-
1
-
-
8244254377
-
Improvements in survival and clinical benefit with gemcitabine as first- line therapy for patients with advanced pancreas cancer: A randomized trial
-
Burris 3rd HA, Moore MJ, Andersen J, Green MR, Rothenberg ML, Modiano MR, et al. Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: a randomized trial. J Clin Oncol. 1997;15(6):2403-13. (Pubitemid 27251144)
-
(1997)
Journal of Clinical Oncology
, vol.15
, Issue.6
, pp. 2403-2413
-
-
Burris III, H.A.1
Moore, M.J.2
Andersen, J.3
Green, M.R.4
Rothenberg, M.L.5
Modiano, M.R.6
Cripps, M.C.7
Portenoy, R.K.8
Storniolo, A.M.9
Tarassoff, P.10
Nelson, R.11
Dorr, F.A.12
Stephens, C.D.13
Von Hoff, D.D.14
-
2
-
-
42349093032
-
Meta-analysis of randomized trials: Evaluation of benefit from gemcitabine-based combination chemotherapy applied in advanced pancreatic cancer
-
Heinemann V, Boeck S, Hinke A, Labianca R, Louvet C. Meta-analysis of randomized trials: Evaluation of benefit from gemcitabine-based combination chemotherapy applied in advanced pancreatic cancer. BMC Cancer. 2008;8:82.
-
(2008)
BMC Cancer
, vol.8
, pp. 82
-
-
Heinemann, V.1
Boeck, S.2
Hinke, A.3
Labianca, R.4
Louvet, C.5
-
3
-
-
79955921754
-
FOLFIRINOX versus gemcitabine for metastatic pancreatic cancer
-
Conroy T, Desseigne F, Ychou M, Bouche O, Guimbaud R, Becouarn Y, et al. FOLFIRINOX versus gemcitabine for metastatic pancreatic cancer. N Engl J Med. 2011;364(19):1817-25.
-
(2011)
N Engl J Med
, vol.364
, Issue.19
, pp. 1817-1825
-
-
Conroy, T.1
Desseigne, F.2
Ychou, M.3
Bouche, O.4
Guimbaud, R.5
Becouarn, Y.6
-
4
-
-
84872967522
-
Cancer statistics, 2013
-
Siegel R, Naishadham D, Jemal A. Cancer statistics, 2013. CA Cancer J Clin. 2013;63(1):11-30.
-
(2013)
CA Cancer J Clin
, vol.63
, Issue.1
, pp. 11-30
-
-
Siegel, R.1
Naishadham, D.2
Jemal, A.3
-
5
-
-
20044374358
-
Irinotecan plus oxaliplatin and leucovorin-modulated fluorouracil in advanced pancreatic cancer - A Groupe Tumeurs Digestives of the Fédération Nationale des Centres de Lutte Contre le Cancer study
-
DOI 10.1200/JCO.2005.06.050
-
Conroy T, Paillot B, Francois E, Bugat R, Jacob JH, Stein U, et al. Irinotecan plus oxaliplatin and leucovorin-modulated fluorouracil in advanced pancreatic cancer - A groupe tumeurs digestives of the federation nationale des centres de lutte contre le cancer study. J Clin Oncol. 2005;23(6):1228-36. (Pubitemid 46202280)
-
(2005)
Journal of Clinical Oncology
, vol.23
, Issue.6
, pp. 1228-1236
-
-
Conroy, T.1
Paillot, B.2
Francois, E.3
Bugat, R.4
Jacob, J.-H.5
Stein, U.6
Nasca, S.7
Metges, J.-P.8
Rixe, O.9
Michel, P.10
Magherini, E.11
Hua, A.12
Deplanque, G.13
-
6
-
-
84871246158
-
Defining eligibility of FOLFIRINOX for first-line metastatic pancreatic adenocarcinoma (MPC) in the province of British Columbia: A population-based retrospective study
-
Gill S, Ho MY, Kennecke HF, Renouf DJ, Cheung WY, Lim HJ. Defining eligibility of FOLFIRINOX for first-line metastatic pancreatic adenocarcinoma (MPC) in the province of British Columbia: a population-based retrospective study. ASCO Meet Abstr. 2012;30(15-suppl):e14588.
-
(2012)
ASCO Meet Abstr
, vol.30
, Issue.15 SUPPL.
-
-
Gill, S.1
Ho, M.Y.2
Kennecke, H.F.3
Renouf, D.J.4
Cheung, W.Y.5
Lim, H.J.6
-
7
-
-
84871186668
-
Optimizing supportive measures for the safe administration of FOLFIRINOX as first-line treatment in advanced, inoperable pancreatic cancer (aPDAC) patients (pts) in routine clinical practice
-
Vaccaro V, Bria E, Sperduti I, Pino MS, Massari F, Gelibter A, et al. Optimizing supportive measures for the safe administration of FOLFIRINOX as first-line treatment in advanced, inoperable pancreatic cancer (aPDAC) patients (pts) in routine clinical practice. ASCO Meet Abstr. 2012;30:e14661.
-
(2012)
ASCO Meet Abstr
, vol.30
-
-
Vaccaro, V.1
Bria, E.2
Sperduti, I.3
Pino, M.S.4
Massari, F.5
Gelibter, A.6
-
8
-
-
84866378244
-
Multi-institutional experience with FOLFIRINOX in pancreatic adenocarcinoma
-
Peddi P, Lubner S, McWilliams R, et al. Multi-institutional experience with FOLFIRINOX in pancreatic adenocarcinoma. JOP. 2012;13(5):497-501.
-
(2012)
JOP
, vol.13
, Issue.5
, pp. 497-501
-
-
Peddi, P.1
Lubner, S.2
McWilliams, R.3
-
9
-
-
84878165472
-
FOLFIRINOX in locally advanced pancreatic cancer: The Massachusetts General Hospital Cancer Center experience
-
Faris J, Blaszkowsky L,McDermott S, et al. FOLFIRINOX in locally advanced pancreatic cancer: the Massachusetts General Hospital Cancer Center experience. Oncologist. 2013;18(5):543-8.
