vol.16 , pp. 406-412
    • Axtell, R.C.1    De Jong, B.A.2    Boniface, K.3    Van Der Voort, L.F.4    Bhat, R.5    De Sarno, P.6
  • 41
    • 84899765494 scopus 로고    scopus 로고
    • AT-rich-interactive domain-containing protein 5A functions as a negative regulator of retinoic acid receptor-related orphan nuclear receptor γt-induced Th17 cell differentiation
    • et al.
    • Saito Y, Kagami S, Sanayama Y, Ikeda K, Suto A, Kashiwakuma D, et al. AT-rich-interactive domain-containing protein 5A functions as a negative regulator of retinoic acid receptor-related orphan nuclear receptor γt-induced Th17 cell differentiation. Arthritis Rheumatol 2014; 66: 1185-94.
    • (2014) Arthritis Rheumatol , vol.66 , pp. 1185-1194
    • Saito, Y.1    Kagami, S.2    Sanayama, Y.3    Ikeda, K.4    Suto, A.5    Kashiwakuma, D.6
  • 42
    • 0034884781 scopus 로고    scopus 로고
    • Cross talk of the interferon-α/β signalling complex with gp130 for effective interleukin-6 signalling
    • et al.
    • Mitani Y, Takaoka A, Kim SH, Kato Y, Yokochi T, Tanaka N, et al. Cross talk of the interferon-α/β signalling complex with gp130 for effective interleukin-6 signalling. Genes Cells 2001; 6: 631-40.
    • (2001) Genes Cells , vol.6 , pp. 631-640
    • Mitani, Y.1    Takaoka, A.2    Kim, S.H.3    Kato, Y.4    Yokochi, T.5    Tanaka, N.6
  • 43
    • 0019932125 scopus 로고
    • Human metallothionein genes-primary structure of the metallothionein-II gene and a related processed gene
    • Karin M, Richards RI,. Human metallothionein genes-primary structure of the metallothionein-II gene and a related processed gene. Nature 1982; 299: 797-802.
    • (1982) Nature , vol.299 , pp. 797-802
    • Karin, M.1    Richards, R.I.2
  • 44
    • 0021173920 scopus 로고
    • Structural and functional analysis of the human metallothionein-IA gene: Differential induction by metal ions and glucocorticoids
    • Richards RI, Heguy A, Karin M,. Structural and functional analysis of the human metallothionein-IA gene: differential induction by metal ions and glucocorticoids. Cell 1984; 37: 263-72.
    • (1984) Cell , vol.37 , pp. 263-272
    • Richards, R.I.1    Heguy, A.2    Karin, M.3
  • 46
    • 0025228503 scopus 로고
    • Interleukin 6 regulates metallothionein gene expression and zinc metabolism in hepatocyte monolayer cultures
    • Schroeder JJ, Cousins RJ,. Interleukin 6 regulates metallothionein gene expression and zinc metabolism in hepatocyte monolayer cultures. Proc Natl Acad Sci U S A 1990; 87: 3137-41.
    • (1990) Proc Natl Acad Sci U S A , vol.87 , pp. 3137-3141
    • Schroeder, J.J.1    Cousins, R.J.2
  • 47
    • 0032952723 scopus 로고    scopus 로고
    • Identification of a signal transducer and activator of transcription (STAT) binding site in the mouse metallothionein-I promoter involved in interleukin-6-induced gene expression
    • Lee DK, Carrasco J, Hidalgo J, Andrews GK,. Identification of a signal transducer and activator of transcription (STAT) binding site in the mouse metallothionein-I promoter involved in interleukin-6-induced gene expression. Biochem J 1999; 337: 59-65.
    • (1999) Biochem J , vol.337 , pp. 59-65
    • Lee, D.K.1    Carrasco, J.2    Hidalgo, J.3    Andrews, G.K.4
  • 48
    • 0032101104 scopus 로고    scopus 로고
    • Activation of nuclear factor κb: Potential role in metallothionein-mediated mitogenic response
    • Abdel-Mageed AB, Agrawal KC,. Activation of nuclear factor κB: potential role in metallothionein-mediated mitogenic response. Cancer Res 1998; 58: 2335-8.
    • (1998) Cancer Res , vol.58 , pp. 2335-2338
    • Abdel-Mageed, A.B.1    Agrawal, K.C.2
  • 50
    • 33646128026 scopus 로고    scopus 로고
    • Nutrient-gene interaction in ageing and successful ageing: A single nutrient (zinc) and some target genes related to inflammatory/immune response
    • et al.
    • Mocchegiani E, Costarelli L, Giacconi R, Cipriano C, Muti E, Tesei S, et al. Nutrient-gene interaction in ageing and successful ageing: a single nutrient (zinc) and some target genes related to inflammatory/immune response. Mech Ageing Dev 2006; 127: 517-25.
    • (2006) Mech Ageing Dev , vol.127 , pp. 517-525
    • Mocchegiani, E.1    Costarelli, L.2    Giacconi, R.3    Cipriano, C.4    Muti, E.5    Tesei, S.6
  • 51
    • 84858650504 scopus 로고    scopus 로고
    • Validation study of existing gene expression signatures for anti-TNF treatment in patients with rheumatoid arthritis
    • et al.
    • Toonen EJ, Gilissen C, Franke B, Kievit W, Eijsbouts AM, den Broeder AA, et al. Validation study of existing gene expression signatures for anti-TNF treatment in patients with rheumatoid arthritis. PLoS One 2012; 7: e33199.
    • (2012) PLoS One , vol.7
    • Toonen, E.J.1    Gilissen, C.2    Franke, B.3    Kievit, W.4    Eijsbouts, A.M.5    Den Broeder, A.A.6
  • 52
    • 44449110026 scopus 로고    scopus 로고
    • Molecular discrimination of responders and nonresponders to anti-TNFα therapy in rheumatoid arthritis by etanercept
    • et al.
    • Koczan D, Drynda S, Hecker M, Drynda A, Guthke R, Kekow J, et al. Molecular discrimination of responders and nonresponders to anti-TNFα therapy in rheumatoid arthritis by etanercept. Arthritis Res Ther 2008; 10: R50.
    • (2008) Arthritis Res Ther , vol.10
    • Koczan, D.1    Drynda, S.2    Hecker, M.3    Drynda, A.4    Guthke, R.5    Kekow, J.6
  • 53
    • 83255162593 scopus 로고    scopus 로고
    • Disease Activity Score 28 may overestimate the remission induction of rheumatoid arthritis patients treated with tocilizumab: Comparison with the remission by the Clinical Disease Activity Index
    • et al.
    • Kawashiri SY, Kawakami A, Iwamoto N, Fujikawa K, Aramaki T, Tamai M, et al. Disease Activity Score 28 may overestimate the remission induction of rheumatoid arthritis patients treated with tocilizumab: comparison with the remission by the Clinical Disease Activity Index. Mod Rheumatol 2011; 21: 365-9.
    • (2011) Mod Rheumatol , vol.21 , pp. 365-369
    • Kawashiri, S.Y.1    Kawakami, A.2    Iwamoto, N.3    Fujikawa, K.4    Aramaki, T.5    Tamai, M.6


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