-
(2013)
Oncologist
, vol.18
, Issue.5
, pp. 543-548
-
-
Faris, J.1
Blaszkowsky, L.2
McDermott, S.3
-
10
-
-
84871233118
-
Multi-institutional experience using 5-fluorouracil, leucovorin, irinotecan, and oxaliplatin (FOLFIRINOX) in patients with pancreatic cancer (PCA)
-
Goncalves PH, Ruch JM, Byer J, Shields AF, ChoiM, Kim RD, et al. Multi-institutional experience using 5-fluorouracil, leucovorin, irinotecan, and oxaliplatin (FOLFIRINOX) in patients with pancreatic cancer (PCA). ASCO Meet Abstr. 2012;30(15-suppl):e14519.
-
(2012)
ASCO Meet Abstr
, vol.30
, Issue.15 SUPPL.
-
-
Goncalves, P.H.1
Ruch, J.M.2
Byer, J.3
Shields, A.F.4
Choi, M.5
Kim, R.D.6
-
11
-
-
84871181250
-
Safety and efficacy of modified FOLFIRINOX in pancreatic cancer: A retrospective experience
-
Mahaseth H, Kauh JS, Brutcher E, Hawk NN, Kim S, Chen Z, et al. Safety and efficacy of modified FOLFIRINOX in pancreatic cancer: a retrospective experience. ASCO Meet Abstr. 2012;30(15-suppl):e14614.
-
(2012)
ASCO Meet Abstr
, vol.30
, Issue.15 SUPPL.
-
-
Mahaseth, H.1
Kauh, J.S.2
Brutcher, E.3
Hawk, N.N.4
Kim, S.5
Chen, Z.6
-
12
-
-
84871492380
-
FOLFIRINOXfor locally advanced andmetastatic pancreatic cancer: Single institution retrospective review of efficacy and toxicity
-
Gunturu K, Yao X, Cong X, Thumar J, Hochster H, Stein S, et al. FOLFIRINOXfor locally advanced andmetastatic pancreatic cancer: single institution retrospective review of efficacy and toxicity. Med Oncol. 2013;30(1):361.
-
(2013)
Med Oncol
, vol.30
, Issue.1
, pp. 361
-
-
Gunturu, K.1
Yao, X.2
Cong, X.3
Thumar, J.4
Hochster, H.5
Stein, S.6
-
13
-
-
84858733250
-
Is there a role for the quantification of RRM1 and ERCC1 expression in pancreatic ductal adenocarcinoma?
-
ValsecchiME,Holdbrook T, Leiby BE, Pequignot E, Littman SJ,Yeo CJ, et al. Is there a role for the quantification of RRM1 and ERCC1 expression in pancreatic ductal adenocarcinoma? BMC Cancer. 2012;12:104.
-
(2012)
BMC Cancer
, vol.12
, pp. 104
-
-
Valsecchi, M.E.1
Holdbrook, T.2
Leiby, B.E.3
Pequignot, E.4
Littman, S.J.5
Yeo, C.J.6
-
14
-
-
84892808887
-
5-FU/leucovorin, irinotecan, oxaliplatin (FOLFIRINOX) induction followed by chemoXRT in borderline resectable pancreatic cancer
-
Kharofa J, Kelly TR, Ritch PS, George B, Wiebe LA, Thomas JP, et al. 5-FU/leucovorin, irinotecan, oxaliplatin (FOLFIRINOX) induction followed by chemoXRT in borderline resectable pancreatic cancer. ASCO Meet Abstr. 2012;30(15-suppl)):e14613.
-
(2012)
ASCO Meet Abstr
, vol.30
, Issue.15 SUPPL.
-
-
Kharofa, J.1
Kelly, T.R.2
Ritch, P.S.3
George, B.4
Wiebe, L.A.5
Thomas, J.P.6
-
15
-
-
84861465672
-
A retrospective study of neoadjuvant FOLFIRINOX in unresectable or borderline-resectable locally advanced pancreatic adenocarcinoma
-
Hosein PJ, Macintyre J, Kawamura C, et al. A retrospective study of neoadjuvant FOLFIRINOX in unresectable or borderline-resectable locally advanced pancreatic adenocarcinoma. BMC Cancer. 2012;12:199.
-
(2012)
BMC Cancer
, vol.12
, pp. 199
-
-
Hosein, P.J.1
Macintyre, J.2
Kawamura, C.3
-
16
-
-
84882402665
-
Outcomes with FOLFIRINOX for borderline resectable and locally unresectable pancreatic cancer
-
Boone B, Steve J, Krasinskas A, Zureikat A, Lembersky B, Gibson M, et al. Outcomes with FOLFIRINOX for borderline resectable and locally unresectable pancreatic cancer. J Surg Oncol. 2013;108(4):236.
-
(2013)
J Surg Oncol
, vol.108
, Issue.4
, pp. 236
-
-
Boone, B.1
Steve, J.2
Krasinskas, A.3
Zureikat, A.4
Lembersky, B.5
Gibson, M.6
-
17
-
-
66149129222
-
Albumin-bound formulation of paclitaxel (abraxane ABI-007) in the treatment of breast cancer
-
Miele E, Spinelli GP, Miele E, Tomao F, Tomao S. Albumin-bound formulation of paclitaxel (abraxane ABI-007) in the treatment of breast cancer. Int J Nanomed. 2009;4:99-105.
-
(2009)
Int J Nanomed
, vol.4
, pp. 99-105
-
-
Miele, E.1
Spinelli, G.P.2
Miele, E.3
Tomao, F.4
Tomao, S.5
-
18
-
-
33644753906
-
Increased antitumor activity, intratumor paclitaxel concentrations, and endothelial cell transport of cremophor-free, albumin-bound paclitaxel, ABI-007, compared with cremophor-based paclitaxel
-
DOI 10.1158/1078-0432.CCR-05-1634
-
Desai N, Trieu V, Yao Z, Louie L, Ci S, Yang A, et al. Increased antitumor activity, intratumor paclitaxel concentrations, and endothelial cell transport of cremophor-free, albumin-bound paclitaxel, ABIJ 007, compared with cremophor-based paclitaxel. Clin Cancer Res. 2006;12(4):1317-24. (Pubitemid 43342524)
-
(2006)
Clinical Cancer Research
, vol.12
, Issue.4
, pp. 1317-1324
-
-
Desai, N.1
Trieu, V.2
Yao, Z.3
Louie, L.4
Ci, S.5
Yang, A.6
Tao, C.7
De, T.8
Beals, B.9
Dykes, D.10
Noker, P.11
Yao, R.12
Labao, E.13
Hawkins, M.14
Soon-Shiong, P.15
-
19
-
-
84892990008
-
Nanoparticle albumin bound paclitaxel in the treatment of human cancer: Nanodelivery reaches prime-time?
-
Epub 2013 May 2
-
Cucinotto I, Fiorillo L, Gualtieri S, ArbitrioM. Nanoparticle albumin bound paclitaxel in the treatment of human cancer: nanodelivery reaches prime-time? J Drug Deliv. Epub 2013 May 2
-
J Drug Deliv
-
-
Cucinotto, I.1
Fiorillo, L.2
Gualtieri, S.3
Arbitrio, M.4
-
20
-
-
84863849090
-
Nab-Paclitaxel potentiates gemcitabine activity by reducing cytidine deaminase levels in a mouse model of pancreatic cancer
-
Frese K, Neesse A, Cook N, Bapiro T, Lolkema M, Jodrell D, et al. Nab-Paclitaxel potentiates gemcitabine activity by reducing cytidine deaminase levels in a mouse model of pancreatic cancer. Cancer Discov. 2012;2:260.
-
(2012)
Cancer Discov
, vol.2
, pp. 260
-
-
Frese, K.1
Neesse, A.2
Cook, N.3
Bapiro, T.4
Lolkema, M.5
Jodrell, D.6
-
21
-
-
83355169753
-
Gemcitabine plus nab-paclitaxel is an active regimen in patients with advanced pancreatic cancer: A phase I/II trial
-
Von Hoff DD, Ramanathan RK, Borad MJ, Laheru DA, Smith LS, Wood TE, et al. Gemcitabine plus nab-paclitaxel is an active regimen in patients with advanced pancreatic cancer: a phase I/II trial. J Clin Oncol. 2011;29(34):4548-54.
-
(2011)
J Clin Oncol
, vol.29
, Issue.34
, pp. 4548-4554
-
-
Von Hoff, D.D.1
Ramanathan, R.K.2
Borad, M.J.3
Laheru, D.A.4
Smith, L.S.5
Wood, T.E.6
-
22
-
-
84886741654
-
Increased Survival in Pancreatic Cancerwith nab-Paclitaxel plus Gemcitabine
-
Von Hoff DD, Ervin T, Arena FP, Chiorean EG, Infante J, Moore M, et al. Increased Survival in Pancreatic Cancerwith nab-Paclitaxel plus Gemcitabine. N Engl J Med. 2013;369:1691-1703.
-
(2013)
N Engl J Med
, vol.369
, pp. 1691-1703
-
-
Von Hoff, D.D.1
Ervin, T.2
Arena, F.P.3
Chiorean, E.G.4
Infante, J.5
Moore, M.6
-
23
-
-
84901629211
-
Gemcitabine with nab-paclitaxel in neoadjuvant treatment of pancreatic adenocarcinoma: GAIN-1 study
-
Desai NV, Hughes S, Ivey A, Hochwald SN, Allegra CJ, Trevino JG, et al. Gemcitabine with nab-paclitaxel in neoadjuvant treatment of pancreatic adenocarcinoma: GAIN-1 study. ASCO Meet Abstr. 2012;30(15-suppl)):TPS4136.
-
(2012)
ASCO Meet Abstr
, vol.30
, Issue.15 SUPPL.
-
-
Desai, N.V.1
Hughes, S.2
Ivey, A.3
Hochwald, S.N.4
Allegra, C.J.5
Trevino, J.G.6
-
24
-
-
84872206732
-
Antitumor activity of nab-paclitaxel and gemcitabine in resectable pancreatic cancer
-
Alvarez-Gallego R, Cubillo A, Rodriguez-Pascual J, Quijano Y, De Vicente E, Garcia L, et al. Antitumor activity of nab-paclitaxel and gemcitabine in resectable pancreatic cancer. ASCO Meet Abstr. 2012;30(15-suppl):4040.
-
(2012)
ASCO Meet Abstr
, vol.30
, Issue.15 SUPPL.
, pp. 4040
-
-
Alvarez-Gallego, R.1
Cubillo, A.2
Rodriguez-Pascual, J.3
Quijano, Y.4
De Vicente, E.5
Garcia, L.6
-
25
-
-
34249933404
-
Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: A phase III trial of the National Cancer Institute of Canada Clinical Trials Group
-
DOI 10.1200/JCO.2006.07.9525
-
Moore MJ, Goldstein D, Hamm J, Figer A, Hecht JR, Gallinger S, et al. Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: a phase III trial of the national cancer institute of canada clinical trials group. J Clin Oncol. 2007;25(15):1960-6. (Pubitemid 46972777)
-
(2007)
Journal of Clinical Oncology
, vol.25
, Issue.15
, pp. 1960-1966
-
-
Moore, M.J.1
Goldstein, D.2
Hamm, J.3
Figer, A.4
Hecht, J.R.5
Gallinger, S.6
Au, H.J.7
Murawa, P.8
Walde, D.9
Wolff, R.A.10
Campos, D.11
Lim, R.12
Ding, K.13
Clark, G.14
Voskoglou-Nomikos, T.15
Ptasynski, M.16
Parulekar, W.17
-
26
-
-
84880830066
-
First-line erlotinib and fixed dose-rate gemcitabine for advanced pancreatic cancer
-
Vaccaro V, Bria E, Sperduti I, Gelibter A, Moscetti L, Mansueto G, et al. First-line erlotinib and fixed dose-rate gemcitabine for advanced pancreatic cancer. World J Gastroenterol. 2013;19(28):4511-9.
-
(2013)
World J Gastroenterol
, vol.19
, Issue.28
, pp. 4511-4519
-
-
Vaccaro, V.1
Bria, E.2
Sperduti, I.3
Gelibter, A.4
Moscetti, L.5
Mansueto, G.6
-
27
-
-
68949114505
-
Phase III, randomized study of gemcitabine and oxaliplatin versus gemcitabine (fixed-dose rate infusion) comparedwith gemcitabine (30-minute infusion) in patients with pancreatic carcinoma E6201: A trial of the Eastern Cooperative Oncology Group
-
Poplin E, Feng Y, Berlin J, et al. Phase III, randomized study of gemcitabine and oxaliplatin versus gemcitabine (fixed-dose rate infusion) comparedwith gemcitabine (30-minute infusion) in patients with pancreatic carcinoma E6201: a trial of the Eastern Cooperative Oncology Group. J Clin Oncol. 2009;27(23):3778-85.
-
(2009)
J Clin Oncol
, vol.27
, Issue.23
, pp. 3778-3785
-
-
Poplin, E.1
Feng, Y.2
Berlin, J.3
-
28
-
-
84901631823
-
Dose escalation to rash for erlotinib plus gemcitabine in patients with metastatic pancreatic cancer: The phase II Rachel (BO21128) study
-
Abstract O-0006
-
Van Cutsem E, Nowara E, Ciuleanu T, et al. Dose escalation to rash for erlotinib plus gemcitabine in patients with metastatic pancreatic cancer: the phase II Rachel (BO21128) study. Ann Oncol. 2012;23 suppl 4:iv5-18. Abstract O-0006.
-
(2012)
Ann Oncol
, vol.23
, Issue.SUPPL. 4
-
-
Van Cutsem, E.1
Nowara, E.2
Ciuleanu, T.3
-
29
-
-
77955066199
-
Sipuleucel-T immunotherapy for castration-resistant prostate cancer
-
Kantoff PW, Higano CS, Shore ND, Berger ER, Small EJ, Penson DF, et al. Sipuleucel-T immunotherapy for castration-resistant prostate cancer. N Engl J Med. 2010;363(5):411-22.
-
(2010)
N Engl J Med
, vol.363
, Issue.5
, pp. 411-422
-
-
Kantoff, P.W.1
Higano, C.S.2
Shore, N.D.3
Berger, E.R.4
Small, E.J.5
Penson, D.F.6
-
30
-
-
79959772576
-
Ipilimumab plus dacarbazine for previously untreated metastatic melanoma
-
MD
-
Robert C, Thomas L, Bondarenko I, O'Day SMDJW, Garbe C, Lebbe C, et al. Ipilimumab plus dacarbazine for previously untreated metastatic melanoma. N Engl J Med. 2011;364(26):2517-26.
-
(2011)
N Engl J Med
, vol.364
, Issue.26
, pp. 2517-2526
-
-
Robert, C.1
Thomas, L.2
Bondarenko, I.3
O'Day, S.4
W, J.5
Garbe, C.6
Lebbe, C.7
-
31
-
-
79953828406
-
Potential targets for pancreatic cancer immunotherapeutics
-
Dodson LF, Hawkins WG, Goedegebuure P. Potential targets for pancreatic cancer immunotherapeutics. Immunotherapy. 2011;3(4):517-37.
-
(2011)
Immunotherapy
, vol.3
, Issue.4
, pp. 517-537
-
-
Dodson, L.F.1
Hawkins, W.G.2
Goedegebuure, P.3
-
32
-
-
84901598432
-
Addition of Algenpantucel-L immunotherapy to standard adjuvant therapy for pancreatic cancer: A Phase 2 study
-
Epub November 15
-
Hardacre J, Mulcahy M, Small M, et al. Addition of Algenpantucel-L immunotherapy to standard adjuvant therapy for pancreatic cancer: a Phase 2 study. J Gastrointest Surg. 2012; Epub November 15
-
(2012)
J Gastrointest Surg
-
-
Hardacre, J.1
Mulcahy, M.2
Small, M.3
-
33
-
-
79151486551
-
A lethally irradiated allogeneic granulocyte-macrophage colony stimulating factor-secreting tumor vaccine for pancreatic adenocarcinoma. A phase II trial of safety, efficacy, and immune activation
-
Lutz E, Yeo CJ, Lillemoe KD, Biedrzycki B, Kobrin B, Herman J, et al. A lethally irradiated allogeneic granulocyte-macrophage colony stimulating factor-secreting tumor vaccine for pancreatic adenocarcinoma. A phase II trial of safety, efficacy, and immune activation. Ann Surg. 2011;253(2):328-35.
-
(2011)
Ann Surg
, vol.253
, Issue.2
, pp. 328-335
-
-
Lutz, E.1
Yeo, C.J.2
Lillemoe, K.D.3
Biedrzycki, B.4
Kobrin, B.5
Herman, J.6
-
34
-
-
84859102950
-
An international multicenter randomized controlled trial of G17DT in patients with pancreatic cancer
-
Gilliam AD, Broome P, Topuzov EG, Garin AM, Pulay I, Humphreys J, et al. An international multicenter randomized controlled trial of G17DT in patients with pancreatic cancer. Pancreas. 2012;41(3):374-9.
-
(2012)
Pancreas
, vol.41
, Issue.3
, pp. 374-379
-
-
Gilliam, A.D.1
Broome, P.2
Topuzov, E.G.3
Garin, A.M.4
Pulay, I.5
Humphreys, J.6
-
35
-
-
77956310379
-
A phase II study of personalized peptide vaccination combined with gemcitabine for non-resectable pancreatic cancer patients
-
Yanagimoto H, Shiomi H, Satoi S, Mine T, Toyokawa H, Yamamoto T, et al. A phase II study of personalized peptide vaccination combined with gemcitabine for non-resectable pancreatic cancer patients. Oncol Rep. 2010;24(3):795-801.
-
(2010)
Oncol Rep
, vol.24
, Issue.3
, pp. 795-801
-
-
Yanagimoto, H.1
Shiomi, H.2
Satoi, S.3
Mine, T.4
Toyokawa, H.5
Yamamoto, T.6
-
36
-
-
79551509386
-
Three-dimensional collagen I promotes gemcitabine resistance in pancreatic cancer through MT1-MMP-mediated expression of HMGA2
-
Dangi-Garimella S, Krantz SB, Barron MR, Shields MA, Heiferman MJ, Grippo PJ, et al. Three-dimensional collagen I promotes gemcitabine resistance in pancreatic cancer through MT1-MMP-mediated expression of HMGA2. Cancer Res. 2011;71(3):1019-28.
-
(2011)
Cancer Res
, vol.71
, Issue.3
, pp. 1019-1028
-
-
Dangi-Garimella, S.1
Krantz, S.B.2
Barron, M.R.3
Shields, M.A.4
Heiferman, M.J.5
Grippo, P.J.6
-
37
-
-
53549118325
-
Pancreatic stellate cells role in pancreas cancer
-
Bachem MG, Zhou S, Buck K, Schneiderhan W, Siech M. Pancreatic stellate cells role in pancreas cancer. Langenbecks Arch Surg. 2008;393(6):891-900.
-
(2008)
Langenbecks Arch Surg
, vol.393
, Issue.6
, pp. 891-900
-
-
Bachem, M.G.1
Zhou, S.2
Buck, K.3
Schneiderhan, W.4
Siech, M.5
-
38
-
-
0035424135
-
Marimastat as first-line therapy for patients with unresectable pancreatic cancer: A randomized trial
-
Bramhall SR, Rosemurgy A, Brown PD, Bowry C, Buckels JA, Marimastat Pancreatic Cancer Study Group. Marimastat as first-line therapy for patients with unresectable pancreatic cancer: a randomized trial. J Clin Oncol. 2001;19(15):3447-55. (Pubitemid 32730080)
-
(2001)
Journal of Clinical Oncology
, vol.19
, Issue.15
, pp. 3447-3455
-
-
Bramhall, S.R.1
Rosemurgy, A.2
Brown, P.D.3
Bowry, C.4
Buckles, J.A.C.5
-
39
-
-
32944478346
-
Phase II trial of bevacizumab plus gemcitabine in patients with advanced pancreatic cancer
-
DOI 10.1200/JCO.2005.01.9661
-
Kindler HL, Friberg G, Singh DA, Locker G, Nattam S, Kozloff M, et al. Phase II trial of bevacizumab plus gemcitabine in patients with advanced pancreatic cancer. J Clin Oncol. 2005;23(31):8033-40. (Pubitemid 46657405)
-
(2005)
Journal of Clinical Oncology
, vol.23
, Issue.31
, pp. 8033-8040
-
-
Kindler, H.L.1
Friberg, G.2
Singh, D.A.3
Locker, G.4
Nattam, S.5
Kozloff, M.6
Taber, D.A.7
Karrison, T.8
Dachman, A.9
Stadler, W.M.10
Vokes, E.E.11
-
40
-
-
84856547073
-
Gemcitabine plus sorafenib in patients with advanced pancreatic cancer: A phase II trial of the university of chicago phase II consortium
-
Kindler HL,Wroblewski K,Wallace JA, HallMJ, Locker G, Nattam S, et al. Gemcitabine plus sorafenib in patients with advanced pancreatic cancer: a phase II trial of the university of chicago phase II consortium. Invest New Drugs. 2012;30(1):382-6.
-
(2012)
Invest New Drugs
, vol.30
, Issue.1
, pp. 382-386
-
-
Kindler, H.L.1
Wroblewski, K.2
Wallace, J.A.3
Hall, M.J.4
Locker, G.5
Nattam, S.6
-
41
-
-
77953048032
-
Safety and activity of masitinib in combination with gemcitabine in patients with advanced pancreatic cancer
-
Mitry E, Hammel P, Deplanque G, Mornex F, Levy P, Seitz JF, et al. Safety and activity of masitinib in combination with gemcitabine in patients with advanced pancreatic cancer. Cancer Chemother Pharmacol. 2010;66(2):395-403.
-
(2010)
Cancer Chemother Pharmacol
, vol.66
, Issue.2
, pp. 395-403
-
-
Mitry, E.1
Hammel, P.2
Deplanque, G.3
Mornex, F.4
Levy, P.5
Seitz, J.F.6
-
42
-
-
84901616590
-
Masitinib in nonresectable pancreatic cancer: Results of a phase III randomized placebo-controlled trial
-
abstr 158
-
Deplanque G, Hebbar M, Flynn P, et al. Masitinib in nonresectable pancreatic cancer: results of a phase III randomized placebo-controlled trial. J Clin Oncol. 2012;30(suppl 34; abstr 158):2013.
-
(2012)
J Clin Oncol
, vol.30
, Issue.SUPPL. 34
, pp. 2013
-
-
Deplanque, G.1
Hebbar, M.2
Flynn, P.3
-
43
-
-
84859402436
-
Phase I study of rigosertib, an inhibitor of the phosphatidylinositol 3-kinase and polo-like kinase 1 pathways, combined with gemcitabine in patients with solid tumors and pancreatic cancer
-
Ma WW, Messersmith WA, Dy GK, Weekes CD, Whitworth A, Ren C, et al. Phase I study of rigosertib, an inhibitor of the phosphatidylinositol 3-kinase and polo-like kinase 1 pathways, combined with gemcitabine in patients with solid tumors and pancreatic cancer. Clin Cancer Res. 2012;18(7):2048-55.
-
(2012)
Clin Cancer Res
, vol.18
, Issue.7
, pp. 2048-2055
-
-
Ma, W.W.1
Messersmith, W.A.2
Dy, G.K.3
Weekes, C.D.4
Whitworth, A.5
Ren, C.6
-
44
-
-
84864528071
-
Final results of a phase I/II study in patients with pancreatic cancer, malignant melanoma, and colorectal carcinoma with trabedersen
-
abstr 4034
-
Oettle H, Seufferlein T, Luger T, Schmid RM, von Wichert G, Endlicher E, Garbe C, Kaehler KK, Enk A, Schneider A, Rothhammer-Hampl T, Grosser S, et al. Final results of a phase I/II study in patients with pancreatic cancer, malignant melanoma, and colorectal carcinoma with trabedersen. J Clin Oncol. 2012;30(suppl; abstr 4034)
-
(2012)
J Clin Oncol
, vol.30
, Issue.SUPPL.
-
-
Oettle, H.1
Seufferlein, T.2
Luger, T.3
Schmid, R.M.4
Von Wichert, G.5
Endlicher, E.6
Garbe, C.7
Kaehler, K.K.8
Enk, A.9
Schneider, A.10
Rothhammer-Hampl, T.11
Grosser, S.12
-
45
-
-
79551600015
-
Targeting cancer stem cells by inhibiting wnt, notch, and hedgehog pathways
-
Takebe N, Harris PJ,Warren RQ, Ivy SP. Targeting cancer stem cells by inhibiting wnt, notch, and hedgehog pathways. Nat Rev Clin Oncol. 2011;8(2):97-106.
-
(2011)
Nat Rev Clin Oncol
, vol.8
, Issue.2
, pp. 97-106
-
-
Takebe, N.1
Harris, P.J.2
Warren, R.Q.3
Ivy, S.P.4
-
46
-
-
84871222892
-
A phase ib trial of FOLFIRINOX plus saridegib, an oral hedgehog (hh) inhibitor, in pts with advanced pancreatic cancer (PDAC)
-
Ko AH, LoConte NK, Kantoff E, Ross RW, Trehu EG, Tempero MA, et al. A phase ib trial of FOLFIRINOX plus saridegib, an oral hedgehog (hh) inhibitor, in pts with advanced pancreatic cancer (PDAC). ASCO Meet Abstr. 2012;30(15-suppl):3105.
-
(2012)
ASCO Meet Abstr
, vol.30
, Issue.15 SUPPL.
, pp. 3105
-
-
Ko, A.H.1
LoConte, N.K.2
Kantoff, E.3
Ross, R.W.4
Trehu, E.G.5
Tempero, M.A.6
-
47
-
-
84864018642
-
Phase I study of RO4929097, a gamma secretase inhibitor of Notch signaling, in patients with refractory metastatic or locally advanced solid tumors
-
Tolcher AW, Messersmith WA, Mikulski SM, et al. Phase I study of RO4929097, a gamma secretase inhibitor of Notch signaling, in patients with refractory metastatic or locally advanced solid tumors. J Clin Oncol. 2012;30:2348-53.
-
(2012)
J Clin Oncol
, vol.30
, pp. 2348-2353
-
-
Tolcher, A.W.1
Messersmith, W.A.2
Mikulski, S.M.3
-
48
-
-
84864005118
-
Phase I pharmacologic and pharmacodynamic study of the gamma secretase (Notch) inhibitor MK-0752 in adult patients with advanced solid tumors
-
Krop I, Demuth T, Guthrie T, et al. Phase I pharmacologic and pharmacodynamic study of the gamma secretase (Notch) inhibitor MK-0752 in adult patients with advanced solid tumors. J Clin Oncol. 2012;30:2307-13.
-
(2012)
J Clin Oncol
, vol.30
, pp. 2307-2313
-
-
Krop, I.1
Demuth, T.2
Guthrie, T.3
-
49
-
-
0026324378
-
Reported family aggregation of pancreatic cancer within a population-based case-control study in the Francophone community in Montreal Canada
-
Ghadirian P, Boyle P, Simard A, Baillargeon J, Maisonneuve P, Perret C. Reported family aggregation of pancreatic cancer within a population-based case-control study in the Francophone community in Montreal Canada. Int J Pancreatol. 1991;10(3-4):183-96.
-
(1991)
Int J Pancreatol
, vol.10
, Issue.3-4
, pp. 183-196
-
-
Ghadirian, P.1
Boyle, P.2
Simard, A.3
Baillargeon, J.4
Maisonneuve, P.5
Perret, C.6
-
50
-
-
16044366171
-
Frequency of recurrent BRCA1 and BRCA2 mutations in Ashkenazi Jewish breast cancer families
-
DOI 10.1038/nm1196-1179
-
Tonin P, Weber B, Offit K, et al. Frequency of recurrent BRCA1 and BRCA2 mutations in Ashkenazi Jewish breast cancer families. Nat Med. 1996;2(11):1179-83. (Pubitemid 26375392)
-
(1996)
Nature Medicine
, vol.2
, Issue.11
, pp. 1179-1183
-
-
Tonin, P.1
Weber, B.2
Offit, K.3
Couch, F.4
Rebbeck, T.R.5
Neuhausen, S.6
Godwin, A.K.7
Daly, M.8
Wagner-Costalos, J.9
Berman, D.10
Grana, G.11
Fox, E.12
Kane, M.F.13
Kolodner, R.D.14
Krainer, M.15
Haber, D.A.16
Struewing, J.P.17
Warner, E.18
Rosen, B.19
-
51
-
-
77956139057
-
Update on familial pancreatic cancer
-
Hruban RH, CantoMI, GogginsM, Schulick R, Klein AP. Update on familial pancreatic cancer. Adv Surg. 2010;44:293-311.
-
(2010)
Adv Surg
, vol.44
, pp. 293-311
-
-
Hruban, R.H.1
Canto, M.I.2
Goggins, M.3
Schulick, R.4
Klein, A.P.5
-
52
-
-
45749088199
-
Response to a third-line mitomycin C (MMC)-based chemotherapy in a patient with metastatic pancreatic adenocarcinoma carrying germline BRCA2 mutation
-
Chalasani P, Kurtin S, Dragovich T. Response to a third-line mitomycin C (MMC)-based chemotherapy in a patient with metastatic pancreatic adenocarcinoma carrying germline BRCA2 mutation. JOP. 2008;9(3):305-8. (Pubitemid 351864891)
-
(2008)
Journal of the Pancreas
, vol.9
, Issue.3
, pp. 305-308
-
-
Chalasani, P.1
Kurtin, S.2
Dragovich, T.3
-
53
-
-
84875049769
-
A phase I/II study of ABT-888 in combination with 5-fluorouracil (5-FU) and oxaliplatin (Ox) in patients with metastatic pancreatic cancer (MPC)
-
Pishvaian MJ, Wang H, Zhuang T, et al. A phase I/II study of ABT-888 in combination with 5-fluorouracil (5-FU) and oxaliplatin (Ox) in patients with metastatic pancreatic cancer (MPC). ASCO Meet Abstr. 2013;31(4-suppl):147.
-
(2013)
ASCO Meet Abstr
, vol.31
, Issue.4 SUPPL.
, pp. 147
-
-
Pishvaian, M.J.1
Wang, H.2
Zhuang, T.3
-
54
-
-
84880051282
-
Olaparib monotherapy in patients with advanced cancer and a germ-line BRCA1/2 mutation: An open-label phase II study
-
Kaufman B, Shapira-Frommer R, Schmutzler RK, et al. Olaparib monotherapy in patients with advanced cancer and a germ-line BRCA1/2 mutation: an open-label phase II study. ASCO Meet Abstr. 2013;31(15-suppl):11024.
-
(2013)
ASCO Meet Abstr
, vol.31
, Issue.15 SUPPL.
, pp. 11024
-
-
Kaufman, B.1
Shapira-Frommer, R.2
Schmutzler, R.K.3
-
55
-
-
84867081102
-
A multinational phase II study of PEP02 (liposome irinotecan) for patients with gemcitabine-refractory metastatic pancreatic cancer
-
Ko AH, Tempero MA, Shan Y, Su W, Lin Y, Dito E, et al. A multinational phase II study of PEP02 (liposome irinotecan) for patients with gemcitabine-refractory metastatic pancreatic cancer. ASCO Meet Abstr. 2011;29(15-suppl):4069.
-
(2011)
ASCO Meet Abstr
, vol.29
, Issue.15 SUPPL.
, pp. 4069
-
-
Ko, A.H.1
Tempero, M.A.2
Shan, Y.3
Su, W.4
Lin, Y.5
Dito, E.6
-
56
-
-
84862290986
-
Randomized phase II study of gemcitabine and S-1 combination versus gemcitabine alone in the treatment of unresectable advanced pancreatic cancer (Japan clinical cancer research organization PC-01 study)
-
Ozaka M, Matsumura Y, Ishii H, Omuro Y, Itoi T, Mouri H, et al. Randomized phase II study of gemcitabine and S-1 combination versus gemcitabine alone in the treatment of unresectable advanced pancreatic cancer (Japan clinical cancer research organization PC-01 study). Cancer Chemother Pharmacol. 2012;69(5):1197-204.
-
(2012)
Cancer Chemother Pharmacol
, vol.69
, Issue.5
, pp. 1197-1204
-
-
Ozaka, M.1
Matsumura, Y.2
Ishii, H.3
Omuro, Y.4
Itoi, T.5
Mouri, H.6
-
57
-
-
84880073605
-
Randomized phase III trial of adjuvant chemotherapy with gemcitabine versus S-1 for patients with resected pancreatic cancer
-
Fukutomi A, Uesaka K, Boku N, et al. Randomized phase III trial of adjuvant chemotherapy with gemcitabine versus S-1 for patients with resected pancreatic cancer. J Clin Oncol. 2013;31(15-suppl):4008.
-
(2013)
J Clin Oncol
, vol.31
, Issue.15 SUPPL.
, pp. 4008
-
-
Fukutomi, A.1
Uesaka, K.2
Boku, N.3
-
58
-
-
84855858767
-
Phase I evaluation of intravenous ascorbic acid in combination with gemcitabine and erlotinib in patients with metastatic pancreatic cancer
-
Epub 2012 Jan 17
-
Monti D, Mitchell E, Bazzan A, Littman S, Zabrecky G, Yeo C, et al. Phase I evaluation of intravenous ascorbic acid in combination with gemcitabine and erlotinib in patients with metastatic pancreatic cancer. PLoS One. 2012;7(1):e29794. Epub 2012 Jan 17.
-
(2012)
PLoS One
, vol.7
, Issue.1
-
-
Monti, D.1
Mitchell, E.2
Bazzan, A.3
Littman, S.4
Zabrecky, G.5
Yeo, C.6
-
59
-
-
84875857303
-
Pharmacological ascorbate with gemcitabine for the control of metastatic and node-positive pancreatic cancer (PACMAN): Results from a phase I clinical trial
-
Welsh J, Wagner B, van't Erve T, et al. Pharmacological ascorbate with gemcitabine for the control of metastatic and node-positive pancreatic cancer (PACMAN): results from a phase I clinical trial. Cancer Chemother Pharmacol. 2013;71(3):765-75.
-
(2013)
Cancer Chemother Pharmacol
, vol.71
, Issue.3
, pp. 765-775
-
-
Welsh, J.1
Wagner, B.2
Van'T Erve, T.3
-
60
-
-
77955887676
-
Gemcitabine plus bevacizumab compared with gemcitabine plus placebo in patients with advanced pancreatic cancer: Phase III trial of the Cancer and Leukemia Group B (CALGB 80303)
-
Kindler HL, Niedzwiecki D, Hollis D, et al. Gemcitabine plus bevacizumab compared with gemcitabine plus placebo in patients with advanced pancreatic cancer: phase III trial of the Cancer and Leukemia Group B (CALGB 80303). J Clin Oncol. 2010;28(22):3617-22.
-
(2010)
J Clin Oncol
, vol.28
, Issue.22
, pp. 3617-3622
-
-
Kindler, H.L.1
Niedzwiecki, D.2
Hollis, D.3
-
61
-
-
84886095861
-
Phase II study of induction fixed-dose rate gemcitabine and bevacizumab followed by 30 Gy radiotherapy as preoperative treatment for potentially resectable pancreatic adenocarcinoma
-
Epub ahead of print Aug 1
-
Van Buren G 2nd, Ramanathan RK, Krasinskas AM, et al. Phase II study of induction fixed-dose rate gemcitabine and bevacizumab followed by 30 Gy radiotherapy as preoperative treatment for potentially resectable pancreatic adenocarcinoma. Ann Surg Oncol. 2013;Epub ahead of print Aug 1
-
(2013)
Ann Surg Oncol
-
-
Van Buren II, G.1
Ramanathan, R.K.2
Krasinskas, A.M.3
-
62
-
-
45449090215
-
Efficacy of gemcitabine plus axitinib compared with gemcitabine alone in patients with advanced pancreatic cancer: An open-label randomised phase II study
-
Spano JP, Chodkiewicz C, Maurel J, Wong R, Wasan H, Barone C, et al. Efficacy of gemcitabine plus axitinib compared with gemcitabine alone in patients with advanced pancreatic cancer: an open-label randomised phase II study. Lancet. 2008;371(9630):2101-8.
-
(2008)
Lancet
, vol.371
, Issue.9630
, pp. 2101-2108
-
-
Spano, J.P.1
Chodkiewicz, C.2
Maurel, J.3
Wong, R.4
Wasan, H.5
Barone, C.6
-
63
-
-
79952036599
-
Axitinib plus gemcitabine versus placebo plus gemcitabine in patients with advanced pancreatic adenocarcinoma: A double-blind randomised phase 3 study
-
Kindler HL, Ioka T, Richel DJ, Bennouna J, Letourneau R, Okusaka T, et al. Axitinib plus gemcitabine versus placebo plus gemcitabine in patients with advanced pancreatic adenocarcinoma: a double-blind randomised phase 3 study. Lancet Oncol. 2011;12(3):256-62.
-
(2011)
Lancet Oncol
, vol.12
, Issue.3
, pp. 256-262
-
-
Kindler, H.L.1
Ioka, T.2
Richel, D.J.3
Bennouna, J.4
Letourneau, R.5
Okusaka, T.6
-
64
-
-
77955914277
-
Phase III study comparing gemcitabine plus cetuximab versus gemcitabine in patients with advanced pancreatic adenocarcinoma: Southwest oncology group-directed intergroup trial S0205
-
Philip PA, Benedetti J, Corless CL,Wong R, O'Reilly EM, Flynn PJ, et al. Phase III study comparing gemcitabine plus cetuximab versus gemcitabine in patients with advanced pancreatic adenocarcinoma: southwest oncology group-directed intergroup trial S0205. J Clin Oncol. 2010;28(22):3605-10.
-
(2010)
J Clin Oncol
, vol.28
, Issue.22
, pp. 3605-3610
-
-
Philip, P.A.1
Benedetti, J.2
Corless, C.L.3
Wong, R.4
O'Reilly, E.M.5
Flynn, P.J.6
-
65
-
-
4344590997
-
Cetuximab, a monoclonal antibody targeting the epidermal growth factor receptor, in combination with gemcitabine for advanced pancreatic cancer: A multicenter phase II trial
-
DOI 10.1200/JCO.2004.12.040
-
Xiong H, Rosenberg A, LoBuglio A, Schmidt W, Wolff R, Deutsch J, et al. Cetuximab, a monoclonal antibody targeting the epidermal growth factor receptor, in combination with gemcitabine for advanced pancreatic cancer: a multicenter phase II Trial. J Clin Oncol. 2004;22(13):2610-6. (Pubitemid 41103748)
-
(2004)
Journal of Clinical Oncology
, vol.22
, Issue.13
, pp. 2610-2616
-
-
Xiong, H.Q.1
Rosenberg, A.2
LoBuglio, A.3
Schmidt, W.4
Wolff, R.A.5
Deutsch, J.6
Needle, M.7
Abbruzzese, J.L.8
-
66
-
-
84884721540
-
Multicenter phase II trial to investigate safety and efficacy of gemcitabine combined with cetuximab as adjuvant therapy in pancreatic cancer (ATIP)
-
Epub ahead of print Jul 29
-
Fensterer H, Schade-Brittinger C, Müller HH, et al. Multicenter phase II trial to investigate safety and efficacy of gemcitabine combined with cetuximab as adjuvant therapy in pancreatic cancer (ATIP). Ann Oncol. 2013; Epub ahead of print Jul 29.
-
(2013)
Ann Oncol
-
-
Fensterer, H.1
Schade-Brittinger, C.2
Müller, H.H.3
-
67
-
-
84863319601
-
Epidermal growth factor receptor and insulinlike growth factor 1 receptor expression predict poor survival in pancreatic ductal adenocarcinoma
-
Valsecchi ME, McDonald M, Brody JR, Hyslop T, Freydin B, Yeo CJ, et al. Epidermal growth factor receptor and insulinlike growth factor 1 receptor expression predict poor survival in pancreatic ductal adenocarcinoma. Cancer. 2012;118(14):3484-93.
-
(2012)
Cancer
, vol.118
, Issue.14
, pp. 3484-3493
-
-
Valsecchi, M.E.1
McDonald, M.2
Brody, J.R.3
Hyslop, T.4
Freydin, B.5
Yeo, C.J.6
-
68
-
-
80052886108
-
Emerging pathways and future targets for the molecular therapy of pancreatic cancer
-
Vaccaro V, Melisi D, Bria E, Cuppone F, Ciuffreda L, Pino MS, et al. Emerging pathways and future targets for the molecular therapy of pancreatic cancer. Expert Opin Ther Targets. 2011;15(10):1183-96.
-
(2011)
Expert Opin Ther Targets
, vol.15
, Issue.10
, pp. 1183-1196
-
-
Vaccaro, V.1
Melisi, D.2
Bria, E.3
Cuppone, F.4
Ciuffreda, L.5
Pino, M.S.6
-
69
-
-
84862531853
-
A randomized, placebo-controlled phase 2 study of ganitumab (AMG 479) or conatumumab (AMG 655) in combination with gemcitabine in patients with metastatic pancreatic cancer
-
Kindler HL, Richards DA, Garbo LE, Garon EB, Stephenson Jr JJ, Rocha-Lima CM, et al. A randomized, placebo-controlled phase 2 study of ganitumab (AMG 479) or conatumumab (AMG 655) in combination with gemcitabine in patients with metastatic pancreatic cancer. Ann Oncol. 2012;23(11):2834-42.
-
(2012)
Ann Oncol
, vol.23
, Issue.11
, pp. 2834-2842
-
-
Kindler, H.L.1
Richards, D.A.2
Garbo, L.E.3
Garon, E.B.4
Stephenson Jr., J.J.5
Rocha-Lima, C.M.6
-
70
-
-
84858671578
-
Phase I randomized phase II trial of gemcitabine, erlotinib, and cixutumumab versus gemcitabine plus erlotinib as first-line treatment in patients with metastatic pancreatic cancer (SWOG-0727)
-
Philip PA, Goldman BH, Ramanathan RK, et al. Phase I randomized phase II trial of gemcitabine, erlotinib, and cixutumumab versus gemcitabine plus erlotinib as first-line treatment in patients with metastatic pancreatic cancer (SWOG-0727). ASCO Meet Abstr. 2012;30(4-suppl):198.
-
(2012)
ASCO Meet Abstr
, vol.30
, Issue.4 SUPPL.
, pp. 198
-
-
Philip, P.A.1
Goldman, B.H.2
Ramanathan, R.K.3
-
71
-
-
84862520041
-
A multicenter, randomized, controlled study of CO-1.01 versus gemcitabine in patients with metastatic pancreatic ductal adenocarcinoma (mPDAC) and low tumor expression of human equilibrative nucleoside transporter-1 (hENT1) determined by metastasis biopsy
-
Ikdahl T, Davidenko I, Bassi C, Tomasetto E, Smith L,McLachlan S, et al. A multicenter, randomized, controlled study of CO-1.01 versus gemcitabine in patients with metastatic pancreatic ductal adenocarcinoma (mPDAC) and low tumor expression of human equilibrative nucleoside transporter-1 (hENT1) determined by metastasis biopsy. ASCO Meet Abstr. 2011;29(15-suppl):TPS144.
-
(2011)
ASCO Meet Abstr
, vol.29
, Issue.15 SUPPL.
-
-
Ikdahl, T.1
Davidenko, I.2
Bassi, C.3
Tomasetto, E.4
Smith, L.5
McLachlan, S.6
|